Genomics of ADME gene expression: Mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

Pharmacogenomics Journal

Volumn 13, Issue 1, 2013, Pages 12-20

  Schroder A ^a   Klein, K ^a,b   Winter, S ^a,b   Schwab, M ^a,b,c   Bonin, M ^a   Zell, A ^a   Zanger, U M ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

ADME; eQTL; gene expression; pharmacogenetics; quantitative trait loci; SNP

Indexed keywords

CARRIER PROTEIN; ENZYME; MESSENGER RNA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADME GENE; ADULT; ARTICLE; CAUCASIAN; CONTROLLED STUDY; COVARIANCE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOMICS; HUMAN; HUMAN TISSUE; LIVER; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; REGULATOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; TISSUE SECTION; VALIDATION PROCESS;

ABSORPTION; BIOLOGICAL TRANSPORT; CHROMOSOME MAPPING; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION STUDIES; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MIDDLE AGED; PHARMACOGENETICS; PHARMACOKINETICS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 84872968966     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2011.44     Document Type: Article

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