Melanopsin phototransduction: Slowly emerging from the dark

Progress in Brain Research

Volumn 199, Issue , 2012, Pages 19-40

  Hughes, Steven ^a   Hankins, Mark W ^a   Foster, Russell G ^a   Peirson, Stuart N ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Melanopsin; Opn4; Phototransduction; PRGC; Retina; TRPC

Indexed keywords

CYCLIC GMP; G PROTEIN COUPLED RECEPTOR; ISOPROTEIN; MELANOPSIN; OPSIN; PHOSPHOLIPASE C; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; SCOTOPSIN;

ARTICLE; BINDING KINETICS; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; GLYCOSYLATION; LIGHT; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MICROARRAY ANALYSIS; NONHUMAN; PHOTOSENSITIVITY; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN LOCALIZATION; RETINA AMACRINE CELL; RETINA CONE; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA ROD; RETINA ROD OUTER SEGMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; CIRCADIAN RHYTHM; DARKNESS; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; CIRCADIAN RHYTHM; DARKNESS; HUMANS; LIGHT SIGNAL TRANSDUCTION; RETINAL GANGLION CELLS; ROD OPSINS;

EID: 84872176280     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/B978-0-444-59427-3.00002-2     Document Type: Chapter

References (125)

1. Adamski F.M., Timms K.M., Shieh B.H. A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Biochimica et Biophysica Acta 1999, 1444:55-60.
2. Amatruda T.T., Steele D.A., Slepak V.Z., Simon M.I. G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:5587-5591.
3. Baver S.B., Pickard G.E., Sollars P.J. Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus. The European Journal of Neuroscience 2008, 27:1763-1770.
4. Belenky M.A., Smeraski C.A., Provencio I., Sollars P.J., Pickard G.E. Melanopsin retinal ganglion cells receive bipolar and amacrine cell synapses. The Journal of Comparative Neurology 2003, 460:380-393.
5. Bellingham J., Chaurasia S.S., Melyan Z., Liu C., Cameron M.A., Tarttelin E.E., et al. Evolution of melanopsin photoreceptors: Discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biology 2006, 4:e254.
6. Berson D.M. Phototransduction in ganglion-cell photoreceptors. Pflügers Archiv 2007, 454:849-855.
7. Berson D.M., Castrucci A.M., Provencio I. Morphology and mosaics of melanopsin-expressing retinal ganglion cell types in mice. The Journal of Comparative Neurology 2010, 518:2405-2422.
8. Berson D.M., Dunn F.A., Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 2002, 295:1070-1073.
9. Brainard G.C., Hanifin J.P., Greeson J.M., Byrne B., Glickman G., Gerner E., et al. Action spectrum for melatonin regulation in humans: Evidence for a novel circadian photoreceptor. The Journal of Neuroscience 2001, 21:6405-6412.
10. Brown T.M., Gias C., Hatori M., Keding S.R., Semo M., Coffey P.J., et al. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biology 2010, 8:e1000558.
11. Cabrera-Vera T.M., Vanhauwe J., Thomas T.O., Medkova M., Preininger A., Mazzoni M.R., et al. Insights into G protein structure, function, and regulation. Endocrine Reviews 2003, 24:765-781.
12. Chen S.K., Badea T.C., Hattar S. Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 2011, 476:92-95.
13. Chyb S., Hevers W., Forte M., Wolfgang W.J., Selinger Z., Hardie R.C. Modulation of the light response by cAMP in Drosophila photoreceptors. The Journal of Neuroscience 1999, 19:8799-8807.
14. Chyb S., Raghu P., Hardie R.C. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 1999, 397:255-259.
15. Contin M.A., Verra D.M., Guido M.E. An invertebrate-like phototransduction cascade mediates light detection in the chicken retinal ganglion cells. The FASEB Journal 2006, 20:2648-2650.
16. Dacey D.M., Liao H.W., Peterson B.B., Robinson F.R., Smith V.C., Pokorny J., et al. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature 2005, 433:749-754.
