-
1
-
-
84859179083
-
Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis
-
22415826 10.1038/ncomms1734
-
Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, MacDougald OA, Distler O, Schett G, Distler JH (2012) Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun 3:735
-
(2012)
Nat Commun
, vol.3
, pp. 735
-
-
Akhmetshina, A.1
Palumbo, K.2
Dees, C.3
Bergmann, C.4
Venalis, P.5
Zerr, P.6
Horn, A.7
Kireva, T.8
Beyer, C.9
Zwerina, J.10
Schneider, H.11
Sadowski, A.12
Riener, M.O.13
MacDougald, O.A.14
Distler, O.15
Schett, G.16
Distler, J.H.17
-
2
-
-
80051531363
-
Notch signaling: Simplicity in design, versatility in function
-
21828089 10.1242/dev.063610 1:CAS:528:DC%2BC3MXhtl2itLzJ
-
Andersson ER, Sandberg R, Lendahl U (2011) Notch signaling: simplicity in design, versatility in function. Development 138(17):3593-3612
-
(2011)
Development
, vol.138
, Issue.17
, pp. 3593-3612
-
-
Andersson, E.R.1
Sandberg, R.2
Lendahl, U.3
-
3
-
-
40649105572
-
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: Role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
-
17943183 10.1038/sj.jid.5701101 1:CAS:528:DC%2BD1cXjtFOms78%3D
-
Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R (2008) Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol 128(4):871-881
-
(2008)
J Invest Dermatol
, vol.128
, Issue.4
, pp. 871-881
-
-
Bayle, J.1
Fitch, J.2
Jacobsen, K.3
Kumar, R.4
Lafyatis, R.5
Lemaire, R.6
-
4
-
-
82755197822
-
Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway
-
21873331 10.1136/ard.2010.147140 1:CAS:528:DC%2BC38Xjs1ersA%3D%3D
-
Bergmann C, Akhmetshina A, Dees C, Palumbo K, Zerr P, Beyer C, Zwerina J, Distler O, Schett G, Distler JH (2011) Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis 70(12):2191-2198
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.12
, pp. 2191-2198
-
-
Bergmann, C.1
Akhmetshina, A.2
Dees, C.3
Palumbo, K.4
Zerr, P.5
Beyer, C.6
Zwerina, J.7
Distler, O.8
Schett, G.9
Distler, J.H.10
-
6
-
-
84859247939
-
Innovative antifibrotic therapies in systemic sclerosis
-
22450392 10.1097/BOR.0b013e3283524b9a 1:CAS:528:DC%2BC38XkvFOmsL4%3D
-
Beyer C, Distler O, Distler JH (2012) Innovative antifibrotic therapies in systemic sclerosis. Curr Opin Rheumatol 24(3):274-280
-
(2012)
Curr Opin Rheumatol
, vol.24
, Issue.3
, pp. 274-280
-
-
Beyer, C.1
Distler, O.2
Distler, J.H.3
-
7
-
-
84872323731
-
Blockade of canonical Wnt signaling inhibits experimental dermal fibrosis
-
submitted
-
Beyer C, Schramm A, Akan H, Dees C, Lin N-Y, Distler A, Gelse K, Varga J, Distler O, Schett G, Distler JH (2012) Blockade of canonical Wnt signaling inhibits experimental dermal fibrosis. Ann Rheum Dis (submitted)
-
(2012)
Ann Rheum Dis
-
-
Beyer, C.1
Schramm, A.2
Akan, H.3
Dees, C.4
Lin, N.-Y.5
Distler, A.6
Gelse, K.7
Varga, J.8
Distler, O.9
Schett, G.10
Distler, J.H.11
-
8
-
-
84859500585
-
Beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
-
22328737 10.1136/annrheumdis-2011-200568 1:CAS:528:DC%2BC38XptFWnt78%3D
-
Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, Sonnylal S, de Crombrugghe B, Taketo MM, Distler O, Schett G, Distler JH (2012) Beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 71(5):761-767
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.5
, pp. 761-767
-
-
Beyer, C.1
Schramm, A.2
Akhmetshina, A.3
Dees, C.4
Kireva, T.5
Gelse, K.6
Sonnylal, S.7
De Crombrugghe, B.8
Taketo, M.M.9
Distler, O.10
Schett, G.11
Distler, J.H.12
-
9
-
-
75949106376
-
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
-
20081843 10.1038/ncb2013 1:CAS:528:DC%2BC3cXhtlCqtbw%3D
-
Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A (2010) Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol 12(2):132-142
-
(2010)
Nat Cell Biol
, vol.12
, Issue.2
, pp. 132-142
-
-
Canettieri, G.1
Di Marcotullio, L.2
Greco, A.3
Coni, S.4
Antonucci, L.5
Infante, P.6
Pietrosanti, L.7
De Smaele, E.8
Ferretti, E.9
Miele, E.10
Pelloni, M.11
De Simone, G.12
Pedone, E.M.13
Gallinari, P.14
Giorgi, A.15
Steinkuhler, C.16
Vitagliano, L.17
Pedone, C.18
Schinin, M.E.19
Screpanti, I.20
Gulino, A.21
more..
