Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice

Apoptosis

Volumn 12, Issue 4, 2007, Pages 685-694

  Dimas, Konstantinos ^a   Hatziantoniou, Sophia ^b   Tseleni, Sophia ^c   Khan, Humaira ^d   Georgopoulos, Aristidis ^b   Alevizopoulos, Konstantinos ^d   Wyche, James H ^e   Pantazis, Panayotis ^a,e   Demetzos, Costas ^b  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d Medexis Biotech SA   (Greece)

^e UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Labdane diterpene; Plant product; Sclareol; Tumor suppression

Indexed keywords

CASPASE 8; CASPASE 9; DNA FRAGMENT; LIPOSOME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SCLAREOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DNA SYNTHESIS; DRUG POTENCY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; XENOGRAFT;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASES; CELL CYCLE; COLONIC NEOPLASMS; DITERPENES; DNA DAMAGE; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; MICE; MICE, SCID;

MUS;

EID: 33947126402     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0026-8     Document Type: Article

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