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Volumn 18, Issue 10, 2005, Pages 623-629

Potential therapeutic targets in the NF-κB pathway for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BMS 345541; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; I KAPPA B; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PS 1145; SPC 839; THALIDOMIDE; UNCLASSIFIED DRUG;

EID: 33645046630     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2005.18.10.959576     Document Type: Review
Times cited : (34)

References (49)
  • 2
    • 0002595552 scopus 로고
    • Chapter 4 - The first stage of perception: Growth and assembly
    • Wiley: New York
    • Hebb, D.O. Chapter 4 - The first stage of perception: growth and assembly. In: The Organization of Behavior. Wiley: New York 1949.
    • (1949) The Organization of Behavior
    • Hebb, D.O.1
  • 3
    • 0036792096 scopus 로고    scopus 로고
    • Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling
    • Vitolo, O.V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O. and Shelanski, M. Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A 2002, 99: 13217-21.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13217-13221
    • Vitolo, O.V.1    Sant'Angelo, A.2    Costanzo, V.3    Battaglia, F.4    Arancio, O.5    Shelanski, M.6
  • 4
    • 0028898888 scopus 로고
    • Mechanisms of synaptic dysfunction in Alzheimer's disease
    • Masliah, E. Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 1995, 10: 509-19.
    • (1995) Histol Histopathol , vol.10 , pp. 509-519
    • Masliah, E.1
  • 5
    • 0030460740 scopus 로고    scopus 로고
    • Cognitive and neurobiologic markers of early Alzheimer disease
    • Albert, M.S. Cognitive and neurobiologic markers of early Alzheimer disease. Proc Natl Acad Sci U S A 1996, 93: 13547-51.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13547-13551
    • Albert, M.S.1
  • 6
    • 0030460739 scopus 로고    scopus 로고
    • Regional and cellular fractionation of working memory
    • Goldman-Rakic, P.S. Regional and cellular fractionation of working memory. Proc Natl Acad Sci U S A 1996, 93: 13473-80.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13473-13480
    • Goldman-Rakic, P.S.1
  • 7
    • 0033899864 scopus 로고    scopus 로고
    • Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease
    • Mukaetova-Ladinska, E.B., Garcia-Siera, F., Hurt, J. et al. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. Am J Pathol 2000, 157: 623-36.
    • (2000) Am J Pathol , vol.157 , pp. 623-636
    • Mukaetova-Ladinska, E.B.1    Garcia-Siera, F.2    Hurt, J.3
  • 8
    • 2142809686 scopus 로고    scopus 로고
    • Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory
    • Yeh, S.H., Lin, C.H. and Gean, P.W. Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory. Mol Pharmacol 2004, 65: 1286-92.
    • (2004) Mol Pharmacol , vol.65 , pp. 1286-1292
    • Yeh, S.H.1    Lin, C.H.2    Gean, P.W.3
  • 9
    • 0033989375 scopus 로고    scopus 로고
    • Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity
    • Albensi, B.C. and Mattson, M.P. Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity. Synapse 2000, 35: 151-9.
    • (2000) Synapse , vol.35 , pp. 151-159
    • Albensi, B.C.1    Mattson, M.P.2
  • 11
    • 0036828992 scopus 로고    scopus 로고
    • Memory enhancement: The search for mechanism-based drugs
    • Lynch, G. Memory enhancement: the search for mechanism-based drugs. Nat Neurosci 2002, 5: 1035-8.
    • (2002) Nat Neurosci , vol.5 , pp. 1035-1038
    • Lynch, G.1
  • 12
    • 0032053963 scopus 로고    scopus 로고
    • Facilitative effects of the ampakine CX516 on short-term memory in rats: Correlations with hippocampal neuronal activity
    • Hampson, R.E., Rogers, G., Lynch, G. and Deadwyler, S.A. Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity. J Neurosci 1998, 18: 2748-63.
