메뉴 건너뛰기




Volumn 71, Issue 1, 2013, Pages 13-20

Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer

Author keywords

Cancer therapy; Ceramide; Drug resistance; Glucosylceramide; Glucosylceramide synthase; Sphingolipid

Indexed keywords

CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; DOXORUBICIN; GLUCOSYLCERAMIDE; LACTOFERRICIN; PACLITAXEL; RESVERATROL; TAMOXIFEN; VINBLASTINE;

EID: 84872356927     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-1984-x     Document Type: Review
Times cited : (50)

References (91)
  • 1
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • 15286740 10.1038/nrc1411 1:CAS:528:DC%2BD2cXmtVOhsb4%3D
    • Ogretmen B, Hannun YA (2004) Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4:604-616
    • (2004) Nat Rev Cancer , vol.4 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 2
    • 58149277751 scopus 로고    scopus 로고
    • Roles of bioactive sphingolipids in cancer biology and therapeutics
    • 18751921 10.1007/978-1-4020-8831-5-16
    • Saddoughi SA, Song P, Ogretmen B (2008) Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem 49:413-440
    • (2008) Subcell Biochem , vol.49 , pp. 413-440
    • Saddoughi, S.A.1    Song, P.2    Ogretmen, B.3
  • 3
    • 33845346791 scopus 로고    scopus 로고
    • Inhibitors of sphingolipid metabolism enzymes
    • 17049336 10.1016/j.bbamem.2006.08.017 1:CAS:528:DC%2BD28Xht12kt7zO
    • Delgado A, Casas J, Llebaria A, Abad JL, Fabrias G (2006) Inhibitors of sphingolipid metabolism enzymes. Bba-Biomembranes 1758:1957-1977
    • (2006) Bba-Biomembranes , vol.1758 , pp. 1957-1977
    • Delgado, A.1    Casas, J.2    Llebaria, A.3    Abad, J.L.4    Fabrias, G.5
  • 4
    • 0037518448 scopus 로고    scopus 로고
    • Salvage pathways in glycosphingolipid metabolism
    • 12770781 10.1016/S0300-9084(03)00047-6 1:CAS:528:DC%2BD3sXjvV2ms7Y%3D
    • Tettamanti G, Bassi R, Viani P, Riboni L (2003) Salvage pathways in glycosphingolipid metabolism. Biochimie 85(3-4):423-437
    • (2003) Biochimie , vol.85 , Issue.3-4 , pp. 423-437
    • Tettamanti, G.1    Bassi, R.2    Viani, P.3    Riboni, L.4
  • 5
    • 77954142351 scopus 로고    scopus 로고
    • Drug target identification in sphingolipid metabolism by computational systems biology tools: Metabolic control analysis and metabolic pathway analysis
    • 20348024 10.1016/j.jbi.2010.03.006
    • Ozbayraktar FBK, Ulgen KO (2010) Drug target identification in sphingolipid metabolism by computational systems biology tools: metabolic control analysis and metabolic pathway analysis. J Biomed Inform 43:537-549
    • (2010) J Biomed Inform , vol.43 , pp. 537-549
    • Ozbayraktar, F.B.K.1    Ulgen, K.O.2
  • 6
    • 77956605840 scopus 로고    scopus 로고
    • Therapeutic applications of bioactive sphingolipids in hematological malignancies
    • 20503271 10.1002/ijc.25478 1:CAS:528:DC%2BC3cXpvV2iurg%3D
    • Ekiz HA, Baran Y (2010) Therapeutic applications of bioactive sphingolipids in hematological malignancies. Int J Cancer 127:1497-1506
    • (2010) Int J Cancer , vol.127 , pp. 1497-1506
    • Ekiz, H.A.1    Baran, Y.2
  • 7
    • 70350228425 scopus 로고    scopus 로고
    • Molecular facets of sphingolipids: Mediators of diseases
    • 19579220 10.1002/biot.200800322 1:CAS:528:DC%2BD1MXptVGisbo%3D
    • Ozbayraktar FB, Ulgen KO (2009) Molecular facets of sphingolipids: mediators of diseases. Biotechnol J 4:1028-1041
    • (2009) Biotechnol J , vol.4 , pp. 1028-1041
    • Ozbayraktar, F.B.1    Ulgen, K.O.2
  • 9
    • 78650682926 scopus 로고    scopus 로고
    • Sphingolipids and expression regulation of genes in cancer
    • 20970453 10.1016/j.plipres.2010.10.003 1:CAS:528:DC%2BC3cXhs1Wkt7fF
    • Patwardhan GA, Liu YY (2011) Sphingolipids and expression regulation of genes in cancer. Prog Lipid Res 50:104-114
    • (2011) Prog Lipid Res , vol.50 , pp. 104-114
    • Patwardhan, G.A.1    Liu, Y.Y.2
  • 10
    • 33748765535 scopus 로고    scopus 로고
    • Sphingolipid-binding proteins
    • 16901751 10.1016/j.bbalip.2006.06.004 1:CAS:528:DC%2BD28XpsVajsbY%3D
    • Snook CF, Jones JA, Hannun YA (2006) Sphingolipid-binding proteins. Biochim Biophys Acta 1761:927-946
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 927-946
    • Snook, C.F.1    Jones, J.A.2    Hannun, Y.A.3
  • 11
    • 1542358155 scopus 로고    scopus 로고
    • Ceramide synthesis and metabolism as a target for cancer therapy
    • 15013522 10.1016/j.canlet.2003.08.034 1:CAS:528:DC%2BD2cXhvFaiu7c%3D
    • Reynolds CP, Maurer BJ, Kolesnick RN (2004) Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett 206:169-180
    • (2004) Cancer Lett , vol.206 , pp. 169-180
    • Reynolds, C.P.1    Maurer, B.J.2    Kolesnick, R.N.3
  • 13
    • 0037401402 scopus 로고    scopus 로고
    • Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer
    • 12676517 10.1016/S1043-6618(03)00053-7 1:CAS:528:DC%2BD3sXisFWlsbo%3D
