Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro

Toxicology and Applied Pharmacology

Volumn 238, Issue 1, 2009, Pages 64-70

  Zhang, Dan ^a   Hu, Xiaoming ^a   Qian, Li ^a,b   Wilson, Belinda ^a   Lee, Christopher ^a   Flood, Patrick ^b   Langenbach, Robert ^a   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Astrocyte; Cyclooxygenase 2; LPS; Microglia; Prostaglandin E2

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; ASTROCYTOMA; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIOMA; IN VITRO STUDY; MICROGLIA; MOUSE; NONHUMAN; PROSTAGLANDIN RELEASE; RAT;

ANIMALS; ASTROCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; PROSTAGLANDIN ANTAGONISTS; RATS; RATS, INBRED F344; THIOPHENES; XANTHONES;

EID: 67349196783     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.015     Document Type: Article

References (55)

1. Balasingam V., and Yong V.W. Attenuation of astroglial reactivity by interleukin-10. J. Neurosci. 16 (1996) 2945-2955
2. Balasingam V., Tejada-Berges T., Wright E., Bouckova R., and Yong V.W. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J. Neurosci. 14 (1994) 846-856
3. Barbeito L.H., Pehar M., Cassina P., Vargas M.R., Peluffo H., Viera L., Estevez A.G., and Beckman J.S. A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res. Brain Res. Rev. 47 (2004) 263-274
4. Barna B.P., Estes M.L., Jacobs B.S., Hudson S., and Ransohoff R.M. Human astrocytes proliferate in response to tumor necrosis factor alpha. J. Neuroimmunol. 30 (1990) 239-243
5. Cardenas H., and Bolin L.M. Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain Res. 985 (2003) 89-97
6. Cernak I., Stoica B., Byrnes K.R., Di Giovanni S., and Faden A.I. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 4 (2005) 1286-1293
7. Douhou A., Debeir T., Michel P.P., Stankovski L., Oueghlani-Bouslama L., Verney C., and Raisman-Vozari R. Differential activation of astrocytes and microglia during post-natal development of dopaminergic neuronal death in the weaver mouse. Brain Res. Dev. Brain Res. 145 (2003) 9-17
8. Giglio P., and Levin V. Cyclooxygenase-2 inhibitors in glioma therapy. Am. J. Ther. 11 (2004) 141-143
9. Glodny B., and Pauli G.F. The vasodepressor function of the kidney: prostaglandin E2 is not the principal vasodepressor lipid of the renal medulla. Acta Physiol. (Oxf) 187 (2006) 419-430
10. Graeber M.B., Scheithauer B.W., and Kreutzberg G.W. Microglia in brain tumors. Glia 40 (2002) 252-259
11. Griswold D.E., and Adams J.L. Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date. Med. Res. Rev. 16 (1996) 181-206
12. Gunther A., Kuppers-Tiedt L., Schneider P.M., Kunert I., Berrouschot J., Schneider D., and Rossner S. Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur. J. Neurosci. 21 (2005) 3189-3194
13. Haga S., Haga C., Aizawa T., and Ikeda K. Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat. Acta Neuropathol. 103 (2002) 575-582
14. Hata A.N., and Breyer R.M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103 (2004) 147-166
15. Herber D.L., Maloney J.L., Roth L.M., Freeman M.J., Morgan D., and Gordon M.N. Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia 53 (2006) 382-391
16. Herx L.M., and Yong V.W. Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J. Neuropathol. Exp. Neurol. 60 (2001) 961-971
17. Hirsch E.C., Breidert T., Rousselet E., Hunot S., Hartmann A., and Michel P.P. The role of glial reaction and inflammation in Parkinson's disease. Ann. N. Y. Acad. Sci. 991 (2003) 214-228
18. Hori T., Oka T., Hosoi M., and Aou S. Pain modulatory actions of cytokines and prostaglandin E2 in the brain. Ann. N. Y. Acad. Sci. 840 (1998) 269-281
19. Iravani M.M., Leung C.C., Sadeghian M., Haddon C.O., Rose S., and Jenner P. The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation. Eur. J. Neurosci. 22 (2005) 317-330
20. Joki T., Heese O., Nikas D.C., Bello L., Zhang J., Kraeft S.K., Seyfried N.T., Abe T., Chen L.B., Carroll R.S., and Black P.M. Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res. 60 (2000) 4926-4931
21. Kiriyama M., Ushikubi F., Kobayashi T., Hirata M., Sugimoto Y., and Narumiya S. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122 (1997) 217-224
22. Langenbach R., Loftin C., Lee C., and Tiano H. Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. Biochem. Pharmacol. 58 (1999) 1237-1246
23. Lee S.C., Dickson D.W., and Brosnan C.F. Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav. Immun. 9 (1995) 345-354
24. Liu Y., Qin L., Li G., Zhang W., An L., Liu B., and Hong J.S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J. Pharmacol. Exp. Ther. 305 (2003) 212-218
25. Loh J.K., Hwang S.L., Lieu A.S., Huang T.Y., and Howng S.L. The alteration of prostaglandin E2 levels in patients with brain tumors before and after tumor removal. J. Neuro-oncol. 57 (2002) 147-150
