Addition of human melanopsin renders mammalian cells photoresponsive

Nature

Volumn 433, Issue 7027, 2005, Pages 741-745

  Melyan, Z ^a   Tarttelin, E E ^a,b   Bellingham, J ^b   Lucas, R J ^b   Hankins, M W ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENES; LIGHT; PHYSIOLOGY; PIGMENTS; PROTEINS;

MAMMALIAN CELLS; PHOTOPIGMENTS; PHOTORESPONSES; PHYSIOLOGICAL LIGHT DETECTION;

CELLS;

GUANINE NUCLEOTIDE BINDING PROTEIN; MELANOPSIN; RETINAL; CYCLIC GMP; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; OPSIN;

CELLS AND CELL COMPONENTS; PHOTORECEPTION;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE EXPRESSION; GENETIC CODE; ISOMERISM; MAMMAL CELL; NERVE CELL; NONHUMAN; PHOTORECEPTOR; PHOTOSENSITIVITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; CALCIUM SIGNALING; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; LIGHT; METABOLISM; MOUSE; NASA DISCIPLINE SPACE HUMAN FACTORS; NON-NASA CENTER; PHOTOTRANSDUCTION; RADIATION EXPOSURE;

ANIMALIA; MAMMALIA;

NASA DISCIPLINE SPACE HUMAN FACTORS; NON-NASA CENTER;

ANIMALS; CALCIUM SIGNALING; CELL LINE; CYCLIC GMP; GENE EXPRESSION; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LIGHT; MICE; NEURONS; OPSIN; PHOTOTRANSDUCTION; PROTEIN ISOFORMS; RETINALDEHYDE;

EID: 13944275251     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03344     Document Type: Article

References (32)

1. Berson, D. M., Dunn, F. A. & Takao, M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 295, 1070-1073 (2002).
2. Hattar, S. et al. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424, 75-81 (2003).
3. Panda, S. et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science 301, 525-527 (2003).
4. Sekaran, S., Foster, R. G., Lucas, R. J. & Hankins, M. W. Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons. Curr. Biol. 13, 1290-1298 (2003).
5. Warren, E. J., Allen, C. N., Brown, R. L. & Robinson, D. W. Intrinsic light responses of retinal ganglion cells projecting to the arcadian system. Eur. J. Neurosci. 17, 1727-1735 (2003).
6. Lucas, R., Douglas, R. & Foster, R. Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nature Neurosci. 4, 621-626 (2001).
7. Lucas, R. J. et al. Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice. Behav. Brain Res. 125, 97-102 (2001).
8. Czeisler, C. A. et al. Suppression of melatonin secretion in some blind patients by exposure to bright light. N. Engl. J. Med. 332, 6-11 (1995).
9. Mrosovsky, N., Lucas, R. & Foster, R. Persistence of masking responses to light in mice lacking rods and cones. J. Biol. Rhythms 16, 585-587 (2001).
10. Lockley, S. W. et al. Relationship between melatonin rhythms and visual loss in the blind. J. Clin. Endocrinol. Metab. 82, 3763-3770 (1997).
11. Hattar, S., Liao, H. W., Takao, M., Berson, D. M. & Yau, K. W. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295, 1065-1070 (2002).
12. Gooley, J. J., Lu, J., Chou, T. C., Scammell, T. E. & Saper, C. B. Melanopsin in cells of origin of the retinohypothalamic tract. Nature Neurosci. 4, 1165 (2001).
13. Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B. & Fahrenkrug, J. The photopigment melanopsin is exclusively present in pituitary adenylate cyclase-activating polypeptide-containing retinal ganglion cells of the retinohypothalamic tract. J. Neurosci. 22, RC191 (2002).
14. Lucas, R. J. et al Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science 299, 245-247 (2003).
15. Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P. & Rollag, M. D. Melanopsin: An opsin in melanophores, brain, and eye. Proc. Natl Acad. Sci. USA 95, 340-345 (1998).
16. Hubbard, R. & St. George, R. The rhodopsin system of the squid. J. Gen. Physiol. 41, 501-528 (1958).
17. Liu, R. S., Crescitelli, F., Denny, M., Matsumoto, H.& Asato, A. E. Photosensitivity of 10-substituted visual pigment analogues: detection of a specific secondary opsin-retinal interaction. Biochemistry 25, 7026-7030 (1986).
18. Hao, W. & Fong, H. The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium. J. Biol Chem. 274, 6085-6090 (1999).
19. Koyanagi, M. et al. Bistable UV pigment in the lamprey pineal. Proc. Natl Acad. Sci. USA 101, 6687-6691 (2004).
20. Brainard, G. et al Action spectrum for melatonin reguiation in humans: evidence for a novel circadian photo receptor. J. Neurosci. 21, 6405-6412 (2001).
21. Thapan, K., Arendt, J. & Skene, D. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photo receptor system in humans. J. Physiol. (Lond.) 535, 261-267 (2001).
22. Hankins, M. W. & Lucas, R. J. The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment Curr. Biol. 12, 191-198 (2002).
23. Newman, L. A., Walker, M. T., Brown, R. L., Cronin, T. W. & Robinson, P. R. Melanopsin forms a functional short-wavelength photopigment. Biochemistry 42, 12734-12738 (2003).
24. Provencio, I. et al. A novel human opsin in the inner retina. J. Neurosci. 20, 600-605 (2000).
25. Bellingham, J., Whitmore, D., Philp, A. R., Wells, D. J. & Foster, R. G. Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position. Brain Res. Mol. Brain Res. 107, 128-136 (2002).
26. Beindl, W. et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol. Pharmacol. 50, 415-423 (1996).
27. Gilman, A. G proteins and dual control of adenylate cyclase. Cell 36, 577-579 (1984).
28. Asano, T. & Ogasawara, N. Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins. Mol. Pharmacol. 29, 244-249 (1986).
29. Zemelman, B. V., Lee, G. A., Ng, M. & Miesenbock, G. Selective photostimulation of genetically chARGed neurons. Neuron 33, 15-22 (2002).
30. Leszkiewicz, D., Kandler, K. & Aizenrnan, E. Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro. J. Physiol. (Lond.) 524, 365-374 (2000).
31. Qiu, X. et al. Induction of photosensitivity by heterologous expression of melanopsin. Nature doi:10.1038/nature03345 (this issue).
32. Panda, S. et al. Illumination of the meianopsin signaling pathway. Science 307, 600-604 (2005).