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Volumn 5, Issue 1, 2013, Pages

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CARRIER PROTEINS AND BINDING PROTEINS; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 4; SLCO1B3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84872149285     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm405     Document Type: Article
Times cited : (145)

References (80)
  • 1
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties.
    • 10.1007/s00424-003-1168-y, 14579113
    • Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 2004, 447:653-665. 10.1007/s00424-003-1168-y, 14579113.
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 2
    • 24344439264 scopus 로고    scopus 로고
    • Transporters and drug therapy: implications for drug disposition and disease.
    • 10.1016/j.clpt.2005.05.011, 16153397
    • Ho RH, Kim RB. Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther 2005, 78:260-277. 10.1016/j.clpt.2005.05.011, 16153397.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 260-277
    • Ho, R.H.1    Kim, R.B.2
  • 4
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.
    • 10.1124/pr.110.002857, 21245207
    • Niemi M, Pasanen MK, Neuvonen PJ. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 2011, 63:157-181. 10.1124/pr.110.002857, 21245207.
    • (2011) Pharmacol Rev , vol.63 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 5
    • 45949102855 scopus 로고    scopus 로고
    • Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.
    • 10.1517/17425255.4.5.545, 18484914
    • Nies AT, Schwab M, Keppler D. Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Expert Opin Drug Metab Toxicol 2008, 4:545-568. 10.1517/17425255.4.5.545, 18484914.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 545-568
    • Nies, A.T.1    Schwab, M.2    Keppler, D.3
  • 7
    • 33751096467 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.
    • 10.1097/01.fpc.0000230416.82349.90, 17108811
    • Pasanen MK, Neuvonen M, Neuvonen PJ, Niemi M. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics 2006, 16:873-879. 10.1097/01.fpc.0000230416.82349.90, 17108811.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 873-879
    • Pasanen, M.K.1    Neuvonen, M.2    Neuvonen, P.J.3    Niemi, M.4
  • 9
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy -- a genomewide study.
    • SEARCH Collaborative Group
    • SEARCH Collaborative Group SLCO1B1 variants and statin-induced myopathy -- a genomewide study. N Engl J Med 2008, 359:789-799. SEARCH Collaborative Group.
    • (2008) N Engl J Med , vol.359 , pp. 789-799
  • 10
    • 22544454498 scopus 로고    scopus 로고
    • Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.
    • 10.1097/01.fpc.0000170913.73780.5f, 15970799
    • Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K. Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics 2005, 15:513-522. 10.1097/01.fpc.0000170913.73780.5f, 15970799.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 513-522
    • Kameyama, Y.1    Yamashita, K.2    Kobayashi, K.3    Hosokawa, M.4    Chiba, K.5
  • 11
    • 84857349066 scopus 로고    scopus 로고
    • Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.
    • 10.1517/17425255.2012.656087, 22280100
    • Clarke JD, Cherrington NJ. Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions. Expert Opin Drug Metab Toxicol 2012, 8:349-360. 10.1517/17425255.2012.656087, 22280100.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 349-360
    • Clarke, J.D.1    Cherrington, N.J.2
  • 12
    • 68049131203 scopus 로고    scopus 로고
    • New molecular insights into the mechanisms of cholestasis.
    • 10.1016/j.jhep.2009.05.012, 19595470
    • Wagner M, Zollner G, Trauner M. New molecular insights into the mechanisms of cholestasis. J Hepatol 2009, 51:565-580. 10.1016/j.jhep.2009.05.012, 19595470.
    • (2009) J Hepatol , vol.51 , pp. 565-580
    • Wagner, M.1    Zollner, G.2    Trauner, M.3
  • 13
    • 70350075408 scopus 로고    scopus 로고
    • Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
    • 10.1002/hep.23103, 19591196
    • Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 2009, 50:1227-1240. 10.1002/hep.23103, 19591196.
