Chemical and antimicrobial studies on the essential oil from Salvia santolinifolia Boiss.

Pakistan Journal of Pharmaceutical Sciences

Volumn 26, Issue 1, 2013, Pages 39-52

  Nadir, Muhammad ^a   Rasheed, Munawwer ^a   Sherwani, Sikandar Khan ^a   Kazmi, Shahana Urooj ^a   Ahmad, Viqar Uddin ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Antimicrobial activity; C 13 NMR; Essential oil; GC MS; Salvia santolinifolia Boiss.

Indexed keywords

1 OCTEN 3 OL; 2,6 DIMETHYL 2,6 OCTADIENE; 3 CYMENE; 3 OCTANOL; 3 OCTANONE; 4 CARENE; ALPHA CYMENE; ALPHA PHELLANDRENE; ALPHA THUJENE; ANTIINFECTIVE AGENT; BANZALDEHYDE; BETA PHELLANDRENE; BETA PINENE; BORNEOL; CAMPHENE; CAMPHOR; ESSENTIAL OIL; LIMONENE; LINALOOL; LINALOOL OXIDE; MYRCENE; OCIMENE; PINENE; SABINENE; SANTOLINA TRIENE; TERPINENE; TERPINEOL; TERPINOLENE; TRICYCLENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CORYNEBACTERIUM; DRUG SCREENING; GAS CHROMATOGRAPHY; KLEBSIELLA PNEUMONIAE; MASS FRAGMENTOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEUS MIRABILIS; PROTEUS VULGARIS; SALVIA; SALVIA SANTOLINIFOLIA; SHIGELLA BOYDII; SHIGELLA DYSENTERIAE; SHIGELLA FLEXNERI; STAPHYLOCOCCUS EPIDERMIDIS; VIBRIO CHOLERAE;

ANTI-INFECTIVE AGENTS; BACTERIA; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OILS, VOLATILE; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANT OILS; PLANTS, MEDICINAL; SALVIA;

EID: 84872174303     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (101)

1. Aboaba OO, Smith SI and Olude FO (2006). Antibacterial effect of edible plant extract on Escherichia coli 0157:H7. Pak. J. Nutr., 5: 325-327.
2. Adam RP (2000). The serrate leaf margined Juniperus (section Sabina) of the Western Hemisphere: Systematics and evolution based on leaf essential oils and random amplified polymorphic DNAs (RAPDs). Biochem. Syst. Ecol., 28: 975-989.
3. Ahmad A, Khan A, Khan LA and Manzoor N (2010). In vitro synergy of eugenol and methyl eugenol with fluconazole against clinical Candida isolates. J. Med. Microbiol., 59: 1178-1184.
4. 13C-NMR of Natural Products. 1st ed., Plenum Press, New York, USA.
5. Ahn Y, Lee S, Okubo T and Kim M (1995). Antignawing factor of crude oil derived from Thujopsis dolabrata S. et Z. var. hondai sawdust against mice. J. Chem. Ecol., 21: 263-271.
6. Ali SI and Nasir YJ, eds. (1990). Flora of Pakistan. Royal Botanic Garden, Edinburgh, Chapter Labiatae. 192: pp.200-202.
7. Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, Rao LV, Habibullah CM, Sechi LA and Ahmed N (2005). Antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann. Clin. Microbiol. Antimicrob., 4: 20-27.
8. Aligiannis N, Kalpoutzakis E, Mitaku S and Chinou IB (2001). Composition and antimicrobial activity of the essential oils of two Origanum species. J. Agri. Food Chem., 49: 4168-4170.
9. Anackov G, Bozin B, Zoric L, Vukov D, Mimica-Dukic N, Merkulov L, Igic R, Jovanovic M and Boza P (2009). Chemical composition of essential oil and leaf anatomy of Salvia bertolonii Vis. and Salvia pratensis L. (Sect. Plethiosphace, Lamiaceae). Molecules, 14: 1-9.
10. Ansorena D, Gimeno O, Astiasaran I and Bello J (2001). Analysis of volatile compounds by GC-MS of a dry fermented sausage: chorizo de Pamplona. Food Res. Int., 34: 67-75.
11. Bader A, Panizzi L, Cioni PL and Flamini G (2007). Achillea ligustica: Composition and antimicrobial activity of essential oils from the leaves, flowers and some pure constituents. Cent. Eur. J., 2: 206-212.
12. Bamoniri A, Mazoochi A and Mirjalili BF (2009). Study of the bioactive and fragrant constituents extracted from leaves and aerial parts of Psammogeton canescens (DC.) Vatke from central Iran by nano scale injection. Dig. J. Nanomater. Biostructure, 4: 411-414.