    • Cuvillier O, Levade T (2003) Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. Pharmacol Res 47:439-445
    • (2003) Pharmacol Res , vol.47 , pp. 439-445
    • Cuvillier, O.1    Levade, T.2
  • 14
    • 33845336495 scopus 로고    scopus 로고
    • Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
    • 17052686 10.1016/j.bbamem.2006.08.009 1:CAS:528:DC%2BD28Xht12kt7%2FK
    • Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards M, Cabot M, Merrill AH (2006) Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Bba-Biomembranes 1758:1864-1884
    • (2006) Bba-Biomembranes , vol.1758 , pp. 1864-1884
    • Zheng, W.1    Kollmeyer, J.2    Symolon, H.3    Momin, A.4    Munter, E.5    Wang, E.6    Kelly, S.7    Allegood, J.C.8    Liu, Y.9    Peng, Q.10    Ramaraju, H.11    Sullards, M.12    Cabot, M.13    Merrill, A.H.14
  • 15
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • 10.1038/nrm2329 1:CAS:528:DC%2BD1cXovFOntg%3D%3D
    • Hannun YA, Obeid LM (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Bio 9:139-150
    • (2008) Nat Rev Mol Cell Bio , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 16
    • 66349086742 scopus 로고    scopus 로고
    • Bioactive sphingolipids: Metabolism and function
    • 19017611 10.1194/jlr.R800080-JLR200
    • Bartke N, Hannun YA (2009) Bioactive sphingolipids: metabolism and function. J Lipid Res 50(Suppl):S91-S96
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Bartke, N.1    Hannun, Y.A.2
  • 17
    • 20444402239 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of ceramide transport
    • 15907394 10.1016/j.bbalip.2005.04.001 1:CAS:528:DC%2BD2MXltVaquro%3D
    • Perry RJ, Ridgway ND (2005) Molecular mechanisms and regulation of ceramide transport. Biochim Biophys Acta 1734:220-234
    • (2005) Biochim Biophys Acta , vol.1734 , pp. 220-234
    • Perry, R.J.1    Ridgway, N.D.2
  • 18
    • 42249105215 scopus 로고    scopus 로고
    • The sphingolipid salvage pathway in ceramide metabolism and signaling
    • 18191382 10.1016/j.cellsig.2007.12.006 1:CAS:528:DC%2BD1cXlsF2rt7s%3D
    • Kitatani K, Idkowiak-Baldys J, Hannun YA (2008) The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 20:1010-1018
    • (2008) Cell Signal , vol.20 , pp. 1010-1018
    • Kitatani, K.1    Idkowiak-Baldys, J.2    Hannun, Y.A.3
  • 19
    • 33644669343 scopus 로고    scopus 로고
    • Role of biologically active sphingolipids in tumor growth
    • 10.1134/S0006297906010020 1:CAS:528:DC%2BD28Xht12lsLk%3D
    • Dyatlovitskaya EV, Kandyba AG (2006) Role of biologically active sphingolipids in tumor growth. Biochemistry (Moscow) 71:10-17
    • (2006) Biochemistry (Moscow) , vol.71 , pp. 10-17
    • Dyatlovitskaya, E.V.1    Kandyba, A.G.2
  • 20
    • 33845346791 scopus 로고    scopus 로고
    • Inhibitors of sphingolipid metabolism enzymes
    • 17049336 10.1016/j.bbamem.2006.08.017 1:CAS:528:DC%2BD28Xht12kt7zO
    • Delgado A, Casas J, Llebaria A, Abad JL, Fabrias G (2006) Inhibitors of sphingolipid metabolism enzymes. Biochim Biophys Acta 1758:1957-1977
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1957-1977
    • Delgado, A.1    Casas, J.2    Llebaria, A.3    Abad, J.L.4    Fabrias, G.5
  • 21
    • 33847376437 scopus 로고    scopus 로고
    • Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas
    • 17308067 10.1158/1535-7163.MCT-06-0558 1:CAS:528:DC%2BD2sXhvVWrt70%3D
    • Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B (2007) Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther 6:712-722
    • (2007) Mol Cancer Ther , vol.6 , pp. 712-722
    • Senkal, C.E.1    Ponnusamy, S.2    Rossi, M.J.3    Bialewski, J.4    Sinha, D.5    Jiang, J.C.6    Jazwinski, S.M.7    Hannun, Y.A.8    Ogretmen, B.9
  • 22
    • 77953291434 scopus 로고    scopus 로고
    • Importance of cytochrome c redox state for ceramide-induced apoptosis of human mammary adenocarcinoma cells
    • 10.1016/j.bbagen.2010.03.022 1:CAS:528:DC%2BC3cXmvVWitrY%3D
    • Parihar A, Parihar MS, Nazarewicz R, Ghafourifar P (2010) Importance of cytochrome c redox state for ceramide-induced apoptosis of human mammary adenocarcinoma cells. Bba Gen Subjects 1800:646-654
    • (2010) Bba Gen Subjects , vol.1800 , pp. 646-654
    • Parihar, A.1    Parihar, M.S.2    Nazarewicz, R.3    Ghafourifar, P.4
  • 23
    • 65349085828 scopus 로고    scopus 로고
    • Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells
    • 19462692 10.1016/S0895-3988(09)60026-X 1:CAS:528:DC%2BD1MXjs12qt7o%3D
    • Wang J, Lv XW, Du YG (2009) Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. Biomed Environ Sci 22:76-85
    • (2009) Biomed Environ Sci , vol.22 , pp. 76-85
    • Wang, J.1    Lv, X.W.2    Du, Y.G.3
  • 24
    • 2142769665 scopus 로고    scopus 로고
    • Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
    • 14967819 10.1194/jlr.M300486-JLR200 1:CAS:528:DC%2BD2cXjsFKis7k%3D
