메뉴 건너뛰기




Volumn 82, Issue 3, 2011, Pages 304-311

Regulation of drug transporter expression by oncostatin M in human hepatocytes

Author keywords

Biliary elimination; Drug transporters; Human hepatocytes; Inflammation; Oncostatin M

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 6; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ONCOSTATIN M; ONCOSTATIN M RECEPTOR; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1; ORGANIC CATION TRANSPORTER 1; RECEPTOR SUBUNIT; SMALL INTERFERING RNA; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 79959556989     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.04.017     Document Type: Article
Times cited : (34)

References (44)
  • 1
    • 0033536565 scopus 로고    scopus 로고
    • Oncostatin M: Signal transduction and biological activity
    • DOI 10.1016/S0024-3205(99)00296-9, PII S0024320599002969
    • M.J. Gomez-Lechon Oncostatin M signal transduction and biological activity Life Sci 65 20 1999 2019 2030 (Pubitemid 29524852)
    • (1999) Life Sciences , vol.65 , Issue.20 , pp. 2019-2030
    • Gomez-Lechon, M.J.1
  • 3
    • 32844471999 scopus 로고    scopus 로고
    • Identification and differentiation of hepatic stem cells during liver development
    • A. Kamiya, F.J. Gonzalez, and H. Nakauchi Identification and differentiation of hepatic stem cells during liver development Front Biosci 11 2006 1302 1310 (Pubitemid 43253423)
    • (2006) Frontiers in Bioscience , vol.11 , Issue.2 , pp. 1302-1310
    • Kamiya, A.1    Gonzalez, F.J.2    Nakauchi, H.3
  • 4
    • 44349149913 scopus 로고    scopus 로고
    • Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
    • U. Dierssen, N. Beraza, H.H. Lutz, C. Liedtke, M. Ernst, and H.E. Wasmuth Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration J Biol Chem 283 15 2008 9886 9895
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9886-9895
    • Dierssen, U.1    Beraza, N.2    Lutz, H.H.3    Liedtke, C.4    Ernst, M.5    Wasmuth, H.E.6
  • 5
    • 26244433119 scopus 로고    scopus 로고
    • Expression of oncostatin M and its receptors in normal and cirrhotic human liver
    • DOI 10.1016/j.jhep.2005.04.020, PII S016882780500454X
    • I. Znoyko, N. Sohara, S.S. Spicer, M. Trojanowska, and A. Reuben Expression of oncostatin M and its receptors in normal and cirrhotic human liver J Hepatol 43 5 2005 893 900 (Pubitemid 41414516)
    • (2005) Journal of Hepatology , vol.43 , Issue.5 , pp. 893-900
    • Znoyko, I.1    Sohara, N.2    Spicer, S.S.3    Trojanowska, M.4    Reuben, A.5
  • 6
    • 1542724878 scopus 로고    scopus 로고
    • Hepatocyte Proliferation and Tissue Remodeling Is Impaired after Liver Injury in Oncostatin M Receptor Knockout Mice
    • DOI 10.1002/hep.20086
    • K. Nakamura, H. Nonaka, H. Saito, M. Tanaka, and A. Miyajima Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice Hepatology 39 3 2004 635 644 (Pubitemid 38337643)
    • (2004) Hepatology , vol.39 , Issue.3 , pp. 635-644
    • Nakamura, K.1    Nonaka, H.2    Saito, H.3    Tanaka, M.4    Miyajima, A.5
  • 7
    • 0026510625 scopus 로고
    • Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro
    • C.D. Richards, T.J. Brown, M. Shoyab, H. Baumann, and J. Gauldie Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro J Immunol 148 6 1992 1731 1736
    • (1992) J Immunol , vol.148 , Issue.6 , pp. 1731-1736
    • Richards, C.D.1    Brown, T.J.2    Shoyab, M.3    Baumann, H.4    Gauldie, J.5
  • 8
    • 71549138697 scopus 로고    scopus 로고