    • (2009) Hepatology , vol.50 , pp. 1227-1240
    • Nies, A.T.1    Koepsell, H.2    Winter, S.3    Burk, O.4    Klein, K.5    Kerb, R.6    Zanger, U.M.7    Keppler, D.8    Schwab, M.9    Schaeffeler, E.10
  • 14
    • 0035813209 scopus 로고    scopus 로고
    • Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha.
    • 10.1074/jbc.M103988200, 11483603
    • Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA. Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha. J Biol Chem 2001, 276:37206-37214. 10.1074/jbc.M103988200, 11483603.
    • (2001) J Biol Chem , vol.276 , pp. 37206-37214
    • Jung, D.1    Hagenbuch, B.2    Gresh, L.3    Pontoglio, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 15
    • 0036080163 scopus 로고    scopus 로고
    • Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
    • 10.1053/gast.2002.33583, 12055601
    • Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 2002, 122:1954-1966. 10.1053/gast.2002.33583, 12055601.
    • (2002) Gastroenterology , vol.122 , pp. 1954-1966
    • Jung, D.1    Podvinec, M.2    Meyer, U.A.3    Mangelsdorf, D.J.4    Fried, M.5    Meier, P.J.6    Kullak-Ublick, G.A.7
  • 16
    • 1642491778 scopus 로고    scopus 로고
    • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.
    • 10.1016/j.jhep.2003.10.008, 14739090
    • Vavricka SR, Jung D, Fried M, Grutzner U, Meier PJ, Kullak-Ublick GA. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. J Hepatol 2004, 40:212-218. 10.1016/j.jhep.2003.10.008, 14739090.
    • (2004) J Hepatol , vol.40 , pp. 212-218
    • Vavricka, S.R.1    Jung, D.2    Fried, M.3    Grutzner, U.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 17
    • 33744809847 scopus 로고    scopus 로고
    • Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.
    • 10.1007/s00535-006-1784-3, 16741617
    • Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, Unno M. Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. J Gastroenterol 2006, 41:369-377. 10.1007/s00535-006-1784-3, 16741617.
    • (2006) J Gastroenterol , vol.41 , pp. 369-377
    • Ohtsuka, H.1    Abe, T.2    Onogawa, T.3    Kondo, N.4    Sato, T.5    Oshio, H.6    Mizutamari, H.7    Mikkaichi, T.8    Oikawa, M.9    Rikiyama, T.10    Katayose, Y.11    Unno, M.12
  • 18
    • 33644917724 scopus 로고    scopus 로고
    • Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation.
    • 10.1007/s11095-006-9572-6, 16489487
    • Maeda T, Hirayama M, Higashi R, Sato M, Tamai I. Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation. Pharm Res 2006, 23:513-520. 10.1007/s11095-006-9572-6, 16489487.
    • (2006) Pharm Res , vol.23 , pp. 513-520
    • Maeda, T.1    Hirayama, M.2    Higashi, R.3    Sato, M.4    Tamai, I.5
  • 19
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
    • 10.1124/dmd.106.010033, 16837569
    • Jigorel E, Le VM, Boursier-Neyret C, Parmentier Y, Fardel O. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos 2006, 34:1756-1763. 10.1124/dmd.106.010033, 16837569.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1756-1763
    • Jigorel, E.1    Le, V.M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 20
    • 35848929707 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers.
    • 10.1007/s11095-007-9458-2, 17932728
    • Furihata T, Satoh T, Yamamoto N, Kobayashi K, Chiba K. Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers. Pharm Res 2007, 24:2327-2332. 10.1007/s11095-007-9458-2, 17932728.
    • (2007) Pharm Res , vol.24 , pp. 2327-2332
    • Furihata, T.1    Satoh, T.2    Yamamoto, N.3    Kobayashi, K.4    Chiba, K.5
  • 21
    • 78049505506 scopus 로고    scopus 로고
    • Liver X receptor alpha and farnesoid X receptor are major transcriptional regulators of OATP1B1.