    • Liu YY, Han TY, Yu JY, Bitterman A, Le A, Giuliano AE, Cabot MC (2004) Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J Lipid Res 45:933-940
    • (2004) J Lipid Res , vol.45 , pp. 933-940
    • Liu, Y.Y.1    Han, T.Y.2    Yu, J.Y.3    Bitterman, A.4    Le, A.5    Giuliano, A.E.6    Cabot, M.C.7
  • 25
    • 40849105177 scopus 로고    scopus 로고
    • Role of glycosphingolipid-enriched microdomains in innate immunity: Microdomain-dependent phagocytic cell functions
    • 10.1016/j.bbagen.2007.11.004 1:CAS:528:DC%2BD1cXjsVSisLs%3D
    • Yoshizaki F, Nakayama H, Wahara C, Takamori K, Ogawa H, Iwabuchi K (2008) Role of glycosphingolipid-enriched microdomains in innate immunity: microdomain-dependent phagocytic cell functions. Bba-Gen Subjects 1780:383-392
    • (2008) Bba-Gen Subjects , vol.1780 , pp. 383-392
    • Yoshizaki, F.1    Nakayama, H.2    Wahara, C.3    Takamori, K.4    Ogawa, H.5    Iwabuchi, K.6
  • 26
    • 40849119996 scopus 로고    scopus 로고
    • Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
    • 10.1016/j.bbagen.2007.08.015 1:CAS:528:DC%2BD1cXjsVSisL4%3D
    • Hakomori SI (2008) Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Bba-Gen Subjects 1780:325-346
    • (2008) Bba-Gen Subjects , vol.1780 , pp. 325-346
    • Hakomori, S.I.1
  • 27
    • 0037203344 scopus 로고    scopus 로고
    • Glucosylceramide synthase and apoptosis
    • 10.1016/S1388-1981(02)00338-4 1:CAS:528:DC%2BD3sXivVyjsw%3D%3D
    • Bleicher RJ, Cabot MC (2002) Glucosylceramide synthase and apoptosis. Bba Mol Cell Biol L 1585:172-178
    • (2002) Bba Mol Cell Biol L , vol.1585 , pp. 172-178
    • Bleicher, R.J.1    Cabot, M.C.2
  • 28
    • 1342268296 scopus 로고    scopus 로고
    • Structure and biological functions of fungal cerebrosides
    • 15048196 10.1590/S0001-37652004000100007 1:CAS:528:DC%2BD2cXhvVKisbg%3D
    • Barreto-Bergter E, Pinto MR, Rodrigues ML (2004) Structure and biological functions of fungal cerebrosides. An Acad Bras Cienc 76:67-84
    • (2004) An Acad Bras Cienc , vol.76 , pp. 67-84
    • Barreto-Bergter, E.1    Pinto, M.R.2    Rodrigues, M.L.3
  • 29
    • 33846354894 scopus 로고    scopus 로고
    • Differences in the domain forming properties of N-palmitoylated neutral glycosphingolipids in bilayer
    • 17055448 10.1016/j.bbamem.2006.09.003 1:CAS:528:DC%2BD2sXhtVKns78%3D
    • Maunula S, Bjorkqvist YJE, Slotte JP, Ramstedt B (2007) Differences in the domain forming properties of N-palmitoylated neutral glycosphingolipids in bilayer. Bba-Biomembranes 1768:336-345
    • (2007) Bba-Biomembranes , vol.1768 , pp. 336-345
    • Maunula, S.1    Bjorkqvist, Y.J.E.2    Slotte, J.P.3    Ramstedt, B.4
  • 30
    • 2942639961 scopus 로고    scopus 로고
    • The cell biology of glycosphingolipids
    • 15207828 10.1016/j.semcdb.2004.03.007 1:CAS:528:DC%2BD2cXltVCisLw%3D
    • Degroote S, Wolthoorn J, van Meer G (2004) The cell biology of glycosphingolipids. Semin Cell Dev Biol 15:375-387
    • (2004) Semin Cell Dev Biol , vol.15 , pp. 375-387
    • Degroote, S.1    Wolthoorn, J.2    Van Meer, G.3
  • 31
    • 0034926817 scopus 로고    scopus 로고
    • The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog
    • 11457441 10.1016/S0009-3084(01)00152-9 1:CAS:528:DC%2BD3MXltFyqsLc%3D
    • Duclos RI (2001) The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog. Chem Phys Lipids 111:111-138
    • (2001) Chem Phys Lipids , vol.111 , pp. 111-138
    • Duclos, R.I.1
  • 32
    • 0034717903 scopus 로고    scopus 로고
    • Sphingolipid transport in eukaryotic cells
    • 10856719 10.1016/S1388-1981(00)00054-8
    • van Meer G, Holthuis JC (2000) Sphingolipid transport in eukaryotic cells. Biochim Biophys Acta 1486:145-170
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 145-170
    • Van Meer, G.1    Holthuis, J.C.2
  • 34
    • 78649767884 scopus 로고    scopus 로고
    • The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment
    • 20875392 10.1016/j.bbamem.2010.09.011 1:CAS:528:DC%2BC3cXhsFart7jM
    • Tuuf J, Kjellberg MA, Molotkovsky JG, Hanada K, Mattjus P (2011) The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment. Biochim Biophys Acta 1808:229-235
    • (2011) Biochim Biophys Acta , vol.1808 , pp. 229-235
    • Tuuf, J.1    Kjellberg, M.A.2    Molotkovsky, J.G.3    Hanada, K.4    Mattjus, P.5
  • 35
    • 0000255378 scopus 로고    scopus 로고
    • Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
    • 9873062 10.1074/jbc.274.2.1140 1:CAS:528:DyaK1MXmtFGrsQ%3D%3D
    • Liu YY, Han TY, Giuliano AE, Cabot MC (1999) Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J Biol Chem 274:1140-1146
    • (1999) J Biol Chem , vol.274 , pp. 1140-1146
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3    Cabot, M.C.4
  • 36
    • 0035823633 scopus 로고    scopus 로고