    • The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
    • A. Pardo-Saganta, M.U. Latasa, J. Castillo, L. Alvarez-Asiain, M.J. Perugorria, and P. Sarobe The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression J Hepatol 51 6 2009 1010 1020
    • (2009) J Hepatol , vol.51 , Issue.6 , pp. 1010-1020
    • Pardo-Saganta, A.1    Latasa, M.U.2    Castillo, J.3    Alvarez-Asiain, L.4    Perugorria, M.J.5    Sarobe, P.6
  • 12
    • 3542995726 scopus 로고    scopus 로고
    • The complexities of hepatic drug transport: Current knowledge and emerging concepts
    • DOI 10.1023/B:PHAM.0000026420.79421.8f
    • P. Chandra, and K.L. Brouwer The complexities of hepatic drug transport: current knowledge and emerging concepts Pharm Res 21 5 2004 719 735 (Pubitemid 39011292)
    • (2004) Pharmaceutical Research , vol.21 , Issue.5 , pp. 719-735
    • Chandra, P.1    Brouwer, K.L.R.2
  • 13
    • 0035813008 scopus 로고    scopus 로고
    • Regulation of biliary drug efflux pump expression by hormones and xenobiotics
    • DOI 10.1016/S0300-483X(01)00456-5, PII S0300483X01004565
    • O. Fardel, L. Payen, A. Courtois, L. Vernhet, and V. Lecureur Regulation of biliary drug efflux pump expression by hormones and xenobiotics Toxicology 167 1 2001 37 46 (Pubitemid 32830945)
    • (2001) Toxicology , vol.167 , Issue.1 , pp. 37-46
    • Fardel, O.1    Payen, L.2    Courtois, A.3    Vernhet, L.4    Lecureur, V.5
  • 14
    • 34247623972 scopus 로고    scopus 로고
    • Regulation of drug transporters: During infection and inflammation
    • DOI 10.1124/mi.7.2.10
    • V. Petrovic, S. Teng, and M. Piquette-Miller Regulation of drug transporters during infection and inflammation Mol Interv 7 2 2007 99 111 (Pubitemid 46683180)
    • (2007) Molecular Interventions , vol.7 , Issue.2 , pp. 99-111
    • Petrovic, V.1    Teng, S.2    Piquette-Miller, M.3
  • 15
    • 38749136631 scopus 로고    scopus 로고
    • Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1β
    • DOI 10.1124/dmd.107.016907
    • M. Le Vee, P. Gripon, B. Stieger, and O. Fardel Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta Drug Metab Dispos 36 2 2008 217 222 (Pubitemid 351185762)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 217-222
    • Le Vee, M.1    Gripon, P.2    Stieger, B.3    Fardel, O.4
  • 16
    • 71049125230 scopus 로고    scopus 로고
    • Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines
    • O. Fardel, and M. Le Vee Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines Expert Opin Drug Metab Toxicol 5 12 2009 1469 1481
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , Issue.12 , pp. 1469-1481
    • Fardel, O.1    Le Vee, M.2
  • 17
    • 77957786509 scopus 로고    scopus 로고
    • Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}
    • L. Diao, N. Li, T.G. Brayman, K.J. Hotz, and Y. Lai Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta} J Biol Chem 285 41 2010 31185 31192
    • (2010) J Biol Chem , vol.285 , Issue.41 , pp. 31185-31192
    • Diao, L.1    Li, N.2    Brayman, T.G.3    Hotz, K.J.4    Lai, Y.5
  • 18
    • 24944537019 scopus 로고    scopus 로고
    • Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes
    • DOI 10.1124/dmd.105.004762
    • E. Jigorel, M. Le Vee, C. Boursier-Neyret, M. Bertrand, and O. Fardel Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes Drug Metab Dispos 33 10 2005 1418 1422 (Pubitemid 41323987)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.10 , pp. 1418-1422
