Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting

Science

Volumn 298, Issue 5601, 2002, Pages 2213-2216

  Panda, Satchidananda ^a,b   Sato, Trey K ^a,b   Castrucci, Ana Maria ^c,d   Rollag, Mark D ^c   DeGrip, Willem J ^e   Hogenesch, John B ^a   Provencio, Ignacio ^c   Kay, Steve A ^a,b  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LIGHT; MONOCHROMATORS; PIGMENTS;

PHOTORECEPTORS;

PATIENT TREATMENT;

MELANOPSIN; OPSIN; UNCLASSIFIED DRUG;

CIRCADIAN RHYTHM; LIGHT;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DARKNESS; LIGHT; LIGHT DARK CYCLE; MOUSE; NONHUMAN; NULL ALLELE; PHOTORECEPTOR; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; TRAINING;

ANIMALS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; DARKNESS; FEMALE; GENE TARGETING; LIGHT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; OPSIN; PHOTOTRANSDUCTION; RETINAL GANGLION CELLS; SUPRACHIASMATIC NUCLEUS;

ANIMALIA; MAMMALIA;

EID: 0037073892     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1076848     Document Type: Article

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28. Supported by the Novartis Science Foundation (to S.P. and J.B.H.), the National Institutes of Health (MH624O5 to I.P.), the National Institute of Mental Health (MH51573 to S.A.K.), the American Cancer Society (PF-02-108-O1-DDC to T.K.S.), and European Union grant BMH4-CT97-2327 (to W.J.d.G.). We thank J. Geskes, S. Kupriyanov, and M. Andahazy for technical assistance, S. Carlson and R. McDowell for animal care and breeding, T. Wiltshire for preliminary mapping of the Opn4 locus, F. A. J. M. van de Klundert for help in generating the targeting vector, and the anonymous reviewers for their valuable comments.