    • Glucosylceramide synthases, a gene family responsible for the biosynthesis of glycosphingolipids in animals, plants, and fungi
    • 11443131 10.1074/jbc.M104952200 1:CAS:528:DC%2BD3MXmslylsLo%3D
    • Leipelt M, Warnecke D, Zahringer U, Ott C, Muller F, Hube B, Heinz E (2001) Glucosylceramide synthases, a gene family responsible for the biosynthesis of glycosphingolipids in animals, plants, and fungi. J Biol Chem 276:33621-33629
    • (2001) J Biol Chem , vol.276 , pp. 33621-33629
    • Leipelt, M.1    Warnecke, D.2    Zahringer, U.3    Ott, C.4    Muller, F.5    Hube, B.6    Heinz, E.7
  • 37
    • 0142138695 scopus 로고    scopus 로고
    • Formation of glucosylceramide and sterol glucoside by a UDP-glucose-dependent glucosylceramide synthase from cotton expressed in Pichia pastoris
    • 14572652 10.1016/S0014-5793(03)01058-5 1:CAS:528:DC%2BD3sXot1yqtb4%3D
    • Hillig I, Leipelt M, Ott C, Zahringer U, Warnecke D, Heinz E (2003) Formation of glucosylceramide and sterol glucoside by a UDP-glucose-dependent glucosylceramide synthase from cotton expressed in Pichia pastoris. FEBS Lett 553:365-369
    • (2003) FEBS Lett , vol.553 , pp. 365-369
    • Hillig, I.1    Leipelt, M.2    Ott, C.3    Zahringer, U.4    Warnecke, D.5    Heinz, E.6
  • 38
    • 17544368169 scopus 로고    scopus 로고
    • Homeostasis of cell-surface glycosphingolipid content in B16 melanoma cells. Evidence revealed by an endoglycoceramidase
    • 8647878 10.1074/jbc.271.21.12655 1:CAS:528:DyaK28XjtFantLk%3D
    • Ito M, Komori H (1996) Homeostasis of cell-surface glycosphingolipid content in B16 melanoma cells. Evidence revealed by an endoglycoceramidase. J Biol Chem 271:12655-12660
    • (1996) J Biol Chem , vol.271 , pp. 12655-12660
    • Ito, M.1    Komori, H.2
  • 39
    • 0025027772 scopus 로고
    • Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action
    • 2145065 1:CAS:528:DyaK3MXlvFOhsA%3D%3D
    • Inokuchi J, Jimbo M, Momosaki K, Shimeno H, Nagamatsu A, Radin NS (1990) Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. Cancer Res 50:6731-6737
    • (1990) Cancer Res , vol.50 , pp. 6731-6737
    • Inokuchi, J.1    Jimbo, M.2    Momosaki, K.3    Shimeno, H.4    Nagamatsu, A.5    Radin, N.S.6
  • 40
    • 0035161429 scopus 로고    scopus 로고
    • Syntheses and interfacial behaviour of neoglycolipid analogues of glycosyl ceramides
    • 11705467 10.1016/S0008-6215(01)00255-5 1:CAS:528:DC%2BD3MXotlWqsr0%3D
    • Lafont D, Bouchu MN, Girard-Egrot A, Boullanger P (2001) Syntheses and interfacial behaviour of neoglycolipid analogues of glycosyl ceramides. Carbohydr Res 336:181-194
    • (2001) Carbohydr Res , vol.336 , pp. 181-194
    • Lafont, D.1    Bouchu, M.N.2    Girard-Egrot, A.3    Boullanger, P.4
  • 41
    • 0032167884 scopus 로고    scopus 로고
    • Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase
    • 9801819 10.1016/S0968-0896(98)00077-7 1:CAS:528:DyaK1cXms1Sisbw%3D
    • Miura T, Kajimoto T, Jimbo M, Yamagishi K, Inokuchi JC, Wong CH (1998) Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase. Bioorg Med Chem 6:1481-1489
    • (1998) Bioorg Med Chem , vol.6 , pp. 1481-1489
    • Miura, T.1    Kajimoto, T.2    Jimbo, M.3    Yamagishi, K.4    Inokuchi, J.C.5    Wong, C.H.6
  • 42
    • 0031888257 scopus 로고    scopus 로고
    • Glucosylceramide synthase activity in murine epidermis: Quantitation, localization, regulation, and requirement for barrier homeostasis
    • 9507988 1:CAS:528:DyaK1cXht1ait7c%3D
    • Chujor CS, Feingold KR, Elias PM, Holleran WM (1998) Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis. J Lipid Res 39:277-285
    • (1998) J Lipid Res , vol.39 , pp. 277-285
    • Chujor, C.S.1    Feingold, K.R.2    Elias, P.M.3    Holleran, W.M.4
  • 44
    • 25844520678 scopus 로고    scopus 로고
    • An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms
    • 16195602 10.1271/bbb.69.1782 1:CAS:528:DC%2BD2MXhtF2ktL%2FO
    • Hillig I, Warnecke D, Heinz E (2005) An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms. Biosci Biotechnol Biochem 69:1782-1785
    • (2005) Biosci Biotechnol Biochem , vol.69 , pp. 1782-1785
    • Hillig, I.1    Warnecke, D.2    Heinz, E.3
  • 46
    • 0032080795 scopus 로고    scopus 로고
    • Glucosylceramide synthase and glycosphingolipid synthesis
    • 9695839 10.1016/S0962-8924(98)01249-5 1:CAS:528:DyaK1cXjtFyjsrs%3D
    • Ichikawa S, Hirabayashi Y (1998) Glucosylceramide synthase and glycosphingolipid synthesis. Trends Cell Biol 8:198-202
    • (1998) Trends Cell Biol , vol.8 , pp. 198-202
    • Ichikawa, S.1    Hirabayashi, Y.2
  • 47
    • 39749144761 scopus 로고    scopus 로고
    • Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells
    • 17709137 10.1016/j.leukres.2007.07.006 1:CAS:528:DC%2BD1cXislWjsb8%3D
    • Xie P, Shen YF, Shi YP, Ge SM, Gu ZH, Wang J, Mu HJ, Zhang B, Qiao WZ, Xie KM (2008) Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells. Leuk Res 32:475-480
