Biosynthesis of 2-arachidonoyl-glycerol, a novel cannabimimetic eicosanoid, in mouse neuroblastoma cells

Advances in Experimental Medicine and Biology

Volumn 433, Issue , 1997, Pages 201-204

  Bisogno, Tiziana ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; GLYCEROL DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ICOSANOID METABOLISM; METABOLIC ACTIVATION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031391174     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-1810-9_42     Document Type: Article

References (14)

1. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R, Isolation and structure of a brain costituent that binds to the cannabinoid receptor, Science 258:1946 (1992).
2. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, Pertwee RG, Griffin G, Bayewitch M, Barg J and Vogel Z, Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem Pharmacol 50:83 (1995).
3. Lee M, Yang KH and Kaminski NE, Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonoyl-glycerol on immune function in B6C3F1 mouse splenocytes, J Pharmacol Exp Ther 275:529 (1995).
4. Bayewitch M, Avidor-Reiss T, Levy R, Barg J, Mechoulam R and Vogel Z, The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS Lett 375:143 (1995).
5. Ben-Shabat S, Fride E, Vogel Z, Bisogno T, De Petrocellis L, Di Marzo V and Mechoulam R, An entourage effect: endogenous, inactive acyl-glycerol esters enhance 2-arachidonoyl-glycerol activity, Mol. Pharmacol, submitted.
6. Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A and Waku K, 2-Arachidonoyl-glycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Comm 215:89 (1995).
7. 2+ in neuroblastoma X glioma hybrid NG108-15 cells, Biochem Biophys Res Commun 229:58 (1996).
8. Di Marzo V, De Petrocellis L, Sepe N and Buono A, Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells, Biochem J 316:977 (1996).
9. Bisogno T, Sepe N, Melck D, Maurelli S, De Petrocellis L and Di Marzo V, Biosynthesis, release and degradation of the novel endogenous cannabinomimetic metabolite 2-arachidonoyl-glycerol in mouse neuroblastoma cells, Biochem J 322:671 (1997).
10. Di Marzo V, De Petrocellis L, Sugiura T and Waku K, Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells, Biochem Biophys Res Comm 227:281 (1996).
11. Sugiura T, Kondo S, Sukagawa A, Tonegawa T, Nakane S, Yamashita A, Ishima Y and Waku K, Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with the synthesis from free arachidonic acid and ethanolamine, Eur J Biochem 240:53 (1996).
12. Allen AC, Gammon CM, Ousley AH, McCarthy KD and Morell P, Bradykinin stimulates arachidonic acid release through the sequential action of an sn-1 diacylglycerol lipase and a monoacylglycerol lipase, J Neurochem 58:1130 (1992).
13. Cadas H , di Tomaso E and Piomelli D, Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl-phosphatidylethanolamine, in rat brain, J Neurosci 17:1226 (1997).
14. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC and Piomelli D, Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Nature 372:686 (1994).