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Bertrand, M.4    Fardel, O.5
  • 19
    • 61449142646 scopus 로고    scopus 로고
    • Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6
    • M. Le Vee, V. Lecureur, B. Stieger, and O. Fardel Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6 Drug Metab Dispos 37 3 2009 685 693
    • (2009) Drug Metab Dispos , vol.37 , Issue.3 , pp. 685-693
    • Le Vee, M.1    Lecureur, V.2    Stieger, B.3    Fardel, O.4
  • 20
    • 70350326029 scopus 로고    scopus 로고
    • Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes
    • M. Le Vee, V. Lecureur, A. Moreau, B. Stieger, and O. Fardel Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes Drug Metab Dispos 37 11 2009 2228 2235
    • (2009) Drug Metab Dispos , vol.37 , Issue.11 , pp. 2228-2235
    • Le Vee, M.1    Lecureur, V.2    Moreau, A.3    Stieger, B.4    Fardel, O.5
  • 22
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • DOI 10.1016/j.cbi.2006.12.003, PII S0009279706003553
    • A. Guillouzo, A. Corlu, C. Aninat, D. Glaise, F. Morel, and C. Guguen-Guillouzo The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics Chem Biol Interact 168 1 2007 66 73 (Pubitemid 46659919)
    • (2007) Chemico-Biological Interactions , vol.168 , Issue.1 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3    Glaise, D.4    Morel, F.5    Guguen-Guillouzo, C.6
  • 23
    • 77956170997 scopus 로고    scopus 로고
    • Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes
    • M. Le Vee, E. Jouan, and O. Fardel Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes Toxicol In Vitro 24 6 2010 1775 1781
    • (2010) Toxicol in Vitro , vol.24 , Issue.6 , pp. 1775-1781
    • Le Vee, M.1    Jouan, E.2    Fardel, O.3
  • 24
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
    • DOI 10.1124/dmd.106.010033
    • E. Jigorel, M. Le Vee, C. Boursier-Neyret, Y. Parmentier, and O. Fardel Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes Drug Metab Dispos 34 10 2006 1756 1763 (Pubitemid 44427479)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 25
    • 33847069574 scopus 로고    scopus 로고
    • Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
    • R.D. Huber, B. Gao, M.A. Sidler Pfandler, W. Zhang-Fu, S. Leuthold, and B. Hagenbuch Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain Am J Physiol Cell Physiol 292 2 2007 C795 C806
    • (2007) Am J Physiol Cell Physiol , vol.292 , Issue.2
    • Huber, R.D.1    Gao, B.2    Sidler Pfandler, M.A.3    Zhang-Fu, W.4    Leuthold, S.5    Hagenbuch, B.6
  • 26
    • 77953525651 scopus 로고    scopus 로고
    • Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
    • B. Chung, F. Verdier, P. Matak, J.C. Deschemin, P. Mayeux, and S. Vaulont Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone FASEB J 24 6 2010 2093 2103
    • (2010) FASEB J , vol.24 , Issue.6 , pp. 2093-2103
    • Chung, B.1    Verdier, F.2    Matak, P.3    Deschemin, J.C.4    Mayeux, P.5    Vaulont, S.6
  • 27
    • 67651181099 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
    • S. Vollmer, V. Kappler, J. Kaczor, D. Flugel, C. Rolvering, and N. Kato Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling Hepatology 50 1 2009 253 260
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 253-260
    • Vollmer, S.1    Kappler, V.2    Kaczor, J.3    Flugel, D.4    Rolvering, C.5    Kato, N.6
  • 28
    • 33644919674 scopus 로고    scopus 로고
    • Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
