Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages

British Journal of Pharmacology

Volumn 152, Issue 2, 2007, Pages 249-255

  De Las Heras, B ^a   Hortelano, S ^b   Giron N ^a   Bermejo, P ^a   Rodriguez B ^c   Bosca L ^b,d  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^d INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Apoptosis; Foliol; Interferon ; Linearol; Lipopolysaccharide; Macrophages; Nitric oxide; Phagocytosis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE 3; CYTOCHROME C; FOLIOL; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAURANE DERIVATIVE; LINEAROL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE DONOR; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; DITERPENES; DITERPENES, KAURANE; INTERFERON-GAMMA, RECOMBINANT; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS; PROTECTIVE AGENTS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34948834618     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707382     Document Type: Article

References (26)

1. Aderem A (2003). Phagocytosis and the inflammatory response. J Infect Dis 187 (Suppl 2): S340-S345.
2. Aderem A, Underhill DM (1999). Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17: 593-623.
3. Brockhaus F, Brune B (1999). p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide. Oncogene 18: 6403-6410.
4. Castrillo A, de las HB, Hortelano S, Rodriguez B, Villar A, Bosca L (2001). Inhibition of the nuclear factor κB (NF-κB) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-κB-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J Biol Chem 276: 15854-15860.
5. da Araujo EC, Lima MA, Montenegro RC, Nogueira M, Costa-Lotufo LV, Pessoa C et al. (2006). Cytotoxic abietane diterpenes from Hyptis martiusii Benth. Z Naturforsch [C] 61: 177-183.
6. de las Heras B, Abad MJ, Silvan AM, Pascual R, Bermejo P, Rodriguez B et al. (2001). Effects of six diterpenes on macrophage eicosanoid biosynthesis. Life Sci 70: 269-278.
7. de las Heras B, Navarro A, Diaz-Guerra MJ, Bermejo P, Castrillo A, Bosca L et al. (1999). Inhibition of NOS-2 expression in macrophages through the inactivation of NF-κB by andalusol. Br J Pharmacol 128: 605-612.
8. Genaro AM, Hortelano S, Alvarez A, Martinez C, Bosca L (1995). Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels. J Clin Invest 95: 1884-1890.
9. Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS et al. (2005). The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105: 4163-4169.
10. Hortelano S, Alvarez AM, Bosca L (1999). Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages. FASEB J 13: 2311-2317.
11. Hortelano S, Castrillo A, Alvarez AM, Bosca L (2000). Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. J Immunol 165: 6525-6531.
12. Hortelano S, Dallaporta B, Zamzami N, Hirsch T, Susin SA, Marzo I et al. (1997). Nitric oxide induces apoptosis via triggering mitochondrial permeability transition. FEBS Lett 410: 373-377.
13. Hortelano S, Zeini M, Castrillo A, Alvarez AM, Bosca L (2002). Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease. Cell Death Differ 9: 643-650.
14. Hwang BY, Lee JH, Koo TH, Kim HS, Hong YS, Ro JS et al. (2001). Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-κB activation in LPS-stimulated macrophage RAW264.7 cells. Planta Med 67: 406-410.
15. Kondoh M, Suzuki I, Sato M, Nagashima F, Simizu S, Harada M et al. (2004). Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway. J Pharmacol Exp Ther 311: 115-122.
16. Kroemer G (1997). The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620.
17. Lavrik IN, Golks A, Krammer PH (2005). Caspases: pharmacological manipulation of cell death. J Clin Invest 115: 2665-2672.
18. Lee JH, Koo TH, Hwang BY, Lee JJ (2002). Kaurane diterpene, kamebakaurin, inhibits NF-κ B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κ B target genes. J Biol Chem 277: 18411-18420.
19. Nagashima F, Kondoh M, Kawase M, Simizu S, Osada H, Fujii M et al. (2003). Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata. Planta Med 69: 377-379.
20. Navarro A, de las HB, Villar AM (1997). Andalusol, a diterpenoid with anti-inflammatory activity from Siderits foetens Clemen. Z Naturforsch [C] 52: 844-849.
21. Petit PX, Zamzami N, Vayssiere JL, Mignotte B, Kroemer G, Castedo M (1997). Implication of mitochondria in apoptosis. Mol Cell Biochem 174: 185-188.
22. Shi Y (2002). Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9: 459-470.
23. Sprick MR, Walczak H (2004). The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim Biophys Acta 1644: 125-132.
24. Suzuki I, Kondoh M, Harada M, Koizumi N, Fujii M, Nagashima F et al. (2004a). An ent-kaurene diterpene enhances apoptosis induced by tumor necrosis factor in human leukemia cells. Planta Med 70: 723-727.
25. Suzuki I, Kondoh M, Nagashima F, Fujii M, Asakawa Y, Watanabe Y (2004b). A comparison of apoptosis and necrosis induced by entkaurene-type diterpenoids in HL-60 cells. Planta Med 70: 401-406.
26. Terenzi F, Diaz-Guerra MJ, Casado M, Hortelano S, Leoni S, Bosca L (1995). Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages. J Biol Chem 270: 6017-6021.