    • 10.1002/hep.23876, 20827719
    • Meyer zu Schwabedissen HE, Bottcher K, Chaudhry A, Kroemer HK, Schuetz EG, Kim RB. Liver X receptor alpha and farnesoid X receptor are major transcriptional regulators of OATP1B1. Hepatology 2010, 52:1797-1807. 10.1002/hep.23876, 20827719.
    • (2010) Hepatology , vol.52 , pp. 1797-1807
    • Meyer zu Schwabedissen, H.E.1    Bottcher, K.2    Chaudhry, A.3    Kroemer, H.K.4    Schuetz, E.G.5    Kim, R.B.6
  • 23
    • 80053509605 scopus 로고    scopus 로고
    • Pathway-targeted pharmacogenomics of CYP1A2 in human liver.
    • 3171976, 21918647
    • Klein K, Winter S, Turpeinen M, Schwab M, Zanger UM. Pathway-targeted pharmacogenomics of CYP1A2 in human liver. Front Pharmacol 2010, 1:129. 3171976, 21918647.
    • (2010) Front Pharmacol , vol.1 , pp. 129
    • Klein, K.1    Winter, S.2    Turpeinen, M.3    Schwab, M.4    Zanger, U.M.5
  • 24
    • 36148953896 scopus 로고    scopus 로고
    • Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin.
    • 10.1038/sj.clpt.6100220, 17473846
    • Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2007, 82:726-733. 10.1038/sj.clpt.6100220, 17473846.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 726-733
    • Pasanen, M.K.1    Fredrikson, H.2    Neuvonen, P.J.3    Niemi, M.4
  • 25
    • 56449116103 scopus 로고    scopus 로고
    • ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin.
    • 10.1038/clpt.2008.25, 19238649
    • Keskitalo JE, Kurkinen KJ, Neuvoneni PJ, Niemi M. ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin. Clin Pharmacol Ther 2008, 84:457-461. 10.1038/clpt.2008.25, 19238649.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 457-461
    • Keskitalo, J.E.1    Kurkinen, K.J.2    Neuvoneni, P.J.3    Niemi, M.4
  • 26
    • 67651172794 scopus 로고    scopus 로고
    • ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.
    • 10.1038/clpt.2009.79, 19474787
    • Keskitalo JE, Zolk O, Fromm MF, Kurkinen KJ, Neuvonen PJ, Niemi M. ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2009, 86:197-203. 10.1038/clpt.2009.79, 19474787.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 197-203
    • Keskitalo, J.E.1    Zolk, O.2    Fromm, M.F.3    Kurkinen, K.J.4    Neuvonen, P.J.5    Niemi, M.6
  • 27
    • 84872968966 scopus 로고    scopus 로고
    • Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver.
    • 3564008, 22006096
    • Schröder A, Klein K, Winter S, Schwab M, Bonin M, Zell A, Zanger UM. Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver. Pharmacogenomics J 2011, 13:12-20. 3564008, 22006096.
    • (2011) Pharmacogenomics J , vol.13 , pp. 12-20
    • Schröder, A.1    Klein, K.2    Winter, S.3    Schwab, M.4    Bonin, M.5    Zell, A.6    Zanger, U.M.7
  • 28
    • 0345700691 scopus 로고    scopus 로고
    • Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.
    • Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Lab Invest 2003, 83:527-538.
    • (2003) Lab Invest , vol.83 , pp. 527-538
    • Cui, Y.1    König, J.2    Nies, A.T.3    Pfannschmidt, M.4    Hergt, M.5    Franke, W.W.6    Alt, W.7    Moll, R.8    Keppler, D.9
  • 30
    • 41149140202 scopus 로고    scopus 로고
    • Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.
    • 10.1016/j.ejphar.2008.01.042, 2376123, 18321482
    • Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol 2008, 584:57-65. 10.1016/j.ejphar.2008.01.042, 2376123, 18321482.