    • (1998) J Neurosci , vol.18 , pp. 2748-2763
    • Hampson, R.E.1    Rogers, G.2    Lynch, G.3    Deadwyler, S.A.4
  • 13
    • 0028088995 scopus 로고
    • Facilitation of glutamate receptors enhances memory
    • Staubli, U., Rogers, G. and Lynch, G. Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci U S A 1994, 91: 777-81.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 777-781
    • Staubli, U.1    Rogers, G.2    Lynch, G.3
  • 14
    • 0142059864 scopus 로고    scopus 로고
    • Prospects of memory-modifying drugs that target the CREB pathway
    • Jackson, T. and Ramaswami, M. Prospects of memory-modifying drugs that target the CREB pathway. Curr Opin Drug Discov Dev 2003, 6: 712-9.
    • (2003) Curr Opin Drug Discov Dev , vol.6 , pp. 712-719
    • Jackson, T.1    Ramaswami, M.2
  • 15
    • 17844368327 scopus 로고    scopus 로고
    • The MAPK signalling pathways and colorectal cancer
    • Fang, J.Y. and Richardson, B.C. The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005, 6: 322-7.
    • (2005) Lancet Oncol , vol.6 , pp. 322-327
    • Fang, J.Y.1    Richardson, B.C.2
  • 16
    • 8444233219 scopus 로고    scopus 로고
    • Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons
    • Echeverria, V., Ducatenzeiler, A., Dowd, E. et al. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience 2004, 129: 583-92.
    • (2004) Neuroscience , vol.129 , pp. 583-592
    • Echeverria, V.1    Ducatenzeiler, A.2    Dowd, E.3
  • 17
    • 0032426667 scopus 로고    scopus 로고
    • Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
    • Barad, M., Bourtchouladze, R., Winder, D.G., Golan, H. and Kandel, E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci U S A 1998, 95: 15020-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15020-15025
    • Barad, M.1    Bourtchouladze, R.2    Winder, D.G.3    Golan, H.4    Kandel, E.5
  • 18
    • 0034746288 scopus 로고    scopus 로고
    • NF-kappaB in neuronal plasticity and neurodegenerative disorders
    • Mattson, M.P. and Camandola, S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 2001, 107: 247-54.
    • (2001) J Clin Invest , vol.107 , pp. 247-254
    • Mattson, M.P.1    Camandola, S.2
  • 19
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen, L.F. and Greene, W.C. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004, 5: 392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 20
    • 14744296474 scopus 로고    scopus 로고
    • Molecular mechanisms of cytokine-induced neuroprotection: NFkappaB and neuroplasticity
    • Barger, S.W., Moerman, A.M. and Mao, X. Molecular mechanisms of cytokine-induced neuroprotection: NFkappaB and neuroplasticity. Curr Pharm Des 2005, 11: 985-98.
    • (2005) Curr Pharm Des , vol.11 , pp. 985-998
    • Barger, S.W.1    Moerman, A.M.2    Mao, X.3
  • 21
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappaB system: A treasure trove for drug development
    • Karin, M., Yamamoto, Y. and Wang, Q.M. The IKK NF-kappaB system: a treasure trove for drug development. Nat Rev Drug Discov 2004, 3: 17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 22
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    • Yamamoto, Y., Verma, U.N., Prajapati, S., Kwak, Y.T. and Gaynor, R.B. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 2003, 423: 655-9.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 23
    • 0037039665 scopus 로고    scopus 로고
    • Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B
    • Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H. and Stark, G.R. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem 2002, 277: 3863-9.
    • (2002) J Biol Chem , vol.277 , pp. 3863-3869
    • Sizemore, N.1    Lerner, N.2    Dombrowski, N.3    Sakurai, H.4    Stark, G.R.5
  • 24
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden, M.S. and Ghosh, S. Signaling to NF-kappaB. Genes Dev 2004, 18: 2195-224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 25
    • 0037383635 scopus 로고    scopus 로고
    • From calcium to NF-kappa B signaling pathways in neurons
    • Lilienbaum, A. and Israel, A. From calcium to NF-kappa B signaling pathways in neurons. Mol Cell Biol 2003, 23: 2680-98.
