Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 294-300

  Kim, Mi Jin ^a   Kim, Dae Won ^a   Lee, Byung Ryong ^a,b   Shin, Min Jea ^a   Kim, Young Nam ^a   Eom, Seon Ae ^a   Park, Byung Jae ^b   Cho, Yoon Shin ^a   Han, Kyu Hyung ^a   Park, Jinseu ^a   Hwang, Hyun Sook ^a   Eum, Won Sik ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

^b Chuncheon Bio Industry Foundation   (South Korea)

Author keywords

Blood glucose; Diabetes mellitus; Insulin; Protein therapy; Tat GLO

Indexed keywords

ANTIDIABETIC AGENT; DNA; GLUCOSE; GLYOXALASE; NITROPRUSSIDE SODIUM; TAT GLYOXALASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; LACTOYLGLUTATHIONE LYASE; MALE; MICE; MICE, INBRED ICR; PEPTIDE FRAGMENTS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

ANIMALIA; MUS;

EID: 84872399120     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.10.134     Document Type: Article

References (42)

1. Atkinson M.A., Eisenbarth G.S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001, 358:221-229.
2. Bach J.F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 1994, 15:516-542.
3. Jaeckel E., Manns M., Von Herrath M. Viruses and diabetes. Ann. NY Acad. Sci. 2002, 9587:7-25.
4. Alberti K.G., Zimmet P.Z. New diagnostic criteria and classification of diabetes again?. Diabet. Med. 1998, 15:535-536.
5. Jin L., Xue H.Y., Jin L.J., et al. Antioxidant and pancreas-protective effect of acubin on rats with streptozotocin-induced diabetes. Eur. J. Pharmacol. 2008, 582:162-167.
6. Coskun O., Kanter M., Korkmaz A., et al. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol. Res. 2005, 51:117-123.
7. Ohkuwa T., Sato Y., Naoi M. Hydroxyl radical formation in diabetic rat induced by strepotzotocin. Life Sci. 1995, 56:1789-1798.
8. Rakieten N., Rakieten M.L., Nadkarni M.V. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother. Rep. 1963, 29:91-98.
9. Beisswenger P.J., Szwergold B.S., Yeo K.T. Glycated proteins in diabetes. Clin. Lab. Med. 2001, 21:53-78.
10. Thornalley P.J., Langborg A., Minhas H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 1999, 344(Pt 1):109-116.
11. Glomb M.A., Lang G. Isolation and characterization of glyoxal arginine modifications. J. Agric. Food Chem. 2001, 49:1493-1501.
12. Kuhla B., Luth H.J., Haferburg D., et al. Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease. Ann. NY Acad. Sci. 2005, 1043:211-216.
13. Brouwers O., Niessen P.M., Ferreira I., et al. Overexpression of glyoxalse-1 reduces hyperglycemia-induced levels of advanced glycation end products and oxidtive stress in diabetic rats. J. Biol. Chem. 2011, 286:1374-1380.
14. Kim K.M., Kim Y.S., Jung D.H., et al. Increased glyoxalase 1 levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose. Exp. Cell Res. 2012, 318:152-159.
15. Shinohara M., Thornalley P.J., Giardino I., et al. Overexpression of glyoxalase-1 in bovine endothelial cells inhibits intracellular advanced glycation end produt formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J. Clin. Invest. 1998, 101:1142-1147.
16. Morcos M., Du X., Pfisterer F., et al. Glyoxalase-1 prevent mitochondria protein modification and enhances life span in Caenorhabditis elegans. Aging Cell 2008, 7:260-269.
17. Chang T., Wang R., Wu L. Mehtylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic. Biol. Med. 2005, 38:286-293.
18. Rosca M.G., Mustata T.G., Kinter M.T., et al. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am. J. Physiol. Renal Physiol. 2005, 289:F420-F430.
19. Schlotterer A., Kukudov G., Bozorgmehr F. C. Elegans as model for the study of high glucose-mediated life span reduction. Diabetes 2009, 58:2450-2456.
