Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Lundberg, Kristina ^a   Albrekt, Ann Sofie ^a   Nelissen, Inge ^b   Santegoets, Saskia ^c   de Gruijl, Tanja D ^c   Gibbs, Sue ^c   Lindstedt, Malin ^a  

^a LUND UNIVERSITY   (Sweden)

^b FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD123 ANTIGEN; CD16 ANTIGEN; CD1C ANTIGEN; CD34 ANTIGEN; FIBRINOGEN RECEPTOR;

ARTICLE; BLOOD CELL; CELL FUNCTION; CELL POPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOGENETICS; IN VITRO STUDY; LANGERHANS CELL; MONOCYTE; MYELOID DENDRITIC CELL; SKIN CELL; TONSIL CELL;

CLUSTER ANALYSIS; DENDRITIC CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNOLOGIC TESTS; MODELS, IMMUNOLOGICAL; PALATINE TONSIL; PHENOTYPE; RNA, MESSENGER; SKIN;

EID: 84872282547     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052875     Document Type: Article

References (75)

1. Steinman RM, Banchereau J, (2007) Taking dendritic cells into medicine. Nature 449: 419-426.
2. Aeby P, Python F, Goebel C, (2007) Skin sensitization: understanding the in vivo situation for the development of reliable in vitro test approaches. ALTEX 24 (Spec No) (): 3-5.
3. Sallusto F, Lanzavecchia A, (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179: 1109-1118.
4. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J, (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360: 258-261.
5. Rosenzwajg M, Canque B, Gluckman JC, (1996) Human dendritic cell differentiation pathway from CD34+ hematopoietic precursor cells. Blood 87: 535-544.
6. Reid CD, Fryer PR, Clifford C, Kirk A, Tikerpae J, et al. (1990) Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood. Blood 76: 1139-1149.
7. Reid CD, Stackpoole A, Meager A, Tikerpae J, (1992) Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 149: 2681-2688.
8. Hu ZB, Ma W, Zaborski M, MacLeod R, Quentmeier H, et al. (1996) Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. Leukemia 10: 1025-1040.
9. Masterson AJ, Sombroek CC, De Gruijl TD, Graus YM, van der Vliet HJ, et al. (2002) MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors. Blood 100: 701-703.
10. Azam P, Peiffer JL, Chamousset D, Tissier MH, Bonnet PA, et al. (2006) The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol Appl Pharmacol 212: 14-23.
11. Johansson H, Lindstedt M, Albrekt AS, Borrebaeck CA, (2011) A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics 12: 399.
12. Santegoets SJ, van den Eertwegh AJ, van de Loosdrecht AA, Scheper RJ, de Gruijl TD, (2008) Human dendritic cell line models for DC differentiation and clinical DC vaccination studies. J Leukoc Biol 84: 1364-1373.
13. MacDonald KP, Munster DJ, Clark GJ, Dzionek A, Schmitz J, et al. (2002) Characterization of human blood dendritic cell subsets. Blood 100: 4512-4520.
14. Lindstedt M, Lundberg K, Borrebaeck CA, (2005) Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells. J Immunol 175: 4839-4846.
15. Toebak MJ, Gibbs S, Bruynzeel DP, Scheper RJ, Rustemeyer T, (2009) Dendritic cells: biology of the skin. Contact Dermatitis 60: 2-20.
16. Robbins SH, Walzer T, Dembele D, Thibault C, Defays A, et al. (2008) Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol 9: R17.
17. Haniffa M, Shin A, Bigley V, McGovern N, Teo P, et al. (2012) Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity 37: 60-73.
18. EC (1907/2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC.
19. KleinJan A, Willart M, van Rijt LS, Braunstahl GJ, Leman K, et al. (2006) An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol 118: 1117-1125.
20. Garcia F, Routy JP, (2011) Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1. Vaccine 29: 6454-6463.
21. Nencioni A, Grunebach F, Schmidt SM, Muller MR, Boy D, et al. (2008) The use of dendritic cells in cancer immunotherapy. Crit Rev Oncol Hematol 65: 191-199.
22. Torres-Aguilar H, Blank M, Jara LJ, Shoenfeld Y, (2010) Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity. Autoimmun Rev 10: 8-17.
23. Van Gulck E, Van Tendeloo VF, Berneman ZN, Vanham G, (2010) Role of dendritic cells in HIV-immunotherapy. Curr HIV Res 8: 310-322.
24. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N, (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193: 233-238.
25. Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, et al. (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194: 769-779.
26. Palucka K, Ueno H, Roberts L, Fay J, Banchereau J, (2011) Dendritic cell subsets as vectors and targets for improved cancer therapy. Curr Top Microbiol Immunol 344: 173-192.
27. Santegoets SJ, Gibbs S, Kroeze K, van de Ven R, Scheper RJ, et al. (2008) Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. J Leukoc Biol 84: 143-151.
28. Lindstedt M, Johansson-Lindbom B, Borrebaeck CA, (2002) Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators. Int Immunol 14: 1203-1213.
29. Schoeters E, Verheyen GR, Nelissen I, Van Rompay AR, Hooyberghs J, et al. (2007) Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol 44: 3222-3233.
30. Lardon F, Snoeck HW, Berneman ZN, Van Tendeloo VF, Nijs G, et al. (1997) Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1. Immunology 91: 553-559.
31. Larsson K, Lindstedt M, Borrebaeck CA, (2006) Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology 117: 156-166.
32. Alter O, Brown PO, Botstein D, (2000) Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A 97: 10101-10106.
33. Genser B, Cooper PJ, Yazdanbakhsh M, Barreto ML, Rodrigues LC, (2007) A guide to modern statistical analysis of immunological data. BMC Immunol 8: 27.
34. de Hoon MJ, Imoto S, Nolan J, Miyano S, (2004) Open source clustering software. Bioinformatics 20: 1453-1454.
35. Saldanha AJ, (2004) Java Treeview-extensible visualization of microarray data. Bioinformatics 20: 3246-3248.