    • (2003) Mol Cell Biol , vol.23 , pp. 2680-2698
    • Lilienbaum, A.1    Israel, A.2
  • 27
    • 0033979815 scopus 로고    scopus 로고
    • Roles of nuclear factor kappaB in neuronal survival and plasticity
    • Mattson, M.P., Culmsee, C., Yu, Z. and Camandola, S. Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 2000, 74: 443-56.
    • (2000) J Neurochem , vol.74 , pp. 443-456
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.3    Camandola, S.4
  • 28
    • 11144249792 scopus 로고    scopus 로고
    • Physiological functions for brain NF-kappaB
    • Meffert, M.K. and Baltimore, D. Physiological functions for brain NF-kappaB. Trends Neurosci 2005, 28: 37-43.
    • (2005) Trends Neurosci , vol.28 , pp. 37-43
    • Meffert, M.K.1    Baltimore, D.2
  • 29
    • 0031606827 scopus 로고    scopus 로고
    • Free radicals, calcium, and the synaptic plasticity-cell death continuum: Emerging roles of the transcription factor NF kappa B
    • Mattson, M.P. Free radicals, calcium, and the synaptic plasticity-cell death continuum: emerging roles of the transcription factor NF kappa B. Int Rev Neurobiol 1998, 42: 103-68.
    • (1998) Int Rev Neurobiol , vol.42 , pp. 103-168
    • Mattson, M.P.1
  • 30
    • 0031970196 scopus 로고    scopus 로고
    • The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons
    • Furukawa, K. and Mattson, M.P. The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons. J Neurochem 1998, 70: 1876-86.
    • (1998) J Neurochem , vol.70 , pp. 1876-1886
    • Furukawa, K.1    Mattson, M.P.2
  • 31
    • 0033582285 scopus 로고    scopus 로고
    • Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation
    • Beraud, C., Henzel, W.J. and Baeuerle, P.A. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci U S A 1999, 96: 429-34.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 429-434
    • Beraud, C.1    Henzel, W.J.2    Baeuerle, P.A.3
  • 32
    • 0034720896 scopus 로고    scopus 로고
    • Kinase regulation in inflammatory response
    • Delhase, M., Li, N. and Karin, M. Kinase regulation in inflammatory response. Nature 2000, 406: 367-8.
    • (2000) Nature , vol.406 , pp. 367-368
    • Delhase, M.1    Li, N.2    Karin, M.3
  • 33
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-kappaB by the Akt/PKB kinase
    • Kane, L.P., Shapiro, V.S., Stokoe, D. and Weiss, A. Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 1999, 9: 601-4.
    • (1999) Curr Biol , vol.9 , pp. 601-604
    • Kane, L.P.1    Shapiro, V.S.2    Stokoe, D.3    Weiss, A.4
  • 34
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M. and Donner, D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401: 82-5.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 35
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova, J.A. and Makarov, S.S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999, 401: 86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 36
    • 0027367765 scopus 로고
    • beta-amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
    • Mattson, M.P., Barger, S.W., Cheng, B., Lieberburg, I., Smith-Swintosky, V.L. and Rydel, R.E. beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease. Trends Neurosci 1993, 16: 409-14.
    • (1993) Trends Neurosci , vol.16 , pp. 409-414
    • Mattson, M.P.1    Barger, S.W.2    Cheng, B.3    Lieberburg, I.4    Smith-Swintosky, V.L.5    Rydel, R.E.6
  • 37
    • 3042700000 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype
    • Marini, A.M., Jiang, X., Wu, X. et al. Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype. Restor Neurol Neurosci 2004, 22: 121-30.
    • (2004) Restor Neurol Neurosci , vol.22 , pp. 121-130
    • Marini, A.M.1    Jiang, X.2    Wu, X.3
  • 38
    • 0032491387 scopus 로고    scopus 로고
    • Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate
    • Marini, A.M., Rabin, S.J., Lipsky, R.H. and Mocchetti, I. Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem 1998, 273: 29394-9.