    • (2008) Leuk Res , vol.32 , pp. 475-480
    • Xie, P.1    Shen, Y.F.2    Shi, Y.P.3    Ge, S.M.4    Gu, Z.H.5    Wang, J.6    Mu, H.J.7    Zhang, B.8    Qiao, W.Z.9    Xie, K.M.10
  • 48
    • 33748556543 scopus 로고    scopus 로고
    • Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease
    • 16871601 10.1002/cbic.200600217 1:CAS:528:DC%2BD28XpslWqu7Y%3D
    • Compain P, Martin OR, Boucheron C, Godin G, Yu L, Ikeda K, Asano N (2006) Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease. ChemBioChem 7:1356-1359
    • (2006) ChemBioChem , vol.7 , pp. 1356-1359
    • Compain, P.1    Martin, O.R.2    Boucheron, C.3    Godin, G.4    Yu, L.5    Ikeda, K.6    Asano, N.7
  • 49
    • 0014410126 scopus 로고
    • Enzymatic synthesis of ceramide-glucose and ceramide-lactose by glycosyltransferases from embryonic chicken brain
    • 5699063 1:CAS:528:DyaF1MXksVE%3D
    • Basu S, Kaufman B, Roseman S (1968) Enzymatic synthesis of ceramide-glucose and ceramide-lactose by glycosyltransferases from embryonic chicken brain. J Biol Chem 243:5802-5804
    • (1968) J Biol Chem , vol.243 , pp. 5802-5804
    • Basu, S.1    Kaufman, B.2    Roseman, S.3
  • 50
    • 0034738011 scopus 로고    scopus 로고
    • Physiology and pathophysiology of sphingolipid metabolism and signaling
    • 10832090 10.1016/S1388-1981(00)00042-1 1:CAS:528:DC%2BD3cXjs1Cntbg%3D
    • Huwiler A, Kolter T, Pfeilschifter J, Sandhoff K (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 1485:63-99
    • (2000) Biochim Biophys Acta , vol.1485 , pp. 63-99
    • Huwiler, A.1    Kolter, T.2    Pfeilschifter, J.3    Sandhoff, K.4
  • 51
    • 77954667920 scopus 로고    scopus 로고
    • GCS induces multidrug resistance by regulating apoptosis-related genes in K562/AO2 cell line
    • 19936984 10.1007/s00280-009-1177-4 1:CAS:528:DC%2BC3cXns1Sisbo%3D
    • Liu Y, Xie KM, Yang GQ, Bai XM, Shi YP, Mu HJ, Qiao WZ, Zhang B, Xie P (2010) GCS induces multidrug resistance by regulating apoptosis-related genes in K562/AO2 cell line. Cancer Chemother Pharmacol 66:433-439
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 433-439
    • Liu, Y.1    Xie, K.M.2    Yang, G.Q.3    Bai, X.M.4    Shi, Y.P.5    Mu, H.J.6    Qiao, W.Z.7    Zhang, B.8    Xie, P.9
  • 52
    • 12344336357 scopus 로고    scopus 로고
    • P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway
    • 15661399 10.1016/j.exphem.2004.10.005 1:CAS:528:DC%2BD2MXmvFCisg%3D%3D
    • Turzanski J, Grundy M, Shang S, Russell N, Pallis M (2005) P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. Exp Hematol 33:62-72
    • (2005) Exp Hematol , vol.33 , pp. 62-72
    • Turzanski, J.1    Grundy, M.2    Shang, S.3    Russell, N.4    Pallis, M.5
  • 53
    • 73649135746 scopus 로고    scopus 로고
    • A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis
    • Fujikawa K, Nohara T, Imamura A,Ando H, Ishida H, Kiso M (2010) A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis. Tetrahedron Lett 51:1126-1130
    • (2010) Tetrahedron Lett , vol.51 , pp. 1126-1130
    • Fujikawa, K.1    Nohara, T.2    Imamura, A.3    Ando, H.4    Ishida, H.5    Kiso, M.6
  • 55
    • 0035367339 scopus 로고    scopus 로고
    • The involvement of sphingolipids in multidrug resistance
    • 11420602 1:CAS:528:DC%2BD3MXks1amtbc%3D
    • Sietsma H, Veldman RJ, Kok JW (2001) The involvement of sphingolipids in multidrug resistance. J Membr Biol 181:153-162
    • (2001) J Membr Biol , vol.181 , pp. 153-162
    • Sietsma, H.1    Veldman, R.J.2    Kok, J.W.3
  • 57
    • 12244284610 scopus 로고    scopus 로고
    • Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
    • 12538495 1:CAS:528:DC%2BD3sXnt1OqtQ%3D%3D
    • Itoh M, Kitano T, Watanabe M, Kondo T, Yabu T, Taguchi Y, Iwai K, Tashima M, Uchiyama T, Okazaki T (2003) Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin Cancer Res 9:415-423
    • (2003) Clin Cancer Res , vol.9 , pp. 415-423
    • Itoh, M.1    Kitano, T.2    Watanabe, M.3    Kondo, T.4    Yabu, T.5    Taguchi, Y.6    Iwai, K.7    Tashima, M.8    Uchiyama, T.9    Okazaki, T.10
  • 58
    • 0031019309 scopus 로고    scopus 로고
    • Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
    • 8999846 10.1074/jbc.272.3.1682 1:CAS:528:DyaK2sXls1Crtg%3D%3D
    • Lavie Y, Cao H, Volner A, Lucci A, Han TY, Geffen V, Giuliano AE, Cabot MC (1997) Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J Biol Chem 272:1682-1687
    • (1997) J Biol Chem , vol.272 , pp. 1682-1687
    • Lavie, Y.1    Cao, H.2    Volner, A.3    Lucci, A.4    Han, T.Y.5    Geffen, V.6    Giuliano, A.E.7    Cabot, M.C.8
  • 59
    • 0035079539 scopus 로고    scopus 로고
    • Ceramide glycosylation potentiates cellular multidrug resistance
    • 11259390 10.1096/fj.00-0223com 1:CAS:528:DC%2BD3MXitFWmsLk%3D
    • Liu YY, Han TY, Giuliano AE, Cabot MC (2001) Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 15:719-730