36. Nimmerjahn F, Ravetch JV, (2006) Fcgamma receptors: old friends and new family members. Immunity 24: 19-28.
37. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529.
38. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12: 71-81.
39. de Jong MA, Vriend LE, Theelen B, Taylor ME, Fluitsma D, et al. (2010) C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. Mol Immunol 47: 1216-1225.
40. van der Vlist M, de Witte L, de Vries RD, Litjens M, de Jong MA, et al. (2011) Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4 T cells but are incapable of cross-presentation. Eur J Immunol 41: 2619-2631.
41. Wang S, Miyazaki Y, Shinozaki Y, Yoshida H, (2007) Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency. J Immunol 179: 6421-6428.
42. Heufler C, Topar G, Grasseger A, Stanzl U, Koch F, et al. (1993) Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 178: 1109-1114.
43. Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, et al. (1989) Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 170: 333-338.
44. Guimond M, Veenstra RG, Grindler DJ, Zhang H, Cui Y, et al. (2009) Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10: 149-157.
45. Saini M, Pearson C, Seddon B, (2009) Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis. Blood 113: 5793-5800.
46. Kunikata T, Yamane H, Segi E, Matsuoka T, Sugimoto Y, et al. (2005) Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol 6: 524-531.
47. Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, et al. (2009) Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 15: 633-640.
48. Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, et al. (2008) Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood 111: 4245-4253.
49. Meyer-Wentrup F, Cambi A, Joosten B, Looman MW, de Vries IJ, et al. (2009) DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. J Leukoc Biol 85: 518-525.
50. Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML, (1997) Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses. Adv Exp Med Biol 417: 363-367.
51. Sugimoto Y, Narumiya S, (2007) Prostaglandin E receptors. J Biol Chem 282: 11613-11617.
52. Quast T, Eppler F, Semmling V, Schild C, Homsi Y, et al. (2011) CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Blood 118: 1818-1827.
53. Cao W, Lee SH, Lu J, (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem J 385: 85-93.
54. Prechtel AT, Turza NM, Theodoridis AA, Steinkasserer A, (2007) CD83 knockdown in monocyte-derived dendritic cells by small interfering RNA leads to a diminished T cell stimulation. J Immunol 178: 5454-5464.
55. Bratke K, Lommatzsch M, Julius P, Kuepper M, Kleine HD, et al. (2007) Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge. Thorax 62: 168-175.
56. Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, et al. (2000) Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol 165: 4062-4068.
57. Jahnsen FL, Moloney ED, Hogan T, Upham JW, Burke CM, et al. (2001) Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 56: 823-826.
58. Lundberg K, Greiff L, Borrebaeck CA, Lindstedt M, (2010) FcepsilonRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis. Hum Immunol 71: 931-933.
59. Yerkovich ST, Roponen M, Smith ME, McKenna K, Bosco A, et al. (2009) Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response. J Allergy Clin Immunol 123: 209-216 e204.
60. Novak N, Valenta R, Bohle B, Laffer S, Haberstok J, et al. (2004) FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J Allergy Clin Immunol 113: 949-957.
61. Lundberg K, Lindstedt M, Larsson K, Dexlin L, Wingren C, et al. (2008) Augmented Phl p 5-specific Th2 response after exposure of dendritic cells to allergen in complex with specific IgE compared to IgG1 and IgG4. Clin Immunol 128: 358-365.
62. Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, et al. (2005) TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 202: 1213-1223.
63. Hooyberghs J, Schoeters E, Lambrechts N, Nelissen I, Witters H, et al. (2008) A cell-based in vitro alternative to identify skin sensitizers by gene expression. Toxicol Appl Pharmacol 231: 103-111.
64. Python F, Goebel C, Aeby P, (2009) Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol 239: 273-283.
65. Reuter H, Spieker J, Gerlach S, Engels U, Pape W, et al. (2011) In vitro detection of contact allergens: development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells. Toxicol In Vitro 25: 315-323.
66. Schuurhuis DH, van Montfoort N, Ioan-Facsinay A, Jiawan R, Camps M, et al. (2006) Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine. J Immunol 176: 4573-4580.
67. Dominguez-Soto A, Aragoneses-Fenoll L, Martin-Gayo E, Martinez-Prats L, Colmenares M, et al. (2007) The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells. Blood 109: 5337-5345.
68. Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, et al. (2003) Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol 171: 4552-4560.
69. Skrzypek F, Cenci E, Pietrella D, Rachini A, Bistoni F, et al. (2009) Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation. Microbes Infect 11: 661-670.
70. LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, et al. (2007) Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8: 630-638.
71. Li D, Romain G, Flamar AL, Duluc D, Dullaers M, et al. (2012) Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med 209: 109-121.
72. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F, (2000) Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1: 311-316.
73. Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27: 3135-3142.
74. Boullart AC, Aarntzen EH, Verdijk P, Jacobs JF, Schuurhuis DH, et al. (2008) Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration. Cancer Immunol Immunother 57: 1589-1597.
75. Demeure CE, Tanaka H, Mateo V, Rubio M, Delespesse G, et al. (2000) CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J Immunol 164: 2193-2199.