13. Baser KHC, Demirci B, Kurkcuoglu M, Satil F and Tumen G (2009). Comparative morphological and phytochemical characterization of Salvia cadmica and S. smyrnaea. Pak. J. Bot., 41: 1545-1555.
14. cam. J. Am. Chem. Soc., 125: 705-714.
15. Berdague JL, Denoyer C, Le-Quere JL and Semon E (1991). Volatile components of dry-cured ham. J. Agri. Food Chem., 39: 1257-1261.
16. Bernotiene G, Nivinskiene O, Butkiene O and Mockute D (2007). Essential oil composition variability in sage. (Salvia officinalis L.). Chemija, 18: 38-43.
17. Bhatia SP, McGinty D, Letizia CS and Api AM (2008). Fragrance material review on sclareol. Food Chem. Toxicol., 46: S270-S274.
18. Bohlmann F, Zeisberg R and Klein E (1975). 13C-NMR-spektren von monoterpenen. Org. Magn. Reson., 7 : 426-432.
19. British Pharmacopeia (2005). Vol. IV, Appendix XI E.
20. Cadwallader KR, Braddock RJ and Parish ME (1992). Isolation of □-terpineol dehydratase from Pseudomonas gladioli. J. Food Sci., 57: 241-244.
21. Cadwallader KR, Braddock RJ, Parish ME and Higgins DP (1989). Bioconversion of (+)-limonene by Pseudomonas gladioli. J. Food Sci., 54: 1241-1245.
22. Cai J, Lin P, Zhu X and Qingde S (2006). Comparative analysis of clary sage (S. sclarea L.) oil volatiles by GC-FTIR and GC-MS. Food Chem., 99: 401-407.
23. Cardeal ZL, Gomes da Silva MDR and Marriott PJ (2006). Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper volatiles. Rapid Commun. Mass Spectrom., 20: 2823-2836.
24. Cardile V, Russo A, Formisano C, Rigano D, Senatore F, Arnold NA and Piozzi F (2009). Essential oils of Salvia bracteata and Salvia rubifolia from Lebanon: Chemical composition, antimicrobial activity and inhibitory effect on human melanoma cells. J. Ethnopharmacol., 126: 265-272.
25. Caredda A, Marongiu B, Porcedda S and Soro C (2002). Supercritical carbondioxide extraction and characterization of Laurus nobilis essential oil. J. Agric. Food Chem., 50: 1492-1496.
26. Cheraif I, Jannet HB, Hammami M, Khouja ML and Mighria Z (2007). Chemical composition and antimicrobial activity of essential oils of Cupressus arizonica Greene. Biochem. Syst. Ecol., 35: 813-820.
27. Choi IY, Lim JH, Hwang S, Lee JC, Cho GS and Kim WK (2010). Anti-ischemic and anti-inflammatory activity of (S) cis-verbenol. Free Radic. Res., 44 : 541-551.
28. 2. Flavour Fragr. J., 17: 239-244.
29. Delamare APL, Moschen-Pistorello IT, Artico L, Atti-Serafini L and Echeverrigaray S (2007). Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South Brazil. Food Chem., 100: 603-608.
30. Dimas K, Hatzaintoniou S, Tselini S, Khan H, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P and Demetzos C (2007). Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. Apoptosis, 12: 685-694.
31. Dimas K, Kokkinopoulos D, Demetzos C, Vaos B, Marselos M, Malamas M and Tzavaras T (1999). The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. Leukemia Res., 23: 217-234.
32. Eriksson E, Auffarth K, Eilersen AM, Henze M and Ledin A (2003). Household chemicals and personal care products as sources for xenobiotic organic compounds in grey wastewater. Water SA, 29: 135-146.
33. Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF and Calixto JB (2007). Anti-inflammatory effects of compounds alpha -humulene and (-)- trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharmacol., 569: 228-236.
34. Filho CA, Silva CM, Quadri MB and Macedo EA (2003). Tracer diffusion coefficients of cifrai and D-limonene in supercritical carbon dioxide. Fluid Phase Equilibr., 204: 65-73.
35. Flamini G, Cioni PL, Morelli I and Bader A (2007). Essential oils of the aerial parts of three Salvia species from Jordan: Salvia lanigera, S. spinosa and S. syriaca. Food Chem., 100: 732-735.
36. Gawdzik J, Mardarowicz M, Suprynowicz Z, Kawka S and Wolski T (1996). Supercritical fluid extraction of essential oils from the fruits of Archangelica off. Hoffm. and their characterization by GC/MS. J. High Res. Chromatogr., 19: 237-240.