-
10
-
-
0037117611
-
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
-
11960000 10.1073/pnas.082096999 1:CAS:528:DC%2BD38XjtFKlsb0%3D
-
Cheng SY, Bishop JM (2002) Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci USA 99(8):5442-5447
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.8
, pp. 5442-5447
-
-
Cheng, S.Y.1
Bishop, J.M.2
-
11
-
-
77957774529
-
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors
-
20711444 10.1371/journal.pone.0011996
-
Cox B, Briscoe J, Ulloa F (2010) SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS One 5(8):e11996
-
(2010)
PLoS One
, vol.5
, Issue.8
, pp. 11996
-
-
Cox, B.1
Briscoe, J.2
Ulloa, F.3
-
13
-
-
79957637197
-
Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
-
21450749 10.1136/ard.2010.134742 1:CAS:528:DC%2BC3MXptlWjt7k%3D
-
Dees C, Tomcik M, Zerr P, Akhmetshina A, Horn A, Palumbo K, Beyer C, Zwerina J, Distler O, Schett G, Distler JH (2011) Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann Rheum Dis 70(7):1304-1310
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.7
, pp. 1304-1310
-
-
Dees, C.1
Tomcik, M.2
Zerr, P.3
Akhmetshina, A.4
Horn, A.5
Palumbo, K.6
Beyer, C.7
Zwerina, J.8
Distler, O.9
Schett, G.10
Distler, J.H.11
-
14
-
-
79955567838
-
Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
-
21312186 10.1002/art.30254 1:CAS:528:DC%2BC3MXltlGht7Y%3D
-
Dees C, Zerr P, Tomcik M, Beyer C, Horn A, Akhmetshina A, Palumbo K, Reich N, Zwerina J, Sticherling M, Mattson MP, Distler O, Schett G, Distler JH (2011) Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum 63(5):1396-1404
-
(2011)
Arthritis Rheum
, vol.63
, Issue.5
, pp. 1396-1404
-
-
Dees, C.1
Zerr, P.2
Tomcik, M.3
Beyer, C.4
Horn, A.5
Akhmetshina, A.6
Palumbo, K.7
Reich, N.8
Zwerina, J.9
Sticherling, M.10
Mattson, M.P.11
Distler, O.12
Schett, G.13
Distler, J.H.14
-
15
-
-
84872309056
-
Inactivation of tankyrases inhibits canonical Wnt signaling and reduces experimental fibrosis
-
submitted
-
Distler A, Deloch L, Huang J, Dees C, Lin NY, Beyer C, Distler O, Schett G, Distler JH (2011) Inactivation of tankyrases inhibits canonical Wnt signaling and reduces experimental fibrosis. Ann Rheum Dis (submitted)
-
(2011)
Ann Rheum Dis
-
-
Distler, A.1
Deloch, L.2
Huang, J.3
Dees, C.4
Lin, N.Y.5
Beyer, C.6
Distler, O.7
Schett, G.8
Distler, J.H.9
-
16
-
-
65549121943
-
Notch signaling: The core pathway and its posttranslational regulation
-
19460341 10.1016/j.devcel.2009.03.010 1:CAS:528:DC%2BD1MXps1yms7c%3D
-
Fortini ME (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 16(5):633-647
-
(2009)
Dev Cell
, vol.16
, Issue.5
, pp. 633-647
-
-
Fortini, M.E.1
-
18
-
-
79953161898
-
Hedgehog morphogen: From secretion to reception
-
21257310 10.1016/j.tcb.2010.12.005 1:CAS:528:DC%2BC3MXkt1Gnt7w%3D
-
Gallet A (2011) Hedgehog morphogen: from secretion to reception. Trends Cell Biol 21(4):238-246
-
(2011)
Trends Cell Biol
, vol.21
, Issue.4
, pp. 238-246
-
-
Gallet, A.1
-
