LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages

Journal of Experimental Medicine

Volumn 204, Issue 11, 2007, Pages 2719-2731

  Kong, Xiao Ni ^a   Yan, He Xin ^a   Chen, Lei ^a   Dong, Li Wei ^a   Yang, Wen ^a   Liu, Qiong ^a   Yu, Le Xing ^a   Huang, Dan Dan ^a   Liu, Shu Qin ^a   Liu, Hui ^a   Wu, Meng Chao ^a   Wang, Hong Yang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, DIFFERENTIATION; CYTOKINES; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, IMMUNOLOGIC; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTORS;

EID: 35748985290     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20062611     Document Type: Article

References (37)

1. Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675-680.
2. Takeda, K., and S. Akira. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14.
3. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
4. Beutler, B. 2000. Tlr4: central component of the sole mammalian LPS sensor. Curr. Opin. Immunol. 12:20-26.
5. Kawai, T., and S. Akira. 2006. TLR signaling. Cell Death Differ. 13:816-825.
6. Barclay, A.N., and M.H. Brown. 2006. The SIRP family of receptors and immune regulation. Nat. Rev. Immunol. 6:457-464.
7. Veillette, A., E. Thibaudeau, and S. Latour. 1998. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J. Biol. Chem. 273:22719-22728.
8. Kharitonenkov, A., Z. Chen, I. Sures, H. Wang, J. Schilling, and A. Ullrich. 1997. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature. 386:181-186.
9. Jiang, P., C.F. Lagenaur, and V. Narayanan. 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J. Biol. Chem. 274:559-562.
10. Gardai, S.J., Y.Q. Xiao, M. Dickinson, J.A. Nick, D.R. Voelker, K.E. Greene, and P.M. Henson. 2003. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell. 115:13-23.
11. Okazawa, H., S. Motegi, N. Ohyama, H. Ohnishi, T. Tomizawa, Y. Kaneko, P.A. Oldenborg, O. Ishikawa, and T. Matozaki. 2005. Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J. Immunol. 174:2004-2011.
12. Inagaki, K., T. Yamao, T. Noguchi, T. Matozaki, K. Fukunaga, T. Takada, T. Hosooka, S. Akira, and M. Kasuga. 2000. SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J. 19:6721-6731.
13. Yamao, T., T. Noguchi, O. Takeuchi, U. Nishiyama, H. Morita, T. Hagiwara, H. Akahori, T. Kato, K. Inagaki, H. Okazawa, et al. 2002. Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J. Biol. Chem. 277:39833-39839.
14. Oldenborg, P.A., A. Zheleznyak, Y.F. Fang, C.F. Lagenaur, H.D. Gresham, and F.P. Lindberg. 2000. Role of CD47 as a marker of self on red blood cells. Science. 288:2051-2054.
15. Oshima, K., A.R. Ruhul Amin, A. Suzuki, M. Hamaguchi, and S. Matsuda. 2002. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519:1-7.
16. Fujioka, Y., T. Matozaki, T. Noguchi, A. Iwamatsu, T. Yamao, N. Takahashi, M. Tsuda, T. Takada, and M. Kasuga. 1996. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16:6887-6899.
17. Timms, J.F., K. Carlberg, H. Gu, H. Chen, S. Kamatkar, M.J. Nadler, L.R. Rohrschneider, and B.G. Neel. 1998. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol. Cell. Biol. 18:3838-3850.
18. Neznanov, N., L. Neznanova, R.V. Kondratov, L. Burdelya, E.S. Kandel, D.M. O ' Rourke, A. Ullrich, and A.V. Gudkov. 2003. Dominant negative form of signal-regulatory protein-alpha (SIRPalpha/SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B. J. Biol. Chem. 278:3809-3815.
19. Pfeffer, K., T. Matsuyama, T.M. Kundig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P.S. Ohashi, M. Kronke, and T.W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 73:457-467.
20. Liew, F.Y., D. Xu, E.K. Brint, and L.A. O'Neill. 2005. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5:446-458.
21. Poltorak, A., X. He, I. Smirnova, M.Y. Liu, H.C. Van, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:2085-2088.
22. Long, E.O. 1999. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875-904.
23. Alblas, J., H. Honing, C. R.de Lavalette, M.H. Brown, C.D. Dijkstra, and T.K. van den Berg. 2005. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/. Mol. Cell. Biol. 25:7181-7192
24. Murai-Takebe, R., T. Noguchi, T. Ogura, T. Mikami, K. Yanagi, K. Inagaki, H. Ohnishi, T. Matozaki, and M. Kasuga. 2004. Ubiquitination-mediated regulation of biosynthesis of the adhesion receptor SHPS-1 in response to endoplasmic reticulum stress. J. Biol. Chem. 279:11616-11625.
25. Saxton, T.M., M. Henkemeyer, S. Gasca, R. Shen, D.J. Rossi, F. Shalaby, G.S. Feng, and T. Pawson. 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16:2352-2364.
26. You, M., L.M. Flick, D. Yu, and G.S. Feng. 2001. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J. Exp. Med. 193:101-110.
27. Fitzgerald, K.A., S.M. McWhirter, K.L. Faia, D.C. Rowe, E. Latz, D.T. Golenbock, A.J. Coyle, S.M. Liao, and T. Maniatis. 2003. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4:491-496.
28. Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-kappaB puzzle. Cell. 109 (Suppl):S81-S96.
29. Hardin, A.O., E.A. Meals, T. Yi, K.M. Knapp, and B.K. English. 2006. SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages. Biochem. Biophys. Res. Commun. 342:547-555.
30. Wang, N., Z. Li, R. Ding, G.D. Frank, T. Senbonmatsu, E.J. Landon, T. Inagami, and Z.J. Zhao. 2006. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J. Biol. Chem. 281:21878-21883.
31. Kapoor, G.S., Y. Zhan, G.R. Johnson, and D.M. O'Rourke. 2004. Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. Mol. Cell. Biol. 24:823-836.
32. Neznanov, N., L. Neznanova, R.V. Kondratov, D.M. O'Rourke, A. Ullrich, and A.V. Gudkov. 2004. The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha. DNA Cell Biol. 23:175-182.
33. Kinjyo, I., T. Hanada, K. Inagaki-Ohara, H. Mori, D. Aki, M. Ohishi, H. Yoshida, M. Kubo, and A. Yoshimura. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 17:583-591.
34. Kobayashi, K., L.D. Hernandez, J.E. Galan, C.A. Janeway Jr., R. Medzhitov, and R.A. Flavell. 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:191-202.
35. Smith, R.E., V. Patel, S.D. Seatter, M.R. Deehan, M.H. Brown, G.P. Brooke, H.S. Goodridge, C.J. Howard, K.P. Rigley, W. Harnett, and M.M. Harnett. 2003. A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes. Blood. 102:2532-2540.
36. Neininger, A., D. Kontoyiannis, A. Kotlyarov, R. Winzen, R. Eckert, H.D. Volk, H. Holtmann, G. Kollias, and M. Gaestel. 2002. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J. Biol. Chem. 277:3065-3068.
37. Kontoyiannis, D., M. Pasparakis, T.T. Pizarro, F. Cominelli, and G. Kollias. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 10:387-398.