    • (2008) Eur J Pharmacol , vol.584 , pp. 57-65
    • Gui, C.1    Miao, Y.2    Thompson, L.3    Wahlgren, B.4    Mock, M.5    Stieger, B.6    Hagenbuch, B.7
  • 31
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: analysis and visualization of LD and haplotype maps.
    • 10.1093/bioinformatics/bth457, 15297300
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265. 10.1093/bioinformatics/bth457, 15297300.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 32
    • 17644379063 scopus 로고    scopus 로고
    • A note on exact tests of Hardy-Weinberg equilibrium.
    • 10.1086/429864, 1199378, 15789306
    • Wigginton JE, Cutler DJ, Abecasis GR. A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 2005, 76:887-893. 10.1086/429864, 1199378, 15789306.
    • (2005) Am J Hum Genet , vol.76 , pp. 887-893
    • Wigginton, J.E.1    Cutler, D.J.2    Abecasis, G.R.3
  • 33
    • 80055091440 scopus 로고    scopus 로고
    • The R project for statistical computing.
    • The R project for statistical computing. http://www.r-project.org
  • 34
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure.
    • Holm S. A simple sequentially rejective multiple test procedure. Scand J Statist 1979, 6:65-70.
    • (1979) Scand J Statist , vol.6 , pp. 65-70
    • Holm, S.1
  • 35
    • 70349739250 scopus 로고    scopus 로고
    • The SLCO1B1*5 genetic variant is associated with statin-induced side effects.
    • 10.1016/j.jacc.2009.04.053, 3417133, 19833260
    • Voora D, Shah SH, Spasojevic I, Ali S, Reed CR, Salisbury BA, Ginsburg GS. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol 2009, 54:1609-1616. 10.1016/j.jacc.2009.04.053, 3417133, 19833260.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3    Ali, S.4    Reed, C.R.5    Salisbury, B.A.6    Ginsburg, G.S.7
  • 37
    • 0036073404 scopus 로고    scopus 로고
    • Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
    • 10.1124/jpet.302.2.804, 12130747
    • Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 2002, 302:804-813. 10.1124/jpet.302.2.804, 12130747.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 804-813
    • Nozawa, T.1    Nakajima, M.2    Tamai, I.3    Noda, K.4    Nezu, J.5    Sai, Y.6    Tsuji, A.7    Yokoi, T.8
  • 38
    • 9244254743 scopus 로고    scopus 로고
    • Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).
    • 10.1097/00008571-200411000-00006, 15564882
    • Iwai M, Suzuki H, Ieiri I, Otsubo K, Sugiyama Y. Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C). Pharmacogenetics 2004, 14:749-757. 10.1097/00008571-200411000-00006, 15564882.
    • (2004) Pharmacogenetics , vol.14 , pp. 749-757
    • Iwai, M.1    Suzuki, H.2    Ieiri, I.3    Otsubo, K.4    Sugiyama, Y.5
  • 39
    • 2042469487 scopus 로고    scopus 로고
    • Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.
