Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo- 11 H-Indeno[1,2-c ]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal Kinase) and c-Myc in HL-60 human leukemia cells

Journal of Natural Products

Volumn 75, Issue 3, 2012, Pages 378-384

  Park, Eun Jung ^a   Kiselev, Evgeny ^b   Conda Sheridan, Martin ^b   Cushman, Mark ^b   Pezzuto, John M ^a  

^a UNIVERSITY OF HAWAII AT HILO   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 6 (3 AMINOPROPYL) 5,6 DIHYDRO 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; AM6 36; ANTINEOPLASTIC AGENT; ISOQUINOLINE DERIVATIVE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYC PROTEIN; RETINOID X RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IC 50; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; ONCOGENE; UPREGULATION;

APOPTOSIS; CASPASES; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G2 PHASE; HL-60 CELLS; HUMANS; INDENES; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASE 8; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RETINOID X RECEPTORS;

EID: 84859078546     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np200791j     Document Type: Article

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