    • (1998) J Biol Chem , vol.273 , pp. 29394-29399
    • Marini, A.M.1    Rabin, S.J.2    Lipsky, R.H.3    Mocchetti, I.4
  • 39
    • 0034742675 scopus 로고    scopus 로고
    • Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection
    • Lipsky, R.H., Xu, K., Zhu, D. et al. Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection. J Neurochem 2001, 78: 254-64.
    • (2001) J Neurochem , vol.78 , pp. 254-264
    • Lipsky, R.H.1    Xu, K.2    Zhu, D.3
  • 40
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss, T.V. and Collingridge, GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993, 361: 31-9.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 41
    • 0028356548 scopus 로고
    • Synaptic plasticity: LTP and LTD
    • Bear, M.F. and Malenka, R.C. Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 1994, 4: 389-99.
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 389-399
    • Bear, M.F.1    Malenka, R.C.2
  • 42
    • 0029825910 scopus 로고    scopus 로고
    • Protein kinase and phosphatase activity regulate the form of synaptic plasticity expressed
    • Coussens, C.M. and Teyler, T.J. Protein kinase and phosphatase activity regulate the form of synaptic plasticity expressed. Synapse 1996, 24: 97-103.
    • (1996) Synapse , vol.24 , pp. 97-103
    • Coussens, C.M.1    Teyler, T.J.2
  • 43
    • 20644440407 scopus 로고    scopus 로고
    • NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice
    • Freudenthal, R., Boccia, M.M., Acosta, G.B. et al. NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice. Eur J Neurosci 2005, 21: 2845-52.
    • (2005) Eur J Neurosci , vol.21 , pp. 2845-2852
    • Freudenthal, R.1    Boccia, M.M.2    Acosta, G.B.3
  • 44
    • 0034645951 scopus 로고    scopus 로고
    • Participation of Rel/NF-kappaB transcription factors in long-term memory in the crab Chasmagnathus
    • Freudenthal, R. and Romano, A. Participation of Rel/NF-kappaB transcription factors in long-term memory in the crab Chasmagnathus. Brain Res 2000, 855: 274-81.
    • (2000) Brain Res , vol.855 , pp. 274-281
    • Freudenthal, R.1    Romano, A.2
  • 45
    • 4544265209 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB activation after in vivo perforant path LTP in mouse hippocampus
    • Freudenthal, R., Romano, A. and Routtenberg, A. Transcription factor NF-kappaB activation after in vivo perforant path LTP in mouse hippocampus. Hippocampus 2004, 14: 677-83.
    • (2004) Hippocampus , vol.14 , pp. 677-683
    • Freudenthal, R.1    Romano, A.2    Routtenberg, A.3
  • 46
    • 0029033167 scopus 로고
    • Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation
    • Barger, S.W., Horster, D., Furukawa, K., Goodman, Y., Krieglstein, J. and Mattson, M.P. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci U S A 1995, 92: 9328-32.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9328-9332
    • Barger, S.W.1    Horster, D.2    Furukawa, K.3    Goodman, Y.4    Krieglstein, J.5    Mattson, M.P.6
  • 47
    • 0032084331 scopus 로고    scopus 로고
    • The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation
    • Bales, K.R., Du, Y., Dodel, R.C., Yan, G.M., Hamilton-Byrd, E. and Paul, S.M. The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation. Brain Res Mol Brain Res 1998, 57: 63-72.
    • (1998) Brain Res Mol Brain Res , vol.57 , pp. 63-72
    • Bales, K.R.1    Du, Y.2    Dodel, R.C.3    Yan, G.M.4    Hamilton-Byrd, E.5    Paul, S.M.6
  • 48
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • Yin, M.J., Yamamoto, Y. and Gaynor, R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998, 396: 77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 49
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity by thalidomide through suppression of IκB kinase activity
    • Keifer, J.A., Guttridge, D.C., Ashburner, B.P. and Baldwin, A.S., Jr. Inhibition of NF-kappa B activity by thalidomide through suppression of IκB kinase activity. J Biol Chem 2001, 276: 22382-7.
    • (2001) J Biol Chem , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin Jr., A.S.4


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