Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 10, 2011, Pages 1535-1544

  Baran, Yusuf ^a   Bielawski, Jacek ^b   Gunduz, Ufuk ^c   Ogretmen, Besim ^b  

^a IZMIR INSTITUTE OF TECHNOLOGY   (Turkey)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Ceramide; CML; Drug resistance; Glucosylceramide

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; GLUCOSYLCERAMIDE; IMATINIB; MESSENGER RNA; TRYPAN BLUE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL ASSAY; CELL DEATH; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE; GLUCOSYLCERAMIDE SYNTHASE GENE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LIPID METABOLISM; LIPID STORAGE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CERAMIDES; DRUG RESISTANCE, NEOPLASM; GLUCOSYLTRANSFERASES; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MORPHOLINES; PIPERAZINES; PYRIMIDINES;

EID: 80054726983     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1016-y     Document Type: Article

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