Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system

Cancer Science

Volumn 99, Issue 11, 2008, Pages 2230-2237

  Ueta, Eisaku ^a   Sasabe, Eri ^a   Yang, Zhu ^a   Osaki, Tokio ^a   Yamamoto, Tetsuya ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE DNA GLYCOSYLASE; DNA DIRECTED DNA POLYMERASE GAMMA; DNA GLYCOSYLTRANSFERASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SUSCEPTIBILITY; CELL LEVEL; CELL STRAIN; CELL STRAIN OSC 1; CELL STRAIN OSC 2; CELL STRAIN OSC 3; CELL STRAIN OSC 4; CELL STRAIN OSC 5; CELL STRAIN OSC 6; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; ENZYME ACTIVITY; GAMMA IRRADIATION; GENE DELETION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUTH CARCINOMA; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STRAIN DIFFERENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA GLYCOSYLASES; DNA REPAIR; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; DOWN-REGULATION; GAMMA RAYS; HUMANS; MITOCHONDRIAL PROTEINS; MOUTH NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 55449126111     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00918.x     Document Type: Article

References (44)

1. Kim R, Emi M, Tanabe K. The role of apoptosis in cancer cell survival and therapeutic outcome. Cancer Biol Ther 2006; 5: 1429-42.
2. Chan DC. Mitochondria: Dynamic organelles in disease, aging, and development. Cell 2006; 125: 1241-52.
3. Panka DJ, Atkins MB, Mier JW. Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma. Clin Cancer Res 2006; 12: 2371s-5s.
4. Kim HJ, Hawke N, Baldwin AS. NF-κB and IKK as therapeutic targeted in cancer. Cell Death Differ 2006; 13: 738-47.
5. Foster DA. Targeting mTOR-mediated survival signals in anticancer therapeutic strategies. Expert Rev Anticancer Ther 2004; 4: 691-701.
6. Murphy FJ, Seery LT, Hayes I. Therapeutic approaches to the modulation of apoptosis. Essays Biochem 2003; 39: 131-53.
7. Ueta E, Yoneda K, Yamamoto T, Osaki T. Manganese superoxide dismutase negatively regulates the induction of apoptosis by 5-fluorouracil, peplomycin and γ-rays in squamous cell carcinoma cells. Jpn J Cancer Res 1999; 90: 555-64.
8. Pattison DI, Dean RT, Davies MJ. Oxidation of DNA, proteins and lipids by DOPA, protein-bound DOPA, and related catechol(amine)s. Toxicology 2002; 177: 23-37.
9. Fujino G, Noguchi T, Takeda K, Ichijo H. Thioredoxin and protein kinases in redox signaling. Semin Cancer Biol 2006; 16: 427-35.
10. Arner ES, Holmgren A. The thioredoxin system in cancer. Semin Cancer Biol 2006; 16: 420-6.
11. Li D, Ueta E, Kimura T, Yamamoto T, Osaki T. Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination. Cancer Sci 2004; 95: 644-50.
12. Ueta E, Yoneda K, Kimura T et al. Mn-SOD antisense upregulates in vitro apoptosis of squamous cell carcinoma cells by anticancer drugs and γ-rays regulating expression of the Bcl-2 family proteins, cox-2 and p21. Int J Cancer 2001; 94: 545-50.
13. Taanman JW. The mitochondrial genome: Structure, transcription, translation and replication. Biochim Biophys Acta 1999; 1410: 103-23.
14. Prithivirajsingh S, Story MD, Bergh SA et al. Accumulation of the common mitochondrial DNA deletion induced by ionizing radiation. FEBS Lett 2004; 571: 227-32.
15. Park SY, Chang I, Kim JY et al. Resistance of mitochondrial DNA-depleted cells against cell death: Role of mitochondrial superoxide dismutase. J Biol Chem 2004; 279: 7512-20.
16. Suematsu N, Tsutsui H, Wen J et al. Oxidative stress mediates tumor necrosis factor-α-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 2003; 18: 1418-23.
17. Stevnsner T, Thorslund T, de Souza-Pinto NC, Bohr VA. Mitochondrial repair of 8-oxoguanine and change with aging. Exp Gerontol 2002; 37: 1189-96.