    • M. Le Vee, E. Jigorel, D. Glaise, P. Gripon, C. Guguen-Guillouzo, and O. Fardel Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line Eur J Pharm Sci 28 1-2 2006 109 117
    • (2006) Eur J Pharm Sci , vol.28 , Issue.12 , pp. 109-117
    • Le Vee, M.1    Jigorel, E.2    Glaise, D.3    Gripon, P.4    Guguen-Guillouzo, C.5    Fardel, O.6
  • 29
    • 78650926991 scopus 로고    scopus 로고
    • Regulation of drug transporter mRNA expression by interferon-gamma in primary human hepatocytes
    • M. Le Vee, E. Jouan, A. Moreau, and O. Fardel Regulation of drug transporter mRNA expression by interferon-gamma in primary human hepatocytes Fundam Clin Pharmacol 25 1 2011 99 103
    • (2011) Fundam Clin Pharmacol , vol.25 , Issue.1 , pp. 99-103
    • Le Vee, M.1    Jouan, E.2    Moreau, A.3    Fardel, O.4
  • 30
    • 36048949007 scopus 로고    scopus 로고
    • Oncostatin M-induced effects on EMT in human proximal tubular cells: Differential role of ERK signaling
    • V. Pollack, R. Sarkozi, Z. Banki, E. Feifel, S. Wehn, and G. Gstraunthaler Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling Am J Physiol Renal Physiol 293 5 2007 F1714 F1726
    • (2007) Am J Physiol Renal Physiol , vol.293 , Issue.5
    • Pollack, V.1    Sarkozi, R.2    Banki, Z.3    Feifel, E.4    Wehn, S.5    Gstraunthaler, G.6
  • 31
    • 78649741783 scopus 로고    scopus 로고
    • Gp130 at the nexus of inflammation, autoimmunity, and cancer
    • J.S. Silver, and C.A. Hunter gp130 at the nexus of inflammation, autoimmunity, and cancer J Leukoc Biol 88 6 2010 1145 1156
    • (2010) J Leukoc Biol , vol.88 , Issue.6 , pp. 1145-1156
    • Silver, J.S.1    Hunter, C.A.2
  • 32
    • 0031818619 scopus 로고    scopus 로고
    • Gp130 and the IL-6 family of cytokines: Signaling mechanisms and thrombopoietic activities
    • K. Nakashima, and T. Taga gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities Semin Hematol 35 3 1998 210 221 (Pubitemid 28337230)
    • (1998) Seminars in Hematology , vol.35 , Issue.3 , pp. 210-221
    • Nakashima, K.1    Taga, T.2
  • 33
    • 0345826123 scopus 로고    scopus 로고
    • Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism
    • DOI 10.1074/jbc.M311498200
    • Y. Yoshida, A. Kumar, Y. Koyama, H. Peng, A. Arman, and J.A. Boch Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism J Biol Chem 279 3 2004 1768 1776 (Pubitemid 38084444)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.3 , pp. 1768-1776
    • Yoshida, Y.1    Kumar, A.2    Koyama, Y.3    Peng, H.4    Arman, A.5    Boch, J.A.6    Auron, P.E.7
  • 34
    • 62649119336 scopus 로고    scopus 로고
    • Knocking down breast cancer resistance protein (ABCG2) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: A novel tool to assess the contribution of ABCG2 to drug biliary excretion
    • W. Yue, K. Abe, and K.L. Brouwer Knocking down breast cancer resistance protein (ABCG2) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of ABCG2 to drug biliary excretion Mol Pharm 6 1 2009 134 143
    • (2009) Mol Pharm , vol.6 , Issue.1 , pp. 134-143
    • Yue, W.1    Abe, K.2    Brouwer, K.L.3
  • 35
    • 70350469962 scopus 로고    scopus 로고
    • Oncostatin M as a target biological molecule of preeclampsia
    • G. Lee, G. Kil, J. Kwon, S. Kim, J. Yoo, and J. Shin Oncostatin M as a target biological molecule of preeclampsia J Obstet Gynaecol Res 35 5 2009 869 875
    • (2009) J Obstet Gynaecol Res , vol.35 , Issue.5 , pp. 869-875
    • Lee, G.1    Kil, G.2    Kwon, J.3    Kim, S.4    Yoo, J.5    Shin, J.6
  • 36
