Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system

Cell Biology and Toxicology

Volumn 28, Issue 6, 2012, Pages 421-433

  Kim, Ki Cheon ^a   Lee, In Kyung ^b   Kang, Kyoung Ah ^a   Kim, Hye Sun ^c   Kang, Sam Sik ^c   Hyun, Jin Won ^a  

^a Jeju National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

8 Oxoguanine DNA glycosylase; Akt kinase; Baicalein; Base excision repair; DNA damage response; Nonhomologous end joining

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE 1; BAICALEIN; DNA DEPENDENT PROTEIN KINASE; DNA GLYCOSYLTRANSFERASE; KU ANTIGEN; MESSENGER RNA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IN VITRO STUDY; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, NUCLEAR; CELL LINE; CRICETINAE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FLAVANONES; GUANINE; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

CRICETULUS GRISEUS;

EID: 84872104211     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-012-9233-y     Document Type: Article

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