Viruses and diabetes

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 7-25

  Jaeckel, Elmar ^a   Manns, Michael ^b   Von Herrath, Matthias ^c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Coxsackie virus; Cytomegalovirus; DNA vaccines; Enterovirus; Epstein Barr virus; IDDM; LCMV; Oral tolerance; Regulatory T cells; Retrovirus; Rubella virus; Viral infection

Indexed keywords

ANTIGEN; DNA VACCINE; VIRUS VACCINE;

CONFERENCE PAPER; CYTOMEGALOVIRUS; DIABETES MELLITUS; ENTEROVIRUS; ENVIRONMENTAL FACTOR; EPSTEIN BARR VIRUS; GENETIC PREDISPOSITION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PATHOGENESIS; RETROVIRUS; RUBELLA VIRUS; TRANSGENIC MOUSE; VIRUS; VIRUS INFECTION; VIRUS ISOLATION;

ANIMALIA; COXSACKIEVIRUS; CYTOMEGALOVIRUS; ENTEROVIRUS; HUMAN HERPESVIRUS 4; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS MUSCULUS; RUBELLA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0036271503     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02943.x     Document Type: Conference Paper

References (102)

1. A genome-wide search for human type 1 diabetes susceptibility genes
2. Genetic analysis of autoimmune disease
3. Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. A population-based case-control study
4. Lessons on the etiology of insulin-dependent diabetes from twin-studies
5. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
6. Concordance rates of insulin dependent diabetes mellitus: A population based study of young Danish twins
7. The epidemiology of diabetes mellitus
8. Migrant populations and the incidence of type 1 diabetes mellitus: An overview of the literature with a focus on the Spanish-heritage countries in Latin America
9. Increasing incidence of early onset type 1 (insulin-dependent) diabetes mellitus: A study of Danish male birth cohorts
10. Rising incidence of IDDM in Europe
11. The Pittsburgh insulin-dependent diabetes mellitus (IDDM) registry. The incidence of insulin-dependent diabetes mellitus in Allegheny County, Pennsylvania (1965-1976)
12. Apparent epidemic of insulin-dependent diabetes mellitus in Midwestern Poland
13. DNA immunization to prevent autoimmune diabetes
14. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
15. Cytotoxic effect of IFN-gamma plus TNF-alpha on human islet cells
16. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
17. Shifting T-cell activation thresholds in autoimmunity and determinant spreading
18. Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells
19. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
20. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
21. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
22. Superantigens in insulin-dependent diabetes mellitus
23. A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes
24. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology
25. No evidence for association between IDDMK(1,2)22, a novel isolated retrovirus, and IDDM
26. IDDM patients neither show humoral reactivities against endogenous retroviral envelope protein nor do they differ in retroviral mRNA expression from healthy relatives or normal individuals
27. Regulatory T cells in autoimmunity
28. Evolution of the CD8 T-cell repertoire during infections
29. Consequences of cross-reactive and bystander CTL responses during viral infections
30. Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
31. The role of enteroviral infections in the development of IDDM: Limitations of current approaches
32. A prospective study of the role of cox-sackie B and other enterovirus infections in the pathogenesis of IDDM
33. Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: A prospective study
34. Is insulin-dependent diabetes mellitus caused by coxsackievirus B infection? A review of the epidemiologic evidence
35. High frequency of Coxsackie-B-virus-specific IgM in children developing type I diabetes during a period of high diabetes morbidity
36. Coxsackie infection and diabetes
37. Reduced Coxsackie antibody titres in type 1 (insulin-dependent) diabetic patients presenting during an outbreak of Coxsackie B3 and B4 infection
38. Coxsackie B virus infection and onset of childhood diabetes
39. Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus
40. Is juvenile diabetes a viral disease?
41. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
42. Pancreatic islet-cell damage in children with fatal viral infections
43. Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie virus B4
44. Coxsackie virus B4 produces transient diabetes in nonhuman primates
45. Coxsackievirus B4 alters pancreatic glutamate decarboxylase expression in mice soon after infection
46. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
47. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
48. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells
49. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
50. Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients
51. Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies
52. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
53. Molecular mimicry and autoimmunity
54. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
55. T cell activation and anergy to islet cell antigen in type I diabetes
56. The viruses in all of us: Characteristics and biological significance of human endogenous retrovirus sequences
57. Retroviruses and autoimmunity
58. Endogenous retroviruses: Potential etiologic agents in autoimmunity
59. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis
60. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV
61. A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus
62. Rubella infection and diabetes mellitus
63. Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: Increased prevalence of islet cell surface antibodies
64. A fifty-year follow-up of congenital rubella
65. Monoclonal antibody to rubella virus capsid protein recognizes a beta-cell antigen
66. Concurrent onset of adult onset Still's disease and insulin dependent diabetes mellitus
67. Rubella virus-induced diabetes in the hamster
68. Congenital cytomegalovirus infection and diabetes
69. Cytomegalovirus infection associated with acute pancreatitis, rhabdomyolysis and renal failure
70. Association of cytomegalovirus infection with autoimmune type 1 diabetes
71. Cytomegalovirus-induced diabetes mellitus in a renal allograft recipient
72. Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: A prospective study
73. Persistent virus infection and type 1 diabetes
74. Correlation between islet cell anti-bodies and anti-cytomegalovirus IgM and IgG antibodies in healthy first-degree relatives of type 1 (insulin-dependent) diabetic patients
75. The prevalence of type 1 diabetes mellitus at follow-up of Swedish infants congenitally infected with cytomegalovirus
76. Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody
77. Immune response to different sequences of the EBNA I molecule in Epstein-Barr virus-related disorders and in autoimmune diseases
78. Acute onset of insulin-dependent diabetes mellitus caused by Epstein-Barr virus infection
79. Various phenotypes of diabetes mellitus at ultimate outcome of acutely developed diabetic state induced by viral infection
80. Relating homology between the Epstein-Barr virus BOLF1 molecule and HLA-DQw8 beta chain to recent onset type 1 (insulin-dependent) diabetes mellitus
81. Allelic sequence variation of the HLA-DQ loci: Relationship to serology and to insulin-dependent diabetes susceptibility
82. The possible role of Coxsackie A and echo viruses in the pathogenesis of type I diabetes mellitus studied by IgM analysis
83. The association of infective hepatitis type A (HAV) and diabetes mellitus
84. Transient diabetes following chicken pox
85. Virus-induced diabetes mellitus
86. Is diabetes of infectious origin?
87. Mumps virus infects beta cells in human fetal islet cell cultures upregulating the expression of HLA class I molecules
88. A case of diabetes mellitus quickly following mumps on the pathological alterations of salivary glands, closely resembling those found in pancreas, in a case of diabetes mellitus
89. Evidence that rotavirus triggers islet autoimmunity
90. Determination of diabetogenicity attributable to a single amino acid, Ala776, on the polyprotein of encephalomyocarditis virus
91. A genetically determined host factor controlling susceptibility to encephalomyocarditis virus-induced diabetes in mice
92. Prevention of type I diabetes in nonobese diabetic mice by virus infection
93. Inhibition of diabetes in BB rats by virus infection
94. Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice
95. Paradoxical lessening of autoimmune processes in non-obese diabetic mice after infection with the diabetogenic variant of encephalomyocarditis virus
96. Immunisation and type 1 diabetes mellitus: Is there a link?
97. Viral effects on antigen processing
98. Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis
99. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
100. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease
101. Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
102. In vivo treatment with a MHC class I-restricted blocking peptide can prevent virus-induced autoimmune diabetes