19
-
-
34547566893
-
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
-
17664336 10.1083/jcb.200702009 1:CAS:528:DC%2BD2sXos1CrsLo%3D
-
Geffers I, Serth K, Chapman G, Jaekel R, Schuster-Gossler K, Cordes R, Sparrow DB, Kremmer E, Dunwoodie SL, Klein T, Gossler A (2007) Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178(3):465-476
-
(2007)
J Cell Biol
, vol.178
, Issue.3
, pp. 465-476
-
-
Geffers, I.1
Serth, K.2
Chapman, G.3
Jaekel, R.4
Schuster-Gossler, K.5
Cordes, R.6
Sparrow, D.B.7
Kremmer, E.8
Dunwoodie, S.L.9
Klein, T.10
Gossler, A.11
-
20
-
-
84861968011
-
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
-
22309842 10.1016/j.semcdb.2012.01.016 1:CAS:528:DC%2BC38XosFSgsL0%3D
-
Groth C, Fortini ME (2012) Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol 23(4):465-472
-
(2012)
Semin Cell Dev Biol
, vol.23
, Issue.4
, pp. 465-472
-
-
Groth, C.1
Fortini, M.E.2
-
21
-
-
65249134946
-
Wnt/beta-catenin signaling promotes renal interstitial fibrosis
-
19297557 10.1681/ASN.2008060566 1:CAS:528:DC%2BD1MXltFOqu70%3D
-
He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y (2009) Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20(4):765-776
-
(2009)
J Am Soc Nephrol
, vol.20
, Issue.4
, pp. 765-776
-
-
He, W.1
Dai, C.2
Li, Y.3
Zeng, G.4
Monga, S.P.5
Liu, Y.6
-
22
-
-
84859503196
-
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
-
22402139 10.1136/annrheumdis-2011-200883 1:CAS:528:DC%2BC38XptFWnt7Y%3D
-
Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G, Distler JH (2012) Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis 71(5):785-789
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.5
, pp. 785-789
-
-
Horn, A.1
Kireva, T.2
Palumbo-Zerr, K.3
Dees, C.4
Tomcik, M.5
Cordazzo, C.6
Zerr, P.7
Akhmetshina, A.8
Ruat, M.9
Distler, O.10
Beyer, C.11
Schett, G.12
Distler, J.H.13
-
23
-
-
84859260199
-
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
-
10.1002/art.34444
-
Horn A, Palumbo K, Cordazzo C, Dees C, Akhmetshina A, Tomcik M, Zerr P, Avouac J, Gusinde J, Zwerina J, Roudaut H, Traiffort E, Ruat M, Distler O, Schett G, Distler JH (2012) Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum. doi: 10.1002/art.34444
-
(2012)
Arthritis Rheum
-
-
Horn, A.1
Palumbo, K.2
Cordazzo, C.3
Dees, C.4
Akhmetshina, A.5
Tomcik, M.6
Zerr, P.7
Avouac, J.8
Gusinde, J.9
Zwerina, J.10
Roudaut, H.11
Traiffort, E.12
Ruat, M.13
Distler, O.14
Schett, G.15
Distler, J.H.16
-
24
-
-
80054022786
-
Gli proteins in development and disease
-
21801010 10.1146/annurev-cellbio-092910-154048 1:CAS:528: DC%2BC3MXhsFyqtbfI
-
Hui CC, Angers S (2011) Gli proteins in development and disease. Annu Rev Cell Dev Biol 27:513-537
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 513-537
-
-
Hui, C.C.1
Angers, S.2
-
25
-
-
79959944588
-
Gamma-secretase inhibitors and modulators for the treatment of Alzheimer's disease: Disappointments and hopes
-
21510832 10.2174/156802611795860942 1:CAS:528:DC%2BC3MXotFOrurw%3D