20. Wadia J.S., Dowdy S.F. Protein transduction technology. Curr. Opin. Biotechnol. 2002, 13:52-56.
21. Wadia J.S., Dowdy S.F. Modulation of cellular function by TAT mediated transduction of full length protein. Curr. Protein Pept. Sci. 2003, 4:97-104.
22. Kwon H.Y., Eum W.S., Jang H.W., et al. Transduction of Cu, Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett. 2000, 485:163-167.
23. Eum W.S., Kim D.W., Hwang I.K., et al. In vivo protein transduction: biologically active intact PEP-1-superoxide dismutase fusion protein efficiently protects against ischemic insult. Free Radic. Biol. Med. 2004, 37:1656-1669.
24. Kim D.W., Lee S.H., Jeong M.S., et al. Transduced Tat-SAG fusion protein protects against oxidative stress and brain ischemic insult. Free Radic. Biol. Med. 2009, 48:969-977.
25. Ahn E.H., Kim D.W., Kang H.W., et al. Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Toxicology 2010, 276:192-197.
26. Kim S.Y., Sohn E.J., Kim D.W., et al. Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice. J. Invest. Dermatol. 2011, 131:1477-1485.
27. Lee S.H., Kim D.W., Back S.S., et al. Transduced Tat-annexin protein suppresses lipopolysaccharide (LPS)-stimulated inflammation gene expression in Raw 264.7 cells. BMB Rep. 2011, 44:484-489.
28. Sohn E.J., Kim D.W., Kim M.J., et al. PEP-1-metallothionein-III protein ameliorates the oxidative stress-induced neuronal cell death and brain ischemic insults. Biochim. Biophys. Acta 1820, 2012:1647-1655.
29. Lee S.H., Kim D.W., Eom S.A., et al. Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-annexin protein. BMB Rep. 2012, 45:354-359.
30. Bradford M.A. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
31. Jack M.M., Ryals J.M., Wright D.E. Chracterization of glyoxalase I in a streptozotocin-induced mouse model of diabetes with painful and insensate neuropathy. Diabetologia 2011, 54:2174-2182.
32. de Arriba S.G., Stuchbury G., Yarin J., et al. Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells-protection by carbonyl scavengers. Neurobiol. Aging 2007, 28:1044-1050.
33. Ulrich P., Cerami A. Protein glycation, diabetes, and aging. Recent Prog. Horm. Res. 2001, 56:1-21.
34. Nemet I., Turk Z., Duvnjak L., et al. Humoral methylglyoxal level reflects glycemic fluctuation. Clin. Biochem. 2005, 38:379-383.
35. Kim H.J., Kong M.K., Kim Y.C. Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. BMB Rep. 2008, 41:710-715.
36. Szkudelski T. The mechanims of alloxan and streptozotocin action in β-cells of rat pancreas. Physiol. Res. 2001, 50:536-546.
37. Senthilkumar G.P., Subramanian S. Evaluation of antioxidant potential of terminalia chebula fruits studied in streptozotocin-induced diabetic rats. Pharm. Biol. 2007, 45:511-518.
38. Thornalley P.J. Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems-role in aging and disease. Drug Metabol. Drug Interact 2008, 23:125-150.
39. Schhlkwijk C.G., Brouwers O., Stehouwer C.D. Modulation of insulin action by advanced glycation end products: a new player in the field. Horm. Metab. Res. 2008, 40:614-619.
40. Mendez J.D., Xie J., Aguilar-Hernandez M., et al. Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases. Mol. Cell Biochem. 2010, 344:185-193.
41. Berner A.K., Brouwers O., Pringle R., et al. Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenrative pathology. Diabetologia 2012, 55:845-854.
42. Miller A.G., Tan G., Binger K.J., et al. Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase I function. Diabetes 2010, 59:3208-3215.