    • (2001) FASEB J , vol.15 , pp. 719-730
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3    Cabot, M.C.4
  • 60
    • 0029761340 scopus 로고    scopus 로고
    • Accumulation of glucosylceramides in multidrug-resistant cancer cells
    • 8702646 10.1074/jbc.271.32.19530 1:CAS:528:DyaK28XkvFymtL0%3D
    • Lavie Y, Cao H, Bursten SL, Giuliano AE, Cabot MC (1996) Accumulation of glucosylceramides in multidrug-resistant cancer cells. J Biol Chem 271:19530-19536
    • (1996) J Biol Chem , vol.271 , pp. 19530-19536
    • Lavie, Y.1    Cao, H.2    Bursten, S.L.3    Giuliano, A.E.4    Cabot, M.C.5
  • 61
    • 78649955814 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity
    • 21042729 1:CAS:528:DC%2BC3cXhs1SmtrbI
    • Chapman JV, Gouaze-Andersson V, Cabot MC (2010) Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. Int J Oncol 37:1591-1597
    • (2010) Int J Oncol , vol.37 , pp. 1591-1597
    • Chapman, J.V.1    Gouaze-Andersson, V.2    Cabot, M.C.3
  • 62
    • 38349045075 scopus 로고    scopus 로고
    • Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
    • 18035065 10.1016/j.bbalip.2007.09.005 1:CAS:528:DC%2BD1cXptlSrtA%3D%3D
    • Gouaze-Andersson V, Yu JY, Kreitenberg AJ, Bielawska A, Giuliano AE, Cabot MC (2007) Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells. Biochim Biophys Acta 1771:1407-1417
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 1407-1417
    • Gouaze-Andersson, V.1    Yu, J.Y.2    Kreitenberg, A.J.3    Bielawska, A.4    Giuliano, A.E.5    Cabot, M.C.6
  • 64
    • 84872337963 scopus 로고    scopus 로고
    • Sphingolipid metabolism inhibitors and cell function
    • 10.2174/1874940200801010072 1:CAS:528:DC%2BD1cXhtlahurnL
    • Albi MVME (2008) Sphingolipid metabolism inhibitors and cell function. Open Enzym Inhib J 1:72-79
    • (2008) Open Enzym Inhib J , vol.1 , pp. 72-79
    • Albi, M.1
  • 65
    • 34250303805 scopus 로고    scopus 로고
    • Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer
    • 17510414 10.1158/0008-5472.CAN-06-1648
    • van Vlerken LE, Duan Z, Seiden MV, Amiji MM (2007) Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer. Cancer Res 67:4843-4850
    • (2007) Cancer Res , vol.67 , pp. 4843-4850
    • Van Vlerken, L.E.1    Duan, Z.2    Seiden, M.V.3    Amiji, M.M.4
  • 66
    • 77957660685 scopus 로고    scopus 로고
    • Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: In vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells
    • 20816930 10.1016/j.ijpharm.2010.08.044 1:CAS:528:DC%2BC3cXht1KgtL7F
    • Siddiqui A, Patwardhan GA, Liu YY, Nazzal S (2010) Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells. Int J Pharm 400:251-259
    • (2010) Int J Pharm , vol.400 , pp. 251-259
    • Siddiqui, A.1    Patwardhan, G.A.2    Liu, Y.Y.3    Nazzal, S.4
  • 68
    • 77953121237 scopus 로고    scopus 로고
    • Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs
    • 19693666 10.1007/s10549-009-0513-z 1:CAS:528:DC%2BC3cXmtVyrsbk%3D
    • Sun Y, Zhang T, Gao P, Meng B, Gao Y, Wang X, Zhang J, Wang H, Wu X, Zheng W, Zhou G (2010) Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs. Breast Cancer Res Treat 121:591-599
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 591-599
    • Sun, Y.1    Zhang, T.2    Gao, P.3    Meng, B.4    Gao, Y.5    Wang, X.6    Zhang, J.7    Wang, H.8    Wu, X.9    Zheng, W.10    Zhou, G.11
  • 69
    • 66449104669 scopus 로고    scopus 로고
    • Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi)
    • 19502811 10.1158/1535-7163.MCT-08-0544 1:CAS:528:DC%2BD1MXhs1ahtrbP
    • Zhang X, Li J, Qiu Z, Gao P, Wu X, Zhou G (2009) Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi). Cancer Biol Ther 8:1117-1121
    • (2009) Cancer Biol Ther , vol.8 , pp. 1117-1121
    • Zhang, X.1    Li, J.2    Qiu, Z.3    Gao, P.4    Wu, X.5    Zhou, G.6
  • 70
    • 80054726983 scopus 로고    scopus 로고
    • Inhibition of glucosylceramide synthase by PDMP resensitizes multidrug-resistant human chronic myeloid leukemia cells to Imatinib
    • 10.1007/s00432-011-1016-y 1:CAS:528:DC%2BC3MXhtFynt73P
    • Baran Y, Bielawski J, Ogretmen B, Gunduz U (2011) Inhibition of glucosylceramide synthase by PDMP resensitizes multidrug-resistant human chronic myeloid leukemia cells to Imatinib. J Can Res Clin Oncol 137(10):1535-1544
    • (2011) J Can Res Clin Oncol , vol.137 , Issue.10 , pp. 1535-1544
    • Baran, Y.1    Bielawski, J.2    Ogretmen, B.3    Gunduz, U.4
  • 71
    • 2342437213 scopus 로고    scopus 로고
    • Sphingolipid metabolism enzymes as targets for anticancer therapy
    • 15134220 10.2174/1389450043345452 1:CAS:528:DC%2BD2cXjs1GnsLY%3D
    • Kok JW, Sietsma H (2004) Sphingolipid metabolism enzymes as targets for anticancer therapy. Curr Drug Targets 5:375-382
    • (2004) Curr Drug Targets , vol.5 , pp. 375-382