37. Gilani AH, Shah AJ, Zubair A, Khalid S, Kiani J, Ahmed A, Rasheed M and Ahmad VU (2009). Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L. J. Ethnopharmacol., 121: 405-411.
38. Gulluce M, Ozer H, Baris O, Daferera D, Sahin F and Polissiou M (2006). Chemical composition of the essential oil of Salvia aethiopis L. Turk. J. Biol., 30: 231-233.
39. He M, Du M, Fan M and Bian Z (2007). In vitro activity of eugenol against Candida albicans biofilms. Mycopathologia, 163: 137-143.
40. Horiuchi K, Shiota S, Kuroda T, Hatano T, Yoshida T and Tsuchiya T (2007). Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. Biol. Pharm. Bull., 30: 287-290.
41. Janes D, Kantar D, Kreft S and Prosen H (2008). Identification of buckwheat (Fagopyrum esculentum Moench) aroma compounds with GC-MS. Food Chem. 112, 120-124.
42. Javidnia K, Miri R, Soltani M, Gholami M, and Khosravi AR (2008). Antimicrobial activity and chemical composition of the essential oils of six Iranian Salvia species. Chem. Nat. Compd. 44, 654-658.
43. Kamatou GPP, Makunga NP, Ramogola WPN and Viljoen AM (2008a). South African Salvia species: A review of biological activities and phytochemistry. J. Ethnopharmacol., 119, 664-672.
44. Kamatou GPP, Van Zyl RL, Van Vuuren SF, Figueiredo AC, Barroso JG, Pedro LG and Viljoen AM (2008b). Seasonal variation in essential oil composition, oil toxicity and the biological activity of solvent extracts of three South African Salvia species. S. Afr. J. Bot., 74: 230-237.
45. Karaman S, Ilcim A and Comlekcioglu N (2007). Composition of the essential oils of Salvia aramiensis Rech. fil. and Salvia cyanescens Boiss. & Bal. Pak. J. Bot., 39: 169-172.
46. Katsuyama M, Kobayashi Y, Ichikawa H, Mizuno A, Miyachi Y, Matsunaga K and Kawashima M (2005). A novel method to control the balance of skin microflora: Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. J. Dermatol. Sci., 38: 207-213.
47. Kaya A, Baser KHC and Demirci B (2009). Composition of essential oil of endemic Salvia wiedemannii in Turkey. Chem. Nat. Compd., 45: 552-553.
48. Kelen M and Tepe B (2008). Chemical composition, antioxidant and antimicrobial properties of the essential oils of three Salvia species from Turkish flora. Bioresource Technol., 99: 4096-4104.
49. Keskitalo M, Pehu E and Simon JE (2001). Variation in volatile compounds from tansy (Tanacetum vulgare L.) related to genetic and morphological differences of genotypes. Biochem. Syst. Ecol., 29, 267-285.
50. Kim H, Kim K, Ku H, Park S, Choi H, Moon J, Park B, Kim J, Yea S, Lee C, Lee HS, Shin J and Liu K (2008). Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China. Drug Metab. Dispos., 36: 1010-1015.
51. Kim K-Y and Chung H-J (2000). Flavor compounds of pine sprout tea and pine needle tea. J. Agric. Food Chem., 48: 1269-1272.
52. Kivrak E, Duru ME, Ozturk M, Mercan N, Harmandar M and Topcu G (2009). Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chem., 116: 470-479.
53. Kotan R, Kordali S, Cakir A, Kesdek M, Kaya Y and Kilic H (2008). Antimicrobial and insecticidal activities of essential oil isolated from Turkish Salvia hydrangea DC. ex Benth. Biochem. Syst. Ecol., 36 : 360-368.
54. Kovats E (1958). Gas-chromatographische charakterisierung organischer verbindungen. Helv. Chim. Acta, 4: 1915-1932.
55. Kubeczka KH and Formacek V, eds. (2002). Essential oil analysis capillary gas chromatography and C-13 spectroscopy. 2nd ed., John Wiley and Sons, Chichester, W. Sussex, England.
56. Kubo I, Muroi H and Himejima M (1992). Antimicrobial activity of green tea flavor components and their combination effects. J. Agric. Food Chem., 40: 245-248.
57. Kuzma L, Kalemba D, Rozalski M, Rozalska B, Wieckowska-Szakiel M, Krajewska U and Wysokinska H (2009). Chemical composition and biological activities of essential oil from Salvia sclarea plants regenerated in vitro. Molecules, 14: 1438-1447.