    • 10.1016/j.clpt.2003.12.016, 15116054
    • Mwinyi J, Johne A, Bauer S, Roots I, Gerloff T. Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics. Clin Pharmacol Ther 2004, 75:415-421. 10.1016/j.clpt.2003.12.016, 15116054.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 415-421
    • Mwinyi, J.1    Johne, A.2    Bauer, S.3    Roots, I.4    Gerloff, T.5
  • 41
    • 56149115550 scopus 로고    scopus 로고
    • Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
    • 10.1097/FPC.0b013e32830d733e, 18854776
    • Kalliokoski A, Backman JT, Neuvonen PJ, Niemi M. Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide. Pharmacogenet Genomics 2008, 18:937-942. 10.1097/FPC.0b013e32830d733e, 18854776.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 937-942
    • Kalliokoski, A.1    Backman, J.T.2    Neuvonen, P.J.3    Niemi, M.4
  • 42
    • 78951469667 scopus 로고    scopus 로고
    • Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
    • 10.1038/clpt.2010.255, 3353487, 21178985
    • Donnelly LA, Doney AS, Tavendale R, Lang CC, Pearson ER, Colhoun HM, McCarthy MI, Hattersley AT, Morris AD, Palmer CN. Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study. Clin Pharmacol Ther 2011, 89:210-216. 10.1038/clpt.2010.255, 3353487, 21178985.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 210-216
    • Donnelly, L.A.1    Doney, A.S.2    Tavendale, R.3    Lang, C.C.4    Pearson, E.R.5    Colhoun, H.M.6    McCarthy, M.I.7    Hattersley, A.T.8    Morris, A.D.9    Palmer, C.N.10
  • 44
    • 25844458977 scopus 로고    scopus 로고
    • Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment.
    • 10.1016/j.clpt.2005.06.013, 16198652
    • Lee E, Ryan S, Birmingham B, Zalikowski J, March R, Ambrose H, Moore R, Lee C, Chen Y, Schneck D. Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment. Clin Pharmacol Ther 2005, 78:330-341. 10.1016/j.clpt.2005.06.013, 16198652.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 330-341
    • Lee, E.1    Ryan, S.2    Birmingham, B.3    Zalikowski, J.4    March, R.5    Ambrose, H.6    Moore, R.7    Lee, C.8    Chen, Y.9    Schneck, D.10
  • 45
    • 77956537712 scopus 로고    scopus 로고
    • A synonymous single nucleotide polymorphism in DeltaF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein.
    • 10.1074/jbc.M110.154575, 2937902, 20628052
    • Bartoszewski RA, Jablonsky M, Bartoszewska S, Stevenson L, Dai Q, Kappes J, Collawn JF, Bebok Z. A synonymous single nucleotide polymorphism in DeltaF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein. J Biol Chem 2010, 285:28741-28748. 10.1074/jbc.M110.154575, 2937902, 20628052.
    • (2010) J Biol Chem , vol.285 , pp. 28741-28748
    • Bartoszewski, R.A.1    Jablonsky, M.2    Bartoszewska, S.3    Stevenson, L.4    Dai, Q.5    Kappes, J.6    Collawn, J.F.7    Bebok, Z.8
  • 46
    • 78650183300 scopus 로고    scopus 로고
    • Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors.
    • 10.3109/00498254.2010.523736, 20946088
    • Choi MK, Shin HJ, Choi YL, Deng JW, Shin JG, Song IS. Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. Xenobiotica 2011, 41:24-34. 10.3109/00498254.2010.523736, 20946088.
    • (2011) Xenobiotica , vol.41 , pp. 24-34
    • Choi, M.K.1    Shin, H.J.2    Choi, Y.L.3    Deng, J.W.4    Shin, J.G.5    Song, I.S.6
  • 47
    • 67349246526 scopus 로고    scopus 로고
    • Transcriptional control of human organic anion transporting polypeptide 2B1 gene.
    • 10.1016/j.jsbmb.2009.04.003, 19383542
    • Pomari E, Nardi A, Fiore C, Celeghin A, Colombo L, Valle LD. Transcriptional control of human organic anion transporting polypeptide 2B1 gene. J Steroid Biochem Mol Biol 2009, 115:146-152. 10.1016/j.jsbmb.2009.04.003, 19383542.
    • (2009) J Steroid Biochem Mol Biol , vol.115 , pp. 146-152
    • Pomari, E.1    Nardi, A.2    Fiore, C.3    Celeghin, A.4    Colombo, L.5    Valle, L.D.6
  • 50
    • 77954355830 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.
    • 10.3109/03602530903491824, 20175646
    • Kusuhara H, Sugiyama Y. Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters. Drug Metab Rev 2010, 42:539-550. 10.3109/03602530903491824, 20175646.