    • Kok, J.W.1    Sietsma, H.2
  • 72
    • 0028356595 scopus 로고
    • Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase
    • 8086032 10.1007/BF02815346 1:CAS:528:DyaK2cXlvFCks7o%3D
    • Radin NS (1994) Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase. Mol Chem Neuropathol 21:111-127
    • (1994) Mol Chem Neuropathol , vol.21 , pp. 111-127
    • Radin, N.S.1
  • 73
    • 0033532912 scopus 로고    scopus 로고
    • Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines
    • 10393722 10.1093/jnci/91.13.1138 1:CAS:528:DyaK1MXkvVyjs7o%3D
    • Maurer BJ, Metelitsa LS, Seeger RC, Cabot MC, Reynolds CP (1999) Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines. J Natl Cancer Inst 91:1138-1146
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1138-1146
    • Maurer, B.J.1    Metelitsa, L.S.2    Seeger, R.C.3    Cabot, M.C.4    Reynolds, C.P.5
  • 74
    • 0033560130 scopus 로고    scopus 로고
    • Chemotherapy by slowing glycosphingolipid synthesis
    • 10037442 10.1016/S0006-2952(98)00274-3 1:CAS:528:DyaK1MXht1Cjs7o%3D
    • Radin NS (1999) Chemotherapy by slowing glycosphingolipid synthesis. Biochem Pharmacol 57:589-595
    • (1999) Biochem Pharmacol , vol.57 , pp. 589-595
    • Radin, N.S.1
  • 75
    • 0038079762 scopus 로고    scopus 로고
    • Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase
    • 12839955 1:CAS:528:DC%2BD3sXltVGru78%3D
    • Weiss M, Hettmer S, Smith P, Ladisch S (2003) Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res 63:3654-3658
    • (2003) Cancer Res , vol.63 , pp. 3654-3658
    • Weiss, M.1    Hettmer, S.2    Smith, P.3    Ladisch, S.4
  • 76
    • 0041742270 scopus 로고    scopus 로고
    • Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells
    • 12873973
    • Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (2003) Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. Cancer Res 63:3860-3865
    • (2003) Cancer Res , vol.63 , pp. 3860-3865
    • Di Sano, F.1    Fazi, B.2    Citro, G.3    Lovat, P.E.4    Cesareni, G.5    Piacentini, M.6
  • 77
    • 18144371163 scopus 로고    scopus 로고
    • Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    • 15867385 10.1158/0008-5472.CAN-04-2329 1:CAS:528:DC%2BD2MXjslGks7k%3D
    • Gouaze V, Liu YY, Prickett CS, Yu JY, Giuliano AE, Cabot MC (2005) Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res 65:3861-3867
    • (2005) Cancer Res , vol.65 , pp. 3861-3867
    • Gouaze, V.1    Liu, Y.Y.2    Prickett, C.S.3    Yu, J.Y.4    Giuliano, A.E.5    Cabot, M.C.6
  • 78
    • 33645462079 scopus 로고    scopus 로고
    • PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy
    • 16546973 10.1158/1535-7163.MCT-05-0457 1:CAS:528:DC%2BD28Xitl2lt7o%3D
    • Dijkhuis AJ, Klappe K, Jacobs S, Kroesen BJ, Kamps W, Sietsma H, Kok JW (2006) PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy. Mol Cancer Ther 5:593-601
    • (2006) Mol Cancer Ther , vol.5 , pp. 593-601
    • Dijkhuis, A.J.1    Klappe, K.2    Jacobs, S.3    Kroesen, B.J.4    Kamps, W.5    Sietsma, H.6    Kok, J.W.7
  • 79
    • 40249087168 scopus 로고    scopus 로고
    • Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin
    • 18292930 1:CAS:528:DC%2BD1cXjs1Cmtbg%3D
    • Furlong SJ, Ridgway ND, Hoskin DW (2008) Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin. Int J Oncol 32:537-544
    • (2008) Int J Oncol , vol.32 , pp. 537-544
    • Furlong, S.J.1    Ridgway, N.D.2    Hoskin, D.W.3
  • 80
    • 34447115107 scopus 로고    scopus 로고
    • Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
    • 17283068 10.1074/jbc.M700647200 1:CAS:528:DC%2BD2sXmt1agsr8%3D
    • Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A (2007) Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 282:16718-16728
    • (2007) J Biol Chem , vol.282 , pp. 16718-16728
    • Kraveka, J.M.1    Li, L.2    Szulc, Z.M.3    Bielawski, J.4    Ogretmen, B.5    Hannun, Y.A.6    Obeid, L.M.7    Bielawska, A.8
  • 81
    • 77953294709 scopus 로고    scopus 로고
    • Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
    • 20540746 10.1186/1476-4598-9-145
    • Liu YY, Gupta V, Patwardhan GA, Bhinge K, Zhao Y, Bao J, Mehendale H, Cabot MC, Li YT, Jazwinski SM (2010) Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 9:145
    • (2010) Mol Cancer , vol.9 , pp. 145
    • Liu, Y.Y.1    Gupta, V.2    Patwardhan, G.A.3    Bhinge, K.4    Zhao, Y.5    Bao, J.6    Mehendale, H.7    Cabot, M.C.8    Li, Y.T.9    Jazwinski, S.M.10
  • 82
    • 59649110566 scopus 로고    scopus 로고
    • De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma
    • 19027085 10.1016/j.biocel.2008.10.021 1:CAS:528:DC%2BD1MXitVGjtr0%3D
    • Rath G, Schneider C, Langlois B, Sartelet H, Morjani H, Btaouri HE, Dedieu S, Martiny L (2009) De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma. Int J Biochem Cell Biol 41:1165-1172
