The integrin αvβ3-5 ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER+ and erbB2+ breast cancers

Cancer Research

Volumn 71, Issue 3, 2011, Pages 937-945

  Yang, Chuanwei ^a   Hayashida, Tetsu ^a   Forster, Nicole ^a   Li, Cuiqi ^a   Shen, Dejun ^b   Maheswaran, Shyamala ^a   Chen, Li ^a   Anderson, Karen S ^c   Ellisen, Leif W ^a   Sgroi, Dennis ^a   Schmidt, Emmett V ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; LACTADHERIN; PROGESTERONE RECEPTOR; PROTEIN P63; PROTEIN P73; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CANCER GROWTH; CANCER TISSUE; CELL PROLIFERATION; CHEMOSENSITIZATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTRADUCTAL CARCINOMA; LASER CAPTURE MICRODISSECTION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; UPREGULATION;

ANIMALS; ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CISPLATIN; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION; INTEGRIN ALPHAVBETA3; LIGANDS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MILK PROTEINS; NUCLEAR PROTEINS; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, VITRONECTIN; RNA INTERFERENCE; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 79551560268     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1471     Document Type: Article

References (25)

1. Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-8.
2. Yang C, Trent S, Ionescu-Tiba V, Lan L, Shioda T, Sgroi D, et al. Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression. Cancer Res 2006;66:11649-58.
3. Larocca D, Peterson JA, Urrea R, Kuniyoshi J, Bistrain AM, Ceriani RL. A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains. Cancer Res 1991;51:4994-8.
4. Ceriani RL, Sasaki M, Sussman H, Wara WM, Blank EW. Circulating human mammary epithelial antigens in breast cancer. Proc Natl Acad Sci USA 1982;79:5420-4.
5. Salinas FA, Wee KH, Ceriani RL. Significance of breast carcinoma-associated antigens as a monitor of tumor burden: characterization by monoclonal antibodies. Cancer Res 1987;47:907-13.
6. Ceriani RL, Blank EW. Experimental therapy of human breast tumors with 131I-labeled monoclonal antibodies prepared against the human milk fat globule. Cancer Res 1988;48:4664-72.
7. Taylor MR, Couto JR, Scallan CD, Ceriani RL, Peterson JA. Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. DNA Cell Biol 1997;16:861-9.
8. Andersen MH, Graversen H, Fedosov SN, Petersen TE, Rasmussen JT. Functional analyses of two cellular binding domains of bovine lactadherin. Biochemistry 2000;39:6200-6.
9. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182-7.
10. Ensslin MA, Shur BD. The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis. Proc Natl Acad Sci USA 2007;104:2715-20.
11. Hanayama R, Nagata S. Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8. Proc Natl Acad Sci USA 2005;102:16886-91. (Pubitemid 41688872)
12. Taverna D, Crowley D, Connolly M, Bronson RT, Hynes RO. A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res 2005;65:10324-9.
13. Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006;9:121-32.
14. Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 2006;10:529-41.
15. Leong CO, Vidnovic N, DeYoung MP, Sgroi D, Ellisen LW. The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. J Clin Invest 2007;117:1370-80.
16. Tan AR, Swain SM. Therapeutic strategies for triple-negative breast cancer. Cancer J 2008;14:343-51.
17. Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, et al. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer 2003;88:1285-91.
18. Okuyama T, Kurata S, Tomimori Y, Fukunishi N, Sato S, Osada M, et al. p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms. Oncogene 2008;27: 308-17.
19. Ensslin MA, Shur BD. Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding. Cell 2003;114:405-17.
20. Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, et al. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 2003;100:5974-9.
21. Kawakubo H, Brachtel E, Hayashida T, Yeo G, Kish J, Muzikansky A, et al. Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Cancer Res 2006;66:7075-82. (Pubitemid 44197684)
22. Brassard DL, Maxwell E, Malkowski M, Nagabhushan TL, Kumar CC, Armstrong L. Integrin alpha(v)beta(3)-mediated activation of apoptosis. Exp Cell Res 1999;251:33-45.
23. Kozlova NI, Morozevich GE, Chubukina AN, Berman AE. Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells. Oncogene 2001;20:4710-7.
24. Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, et al. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell 2004;116:751-62.
25. Yamaguchi H, Takagi J, Miyamae T, Yokota S, Fujimoto T, Nakamura S, et al. Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus. J Leukocyte Biol 2008;83:1300-7.