    • (2010) Drug Metab Rev , vol.42 , pp. 539-550
    • Kusuhara, H.1    Sugiyama, Y.2
  • 52
    • 79959556989 scopus 로고    scopus 로고
    • Regulation of drug transporter expression by oncostatin M in human hepatocytes.
    • 10.1016/j.bcp.2011.04.017, 21570956
    • Le Vee M, Jouan E, Stieger B, Lecureur V, Fardel O. Regulation of drug transporter expression by oncostatin M in human hepatocytes. Biochem Pharmacol 2011, 82:304-311. 10.1016/j.bcp.2011.04.017, 21570956.
    • (2011) Biochem Pharmacol , vol.82 , pp. 304-311
    • Le Vee, M.1    Jouan, E.2    Stieger, B.3    Lecureur, V.4    Fardel, O.5
  • 53
    • 84155173299 scopus 로고    scopus 로고
    • DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma.
    • 10.1186/gm298, 3334547, 22196450
    • Schaeffeler E, Hellerbrand C, Nies AT, Winter S, Kruck S, Hofmann U, van der Kuip H, Zanger UM, Koepsell H, Schwab M. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med 2011, 3:82. 10.1186/gm298, 3334547, 22196450.
    • (2011) Genome Med , vol.3 , pp. 82
    • Schaeffeler, E.1    Hellerbrand, C.2    Nies, A.T.3    Winter, S.4    Kruck, S.5    Hofmann, U.6    van der Kuip, H.7    Zanger, U.M.8    Koepsell, H.9    Schwab, M.10
  • 54
    • 84857439681 scopus 로고    scopus 로고
    • Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.
    • 10.1002/hep.24682, 21932399
    • Borel F, Han R, Visser A, Petry H, van Deventer SJ, Jansen PL, Konstantinova P. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Hepatology 2012, 55:821-832. 10.1002/hep.24682, 21932399.
    • (2012) Hepatology , vol.55 , pp. 821-832
    • Borel, F.1    Han, R.2    Visser, A.3    Petry, H.4    van Deventer, S.J.5    Jansen, P.L.6    Konstantinova, P.7
  • 55
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
    • 10.1097/00008571-200107000-00004, 11470993
    • Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001, 11:399-415. 10.1097/00008571-200107000-00004, 11470993.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3    Nussler, A.K.4    Neuhaus, P.5    Hofmann, U.6    Eichelbaum, M.7    Schwab, M.8    Zanger, U.M.9
  • 56
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.
    • König J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 2000, 278:G156-G164.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 57
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.
    • 10.1053/j.gastro.2006.02.034, 16697742
    • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 2006, 130:1793-1806. 10.1053/j.gastro.2006.02.034, 16697742.
    • (2006) Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1    Tirona, R.G.2    Leake, B.F.3    Glaeser, H.4    Lee, W.5    Lemke, C.J.6    Wang, Y.7    Kim, R.B.8
  • 58
    • 38349168958 scopus 로고    scopus 로고
    • Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).
    • 10.1007/s00210-007-0219-x, 18157518
    • Nies AT, Herrmann E, Brom M, Keppler D. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol 2008, 376:449-461. 10.1007/s00210-007-0219-x, 18157518.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.376 , pp. 449-461
    • Nies, A.T.1    Herrmann, E.2    Brom, M.3    Keppler, D.4
  • 59
    • 25144494314 scopus 로고    scopus 로고
    • Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells.
    • 10.1124/mol.105.014605, 16046661
    • Kopplow K, Letschert K, König J, Walter B, Keppler D. Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 2005, 68:1031-1038. 10.1124/mol.105.014605, 16046661.
    • (2005) Mol Pharmacol , vol.68 , pp. 1031-1038
    • Kopplow, K.1    Letschert, K.2    König, J.3    Walter, B.4    Keppler, D.5
  • 60
    • 79960295006 scopus 로고    scopus 로고
    • Proton pump inhibitors inhibit metformin uptake by organic cation uptake transporters (OCTs).
