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Volumn 298, Issue 5601, 2002, Pages 2211-2213

Role of melanopsin in circadian responses to light

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIORAL RESEARCH; LIGHT;

EID: 2242439918     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1076701     Document Type: Article
Times cited : (558)

References (29)
  • 17
    • 2242486661 scopus 로고    scopus 로고
    • note
    • DD was initiated at the time of light onset in the animal room. Light pulses (30 min) were administered 16 days after onset of DD and began four circadian hours (CT 16) after activity onset (CT 12). Fluorescent lights (Philips F32T8/TL741 Hi-Vision, 4100k) were used both for light pulses and for overhead y lighting in the activity recording room. Light intensity on the cage floor ranged from 20 to 60 uW-cm-2 or 70 to 280 lux for light pulses and from 10 to 3O uW.cm-2 or 3O to 120 lux for LD and LL conditions, depending on the location of the sensor in the cage. Light was measured in both radiometric (International Light, model IL-1405 Radiometer System) and photometric (Iso- Tech, ILM 350) units of measure to facilitate comparison between traditional photoreception and circadian studies. Mice used for in situ hybridization were sacrificed at the end of the light or dark pulse and their brains were frozen on dry ice. In situ experiments were performed as described in (16). Small sample sizes precluded statistical evaluation of c-fos levels.
  • 18
    • 2242487548 scopus 로고    scopus 로고
    • note
    • See supporting materials and methods for details of activity measurement on Science Online.
  • 29
    • 2242442816 scopus 로고    scopus 로고
    • note
    • We thank P. Gip and M. 5amra for technical assistance and D.-J. Dijk, J. M. Zeitzer and A. 5ancar and anonymous reviewers for helpful comments. Supyported by National Institutes of Health grants MH60385 (N.F.R.) HL64148 (P,F.), and DA13349 (B.F.O.) and by Deltagen, Inc.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.