26. Lukas R.V., Boire A., and Nicholas M.K. Emerging therapies for malignant glioma. Expert Rev. Anticancer Ther. 7 (2007) S29-36
27. Miller J.M., and McAllister II J.P. Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus. Cerebrospinal. Fluid. Res. 4 5 (2007)
28. Mohri I., Taniike M., Taniguchi H., Kanekiyo T., Aritake K., Inui T., Fukumoto N., Eguchi N., Kushi A., Sasai H., Kanaoka Y., Ozono K., Narumiya S., Suzuki K., and Urade Y. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J. Neurosci. 26 (2006) 4383-4393
29. Murakami M., and Kudo I. Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog. Lipid Res. 43 (2004) 3-35
30. Murphy Jr. G.M., Lee Y.L., Jia X.C., Yu A.C., Majewska A., Song Y., Schmidt K., and Eng L.F. Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J. Neurochem. 65 (1995) 2716-2724
31. Neary J.T., Rathbone M.P., Cattabeni F., Abbracchio M.P., and Burnstock G. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 19 (1996) 13-18
32. New P. Cyclooxygenase in the treatment of glioma: its complex role in signal transduction. Cancer Control 11 (2004) 152-164
33. Noble M., and Mayer-Proschel M. Growth factors, glia and gliomas. J. Neuro-oncol. 35 (1997) 193-209
34. O, Callaghan J.P., and Sriram K. Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin. Drug Saf. 4 (2005) 433-442
35. Office of Laboratory Animal Welfare. Public Health Services Policy on Humane Care and Use of Laboratory Animals (2002), Office of Laboratory Animal Welfare, Bethesda, MD
36. Oh Y.J., Markelonis G.J., and Oh T.H. Effects of interleukin-1 beta and tumor necrosis factor-alpha on the expression of glial fibrillary acidic protein and transferrin in cultured astrocytes. Glia 8 (1993) 77-86
37. Oksenberg J.R., Seboun E., and Hauser S.L. Genetics of demyelinating diseases. Brain Pathol. 6 (1996) 289-302
38. Park J.Y., Pillinger M.H., and Abramson S.B. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin. Immunol. 119 (2006) 229-240
39. Pehar M., Vargas M.R., Cassina P., Barbeito A.G., Beckman J.S., and Barbeito L. Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis. Neurodegener. Dis. 2 (2005) 139-146
40. Penkowa M., Poulsen C., Carrasco J., and Hidalgo J. M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment. Exp. Neurol. 176 (2002) 308-321
41. Ridet J.L., Malhotra S.K., Privat A., and Gage F.H. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20 (1997) 570-577
42. Rohl C., Lucius R., and Sievers J. The effect of activated microglia on astrogliosis parameters in astrocyte cultures. Brain Res. 1129 (2007) 43-52
43. Salgaller M.L., and Liau L.M. Current status of clinical trials for glioblastoma. Rev. Recent. Clin. Trials. 1 (2006) 265-281
44. Selmaj K., Shafit-Zagardo B., Aquino D.A., Farooq M., Raine C.S., Norton W.T., and Brosnan C.F. Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J. Neurochem. 57 (1991) 823-830
45. Shapiro J.R. Genetics of brain neoplasms. Curr. Neurol. Neurosci. Rep. 1 (2001) 217-224
46. Takemiya T., Matsumura K., and Yamagata K. Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem. Int. 51 (2007) 112-120
47. Terlain B., Jouzeau J.Y., Gillet P., Lecompte T., and Netter P. [Inducible cyclooxygenase. New relationships between non-steroidal anti-inflammatory agents and inhibition of synthesis of prostaglandins]. Presse Med. 24 (1995) 491-496
48. Tian D.S., Dong Q., Pan D.J., He Y., Yu Z.Y., Xie M.J., and Wang W. Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Brain Res. 1154 (2007) 206-214
49. Tilleux S., Berger J., and Hermans E. Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. J. Neuroimmunol. 189 (2007) 23-30
50. Watters J.J., Schartner J.M., and Badie B. Microglia function in brain tumors. J. Neurosci. Res. 81 (2005) 447-455
51. Widmer M., Hanemann C.O., and Zajicek J. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J. Neurosci. Res. (2008)
52. Wierzba-Bobrowicz T., Kuchna I., and Matyja E. Reaction of microglial cells in human astrocytomas (preliminary report). Folia Neuropathol. 32 (1994) 251-252
53. Yang S., Zhang D., Yang Z., Hu X., Qian S., Liu J., Wilson B., Block M., and Hong J.S. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem. Res. 33 (2008) 2044-2053
54. Zacharieva S., Atanassova I., Orbetzova M., Kirilov G., Nachev E., Kalinov K., and Shigarminova R. Vascular endothelial growth factor (VEGF), prostaglandin E2(PGE2) and active renin in hypertension of adrenal origin. J. Endocrinol. Invest. 27 (2004) 742-746
55. Zhang D., Hu X., Wei S.J., Liu J., Gao H., Qian L., Wilson B., Liu G., and Hong J.S. Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity. J. Neuroinflammation 5 21 (2008)