    • 49449100341 scopus 로고    scopus 로고
    • Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor
    • I. Rioja, F.J. Hughes, C.H. Sharp, L.C. Warnock, D.S. Montgomery, and M. Akil Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor Arthritis Rheum 58 8 2008 2257 2267
    • (2008) Arthritis Rheum , vol.58 , Issue.8 , pp. 2257-2267
    • Rioja, I.1    Hughes, F.J.2    Sharp, C.H.3    Warnock, L.C.4    Montgomery, D.S.5    Akil, M.6
  • 37
    • 0030807922 scopus 로고    scopus 로고
    • Circulating interleukin-6 type cytokines in patients with systemic lupus erythematosus
    • E. Robak, A. Sysa-Jedrzejowska, H. Stepien, and T. Robak Circulating interleukin-6 type cytokines in patients with systemic lupus erythematosus Eur Cytokine Netw 8 3 1997 281 286 (Pubitemid 27470099)
    • (1997) European Cytokine Network , vol.8 , Issue.3 , pp. 281-286
    • Robak, E.1    Sysa-Jedrzejowska, A.2    Stepien, H.3    Robak, T.4
  • 38
    • 77951676088 scopus 로고    scopus 로고
    • Serum levels of oncostatin M (a gp 130 cytokine): An inflammatory biomarker in periodontal disease
    • A.R. Pradeep, T.M. S, G. Garima, and A. Raju Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease Biomarkers 15 3 2010 277 282
    • (2010) Biomarkers , vol.15 , Issue.3 , pp. 277-282
    • Pradeep, A.R.1    T, M.S.2    Garima, G.3    Raju, A.4
  • 39
    • 0031025723 scopus 로고    scopus 로고
    • Serum oncostatin M in multiple myeloma: Association with prognostic factors
    • K. Koskela, T.T. Pelliniemi, K. Remes, A. Rajamaki, and K. Pulkki Serum oncostatin M in multiple myeloma: association with prognostic factors Br J Haematol 96 1 1997 158 160
    • (1997) Br J Haematol , vol.96 , Issue.1 , pp. 158-160
    • Koskela, K.1    Pelliniemi, T.T.2    Remes, K.3    Rajamaki, A.4    Pulkki, K.5
  • 40
    • 0033973784 scopus 로고    scopus 로고
    • Oncostatin M: A cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells
    • M.T. Levy, M. Trojanowska, and A. Reuben Oncostatin M: a cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells J Hepatol 32 2 2000 218 226 (Pubitemid 30093900)
    • (2000) Journal of Hepatology , vol.32 , Issue.2 , pp. 218-226
    • Levy, M.T.1    Trojanowska, M.2    Reuben, A.3
  • 41
    • 57049161412 scopus 로고    scopus 로고
    • Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction
    • R.K. Verbeeck Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction Eur J Clin Pharmacol 64 12 2008 1147 1161
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.12 , pp. 1147-1161
    • Verbeeck, R.K.1
  • 42
    • 77955300958 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
    • E. van de Steeg, E. Wagenaar, C.M. van der Kruijssen, J.E. Burggraaff, D.R. de Waart, and R.P. Elferink Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs J Clin Invest 120 8 2010 2942 2952
    • (2010) J Clin Invest , vol.120 , Issue.8 , pp. 2942-2952
    • Van De Steeg, E.1    Wagenaar, E.2    Van Der Kruijssen, C.M.3    Burggraaff, J.E.4    De Waart, D.R.5    Elferink, R.P.6
  • 43
    • 46749116318 scopus 로고    scopus 로고
    • Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells
    • F. Takata, N. Sumi, T. Nishioku, E. Harada, T. Wakigawa, and H. Shuto Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells Neurosci Lett 441 2 2008 163 166
    • (2008) Neurosci Lett , vol.441 , Issue.2 , pp. 163-166
    • Takata, F.1    Sumi, N.2    Nishioku, T.3    Harada, E.4    Wakigawa, T.5    Shuto, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.