Ungeremine effectively targets mammalian as well as bacterial type i and type II topoisomerases

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7041-7044

  Casu, Laura ^a   Cottiglia, Filippo ^a   Leonti, Marco ^a   De Logu, Alessandro ^a   Agus, Emanuela ^a   Tse Dinh, Yuk Ching ^b   Lombardo, Valentina ^c   Sissi, Claudia ^c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Alkaloid; Antibacterial; Anticancer; Pancratium illyricum L; Topoisomerase

Indexed keywords

AMARYLLIDACEAE ALKALOID; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); LYCORINE; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNGERAMINE; VITTATINE;

ARTICLE; DNA CLEAVAGE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; PANCRATIUM ILLYRICUM; ULTRAVIOLET RADIATION;

AMARYLLIDACEAE ALKALOIDS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; BACTERIAL PROTEINS; DRUG DELIVERY SYSTEMS; HUMANS; INDOLIZINES; INHIBITORY CONCENTRATION 50; LILIACEAE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

BACTERIA (MICROORGANISMS); MAMMALIA; PANCRATIUM;

EID: 80255140248     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.097     Document Type: Article

References (36)

1. D.J. Newman, G.M. Cragg, and K.M. Snader J. Nat. Prod. 66 2003 1022
2. O. Hochino The Alkaloids, Chemistry and Biology Vol. 51 1998 Academic Press San Diego, CA p 323
3. J. Liu, Y. Li, L.J. Tang, G.P. Zhang, and W.X. Hu Biomed. Pharmacother. 61 2007 229
4. A. Evidente, A.S. Kireev, A.R. Jenkins, A.E. Romero, W.F. Steelant, S. Van Slambrouck, and A. Kornienko Planta Med. 75 2009 501
5. J.C. Cedron, M. Del Arco-Aguilar, A. Estevez-Braun, and A.G. Ravelo Alkaloids Chemistry and Biology Vol. 68 2010 Academic Press SanDiego, CA p 1
6. D. Lamoral-Theys, A. Andolfi, G. Van Goietsenoven, A. Cimmino, B. Le Calve, N. Wauthoz, V. Megalizzi, T. Gras, C. Bruyere, J. Dubois, V. Mathieu, A. Kornienko, R. Kiss, and A. Evidente J. Med. Chem. 52 2009 6244
7. G. Van Goietsenoven, J. Hutton, J.P. Becker, B. Lallemand, F. Robert, F. Lefranc, C. Pirker, G. Vandenbussche, P. Van Antwerpen, A. Evidente, W. Berger, M. Prevost, J. Pelletier, R. Kiss, T.G. Kinzy, A. Kornienko, and V. Mathieu FASEB J. 24 2010 4575
8. G. Zou, F. Puig-Basagoiti, B. Zhang, M. Qing, L. Chen, K.W. Pankiewicz, K. Felczak, Z. Yuan, and P.Y. Shi Virology 384 2009 242
9. S.Y. Li, C. Chen, H.Q. Zhang, H.Y. Guo, H. Wang, L. Wang, X. Zhang, S.N. Hua, J. Yu, P.G. Xiao, R.S. Li, and X. Tan Antiviral Res. 67 2005 18
10. A. Evidente, A. Andolfi, A.H. Abou-Donia, S.M. Touema, H.M. Hammoda, E. Shawky, and A. Motta Phytochemistry 65 2004 2113
11. D. Lamoral-Theys, C. Decaestecker, V. Mathieu, J. Dubois, A. Kornienko, R. Kiss, A. Evidente, and L. Pottier Mini-Rev. Med. Chem. 10 2010 41
12. L.M. Stark, X.F. Lin, and L.A. Flippin J. Org. Chem. 65 2000 3227
13. R.K. Zee-Cheng, S.J. Yan, and C.C. Cheng J. Med. Chem. 21 1978 199
14. K.K. Schrader, A. Andolfi, C.L. Cantrell, A. Cimmino, S.O. Duke, W. Osbrink, D.E. Wedge, and A. Evidente Chem. Biodivers. 7 2010 2261
15. S. Ghosal, S.K. Singh, Y. Kumar, S. Unnikrishnan, and S. Chattopadhyay Planta Med. 54 1988 114
16. H.U. Barthelmes, E. Niederberger, T. Roth, K. Schulte, W.C. Tang, F. Boege, H.H. Fiebig, G. Eisenbrand, and D. Marko Br. J. Cancer 85 2001 1585
17. A.J. Schoeffler, and J.M. Berger Q. Rev. Biophys. 41 2008 41
18. M. Palumbo, B. Gatto, and C. Sissi DNA Topoisomerase-Targeted Drugs M. Demeunynch, C. Bailly, W.D. Wilson, DNA and RNA Binders: From Small Molecules to Drugs 2002 Wiley-VCH 503
19. F. Collu, L. Bonsignore, M. Casu, C. Floris, J. Gertsch, and F. Cottiglia Bioorg. Med. Chem. Lett. 18 2008 1559
20. V. Valsecchi Boll. Soc. Sarda Sci. Nat. 21 1982 427
21. A. Evidente, G. Randazzo, G. Surico, P. Lavermicocca, and O. Arrigoni J. Nat. Prod. 48 1985 564
22. K. Likhitwitayawuid, C.K. Angerhofer, H. Chai, J.M. Pezzuto, G.A. Cordell, and N. Ruangrungsi J. Nat. Prod. 56 1993 1331
23. A.W. Frahm, A.A. Ali, and M.A. Ramadan Magn. Res. Chem. 23 1985 804
24. A. Numata, G.R. Pettit, M. Nabae, K. Yamamoto, E. Yamamoto, E. Matsumura, and T. Kawano Agric. Biol. Chem. 51 1987 1199
25. M. Masaoud, H. Ripperger, and A. Porzel Phytochemistry 38 1995 745
26. Human topoisomerase I (hTopoI) and human topoisomerase IIα (hTopoIIα) were purchased from Topogen. E. coli topoisomerase IV (EcTopoIV) was purchased from Inspiralis. E. coli topoisomerase I (EcTopoI) was produced and purified according to protocol reported in C.X. Zhu, and Y.C. Tse-Dinh Methods Mol. Biol. 94 1999 145
27. Y. Pommier, E. Leo, H. Zhang, and C. Marchand Chem. Biol. 17 2010 421
28. J. Liu, S.L. Yang, and B. Xu Zhongguo Yao Li Xue Bao 10 1989 437
29. J.L. Nitiss Nat. Rev. Cancer 9 2009 327
30. C. Sissi, and M. Palumbo Cell. Mol. Life Sci. 67 2010 2001
31. C. Ullsperger, and N.R. Cozzarelli J. Biol. Chem. 271 1996 31549
32. V.E. Anderson, T.D. Gootz, and N. Osheroff J. Biol. Chem. 273 1998 17879
33. B. Cheng, I.F. Liu, and Y.C. Tse-Dinh J. Antimicrob. Chemother. 59 2007 640
34. M.T. Garcia, M.A. Blazquez, M.J. Ferrandiz, M.J. Sanz, N. Silva-Martin, J.A. Hermoso, and A.G. de la Campa J. Biol. Chem. 286 2011 6402
35. J. Gertsch, O. Sticher, T. Schmidt, and J. Heilmann Biochem. Pharmacol. 66 2003 2141
36. L. Bonsignore, A. De Logu, G. Loy, S.M. Lavagna, and D. Secci Eur. J. Med. Chem. 29 1994 479