18. Pinz KG, Bogenhagen DF. The influence of the DNA polymerase gamma accessory subunit on base excision repair by the catalytic subunit. DNA Repair 2006; 5: 121-8.
19. Yakubovskaya E, Chen Z, Carrodeguas JA, Kisker C, Bogenhagen DF. Functional human mitochondrial DNA polymerase gamma forms a heterotrimer. J Biol Chem 2006; 281: 374-82.
20. Gaspari M, Larsson NG, Gustafsson CM. The transcription machinery in mammalian mitochondria. Biochim Biophys Acta 2004; 1659: 148-52.
21. Piantadosi CA, Suliman HB. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J Biol Chem 2006; 281: 324-33.
22. Hyun JW, Cheon GJ, Kim HS et al. Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines. Free Radic Biol Med 2002; 32: 212-20.
23. Jeong HG, Youn CK, Cho HJ et al. Metallothionein-III prevents γ-ray-induced 8-oxoguanine accumulation in normal and hOGG1-depleted cells. J Biol Chem 2004; 279: 34.138-49.
24. Pekkola-Heino K, Servomaa K, Kiuru A, Grenman R. Sublethal damage repair capacity in carcinoma cell lines with p53 mutations. Head Neck 1998; 20: 298-303.
25. De Martinis BS, de Lourdes Pires Bianchi M. Methodology for urinary 8-hydroxy-2′-deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res 2002; 46: 129-31.
26. Yoshida Y, Izumi H, Torigoe T et al. p53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. Cancer Res 2003; 63: 3729-34.
27. Spelbrink JN, Toivonen JM, Hakkaart GAI et al. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells. J Biol Chem 2000; 275: 24.818-28.
28. Modica-Napolitano JS, Singh KK. Mitochondrial dysfunction in cancer. Mitochondrion 2004; 4: 755-62.
29. DiMauro S. Mitochondrial medicine. Biochim Biophys Acta 2004; 1659: 107-14.
30. 6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer Res 2005; 65: 3319-27.
31. Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004; 7: 97-110.
32. Rachek LI, Grishko VI, Ledoux SP, Wilson GL. Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis. Free Radic Biol Med 2006; 40: 754-62.
33. Xiao J, Biaglow JE, Chae-Park HJ et al. Role of hydroxyl radicals in radiation-induced activation of lyn tyrosine kinase in human B-cell precursors. Leuk Lymphoma 1996; 22: 421-30.
34. Kang D, Hamasaki N. Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: Overview of its multiple roles. Ann NY Acad Sci 2005; 1042: 101-8.
35. Klungland A, Bjelland S. Oxidative damage to purines in DNA: Role of mammalian Ogg1. DNA Repair 2007; 6: 481-8.
36. Hudson G, Chinnery PF. Mitochondrial DNA polymerase-γ and human disease. Hum Mol Genet 2006; 15: R244-52.
37. Graziewicz MA, Day BJ, Copeland WC. The mitochondrial DNA polymerase as a target of oxidative damage. Nucl Acids Res 2002; 30: 2817-24.
38. Hance N, Ekstrand MI, Trifunovic A. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet 2005; 14: 1775-83.
39. Kang MK, Kim RH, Shin KH, Zhong W, Faull KF, Park NH. Senescence-associated decline in the intracellular accumulation of hOGG1-α and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo. Exp Cell Res 2005; 310: 186-95.
40. Dhenaut A, Boiteux S, Radicella JP. Characterization of the hOGG1 promotor and its expression during the cell cycle. Mutat Res 2000; 461: 109-18.
41. Kim IA, Bae SS, Fernandes A et al. Selective inhibition of Rss, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res 2005; 65: 7902-10.
42. Lee CM, Fuhrman CB, Planelles V et al. Phosphatidylinositol 3-kinase inhibition by LY 294002 radiosensitizes human cervical cancer cell lines. Clin Cancer Res 2006; 12: 250-6.
43. Nakamura JL, Karlsson A, Arvold ND et al. PKB/Akt mediates radiosensitivity by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol 2005; 71: 215-22.
44. Toulany M, Dittmann K, Kruger M, Baumann M, Rodemann HP. Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway. Radiother Oncol 2005; 76: 143-50.