Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

Gastroenterology

Volumn 127, Issue 1, 2004, Pages 275-286

  Kubisch, Constanze ^a   Dimagno, Matthew J ^b,c   Tietz, Anne Barbara ^a   Welsh, Michael J ^b   Ernst, Stephen A ^b   Brandt Nedelev, Barbara ^d   Diebold, Joachim ^e   Wagner, Andreas C C ^a   Göke, Burkhard ^a   Williams, John A ^b,c   Schäfer, Claus ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

3 (N morpholino)propanesulfonic acid; CMV; cytomegalovirus; heat shock protein; Hsp; huHsp27; human heat shock protein 27; MOPS; MPO; myeloperoxidase; PCR; polymerase chain reaction

Indexed keywords

ACTIN; ALANINE; AMYLASE; CERULETIDE; HEAT SHOCK PROTEIN; MYELOPEROXIDASE; SERINE; TRIACYLGLYCEROL LIPASE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CYTOMEGALOVIRUS; CYTOSKELETON; EDEMA; ENZYME ACTIVITY; EXOCRINE SECRETION; FEMALE; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; INFLAMMATION; MALE; MEASUREMENT; MORPHOLOGY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREAS ACINUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SCORING SYSTEM; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 3242720733     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.04.005     Document Type: Article

References (45)