58. Lalel HJD, Singh Z and Tan SC (2003). Glycosidically-bound aroma volatile compounds in the skin and pulp of 'Kensington Pride' mango fruit at different stages of maturity. Postharvest Biol. Technol., 29: 205-218.
59. Liang Q, Liang Z, Wang J and Xu W (2009). Essential oil composition of Salvia Miltiorrhiza flower. Food Chem., 113: 592-594.
60. Loughlin R, Gilmore BF, McCarron PA and Tunney MM (2008). Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells. Lett. Appl. Microbiol., 46 : 428-433.
61. Maia JGS, Andrade EHA and Zoghbi MGB (2004). Aroma volatiles from two fruit varieties of jackfruit (Artocarpus heterophyllus Lam.). Food Chem., 85 : 195-197.
62. Mehmood S, Riaz N, Nawaz SA, Afza N, Malik A and Choudhary MI (2006). New butyrylcholinesterase inhibitory triterpenes from Salvia santolinifolia. Arch. Pharm. Res., 29: 195-198.
63. Mimica-Dukic N, Bozin B, Sokovic M, Mihajlovic B and Matavulj M (2003). Antimicrobial and antioxidant activities of three Mentha species essential oils. Planta Med., 69: 413-419.
64. Mimica-Dukic N, Bugarin D, Grbovic S, Mitic-Culafic D, Vukovic-Gacic B, Orcic D, Jovin E and Couladis M (2010). Essential oil of Myrtus communis L. as a potential antioxidant and antimutagenic agents. Molecules, 15 : 2759-2770.
65. Mondello F, Bernardis FD, Girolamo A, Cassone A and Salvatore G (2006). In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC Infec. Dis., 6: 158-165.
66. Natali F, Siculella L, Salvati S and Gnoni GV (2007). Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells. J. Lipid Res., 48: 1966-1975.
67. NIST (2005). Mass spectral search program for the NIST/EPA/NIH Mass Spectral Library. version 2.0 d, build Dec. 2.
68. Ozer H, Kilic H, Baris O, Adiguzel A and Gulluce M (2007). Composition of the essential oil of Salvia longipedicellata from Turkey. Chem. Nat. Compd., 43 : 230-231.
69. Paaver U, Orav A, Arak E, Maeorg U and Raal A (2008). Phytochemical analysis of the essential oil of Thymus serpyllum L. growing wild in Estonia. Nat. Prod. Res., 22: 108-115.
70. Park I, Kim J, Lee S and Shin S (2007). Nematicidal activity of plant essential oils and components from Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) essential oils against pine wood nematode (Bursaphelenchus Xylophilus). J. Nematol., 39: 275-279.
71. Pino JA, Mesa J, Muoz Y, Mart MP and Marbot R (2005). Volatile components from mango (Mangifera indica L.) cultivars. J. Agric. Food Chem., 53: 2213-2223.
72. Priestap HA, Baren CM, Lira PDL, Coussio JD and Bandoni AL (2003). Volatile constituents of Aristolochia argentina. Phytochemistry, 63: 221-225.
73. Ragasa CY, Tamboong BG and Rideout JA (2003). Secondary metabolites from Jasminum sambac and Cananga odorata. ACGC Chem. Res. Commun., 16: 40-47.
74. Saeidnia S, Gohari AR, Yassa N and Shafiee A (2005). Composition of the volatile oil of Achillea conferta DC. from Iran. Daru, 13: 34-36.
75. Sajjadi SE and Ghannadi A (2005). Essential oil of the Persian sage, Salvia rhytidea Benth. Acta Pharm., 55: 321-326.
76. Sajjadi SE and Shahpiri Z (2004). Chemical composition of the essential oil of Salvia limbata C.A. Mey. Daru, 12: 94-97.
77. Schelz Z, Molnar J and Hohmann J (2006). Antimicrobial and antiplasmid activities of essential oils. Fitoterapia, 77: 279-285.
78. Schieberle P (1996). Odour-active compounds in moderately roasted sesame. Food Chem., 55: 145-152.
79. SDBS:Http://riodb01.ibase.aist.go.jp/sdbs/cgi-bin/direct-frame-top.cgi. 11:45 AM, 17/11/2008.
80. Sefidkon F and Khajavi MS (1999). Chemical composition of essential oil of two Salvia species from Iran: Salvia verticillata L. and Salvia santolinifolia Boiss. Flavour. Frag. J., 14: 77-78.
81. Senatore F, Arnold NA and Piozzi F (2004). Chemical composition of the essential oil of Salvia multicaulis Vahl. var. simplicifolia Boiss. growing wild in Lebanon. J. Chromatogr. A., 1052: 237-240.
