In vitro detection of contact allergens: Development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 315-323

  Reuter, Hendrik ^a   Spieker, Jochem ^a   Gerlach, Silke ^a   Engels, Ursula ^b   Pape, Wolfgang ^a   Kolbe, Ludger ^a   Schmucker, Robert ^a   Wenck, Horst ^a   Diembeck, Walter ^a   Wittern, Klaus Peter ^a   Reisinger, Kerstin ^b   Schepky, Andreas G ^a  

^a BEIERSDORF AG   (Germany)

^b HENKEL KGAA   (Germany)

Author keywords

Alternative method; CD86; Dendritic cell; In vitro toxicology; Sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 4 HYDROXYBENZOIC ACID; ALPHA HEXYLCINNAMALDEHYDE; ASCORBIC ACID; BENZALKONIUM CHLORIDE; CD14 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CINNAMALDEHYDE; CONTACT ALLERGEN; DODECYL SULFATE SODIUM; EUGENOL; GLUTARALDEHYDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HAPTEN; HLA DR ANTIGEN; HYDROXYCITRONELLAL; INTERLEUKIN 4; NICKEL SULFATE; PHTHALIC ACID DIMETHYL ESTER; T6 ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BLOOD DONOR; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL SELECTION; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONOCYTE DERIVED DENDRITIC CELL; PHENOTYPE; REPRODUCIBILITY;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; ANTIGENS, CD14; ANTIGENS, CD86; CELL DIFFERENTIATION; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; COSMETICS; CYTOKINES; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; FLOW CYTOMETRY; HAPTENS; HUMANS; MONOCYTES; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS;

ANIMALIA;

EID: 78650520285     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.09.016     Document Type: Article

References (41)