-
Imbimbo BP, Giardina GA (2011) Gamma-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes. Curr Top Med Chem 11(12):1555-1570
-
(2011)
Curr Top Med Chem
, vol.11
, Issue.12
, pp. 1555-1570
-
-
Imbimbo, B.P.1
Giardina, G.A.2
-
26
-
-
79956308325
-
Mechanisms and functions of Hedgehog signalling across the metazoa
-
21502959 10.1038/nrg2984 1:CAS:528:DC%2BC3MXmtFymsL0%3D
-
Ingham PW, Nakano Y, Seger C (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12(6):393-406
-
(2011)
Nat Rev Genet
, vol.12
, Issue.6
, pp. 393-406
-
-
Ingham, P.W.1
Nakano, Y.2
Seger, C.3
-
27
-
-
78649999605
-
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
-
21076395 10.1038/nm.2251 1:CAS:528:DC%2BC3cXhsVWmurjM
-
Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M (2010) Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat Med 16(12):1429-1433
-
(2010)
Nat Med
, vol.16
, Issue.12
, pp. 1429-1433
-
-
Jagani, Z.1
Mora-Blanco, E.L.2
Sansam, C.G.3
McKenna, E.S.4
Wilson, B.5
Chen, D.6
Klekota, J.7
Tamayo, P.8
Nguyen, P.T.9
Tolstorukov, M.10
Park, P.J.11
Cho, Y.J.12
Hsiao, K.13
Buonamici, S.14
Pomeroy, S.L.15
Mesirov, J.P.16
Ruffner, H.17
Bouwmeester, T.18
Luchansky, S.J.19
Murtie, J.20
Kelleher, J.F.21
Warmuth, M.22
Sellers, W.R.23
Roberts, C.W.24
Dorsch, M.25
more..
-
28
-
-
78249268282
-
Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model
-
20583103 10.1002/art.27626 1:CAS:528:DC%2BC3cXhsFahsrfN
-
Kavian N, Servettaz A, Mongaret C, Wang A, Nicco C, Chereau C, Grange P, Vuiblet V, Birembaut P, Diebold MD, Weill B, Dupin N, Batteux F (2010) Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model. Arthritis Rheum 62(11):3477-3487
-
(2010)
Arthritis Rheum
, vol.62
, Issue.11
, pp. 3477-3487
-
-
Kavian, N.1
Servettaz, A.2
Mongaret, C.3
Wang, A.4
Nicco, C.5
Chereau, C.6
Grange, P.7
Vuiblet, V.8
Birembaut, P.9
Diebold, M.D.10
Weill, B.11
Dupin, N.12
Batteux, F.13
-
29
-
-
61449249121
-
Selective activation mechanisms of Wnt signaling pathways
-
19208479 10.1016/j.tcb.2009.01.003 1:CAS:528:DC%2BD1MXivVWkur4%3D
-
Kikuchi A, Yamamoto H, Sato A (2009) Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol 19(3):119-129
-
(2009)
Trends Cell Biol
, vol.19
, Issue.3
, pp. 119-129
-
-
Kikuchi, A.1
Yamamoto, H.2
Sato, A.3
-
30
-
-
58149333154
-
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
-
19079247 10.1038/ncb1811 1:CAS:528:DC%2BD1MXhtVKjsg%3D%3D
-
Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu TC, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol 11(1):46-55
-
(2009)
Nat Cell Biol
, vol.11
, Issue.1
, pp. 46-55
-
-
Kobayashi, K.1
Luo, M.2
Zhang, Y.3
Wilkes, D.C.4
Ge, G.5
Grieskamp, T.6
Yamada, C.7
Liu, T.C.8
Huang, G.9
Basson, C.T.10
Kispert, A.11
Greenspan, D.S.12
Sato, T.N.13
-
31
-
-
65249088418
-
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
-
19287097
-
Konigshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, Jahn A, Rose F, Fink L, Seeger W, Schaefer L, Gunther A, Eickelberg O (2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119(4):772-787