17. Davies W.I., Zheng L., Hughes S., Tamai T.K., Turton M., Halford S., et al. Functional diversity of melanopsins and their global expression in the teleost retina. Cellular and Molecular Life Sciences 2011, 68(24):4115-4132.
18. Davignon I., Barnard M., Gavrilova O., Sweet K., Wilkie T.M. Gene structure of murine Gna11 and Gna15: Tandemly duplicated Gq class G protein alpha subunit genes. Genomics 1996, 31:359-366.
19. Do M.T., Kang S.H., Xue T., Zhong H., Liao H.W., Bergles D.E., et al. Photon capture and signalling by melanopsin retinal ganglion cells. Nature 2009, 457:281-287.
20. Do M.T., Yau K.W. Intrinsically photosensitive retinal ganglion cells. Physiological Reviews 2010, 90:1547-1581.
21. Drivenes O., Soviknes A.M., Ebbesson L.O., Fjose A., Seo H.C., Helvik J.V. Isolation and characterization of two teleost melanopsin genes and their differential expression within the inner retina and brain. The Journal of Comparative Neurology 2003, 456:84-93.
22. Dumitrescu O.N., Pucci F.G., Wong K.Y., Berson D.M. Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: Contacts with dopaminergic amacrine cells and melanopsin ganglion cells. The Journal of Comparative Neurology 2009, 517:226-244.
23. Dupre D.J., Robitaille M., Rebois R.V., Hebert T.E. The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annual Review of Pharmacology and Toxicology 2009, 49:31-56.
24. Ecker J.L., Dumitrescu O.N., Wong K.Y., Alam N.M., Chen S.K., Legates T., et al. Melanopsin-expressing retinal ganglion-cell photoreceptors: Cellular diversity and role in pattern vision. Neuron 2010, 67:49-60.
25. Elia N., Frechter S., Gedi Y., Minke B., Selinger Z. Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors. The Journal of Cell Biology 2005, 171:517-526.
26. Fahrenkrug J., Falktoft B., Georg B., Rask L. N-linked deglycosylated melanopsin retains its responsiveness to light. Biochemistry 2009, 48:5142-5148.
27. Ferreira P.A., Pak W.L. Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones. The Journal of Biological Chemistry 1994, 269:3129-3131.
28. Ferreira P.A., Shortridge R.D., Pak W.L. Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila. Proceedings of the National Academy of Sciences of the United States of America 1993, 90:6042-6046.
29. Freedman M.S., Lucas R.J., Soni B., von Schantz M., Munoz M., David-Gray Z., et al. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 1999, 284:502-504.
30. Gamlin P.D., Mcdougal D.H., Pokorny J., Smith V.C., Yau K.W., Dacey D.M. Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Research 2007, 47:946-954.
31. 2+ signaling of a mouse melanopsin-eYFP fusion protein in a retinal pigment epithelium cell line. Photochemistry and Photobiology 2008, 84:990-995.
32. Gooley J.J., Lu J., Fischer D., Saper C.B. A broad role for melanopsin in nonvisual photoreception. The Journal of Neuroscience 2003, 23:7093-7106.
33. Graham D.M., Wong K.Y., Shapiro P., Frederick C., Pattabiraman K., Berson D.M. Melanopsin ganglion cells use a membrane-associated rhabdomeric phototransduction cascade. Journal of Neurophysiology 2008, 99:2522-2532.
34. Guler A.D., Ecker J.L., Lall G.S., Haq S., Altimus C.M., Liao H.W., et al. Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature 2008, 453:102-105.
35. Hankins M.W., Lucas R.J. The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment. Current Biology 2002, 12:191-198.
36. Hankins M.W., Peirson S.N., Foster R.G. Melanopsin: An exciting photopigment. Trends in Neurosciences 2008, 31:27-36.
37. Hannibal J., Fahrenkrug J. Target areas innervated by PACAP-immunoreactive retinal ganglion cells. Cell and Tissue Research 2004, 316:99-113.
