Prolonged photoresponses and defective adaptation in rods of Gβ5 -/- mice

Journal of Neuroscience

Volumn 23, Issue 18, 2003, Pages 6965-6971

  Krispel, Claudia M ^a,b   Chen, Ching Kang ^c   Simon, Melvin I ^d   Burns, Marie E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Adaptation; Calcium; cGMP; G protein; Phototransduction; RGS; Transducin

Indexed keywords

CALCIUM; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; PROTEIN SUBUNIT; REGULATOR PROTEIN; RGS PROTEIN; TRANSDUCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DARK ADAPTATION; GENE ACTIVATION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE INDUCTION; KNOCKOUT MOUSE; LIGHT ADAPTATION; MOUSE; MOUSE STRAIN; NONHUMAN; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; RETINA ROD; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; VISION; WILD TYPE;

EID: 0042627701     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-18-06965.2003     Document Type: Article

References (32)

1. Baylor DA, Hodgkin AL (1973) Detection and resolution of visual stimuli by turtle photoreceptors. J Physiol (Lond) 234:163-198.
2. Calvert PD, Govardovskii VI, Arshavsky VY, Makino CL (2002) Two temporal phases of light adaptation in retinal rods. J Gen Physiol 119:129-146.
3. Chen C-K, Burns ME, He W, Wensel TG, Baylor DA, Simon MI (2000) Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature 403:557-560.
4. Chen C-K, Eversole-Cire P, Zhang H, Mancino V, Chen Y-J, He W, Wensel TG, Simon MI (2003) Instability of GGL-domain-containing RGS proteins in mice lacking the G-protein β subunit Gβ5. Proc Natl Acad Sci USA 100:6604-6609.
5. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG (1998) High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci USA 95:5351-5356.
6. Cowan CW, He W, Wensel TG (2001) RGS proteins: lessons from the RGS9 subfamily. Prog Nucleic Acid Res Mol Biol 65:341-359.
7. Fain GL, Lamb TD, Matthews HR, Murphy RL (1989) Cytoplasmic calcium as the messenger for light adaptation in salamander rods. J Physiol (Lond) 416:215-243.
8. Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997) Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci 17:8024-8037.
9. Haynes LW, Kay AR, Yau KW (1986) Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane. Nature 321:66-70.
10. He W, Cowan CW, Wensel TG (1998) RGS9, a GTPase accelerator for phototransduction. Neuron 20:95-102.
11. Hu G, Zhang Z, Wensel TG (2003) Activation of RGS9-1 GTPase acceleration by its membrane anchor, R9AP. J Biol Chem 30:30.
12. Hurley JB, Stryer L (1982) Purification and characterization of the γ regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments. J Biol Chem 257:11094-11099.
13. Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA (2000) Co-expression of Gβ5 enhances the function of two Gγ subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem 275:3397-3402.
14. Lishko PV, Martemyanov KA, Hopp JA, Arshavsky VY (2002) Specific binding of RGS9-Gβ5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. J Biol Chem 277:24376-24381.
15. Lyubarsky AL, Pugh Jr EN (1996) Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings. J Neurosci 16:563-571.
16. 2+i. J Gen Physiol 107:19-34.
17. Lyubarsky AL, Naarendorp F, Zhang X, Wensel T, Simon MI, Pugh EN Jr (2001) RGS9-1 is required for normal inactivation of mouse cone phototransduction. Mol Vis 7:71-78.
18. Makino ER, Handy JW, Li T, Arshavsky VY (1999) The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit. Proc Natl Acad Sci USA 96:1947-1952.
19. Matthews HR (1995) Effects of lowered cytoplasmic calcium concentration and light on the responses of salamander rod photoreceptors. J Physiol (Lond) 484:267-286.
20. 2+ concentration during the bright flash response. J Gen Physiol 109:141-146.
21. Mendez A, Burns ME, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28:153-164.
22. Nikonov S, Lamb TD, Pugh Jr EN (2000) The role of steady phosphodiesterase activity in the kinetics and sensitivity of the light-adapted salamander rod photoresponse. J Gen Physiol 116:795-824.
23. Pepperberg DR, Cornwall MC, Kahlert M, Hofmann KP, Jin J, Jones GJ, Ripps H (1992) Light-dependent delay in the falling phase of the retinal rod photoresponse. Vis Neurosci 8:9-18.
24. Pugh Jr EN, Lamb TD (1993) Amplification and kinetics of the activation steps in phototransduction. Biochim Biophys Acta 1141:111-149.
25. Pugh Jr EN, Lamb TD (2000) Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification, recovery, and light adaptation. In: Handbook of biological physics, Vol 3 (Stavenga DG, Degrip WJ, Pugh EN, eds), pp 183-255. North-Holland, The Netherlands: Elsevier.
26. Pugh Jr EN, Nikonov S, Lamb TD (1999) Molecular mechanisms of vertebrate photoreceptor light adaptation. Curr Opin Neurobiol 9:410-418.
27. Skiba NP, Hopp JA, Arshavsky VY (2000) The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein. J Biol Chem 275:32716-32720.
28. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (1998) A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits. Proc Natl Acad Sci USA 95:13307-13312.
29. Tsang SH, Burns ME, Calvert PD, Gouras P, Baylor DA, Goff SP, Arshavsky VY (1998) Role for the target enzyme in deactivation of photoreceptor G protein in vivo. Science 282:117-121.
30. Watson AJ, Aragay AM, Slepak VZ, Simon MI (1996) A novel form of the G protein β subunit Gβ5 is specifically expressed in the vertebrate retina. J Biol Chem 271:28154-28160.
31. Witherow DS, Wang Q, Levay K, Cabrera JL, Chen J, Willars GB, Slepak VZ (2000) Complexes of the G protein subunit Gβ5 with the regulators of G protein signaling RGS7 and RGS9: characterization in native tissues and in transfected cells. J Biol Chem 275:24872-24880.
32. Zimmerman AL, Baylor DA (1986) Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores. Nature 321:70-72.