-
(2009)
J Clin Invest
, vol.119
, Issue.4
, pp. 772-787
-
-
Konigshoff, M.1
Kramer, M.2
Balsara, N.3
Wilhelm, J.4
Amarie, O.V.5
Jahn, A.6
Rose, F.7
Fink, L.8
Seeger, W.9
Schaefer, L.10
Gunther, A.11
Eickelberg, O.12
-
32
-
-
24944501849
-
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
-
16144902 10.1083/jcb.200503113 1:CAS:528:DC%2BD2MXhtVWks7vE
-
Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster G (2005) The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol 170(6):983-992
-
(2005)
J Cell Biol
, vol.170
, Issue.6
, pp. 983-992
-
-
Ladi, E.1
Nichols, J.T.2
Ge, W.3
Miyamoto, A.4
Yao, C.5
Yang, L.T.6
Boulter, J.7
Sun, Y.E.8
Kintner, C.9
Weinmaster, G.10
-
33
-
-
33845683490
-
Quantitative dissection of the Notch: CSL interaction: Insights into the Notch-mediated transcriptional switch
-
17070841 10.1016/j.jmb.2006.09.071 1:CAS:528:DC%2BD2sXht1Crsw%3D%3D
-
Lubman OY, Ilagan MX, Kopan R, Barrick D (2007) Quantitative dissection of the Notch: CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol 365(3):577-589
-
(2007)
J Mol Biol
, vol.365
, Issue.3
, pp. 577-589
-
-
Lubman, O.Y.1
Ilagan, M.X.2
Kopan, R.3
Barrick, D.4
-
34
-
-
67650230896
-
Wnt/beta-catenin signaling: Components, mechanisms, and diseases
-
19619488 10.1016/j.devcel.2009.06.016 1:CAS:528:DC%2BD1MXpsV2msb8%3D
-
MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17(1):9-26
-
(2009)
Dev Cell
, vol.17
, Issue.1
, pp. 9-26
-
-
MacDonald, B.T.1
Tamai, K.2
He, X.3
-
35
-
-
84865142872
-
Wnt signaling
-
doi: 10.1101/cshperspect.a011163
-
Nusse R (2012) Wnt signaling. Cold Spring Harb Perspect Biol 4 (5). doi: 10.1101/cshperspect.a011163
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
, Issue.5
-
-
Nusse, R.1
-
36
-
-
84862207240
-
Three decades of Wnts: A personal perspective on how a scientific field developed
-
22617420 10.1038/emboj.2012.146 1:CAS:528:DC%2BC38XntlSls7w%3D
-
Nusse R, Varmus H (2012) Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 31(12):2670-2684
-
(2012)
EMBO J
, vol.31
, Issue.12
, pp. 2670-2684
-
-
Nusse, R.1
Varmus, H.2
-
37
-
-
84862170024
-
Drugging Wnt signalling in cancer
-
22617421 10.1038/emboj.2012.126 1:CAS:528:DC%2BC38XntlSit7w%3D
-
Polakis P (2012) Drugging Wnt signalling in cancer. EMBO J 31(12):2737-2746
-
(2012)
EMBO J
, vol.31
, Issue.12
, pp. 2737-2746
-
-
Polakis, P.1
-
38
-
-
0242412482
-
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
-
12949072 10.1074/jbc.M307757200 1:CAS:528:DC%2BD3sXosl2iuro%3D
-
Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, Berridge BR, Gao H, Higgins MA, May PC, Ryan TP (2003) Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem 278(46):46107-46116
-
(2003)
J Biol Chem
, vol.278
, Issue.46
, pp. 46107-46116
-
-
Searfoss, G.H.1
Jordan, W.H.2
Calligaro, D.O.3
Galbreath, E.J.4
Schirtzinger, L.M.5
Berridge, B.R.6
Gao, H.7
Higgins, M.A.8