82. Senatore F, Arnold NA, Piozzi F and Formisano C (2006). Chemical composition of the essential oil of Salvia microstegia Boiss. et Balansa growing wild in Lebanon. J. Chromatogr. A., 1108: 276-278.
83. Siani AC, Ramos MFS, Menezes-de-Lima OJ, Ribeirodos-Santos R, Fernadez-Ferreira E, Soares ROA, Rosas EC, Susunaga GS, Guimaraes AC, Zoghbi MGB and Henriques MGMO (1999). Evaluation of anti-inflammatory- related activity of essential oils from the leaves and resin of species of Protium. J. Ethnopharmacol., 66: 57-69.
84. Siddiqui BS, Ali ST, Rajput MT, Gulzar T, Rasheed M and Mehmood R (2009). GC-based analysis of insecticidal constituents of the flowers of Azadirachta indica A. Juss. Nat. Prod. Res., 23: 271-283.
85. Siddiqui BS, Gulzar T, Mahmood A, Begum S, Khan B, Rasheed M, Afshan F and Rajput MT (2005). Phytochemical studies on the seed extract of Piper nigrum Linn. Nat. Prod. Res., 19: 703-712.
86. Siddiqui BS, Rasheed M, Ilyas F, Gulzar T, Tariq RM and Naqvi SNH (2004). Analysis of insecticidal Azadirachta indica A. Juss. fractions. Z. Naturforsch., 59c: 104-112.
87. Sillam-Dusses D, Semon E, Moreau C, Valterova I, Sobotnik J, Robert A and Bordereau C (2009). Neocembrene A, a major component of the trail-following pheromone in the genus Prorhinotermes (Insecta, Isoptera, Rhinotermitidae). Chemoecology, 15: 1-6.
88. Sivropoulou A, Nikolaou C, Papanikolaou E, Kokkini S, Lanaras T and Arsenakis M (1997). Antimicrobial, cytotoxic, and antiviral activities of Salvia fructicosa essential oil. J. Agric. Food Chem., 45: 3197-3201.
89. Skaltsa HD, Mavrommati A and Constantinidis T (2001). A chemotaxonomic Investigation of volatile constituents in Stachys subsect. swainsonianeae (Labiatae). Phytochemistry, 57: 235-244.
90. Sokovic MD, Brkic DD, Dzamic AM, Ristic MS and Marin PD (2009). Chemical composition and antifungal activity of Salvia desoleana Atzei & Picci essential oil and its major components. Flavour Fragr. J., 24: 83-87
91. Sonboli A, Babakhani B and Mehrabian AR (2006). Antimicrobial activity of six constituents of essential oil from Salvia. Z. Naturforsch., 61c: 160-164.
92. Taarit MB, Msaada K, Hosni K, Chahed T and Marzouk B (2010). Essential oil composition of Salvia verbenaca L. growing wild in Tunisia. J. Food Biochem., 34: 142-151.
93. Tepe B, Daferera D, Sokmen A, Sokmen M and Polissiou M (2005). Antimicrobial and antioxidant activities of the essential oil and various extracts of Salvia tomentosa Miller (Lamiaceae). Food Chem., 90: 333-340.
94. Trytek M and Fiedurek J (2005). A novel psychrotrophic fungus, Mortierella minutissima, for D-limonene biotransformation. J. Biotechnol. Lett., 27: 149-153.
95. Tsokou A, Georgopoulou K, Melliou E, Magiatis P and Tsitsa E (2007). Composition and enantiomeric analysis of the essential oil of the fruits and the leaves of Pistacia vera from Greece. Molecules, 12: 1233-1239.
96. Wang R, Peng S, Zeng R, Ding LW and Xu Z (2009). Cloning expression and wounding induction of β-caryophyllene synthase gene from Mikania micrantha H.B.K. and allelopathic potential of β-caryophyllene. Allelopathy J., 24: 35-44.
97. Wayne PA (1998). A national committee for clinical laboratory standards, methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically. (NCCLS publication).
98. Yanez X, Pinzon ML, Solano F and Sanchez LR (2002). Chemical composition of the essential oil of Psidium caudatum McVaugh. Molecules, 7: 712-716.
99. Yang D, Michel L, Chaumont J-P and Millet-Clerc J (1999). Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis. Mycopathologia, 148: 79-82.
100. Yang H, Wang X, Yu L and Zheng S (1997). The antitumor activity of elemene is associated with apoptosis. Chin. J. Canc. Res., 9: 83-88.
101. Yassa N, Akhani H, Aqaahmadi M and Salimian M (2003). Essential oils from two endemic species of Apiaceae from Iran. Z. Naturforsch., 58c: 459-463.