38. Hardie R.C. Phototransduction in Drosophila melanogaster. The Journal of Experimental Biology 2001, 204:3403-3409.
39. Hardie R.C. TRP channels in Drosophila photoreceptors: The lipid connection. Cell Calcium 2003, 33:385-393.
40. Hardie R.C. TRP channels and lipids: From Drosophila to mammalian physiology. The Journal of Physiology 2007, 578:9-24.
41. Hardie R., Raghu P. Visual transduction in Drosophila. Nature 2001, 413:186-193.
42. Hartwick A.T., Bramley J.R., Yu J., Stevens K.T., Allen C.N., Baldridge W.H., et al. Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells. The Journal of Neuroscience 2007, 27:13468-13480.
43. Hatori M., Le H., Vollmers C., Keding S.R., Tanaka N., Buch T., et al. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One 2008, 3:e2451.
44. Hattar S., Kumar M., Park A., Tong P., Tung J., Yau K.W., et al. Central projections of melanopsin-expressing retinal ganglion cells in the mouse. The Journal of Comparative Neurology 2006, 497:326-349.
45. Hattar S., Liao H.W., Takao M., Berson D.M., Yau K.W. Melanopsin-containing retinal ganglion cells: Architecture, projections, and intrinsic photosensitivity. Science 2002, 295:1065-1070.
46. Hattar S., Lucas R.J., Mrosovsky N., Thompson S., Douglas R.H., Hankins M.W., et al. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 2003, 424:75-81.
47. Hayashida Y., Rodriguez C.V., Ogata G., Partida G.J., Oi H., Stradleigh T.W., et al. Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation. The Journal of Neuroscience 2009, 29:15001-15016.
48. Hoshi H., Liu W.L., Massey S.C., Mills S.L. ON inputs to the OFF layer: Bipolar cells that break the stratification rules of the retina. The Journal of Neuroscience 2009, 29:8875-8883.
49. Hubbard K.B., Hepler J.R. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cellular Signalling 2006, 18:135-150.
50. Isoldi M.C., Rollag M.D., Castrucci A.M., Provencio I. Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:1217-1221.
51. Johnson J., Wu V., Donovan M., Majumdar S., Renteria R.C., Porco T., et al. Melanopsin-dependent light avoidance in neonatal mice. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:17374-17378.
52. Kitamura E., Danciger M., Yamashita C., Rao N.P., Nusinowitz S., Chang B., et al. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Investigative Ophthalmology & Visual Science 2006, 47:1293-1301.
53. Kostenis E., Waelbroeck M., Milligan G. Techniques: Promiscuous Galpha proteins in basic research and drug discovery. Trends in Pharmacological Sciences 2005, 26:595-602.
54. Koyanagi M., Kubokawa K., Tsukamoto H., Shichida Y., Terakita A. Cephalochordate melanopsin: Evolutionary linkage between invertebrate visual cells and vertebrate photosensitive retinal ganglion cells. Current Biology 2005, 15:1065-1069.
55. Koyanagi M., Terakita A. Gq-coupled rhodopsin subfamily composed of invertebrate visual pigment and melanopsin. Photochemistry and Photobiology 2008, 84:1024-1030.
56. -/- mice. The Journal of Neuroscience 2003, 23:6965-6971.
57. Kumbalasiri T., Rollag M.D., Isoldi M.C., Castrucci A.M., Provencio I. Melanopsin triggers the release of internal calcium stores in response to light. Photochemistry and Photobiology 2007, 83:273-279.
58. Lamb T.D. Ida Mann Lecture. Transduction in human photoreceptors. Australian and New Zealand Journal of Ophthalmology 1996, 24:105-110.
59. Lee R.H., Lieberman B.S., Yamane H.K., Bok D., Fung B.K. A third form of the G protein beta subunit. 1. Immunochemical identification and localization to cone photoreceptors. The Journal of Biological Chemistry 1992, 267:24776-24781.