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1165-1172
    • Rath, G.1    Schneider, C.2    Langlois, B.3    Sartelet, H.4    Morjani, H.5    Btaouri, H.E.6    Dedieu, S.7    Martiny, L.8
  • 83
    • 79952767541 scopus 로고    scopus 로고
    • Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells
    • 21278235 10.1158/0008-5472.CAN-10-3107 1:CAS:528:DC%2BC3MXjtFWgtLY%3D
    • Liu YY, Patwardhan GA, Bhinge K, Gupta V, Gu X, Jazwinski SM (2011) Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer Res 71:2276-2285
    • (2011) Cancer Res , vol.71 , pp. 2276-2285
    • Liu, Y.Y.1    Patwardhan, G.A.2    Bhinge, K.3    Gupta, V.4    Gu, X.5    Jazwinski, S.M.6
  • 84
    • 78751643035 scopus 로고    scopus 로고
    • The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells
    • 20401667 10.1007/s00432-010-0884-x 1:CAS:528:DC%2BC3MXkt1SnsQ%3D%3D
    • Cakir Z, Saydam G, Sahin F, Baran Y (2011) The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells. J Cancer Res Clin Oncol 137:279-286
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 279-286
    • Cakir, Z.1    Saydam, G.2    Sahin, F.3    Baran, Y.4
  • 85
    • 79957604463 scopus 로고    scopus 로고
    • Resveratrol triggers apoptosis by increasing intracellular concentrations of ceramides in chronic myeloid leukemia cells
    • 10.1080/01635581.2011.538485 1:CAS:528:DC%2BC3MXmtlahsro%3D
    • Kartal M, Saydam G, Sahin F, Baran Y (2011) Resveratrol triggers apoptosis by increasing intracellular concentrations of ceramides in chronic myeloid leukemia cells. Nutrit Cancer An Internat J 63(4):637-644
    • (2011) Nutrit Cancer An Internat J , vol.63 , Issue.4 , pp. 637-644
    • Kartal, M.1    Saydam, G.2    Sahin, F.3    Baran, Y.4
  • 86
    • 34249737950 scopus 로고    scopus 로고
    • Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
    • 17303574 10.1074/jbc.M610157200 1:CAS:528:DC%2BD2sXjvFags78%3D
    • Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B (2007) Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem 282:10922-10934
    • (2007) J Biol Chem , vol.282 , pp. 10922-10934
    • Baran, Y.1    Salas, A.2    Senkal, C.E.3    Gunduz, U.4    Bielawski, J.5    Obeid, L.M.6    Ogretmen, B.7
  • 87
    • 79960415852 scopus 로고    scopus 로고
    • Targeting ceramide metabolism to increase intracellular concentrations of apoptotic ceramide increased cytotoxic effects of nilotinib in human chronic myeloid leukemia cells
    • 10.3109/10428194.2011.568653 1:CAS:528:DC%2BC3MXovFOqt7c%3D
    • Camgoz A, Ural AU, Avcu F, Baran Y (2011) Targeting ceramide metabolism to increase intracellular concentrations of apoptotic ceramide increased cytotoxic effects of nilotinib in human chronic myeloid leukemia cells. Leuk and Lymph 52(8):1574-1584
    • (2011) Leuk and Lymph , vol.52 , Issue.8 , pp. 1574-1584
    • Camgoz, A.1    Ural, A.U.2    Avcu, F.3    Baran, Y.4
  • 88
    • 84855203360 scopus 로고    scopus 로고
    • Dasatinib induces apoptosis through increasing de novo generation or accumulation of ceramides in human K562 and Meg-01 chronic myeloid leukemia cells
    • 10.1007/s00277-011-1212-5 1:CAS:528:DC%2BC3MXht1ylsLzP
    • Gencer AB, Ural AU, Avcu F, Baran Y (2011) Dasatinib induces apoptosis through increasing de novo generation or accumulation of ceramides in human K562 and Meg-01 chronic myeloid leukemia cells. Annals of Hemat 90(11):1265-1275
    • (2011) Annals of Hemat , vol.90 , Issue.11 , pp. 1265-1275
    • Gencer, A.B.1    Ural, A.U.2    Avcu, F.3    Baran, Y.4
  • 89
    • 84858287935 scopus 로고    scopus 로고
    • Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
    • 10.1016/j.biopha.2011.10.003 1:CAS:528:DC%2BC38XjvVekt7o%3D
    • Bassoy EY, Baran Y (2012) Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. Biomed Pharmacot 66(2):103-110
    • (2012) Biomed Pharmacot , vol.66 , Issue.2 , pp. 103-110
    • Bassoy, E.Y.1    Baran, Y.2
  • 90
    • 0035399826 scopus 로고    scopus 로고
    • Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity
    • 11391632 10.1002/ijc.1301 1:CAS:528:DC%2BD3MXksFanu70%3D
    • Olshefski RS, Ladisch S (2001) Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity. Int J Cancer 93:131-138
    • (2001) Int J Cancer , vol.93 , pp. 131-138
    • Olshefski, R.S.1    Ladisch, S.2
  • 91
    • 39749144761 scopus 로고    scopus 로고
    • Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells
    • 17709137 10.1016/j.leukres.2007.07.006 1:CAS:528:DC%2BD1cXislWjsb8%3D
    • Xie P, Shen YF, Shi YP, Ge SM, Gu ZH, Wang J, Mu HJ, Zhang B, Qiao WZ, Xie KM (2008) Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells. Leuk Res 32:475-480
    • (2008) Leuk Res , vol.32 , pp. 475-480
    • Xie, P.1    Shen, Y.F.2    Shi, Y.P.3    Ge, S.M.4    Gu, Z.H.5    Wang, J.6    Mu, H.J.7    Zhang, B.8    Qiao, W.Z.9    Xie, K.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.