    • 10.1371/journal.pone.0022163, 3136501, 21779389
    • Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M. Proton pump inhibitors inhibit metformin uptake by organic cation uptake transporters (OCTs). PLoS ONE 2011, 6:e22163. 10.1371/journal.pone.0022163, 3136501, 21779389.
    • (2011) PLoS ONE , vol.6
    • Nies, A.T.1    Hofmann, U.2    Resch, C.3    Schaeffeler, E.4    Rius, M.5    Schwab, M.6
  • 61
    • 0036713091 scopus 로고    scopus 로고
    • Definition and prediction of the full range of transcription factor binding sites--the hepatocyte nuclear factor 1 dimeric site.
    • 10.1093/nar/gkf484, 137408, 12202766
    • Locker J, Ghosh D, Luc PV, Zheng J. Definition and prediction of the full range of transcription factor binding sites--the hepatocyte nuclear factor 1 dimeric site. Nucleic Acids Res 2002, 30:3809-3817. 10.1093/nar/gkf484, 137408, 12202766.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3809-3817
    • Locker, J.1    Ghosh, D.2    Luc, P.V.3    Zheng, J.4
  • 62
    • 34249290413 scopus 로고    scopus 로고
    • Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine.
    • 10.1124/dmd.106.013565, 17344340
    • Tegude H, Schnabel A, Zanger UM, Klein K, Eichelbaum M, Burk O. Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine. Drug Metab Dispos 2007, 35:946-954. 10.1124/dmd.106.013565, 17344340.
    • (2007) Drug Metab Dispos , vol.35 , pp. 946-954
    • Tegude, H.1    Schnabel, A.2    Zanger, U.M.3    Klein, K.4    Eichelbaum, M.5    Burk, O.6
  • 63
    • 17844375918 scopus 로고    scopus 로고
    • A natural CYP2B6 TATA box polymorphism (-82T-- > C) leading to enhanced transcription and relocation of the transcriptional start site.
    • 10.1124/mol.104.008086, 15722458
    • Zukunft J, Lang T, Richter T, Hirsch-Ernst KI, Nussler AK, Klein K, Schwab M, Eichelbaum M, Zanger UM. A natural CYP2B6 TATA box polymorphism (-82T-- > C) leading to enhanced transcription and relocation of the transcriptional start site. Mol Pharmacol 2005, 67:1772-1782. 10.1124/mol.104.008086, 15722458.
    • (2005) Mol Pharmacol , vol.67 , pp. 1772-1782
    • Zukunft, J.1    Lang, T.2    Richter, T.3    Hirsch-Ernst, K.I.4    Nussler, A.K.5    Klein, K.6    Schwab, M.7    Eichelbaum, M.8    Zanger, U.M.9
  • 64
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.
    • 10.1074/jbc.M010173200, 11297522
    • Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001, 276:14581-14587. 10.1074/jbc.M010173200, 11297522.
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 66
    • 84872134037 scopus 로고    scopus 로고
    • PolyPhen-2.
    • PolyPhen-2. http://genetics.bwh.harvard.edu/pph2
  • 67
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
    • 10.1038/nprot.2009.86, 19561590
    • Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009, 4:1073-1081. 10.1038/nprot.2009.86, 19561590.
    • (2009) Nat Protoc , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 68
    • 84877794326 scopus 로고    scopus 로고
    • SIFT.
    • SIFT. http://sift.jcvi.org
  • 69
    • 10344242920 scopus 로고    scopus 로고
    • Sequence-based prediction of pathological mutations.
    • 10.1002/prot.20252, 15390262
    • Ferrer-Costa C, Orozco M, de lC X. Sequence-based prediction of pathological mutations. Proteins 2004, 57:811-819. 10.1002/prot.20252, 15390262.