60. Lucas R.J., Douglas R.H., Foster R.G. Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nature Neuroscience 2001, 4:621-626.
61. Lucas R.J., Foster R.G. Neither functional rod photoreceptors nor rod or cone outer segments are required for the photic inhibition of pineal melatonin. Endocrinology 1999, 140:1520-1524.
62. Lucas R.J., Hattar S., Takao M., Berson D.M., Foster R.G., Yau K.W. Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science 2003, 299:245-247.
63. Luo D.G., Xue T., Yau K.W. How vision begins: An odyssey. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:9855-9862.
64. Lupi D., Oster H., Thompson S., Foster R.G. The acute light-induction of sleep is mediated by OPN4-based photoreception. Nature Neuroscience 2008, 11(9):1068-1073.
65. Makino C.L., Wen X.H., Lem J. Piecing together the timetable for visual transduction with transgenic animals. Current Opinion in Neurobiology 2003, 13:404-412.
66. Margolis D.J., Gartland A.J., Euler T., Detwiler P.B. Dendritic calcium signaling in ON and OFF mouse retinal ganglion cells. The Journal of Neuroscience 2010, 30:7127-7138.
67. Mcneill D.S., Sheely C.J., Ecker J.L., Badea T.C., Morhardt D., Guido W., et al. Development of melanopsin-based irradiance detecting circuitry. Neural Development 2011, 6:8.
68. Melyan Z., Tarttelin E.E., Bellingham J., Lucas R.J., Hankins M.W. Addition of human melanopsin renders mammalian cells photoresponsive. Nature 2005, 433:741-745.
69. Mizuno N., Itoh H. Functions and regulatory mechanisms of Gq-signaling pathways. Neuro-Signals 2009, 17:42-54.
70. Mrosovsky N., Lucas R., Foster R. Persistence of masking responses to light in mice lacking rods and cones. Journal of Biological Rhythms 2001, 16:585-587.
71. Mure L.S., Rieux C., Hattar S., Cooper H.M. Melanopsin-dependent nonvisual responses: Evidence for photopigment bistability in vivo. Journal of Biological Rhythms 2007, 22:411-424.
72. Nakamura K., Nukada T., Imai K., Sugiyama H. Importance of N-terminal regions of G protein alpha subunits for the activation of phospholipase C in Xenopus oocytes. Journal of Biochemistry 1996, 120:996-1001.
73. Nasi E., Del Pilar Gomez M. Melanopsin-mediated light-sensing in amphioxus: A glimpse of the microvillar photoreceptor lineage within the deuterostomia. Communicative & Integrative Biology 2009, 2:441-443.
74. Newman L.A., Walker M.T., Brown R.L., Cronin T.W., Robinson P.R. Melanopsin forms a functional short-wavelength photopigment. Biochemistry 2003, 42:12734-12738.
75. Ostergaard J., Hannibal J., Fahrenkrug J. Synaptic contact between melanopsin-containing retinal ganglion cells and rod bipolar cells. Investigative Ophthalmology & Visual Science 2007, 48:3812-3820.
76. Panda S., Nayak S.K., Campo B., Walker J.R., Hogenesch J.B., Jegla T. Illumination of the melanopsin signaling pathway. Science 2005, 307:600-604.
77. Panda S., Provencio I., Tu D.C., Pires S.S., Rollag M.D., Castrucci A.M., et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science 2003, 301:525-527.
78. Panda S., Sato T.K., Castrucci A.M., Rollag M.D., Degrip W.J., Hogenesch J.B., et al. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 2002, 298:2213-2216.
79. Peirson S.N., Oster H., Jones S.L., Leitges M., Hankins M.W., Foster R.G. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Current Biology 2007, 17:1363-1372.
80. Peng Y.W., Robishaw J.D., Levine M.A., Yau K.W. Retinal rods and cones have distinct G protein beta and gamma subunits. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:10882-10886.