1. Ade N., Martinozzi-Teissier S., Pallardy M., Rousset F. Activation of U937 cells by contact sensitizers: CD86 expression is independent of apoptosis. J. Immunotoxicol. 2006, 3(4):189-197.
2. Aeby P., Wyss C., Beck H., Griem P., Scheffler H., Goebel C. Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration. J. Invest. Dermatol. 2004, 122(5):1154-1164.
3. Aiba S., Terunuma A., Manome H., Tagami H. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur. J. Immunol. 1997, 27(11):3031-3038.
4. Ashikaga T., Yoshida Y., Hirota M., Yoneyama K., Itagaki H., Sakaguchi H., Miyazawa M., Ito Y., Suzuki H., Toyoda H. Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol. In Vitro 2006, 20(5):767-773.
5. Azam P., Peiffer J.L., Chamousset D., Tissier M.H., Bonnet P.A., Vian L., Fabre I., Ourlin J.C. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol. Appl. Pharmacol. 2006, 212(1):14-23.
6. Basketter D., Maxwell G. In vitro approaches to the identification and characterization of skin sensitizers. Cutan. Ocul. Toxicol. 2007, 26(4):359-373.
7. Basketter D.A., Evans P., Fielder R.J., Gerberick G.F., Dearman R.J., Kimber I. Local lymph node assay - validation, conduct and use in practice. Food Chem. Toxicol. 2002, 40(5):593-598.
8. Basketter D.A., Scholes E.W. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem. Toxicol. 1992, 30(1):65-69.
9. Basketter D.A., Scholes E.W., Kimber I. The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food Chem. Toxicol. 1994, 32(6):543-547.
10. Basketter D.A., Wright Z.M., Warbrick E.V., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., White I.R. Human potency predictions for aldehydes using the local lymph node assay. Contact Dermatitis 2001, 45(2):89-94.
11. Dearman R.J., Basketter D.A., Kimber I. Local lymph node assay: use in hazard and risk assessment. J. Appl. Toxicol. 1999, 19(5):299-306.
12. Dearman R.J., Wright Z.M., Basketter D.A., Ryan C.A., Gerberick G.F., Kimber I. The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay. Contact Dermatitis 2001, 44(6):357-361.
13. Degwert J., Steckel F., Hoppe U., Kligman L.H. In vitro model for contact sensitization: I. Stimulatory capacities of human blood-derived dendritic cells and their phenotypical alterations in the presence of contact sensitizers. Toxicol. In Vitro 1997, 11613-11618.
14. dos Santos G.G., Reinders J., Ouwehand K., Rustemeyer T., Scheper R.J., Gibbs S. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol. 2009, 236(3):372-382.
15. Gallucci S., Matzinger P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 2001, 13(1):114-119.
16. Gerberick G.F., Cruse L.W., Ryan C.A. Local lymph node assay: differentiating allergic and irritant responses using flow cytometry. Methods 1999, 19(1):48-55.
17. Gerberick G.F., Ryan C.A., Kimber I., Dearman R.J., Lea L.J., Basketter D.A. Local lymph node assay: validation assessment for regulatory purposes. Am. J. Contact Dermatitis 2000, 11(1):3-18.
18. Hilton J., Dearman R.J., Harvey P., Evans P., Basketter D.A., Kimber I. Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde. Am. J. Contact Dermatitis 1998, 9(1):29-33.
19. Hu Q., Frank I., Williams V., Santos J.J., Watts P., Griffin G.E., Moore J.P., Pope M., Shattock R.J. Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue. J. Exp. Med. 2004, 199(8):1065-1075.
20. Kim K.D., Choi S.C., Noh Y.W., Kim J.W., Paik S.G., Yang Y., Kim K., Lim J.S. Impaired responses of leukemic dendritic cells derived from a human myeloid cell line to LPS stimulation. Exp. Mol. Med. 2006, 38(1):72-84.
21. Kimber I., Dearman R.J., Basketter D.A., Ryan C.A., Gerberick G.F. The local lymph node assay: past, present and future. Contact Dermatitis 2002, 47(6):315-328.
22. Kimber I., Dearman R.J., Scholes E.W., Basketter D.A. The local lymph node assay: developments and applications. Toxicology 1994, 93(1):13-31.
23. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Lea L., House R.V., Ladics G.S., Loveless S.E., Hastings K.L. Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation. J. Toxicol. Environ. Health A. 1998, 53(7):563-579.
24. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Scholes E.W., Ladics G.S., Loveless S.E., House R.V., et al. An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 1995, 103(1):63-73.
25. Kitamura T., Tange T., Terasawa T., Chiba S., Kuwaki T., Miyagawa K., Piao Y.F., Miayzono K., Urabe A., Takaku F. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell Physiol. 1989, 140(2):323-324.
26. Larsson K., Lindstedt M., Borrebaeck C.A. Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology 2006, 117(2):156-166.
27. Loveless S.E., Ladics G.S., Gerberick G.F., Ryan C.A., Basketter D.A., Scholes E.W., House R.V., Hilton J., Dearman R.J., Kimber I. Further evaluation of the local lymph node assay in the final phase of an international collaborative trial. Toxicology 1996, 108(1-2):141-152.
28. Nelissen I., Selderslaghs I., Heuvel R.V., Witters H., Verheyen G.R., Schoeters G. MUTZ-3-derived dendritic cells as an in vitro alternative model to CD34+ progenitor-derived dendritic cells for testing of chemical sensitizers. Toxicol. In Vitro 2009, 23(8):1477-1481.
29. Nestle F.O., Di Meglio P., Qin J.Z., Nickoloff B.J. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 2009, 9(10):679-691.
30. Novak N., Haberstok J., Geiger E., Bieber T. Dendritic cells in allergy. Allergy 1999, 54(8):792-803.
31. Ouwehand K., Spiekstra S.W., Reinders J., Scheper R.J., de Gruijl T.D., Gibbs S. Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol. In Vitro 2010, 24(2):578-585.
32. Pickl W.F., Majdic O., Kohl P., Stoeckl J., Riedl E., Scheinecker C., Bello-Fernandez C., Knapp W. Molecular and functional characteristics of dendritic cells generated from highly purified Cd14+ peripheral blood monocytes. J. Immunol. 1996, 157:3850-3859.
33. Python F., Goebel C., Aeby P. Assessment of the U937 cell line for the detection of contact allergens. Toxicol. Appl. Pharmacol. 2007, 220(2):113-124.
34. Python F., Goebel C., Aeby P. Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol. Appl. Pharmacol. 2009, 239(3):273-283.
35. Reutter K., Jaeger D., Degwert J., Hoppe U. In vitro model for contact sensitization: II. Induction of IL-1a mRNA in human blood-derived dendritic cells by contact sensitizers. Toxicol. In Vitro 1997, 11619-11626.
36. Sakaguchi H., Ashikaga T., Miyazawa M., Yoshida Y., Ito Y., Yoneyama K., Hirota M., Itagaki H., Toyoda H., Suzuki H. Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicol. In Vitro 2006, 20(5):774-784.
37. Sakaguchi, H., Ryan, C., Ovigne, J.M., Schroeder, K.R., Ashikaga, T., in press. Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials. Toxicol. In Vitro. doi: 10.1016/j.tiv.2010.05.012.
38. Schafer T., Bohler E., Ruhdorfer S., Weigl L., Wessner D., Filipiak B., Wichmann H.E., Ring J. Epidemiology of contact allergy in adults. Allergy 2001, 56(12):1192-1196.
39. Schmid I., Krall W.J., Uittenbogaart C.H., Braun J., Giorgi J.V. Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry 1992, 13(2):204-208.
40. Staquet M.J., Sportouch M., Jacquet C., Schmitt D., Guesnet J., Peguet-Navarro J. Moderate skin sensitizers can induce phenotypic changes on in vitro generated dendritic cells. Toxicol. In Vitro 2004, 18(4):493-500.
41. Toebak M.J., Gibbs S., Bruynzeel D.P., Scheper R.J., Rustemeyer T. Dendritic cells: biology of the skin. Contact Dermatitis 2009, 60(1):2-20.