May, P.C.9
Ryan, T.P.10
-
39
-
-
79958263078
-
Strategies for homeostatic stem cell self-renewal in adult tissues
-
21663791 10.1016/j.cell.2011.05.033 1:CAS:528:DC%2BC3MXnsVOktrc%3D
-
Simons BD, Clevers H (2011) Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145(6):851-862
-
(2011)
Cell
, vol.145
, Issue.6
, pp. 851-862
-
-
Simons, B.D.1
Clevers, H.2
-
40
-
-
82755160861
-
Notch in the kidney: Development and disease
-
21952830 10.1002/path.2967 1:CAS:528:DC%2BC3MXhsFCqsb3F
-
Sirin Y, Susztak K (2012) Notch in the kidney: development and disease. J Pathol 226(2):394-403
-
(2012)
J Pathol
, vol.226
, Issue.2
, pp. 394-403
-
-
Sirin, Y.1
Susztak, K.2
-
41
-
-
34347266509
-
Changes in causes of death in systemic sclerosis, 1972-2002
-
17329309 10.1136/ard.2006.066068
-
Steen VD, Medsger TA (2007) Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis 66(7):940-944
-
(2007)
Ann Rheum Dis
, vol.66
, Issue.7
, pp. 940-944
-
-
Steen, V.D.1
Medsger, T.A.2
-
42
-
-
84862171364
-
The many faces and functions of beta-catenin
-
22617422 10.1038/emboj.2012.150 1:CAS:528:DC%2BC38XntlSktbY%3D
-
Valenta T, Hausmann G, Basler K (2012) The many faces and functions of beta-catenin. EMBO J 31(12):2714-2736
-
(2012)
EMBO J
, vol.31
, Issue.12
, pp. 2714-2736
-
-
Valenta, T.1
Hausmann, G.2
Basler, K.3
-
43
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
15959515 10.1038/nature03659
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H (2005) Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435(7044):959-963
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 959-963
-
-
Van Es, J.H.1
Van Gijn, M.E.2
Riccio, O.3
Van Den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
44
-
-
33847348491
-
Systemic sclerosis: A prototypic multisystem fibrotic disorder
-
17332883 10.1172/JCI31139 1:CAS:528:DC%2BD2sXis12htrw%3D
-
Varga J, Abraham D (2007) Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 117(3):557-567
-
(2007)
J Clin Invest
, vol.117
, Issue.3
, pp. 557-567
-
-
Varga, J.1
Abraham, D.2
-
45
-
-
84863923526
-
Wnt/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
-
10.1002/art.34424 22328118
-
Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J (2012) Wnt/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum. doi: 10.1002/art.34424
-
(2012)
Arthritis Rheum
-
-
Wei, J.1
Fang, F.2
Lam, A.P.3
Sargent, J.L.4
Hamburg, E.5
Hinchcliff, M.E.6
Gottardi, C.J.7
Atit, R.8
Whitfield, M.L.9
Varga, J.10
-
46
-
-
79958036406
-
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
-
21370225 10.1002/art.30312 1:CAS:528:DC%2BC3MXmslOku7c%3D
-
Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J (2011) Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 63(6):1707-1717
-
(2011)
Arthritis Rheum
, vol.63
, Issue.6
, pp. 1707-1717
-
-
Wei, J.1
Melichian, D.2
Komura, K.3
Hinchcliff, M.4
Lam, A.P.5
Lafyatis, R.6
Gottardi, C.J.7
MacDougald, O.A.8
Varga, J.9
-
47
-
-
84867254044
-
Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
-
doi: 10.1182/blood-2012-01-403428
-
Zerr P, Palumbo-Zerr K, Distler A, Tomcik M, Vollath S, Munoz LE, Beyer C, Dees C, Egberts F, Tinazzi I, Del Galdo F, Distler O, Schett G, Spriewald BM, Distler JH (2012) Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease. Blood. doi: 10.1182/blood-2012-01-403428
-
(2012)
Blood
-
-
Zerr, P.1
Palumbo-Zerr, K.2
Distler, A.3
Tomcik, M.4
Vollath, S.5
Munoz, L.E.6
Beyer, C.7
Dees, C.8
Egberts, F.9
Tinazzi, I.10
Del Galdo, F.11
Distler, O.12
Schett, G.13
Spriewald, B.M.14
Distler, J.H.15
-
48
-
-
0034073379
-
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
-
10713164 10.1128/MCB.20.7.2400-2410.2000 1:CAS:528:DC%2BD3cXhvFegur4%3D Related articles recently published in Archives of Dermatological Research (selected by the journal's editorial staff)
-
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol Cell Biol 20(7):2400-2410
-
(2000)
Mol Cell Biol
, vol.20
, Issue.7
, pp. 2400-2410
-
-
Zhou, S.1
Fujimuro, M.2
Hsieh, J.J.3
Chen, L.4
Miyamoto, A.5
Weinmaster, G.6
Hayward, S.D.7
-
49
-
-
84862681321
-
MicroRNA-146a modulates TGF-beta1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4
-
21968601 10.1007/s00403-011-1178-0 1:CAS:528:DC%2BC38XksVOksL0%3D
-
Liu Z, Lu CL, Cui LP, Hu YL, Yu Q, Jiang Y, Ma T, Jiao DK, Wang D, Jia CY (2012) MicroRNA-146a modulates TGF-beta1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4. Arch Dermatol Res 304:195-202
-
(2012)
Arch Dermatol Res
, vol.304
, pp. 195-202
-
-
Liu, Z.1
Lu, C.L.2
Cui, L.P.3
Hu, Y.L.4
Yu, Q.5
Jiang, Y.6
Ma, T.7
Jiao, D.K.8
Wang, D.9
Jia, C.Y.10
-
50
-
-
84862895329
-
Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis
-
22139405 10.1007/s00403-011-1196-y 1:CAS:528:DC%2BC38XksVOksLk%3D
-
Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S (2012) Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis. Arch Dermatol Res 304:203-208
-
(2012)
Arch Dermatol Res
, vol.304
, pp. 203-208
-
-
Yanaba, K.1
Asano, Y.2
Tada, Y.3
Sugaya, M.4
Kadono, T.5
Sato, S.6
-
51
-
-
84872289842
-
Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis
-
doi: 10.1007/s00403-012-1292-7
-
Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S (2012) Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis. Arch Dermatol Res. doi: 10.1007/s00403-012-1292-7
-
(2012)
Arch Dermatol Res.
-
-
Yanaba, K.1
Asano, Y.2
Noda, S.3
Akamata, K.4
Aozasa, N.5
Taniguchi, T.6
Takahashi, T.7
Ichimura, Y.8
Toyama, T.9
Sumida, H.10
Kuwano, Y.11
Tada, Y.12
Sugaya, M.13
Kadono, T.14
Sato, S.15
-
52
-
-
84864778093
-
A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis
-
22350181 10.1007/s00403-012-1219-3 1:CAS:528:DC%2BC38XhtVOhsLrM
-
Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S (2012) A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis. Arch Dermatol Res 304:459-463.
-
(2012)
Arch Dermatol Res
, vol.304
, pp. 459-463
-
-
Yanaba, K.1
Asano, Y.2
Tada, Y.3
Sugaya, M.4
Kadono, T.5
Sato, S.6
|