Merbarone inhibits the catalytic activity of human topoisomerase IIα by blocking DNA cleavage

Journal of Biological Chemistry

Volumn 273, Issue 28, 1998, Pages 17643-17650

  Fortune, John M ^a   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GYRASE INHIBITOR; MERBARONE;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DROSOPHILA MELANOGASTER; DRUG DNA INTERACTION; DRUG MECHANISM; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATE; ANTIGENS, NEOPLASM; BASE SEQUENCE; CATALYSIS; DNA; DNA PRIMERS; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; ISOENZYMES; PROTEIN BINDING; RECOMBINANT PROTEINS; THIOBARBITURATES;

DROSOPHILA MELANOGASTER; MELANOGASTER; SACCHAROMYCES CEREVISIAE;

EID: 0032504157     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.28.17643     Document Type: Article

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