1. Steer M.L., Saluja A.K. Experimental acute pancreatitis studies of the early events that lead to cell injury. The pancreas biology, pathobiology and disease. 2nd ed. :1993;489-500 Raven, New York, NY
2. O'Konski M.S., Pandol S.J. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell. J Clin Invest. 86:1990;1649-1657
3. Jungermann J., Lerch M.M., Weidenbach H., Lutz M.P., Kruger B., Adler G. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation. Am J Physiol. 268:1995;G328-G338
4. Burnham D.B., Williams J.A. Effects of high concentrations of secretagogues on the morphology and secretory activity of the pancreas a role for microfilaments. Cell Tissue Res. 222:1982;201-212
5. Adler G., Kern H.F., Pan G.Z., Gardner J.D. Secretagogue-induced membrane alterations in dispersed acini from rat pancreas. Eur J Cell Biol. 33:1984;234-241
6. Torgerson R.R., McNiven M.A. The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing. J Cell Sci. 111:1998;2911-2922
7. Schafer C., Ross S.E., Bragado M.J., Groblewski G.E., Ernst S.A., Williams J.A. A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini. J Biol Chem. 273:1998;24173-24180
8. Bendayan M., Marceau N., Beaudoin A.R., Trifaro J.M. Immunocytochemical localization of actin in the pancreatic exocrine cell. J Histochem Cytochem. 30:1982;1075-1078
9. Drenckhahn D., Mannherz H.G. Distribution of actin and the actin-associated proteins myosin, tropomyosin, alpha-actinin, vinculin, and villin in rat and bovine exocrine glands. Eur J Cell Biol. 30:1983;167-176
10. Craig E.A., Weissman J.S., Horwich A.L. Heat shock proteins and molecular chaperones mediators of protein conformation and turnover in the cell. Cell. 78:1994;365-372
11. Parsell D.A., Lindquist S. Heat shock proteins and stress tolerance. The biology of heat shock proteins and molecular chaperons. 1994;457-494 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
12. Ellis J. Proteins as molecular chaperones. Nature. 328:1987;378-379
13. Schlesinger M.J. Heat shock proteins. J Biol Chem. 265:1990;12111-12114
14. Schafer C., Williams J.A. Stress kinases and heat shock proteins in the pancreas possible roles in normal function and disease. J Gastroenterol. 35:2000;1-9
15. Wagner A.C., Weber H., Jonas L., Nizze H., Strowski M., Fiedler F., Printz H., Steffen H., Goke B. Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats. Gastroenterology. 111:1996;1333-1342
16. Grise K., Kim F., McFadden D. Hyperthermia induces heat-shock protein expression, reduces pancreatic injury, and improves survival in necrotizing pancreatitis. Pancreas. 21:2000;120-125
17. Bhagat L., Singh V.P., Song A.M., van Acker G.J., Agrawal S., Steer M.L., Saluja A.K. Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology. 122:2002;156-165
18. Tashiro M., Ernst S.A., Edwards J., Williams J.A. Hyperthermia induces multiple pancreatic heat shock proteins and protects against subsequent arginine-induced acute pancreatitis in rats. Digestion. 65:2002;118-126
19. Bhagat L., Singh V.P., Hietaranta A.J., Agrawal S., Steer M.L., Saluja A.K. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. J Clin Invest. 106:2000;81-89
20. Otaka M., Itoh H., Kuwabara T., Zeniya A., Fujimori S., Tashima Y., Masamune O. Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress. Int J Biochem. 25:1993;1769-1773
21. Lee H.S., Bhagat L., Frossard J.L., Hietaranta A., Singh V.P., Steer M.L., Saluja A.K. Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats. Gastroenterology. 119:2000;220-229
22. Ethridge R.T., Ehlers R.A., Hellmich M.R., Rajaraman S., Evers B.M. Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1. Pancreas. 21:2000;248-256
23. Miron T., Vancompernolle K., Vandekerckhove J., Wilchek M., Geiger B. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol. 114:1991;255-261
24. Benndorf R., Hayess K., Ryazantsev S., Wieske M., Behlke J., Lutsch G. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J Biol Chem. 269:1994;20780-20784
25. Groblewski G.E., Grady T., Mehta N., Lambert H., Logsdon C.D., Landry J., Williams J.A. Cholecystokinin stimulates heat shock protein 27 phosphorylation in rat pancreas both in vivo and in vitro. Gastroenterology. 112:1997;1354-1361
26. Schafer C., Clapp P., Welsh M.J., Benndorf R., Williams J.A. HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells 43. Am J Physiol. 277:1999;C1032-C1043
27. Hickey E., Brandon S.E., Potter R., Stein G., Stein J., Weber L.A. Sequence and organization of genes encoding the human 27 kDa heat shock protein. Nucleic Acids Res. 14:1986;4127-4145
28. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215
29. Tashiro M., Schafer C., Yao H., Ernst S.A., Williams J.A. Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells. Gut. 49:2001;241-250
30. Hofbauer B., Saluja A.K., Lerch M.M., Bhagat L., Bhatia M., Lee H.S., Frossard J.L., Adler G., Steer M.L. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol. 275:1998;G352-G362
31. Kawabata S., Miura T., Morita T., Kato H., Fujikawa K., Iwanaga S., Takada K., Kimura T., Sakakibara S. Highly sensitive peptide-4-methylcoumaryl-7- amide substrates for blood-clotting proteases and trypsin. Eur J Biochem. 172:1988;17-25
32. Halangk W., Lerch M.M., Brandt-Nedelev B., Roth W., Ruthenbuerger M., Reinheckel T., Domschke W., Lippert H., Peters C., Deussing J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest. 106:2000;773-781
33. Ethridge R., Chung D., Slogoff M., Ehlers R., Hellmich M., Saito H., Uchida T., Evers B. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology. 123:2002;1311-1322
34. Groblewski G.E., Yoshida M., Yao H., Williams J.A., Ernst S.A. Immunolocalization of CRHSP28 in exocrine digestive glands and gastrointestinal tissues of the rat. Am J Physiol. 276:1999;G219-G226
35. Landry J., Lambert H., Zhou M., Lavoie J.N., Hickey E., Weber L.A., Anderson C.W. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem. 267:1992;794-803
36. Natori S., King A., Hellwig A., Weiss U., Iguchi H., Tsuchiya B., Kameya T., Takayanagi R., Nawata H., Huttner W.B. Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic mice. EMBO J. 17:1998;3277-3289
37. Lavoie J.N., Hickey E., Weber L.A., Landry J. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J Biol Chem. 268:1993;24210-24214
38. Huot J., Houle F., Spitz D.R., Landry J. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res. 56:1996;273-279
39. Stokoe D., Engel K., Campbell D.G., Cohen P., Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313:1992;307-313
40. Guay J., Lambert H., Gingras-Breton G., Lavoie J.N., Huot J., Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci. 110:1997;357-368
41. Landry J., Chretien P., Lambert H., Hickey E., Weber L.A. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J Cell Biol. 109:1989;7-15
42. Lavoie J.N., Gingras-Breton G., Tanguay R.M., Landry J. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization. J Biol Chem. 268:1993;3420-3429
43. Morrison L.E., Hoover H.E., Thuerauf D.J., Glembotski C.C. Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circ Res. 92:2003;203-211
44. Charette S.J., Lavoie J.N., Lambert H., Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol. 20:2000;7602-7612
45. Park K.J., Gaynor R.B., Kwak Y.T. Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem. 278:2003;35272-35278