81. Perez-Leighton C.E., Schmidt T.M., Abramowitz J., Birnbaumer L., Kofuji P. Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits. The European Journal of Neuroscience 2011, 33:856-867.
82. Pires S.S., Hughes S., Turton M., Melyan Z., Peirson S.N., Zheng L., et al. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. The Journal of Neuroscience 2009, 29:12332-12342.
83. Provencio I., Jiang G., De Grip W.J., Hayes W.P., Rollag M.D. Melanopsin: An opsin in melanophores, brain, and eye. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:340-345.
84. Provencio I., Rodriguez I.R., Jiang G., Hayes W.P., Moreira E.F., Rollag M.D. A novel human opsin in the inner retina. The Journal of Neuroscience 2000, 20:600-605.
85. Provencio I., Rollag M.D., Castrucci A.M. Photoreceptive net in the mammalian retina. This mesh of cells may explain how some blind mice can still tell day from night. Nature 2002, 415:493.
86. Qiu X., Kumbalasiri T., Carlson S.M., Wong K.Y., Krishna V., Provencio I., et al. Induction of photosensitivity by heterologous expression of melanopsin. Nature 2005, 433:745-749.
87. Raghu P. Regulation of Drosophila TRPC channels by protein and lipid interactions. Seminars in Cell & Developmental Biology 2006, 17:646-653.
88. Rao A., Dallman R., Henderson S., Chen C.K. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. The Journal of Neuroscience 2007, 27:14199-14204.
89. Rhee S.G. Regulation of phosphoinositide-specific phospholipase C. Annual Review of Biochemistry 2001, 70:281-312.
90. Ruby N.F., Brennan T.J., Xie X., Cao V., Franken P., Heller H.C., et al. Role of melanopsin in circadian responses to light. Science 2002, 298:2211-2213.
91. Schaefer M. Homo- and heteromeric assembly of TRP channel subunits. Pflügers Archiv 2005, 451:35-42.
92. Schmidt T.M., Chen S.K., Hattar S. Intrinsically photosensitive retinal ganglion cells: Many subtypes, diverse functions. Trends in Neurosciences 2011, 31(11):572-580.
93. Schmidt T.M., Kofuji P. Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. The Journal of Neuroscience 2009, 29:476-482.
94. Schmidt T.M., Kofuji P. Differential cone pathway influence on intrinsically photosensitive retinal ganglion cell subtypes. The Journal of neuroscience: the official journal of the Society for Neuroscience 2010, 30:16262-16271.
95. Schmidt T.M., Kofuji P. Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. The Journal of Comparative Neurology 2011, 519:1492-1504.
96. Schmidt T.M., Taniguchi K., Kofuji P. Intrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse development. Journal of Neurophysiology 2008, 100:371-384.
97. Sekaran S., Foster R.G., Lucas R.J., Hankins M.W. Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons. Current Biology 2003, 13:1290-1298.
98. Sekaran S., Lall G.S., Ralphs K.L., Wolstenholme A.J., Lucas R.J., Foster R.G., et al. 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. The Journal of Neuroscience 2007, 27:3981-3986.
99. Sekaran S., Lupi D., Jones S.L., Sheely C.J., Hattar S., Yau K.W., et al. Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Current Biology 2005, 15:1099-1107.
100. Semo M., Gias C., Ahmado A., Sugano E., Allen A.E., Lawrence J.M., et al. Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. PLoS One 2010, 5:e15009.
101. Shindo Y., Miura H., Carninci P., Kawai J., Hayashizaki Y., Ninomiya Y., et al. G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. Biochemical and Biophysical Research Communications 2008, 376:504-508.
102. Suh B.C., Hille B. PIP2 is a necessary cofactor for ion channel function: How and why?. Annual Review of Biophysics 2008, 37:175-195.
103. Suh B.C., Inoue T., Meyer T., Hille B. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science 2006, 314:1454-1457.
104. Thapan K., Arendt J., Skene D.J. An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans. The Journal of Physiology 2001, 535:261-267.
