Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 3, 2013, Pages 814-823

  Baechler, Simone A ^a   Fehr, Markus ^b   Habermeyer, Michael ^c   Hofmann, Andreas ^c   Merz, Karl Heinz ^c   Fiebig, Heinz Herbert ^d   Marko, Doris ^a   Eisenbrand, Gerhard ^c  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF KARLSRUHE   (Germany)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

DNA topoisomerase; Lycobetaine; N Methylphenanthridinium chlorides; Phenanthridines; Structure activity

Indexed keywords

2 HYDROXY 5 METHYL 8,9 METHYLENEDIOXYPHENANTHRIDINIUM CHLORIDE; 2 HYDROXY 8,9 METHYLENEDIOXYPHENANTHRIDINE; 2 PIVALOYLAMINO 5 TRIISOPROPYLSILYLOXYPHENYLBORONIC ACID; 8,9 METHYLENEDIOXY 2 TRIISOPROPYLSILYLOXYPHENANTHRIDINE; BETAINE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); KINETOPLAST DNA; LYCOBETAINE DERIVATIVE; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION;

AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLIZINES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TUMOR CELLS, CULTURED;

EID: 84872289856     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.011     Document Type: Article

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