    • (2004) Proteins , vol.57 , pp. 811-819
    • Ferrer-Costa, C.1    Orozco, M.2    de lC, X.3
  • 70
    • 84877804617 scopus 로고    scopus 로고
    • PMut.
    • PMut. http://mmb.pcb.ub.es/PMut
  • 71
    • 33645764714 scopus 로고    scopus 로고
    • SNPs3D: candidate gene and SNP selection for association studies.
    • 10.1186/1471-2105-7-166, 1435944, 16551372
    • Yue P, Melamud E, Moult J. SNPs3D: candidate gene and SNP selection for association studies. BMC Bioinformatics 2006, 7:166. 10.1186/1471-2105-7-166, 1435944, 16551372.
    • (2006) BMC Bioinformatics , vol.7 , pp. 166
    • Yue, P.1    Melamud, E.2    Moult, J.3
  • 72
    • 84877811107 scopus 로고    scopus 로고
    • SNPs3D.
    • SNPs3D. http://www.snps3d.org
  • 73
    • 0033591465 scopus 로고    scopus 로고
    • Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure.
    • 10.1006/jmbi.1999.2700, 10329189
    • Mathews DH, Sabina J, Zuker M, Turner DH. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol 1999, 288:911-940. 10.1006/jmbi.1999.2700, 10329189.
    • (1999) J Mol Biol , vol.288 , pp. 911-940
    • Mathews, D.H.1    Sabina, J.2    Zuker, M.3    Turner, D.H.4
  • 74
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction.
    • 10.1093/nar/gkg595, 169194, 12824337
    • Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003, 31:3406-3415. 10.1093/nar/gkg595, 169194, 12824337.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1
  • 75
    • 84877810950 scopus 로고    scopus 로고
    • MFold.
    • MFold. http://mfold.rit.albany.edu/?q=mfold
  • 77
    • 0025227871 scopus 로고
    • Criteria of drug-induced liver disorders. Report of an international consensus meeting.
    • Benichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol 1990, 11:272-276.
    • (1990) J Hepatol , vol.11 , pp. 272-276
    • Benichou, C.1
  • 78
    • 67649386559 scopus 로고    scopus 로고
    • Genetic variations of the SLCO1B1 gene in the Chinese, Malay and Indian populations of Singapore.
    • 10.2133/dmpk.23.476, 19122343
    • Ho WF, Koo SH, Yee JY, Lee EJ. Genetic variations of the SLCO1B1 gene in the Chinese, Malay and Indian populations of Singapore. Drug Metab Pharmacokinet 2008, 23:476-482. 10.2133/dmpk.23.476, 19122343.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 476-482
    • Ho, W.F.1    Koo, S.H.2    Yee, J.Y.3    Lee, E.J.4
  • 79
    • 54049121096 scopus 로고    scopus 로고
    • Highly multiplexed genotyping of thiopurine S-methyltransferase variants using MALDI-TOF mass spectrometry: reliable genotyping in different ethnic groups.
    • 10.1373/clinchem.2008.103457, 18687736
    • Schaeffeler E, Zanger UM, Eichelbaum M, Asante-Poku S, Shin JG, Schwab M. Highly multiplexed genotyping of thiopurine S-methyltransferase variants using MALDI-TOF mass spectrometry: reliable genotyping in different ethnic groups. Clin Chem 2008, 54:1637-1647. 10.1373/clinchem.2008.103457, 18687736.
    • (2008) Clin Chem , vol.54 , pp. 1637-1647
    • Schaeffeler, E.1    Zanger, U.M.2    Eichelbaum, M.3    Asante-Poku, S.4    Shin, J.G.5    Schwab, M.6
  • 80
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.
    • 10.1074/jbc.M103792200, 11477075
    • Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem 2001, 276:35669-35675. 10.1074/jbc.M103792200, 11477075.
    • (2001) J Biol Chem , vol.276 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4


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