105. Tizzano M., Dvoryanchikov G., Barrows J.K., Kim S., Chaudhari N., Finger T.E. Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue. BMC Neuroscience 2008, 9:110.
106. Torii M., Kojima D., Okano T., Nakamura A., Terakita A., Shichida Y., et al. Two isoforms of chicken melanopsins show blue light sensitivity. FEBS Letters 2007, 581:5327-5331.
107. Tu D.C., Zhang D., Demas J., Slutsky E.B., Provencio I., Holy T.E., et al. Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells. Neuron 2005, 48:987-999.
108. Tummala H., Ali M., Getty P., Hocking P.M., Burt D.W., Inglehearn C.F., et al. Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens. Investigative Ophthalmology & Visual Science 2006, 47:4714-4718.
109. Viney T.J., Balint K., Hillier D., Siegert S., Boldogkoi Z., Enquist L.W., et al. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Current Biology 2007, 17:981-988.
110. Vugler A.A., Redgrave P., Semo M., Lawrence J., Greenwood J., Coffey P.J. Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina. Experimental Neurology 2007, 205:26-35.
111. Walker M.T., Brown R.L., Cronin T.W., Robinson P.R. Photochemistry of retinal chromophore in mouse melanopsin. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:8861-8865.
112. Warren E.J., Allen C.N., Brown R.L., Robinson D.W. Intrinsic light responses of retinal ganglion cells projecting to the circadian system. The European Journal of Neuroscience 2003, 17:1727-1735.
113. Warren E.J., Allen C.N., Brown R.L., Robinson D.W. The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. The European Journal of Neuroscience 2006, 23:2477-2487.
114. Watson A.J., Aragay A.M., Slepak V.Z., Simon M.I. A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina. The Journal of Biological Chemistry 1996, 271:28154-28160.
115. Weschler C.J., Wells J.R., Poppendieck D., Hubbard H., Pearce T.A. Workgroup report: Indoor chemistry and health. Environmental Health Perspectives 2006, 114:442-446.
116. Wettschureck N., Offermanns S. Mammalian G proteins and their cell type specific functions. Physiological Reviews 2005, 85:1159-1204.
117. Wilkie T.M., Gilbert D.J., Olsen A.S., Chen X.N., Amatruda T.T., Korenberg J.R., et al. Evolution of the mammalian G protein alpha subunit multigene family. Nature Genetics 1992, 1:85-91.
118. Wilkie T.M., Scherle P.A., Strathmann M.P., Slepak V.Z., Simon M.I. Characterization of G-protein alpha subunits in the Gq class: Expression in murine tissues and in stromal and hematopoietic cell lines. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:10049-10053.
119. Wong K.Y., Dunn F.A., Berson D.M. Photoreceptor adaptation in intrinsically photosensitive retinal ganglion cells. Neuron 2005, 48:1001-1010.
120. Wong K.Y., Dunn F.A., Graham D.M., Berson D.M. Synaptic influences on rat ganglion-cell photoreceptors. The Journal of Physiology 2007, 582:279-296.
121. Xue T., Do M.T., Riccio A., Jiang Z., Hsieh J., Wang H.C., et al. Melanopsin signalling in mammalian iris and retina. Nature 2011, 479:67-73.
122. Yau K.W., Hardie R.C. Phototransduction motifs and variations. Cell 2009, 139:246-264.
123. Yule D.I., Baker C.W., Williams J.A. Calcium signaling in rat pancreatic acinar cells: A role for Galphaq, Galpha11, and Galpha14. The American Journal of Physiology 1999, 276:G271-G279.
124. Zaidi F.H., Hull J.T., Peirson S.N., Wulff K., Aeschbach D., Gooley J.J., et al. Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina. Current Biology 2007, 17:2122-2128.
125. Zhang D.Q., Wong K.Y., Sollars P.J., Berson D.M., Pickard G.E., Mcmahon D.G. Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:14181-14186.