MicroRNA-146a modulates TGF-β1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4

Archives of Dermatological Research

Volumn 304, Issue 3, 2012, Pages 195-202

  Liu, Zhen ^a   Lu, Cui Ling ^a   Hu, Yong Liang ^a   Ma, Tian ^a   Yu, Qi ^a   Jiao, Da Kai ^a   Cui, Li Ping ^a   Jiang, Ying ^a   Wang, Di ^a   Jia, Chi Yu ^a  

^a 309TH HOSPITAL OF PLA   (China)

Author keywords

MiR 146a; Myofibroblast; SMAD4; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; B7 ANTIGEN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MATRIX METALLOPROTEINASE 16; MICRORNA 146A; SMAD4 PROTEIN; TRANSCRIPTION FACTOR 21; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 826;

3' UNTRANSLATED REGION; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MYOFIBROBLAST; PARACRINE SIGNALING; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; TISSUE REPAIR; TRANSCRIPTION REGULATION; UPREGULATION; WOUND HEALING;

ACTINS; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DERMIS; FIBROBLASTS; FORESKIN; HUMANS; MALE; MICRORNAS; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84862681321     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-011-1178-0     Document Type: Article

References (30)

1. Agarwal C, Britton ZT, Alaseirlis DA, Li Y, Wang JH (2006) Healing and normal fibroblasts exhibit differential proliferation, collagen production, a-SMA expression, and contraction. Ann Biomed Eng 34:653-659
2. Ambros V (2004) The functions of animal microRNAs. Nature 431:350-355
3. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297
4. Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK (2008) Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol 82: 1946-1958
5. Desmouliere A, Chaponnier C, Gabbiani G (2005) Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 13:7-12
6. Gregory RI, Shiekhattar R (2005) MicroRNA biogenesis and cancer. Cancer Res 65:3509-3512
7. Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127:526-537
8. Isufi I, Seetharam M, Zhou L, Sohal D, Opalinska J, Pahanish P, Verma A (2007) Transforming growth factor beta signaling in normal and malignant hematopoiesis. J Interferon Cytokine Res 27:543-552
9. Jazdzewski K, de la Chapelle A (2009) Genomic sequence matters: a SNP in microRNA-146a can turn anti-apoptotic. Cell Cycle 8:1642-1643
10. Jazdzewski K, Liyanarachchi S, Swierniak M, Pachucki J, Ringel MD, Jarzab B, de la Chapelle A (2009) Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc Natl Acad Sci USA 106:1502-1505
11. Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105:7269-7274
12. Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ (2008) MicroRNA-155 is regulated by the transforming growth factorb/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 22:6773-6784
13. Lin SL, Chiang A, Chang D, Ying SY (2008) Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14:417-424
14. Liu X, Nelson A, Wang X, Kanaji N, Kim M, Sato T, Nakanishi M, Li Y, Sun J, Michalski J, Patil A, Basma H, Rennard SI (2009) MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis. Biochem Biophys Res Commun 380:177-182
15. Liu Z, Xiao B, Tang B, Li B, Li N, Zhu E, Guo G, Gu J, Zhuang Y, Liu X, Ding H, Zhao X, Guo H, Mao X, Zou Q (2010) Upregulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect 12:854-863
16. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR (2005) MicroRNA expression profiles classify human cancers. Nature 435:834-838
17. Miller MC, Nanchahal J (2005) Advances in the modulation of cutaneous wound healing and scarring. Biodrugs 19:363-381
18. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H (2008) Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum 58:1284-1292
19. Paul Ehrlich H, Sun B, Kainth KS, Kromah F (2006) Elucidating the mechanism of wound contraction: rapid versus sustained myosin ATPase activity in attached-delayed-released compared with free-floating fibroblast-populated collagen lattices. Wound Repair Regen 14:625-632
20. Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10:R101
21. Sheedy FJ, O'Neill LA (2008) Adding fuel to fire: microRNAs as a new class of mediators of inflammation. Ann Rheum Dis 67(SUPPL. 3):iii50-iii55
22. Sonkoly E, Ståhle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18:131-140
23. Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (2008) Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 58:1001-1009
24. Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NFkappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103:12481-12486
25. Urbich C, Kuehbacher A, Dimmeler S (2008) Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 79:581-588
26. Wang G, Wang Y, Feng W, Wang X, Yang JY, Zhao Y, Wang Y, Liu Y (2008) Transcription factor and microRNA regulation in androgen-dependent and independent prostate cancer cells. BMC Genomics 9(SUPPL. 2):S22
27. Williams AE, Perry MM, Moschos SA, Larner-Svensson HM, Lindsay MA (2008) Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Tran 36: 1211-1215
28. Yao Q, Cao S, Li C, Mengesha A, Kong B, Wei M (2011) Micro-RNA-21 regulates TGF-b-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. Int J Cancer 128:1783-1792
29. Zheng L, Xu CC, Chen WD, Shen WL, Ruan CC, Zhu LM, Zhu DL, Gao PJ (2010) MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts. Biochem Biophys Res Commun 400: 483-488
30. Zhong H, Wang HR, Yang S, Zhong JH, Wang T, Wang C, Chen FY (2010) Targeting Smad4 links microRNA-146a to the TGF-b pathway during retinoid acid induction in acute promyelocytic leukemia cell line. Int J Hematol 92:129-135