메뉴 건너뛰기




Volumn 23, Issue 1, 2013, Pages 81-91

Chemical approaches to studying stem cell biology

Author keywords

Differentiation; Self renewal; Small molecules; Stem cells

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

EID: 84872037359     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.182     Document Type: Review
Times cited : (29)

References (83)
  • 1
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • DOI 10.1146/annurev.cellbio.17.1.435
    • Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001; 17: 435-462. (Pubitemid 33096183)
    • (2001) Annual Review of Cell and Developmental Biology , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 2
    • 18844396119 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation: Emergence of a new era in biology and medicine
    • DOI 10.1101/gad.1303605
    • Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005; 19: 1129-1155. (Pubitemid 40696181)
    • (2005) Genes and Development , vol.19 , Issue.10 , pp. 1129-1155
    • Keller, G.1
  • 3
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872. (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 4
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676. (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 5
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • DOI 10.1038/nature05934, PII NATURE05934
    • Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature 2007; 448: 313-317. (Pubitemid 47080336)
    • (2007) Nature , vol.448 , Issue.7151 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 6
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917-1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 8
    • 43749104249 scopus 로고    scopus 로고
    • A chemical approach to stem-cell biology and regenerative medicine
    • DOI 10.1038/nature07042, PII NATURE07042
    • Xu Y, Shi Y, Ding S. A chemical approach to stem-cell biology and regenerative medicine. Nature 2008; 453: 338-344. (Pubitemid 351693140)
    • (2008) Nature , vol.453 , Issue.7193 , pp. 338-344
    • Xu, Y.1    Shi, Y.2    Ding, S.3
  • 9
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998; 12: 2048-2060. (Pubitemid 28323878)
    • (1998) Genes and Development , vol.12 , Issue.13 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 10
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • DOI 10.1016/S0092-8674(03)00847-X
    • Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003; 115: 281-292. (Pubitemid 37487702)
    • (2003) Cell , vol.115 , Issue.3 , pp. 281-292
    • Ying, Q.-L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 12
    • 0034712109 scopus 로고    scopus 로고
    • Out of eden: Stem cells and their niches
    • DOI 10.1126/science.287.5457.1427
    • Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science 2000; 287: 1427-1430. (Pubitemid 30127126)
    • (2000) Science , vol.287 , Issue.5457 , pp. 1427-1430
    • Watt, F.M.1    Hogan, B.L.M.2
  • 13
    • 77956519710 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    • Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345-1348.
    • (2010) Science , vol.329 , pp. 1345-1348
    • Boitano, A.E.1    Wang, J.2    Romeo, R.3
  • 16
    • 77952360137 scopus 로고    scopus 로고
    • Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
    • Xu Y, Zhu X, Hahm HS, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci USA 2010; 107: 8129-8134.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8129-8134
    • Xu, Y.1    Zhu, X.2    Hahm, H.S.3
  • 17
    • 77956243773 scopus 로고    scopus 로고
    • Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells
    • Ohgushi M, Matsumura M, Eiraku M, et al. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 2010; 7: 225-239.
    • (2010) Cell Stem Cell , vol.7 , pp. 225-239
    • Ohgushi, M.1    Matsumura, M.2    Eiraku, M.3
  • 18
    • 77956259698 scopus 로고    scopus 로고
    • Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells
    • Chen G, Hou Z, Gulbranson DR, Thomson JA. Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 2010; 7: 240-248.
    • (2010) Cell Stem Cell , vol.7 , pp. 240-248
    • Chen, G.1    Hou, Z.2    Gulbranson, D.R.3    Thomson, J.A.4
  • 19
    • 42649095149 scopus 로고    scopus 로고
    • Genetic Modification of Human Embryonic Stem Cells for Derivation of Target Cells
    • DOI 10.1016/j.stem.2008.04.003, PII S1934590908001744
    • Giudice A, Trounson A. Genetic modification of human embryonic stem cells for derivation of target cells. Cell Stem Cell 2008; 2: 422-433. (Pubitemid 351598085)
    • (2008) Cell Stem Cell , vol.2 , Issue.5 , pp. 422-433
    • Giudice, A.1    Trounson, A.2
  • 20
    • 47149117047 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells towards hematopoietic cells: Progress and pitfalls
    • Tian X, Kaufman DS. Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfalls. Curr Opin Hematol 2008; 15: 312-318.
    • (2008) Curr Opin Hematol , vol.15 , pp. 312-318
    • Tian, X.1    Kaufman, D.S.2
  • 21
    • 37249066122 scopus 로고    scopus 로고
    • Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
    • DOI 10.1002/dvdy.21366
    • Spence JR, Wells JM. Translational embryology: using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn 2007; 236: 3218-3227. (Pubitemid 350276381)
    • (2007) Developmental Dynamics , vol.236 , Issue.12 , pp. 3218-3227
    • Spence, J.R.1    Wells, J.M.2
  • 22
    • 59849107734 scopus 로고    scopus 로고
    • Human embryonic stem cell differentiation toward regional specific neural precursors
    • Erceg S, Ronaghi M, Stojkovic M. Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells 2009; 27: 78-87.
    • (2009) Stem Cells , vol.27 , pp. 78-87
    • Erceg, S.1    Ronaghi, M.2    Stojkovic, M.3
  • 23
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
    • DOI 10.1016/j.cell.2008.02.008, PII S009286740800216X
    • Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008; 132: 661-680. (Pubitemid 351260059)
    • (2008) Cell , vol.132 , Issue.4 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 24
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002; 110: 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 29
    • 65349086683 scopus 로고    scopus 로고
    • A small molecule primes embryonic stem cells for differentiation
    • Zhu S, Wurdak H, Wang J, et al. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell 2009; 4: 416-426.
    • (2009) Cell Stem Cell , vol.4 , pp. 416-426
    • Zhu, S.1    Wurdak, H.2    Wang, J.3
  • 30
    • 62949210744 scopus 로고    scopus 로고
    • Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells
    • Borowiak M, Maehr R, Chen S, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009; 4: 348-358.
    • (2009) Cell Stem Cell , vol.4 , pp. 348-358
    • Borowiak, M.1    Maehr, R.2    Chen, S.3
  • 31
    • 84870421675 scopus 로고    scopus 로고
    • A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine-and xeno-free conditions
    • Minami I, Yamada K, Otsuji Tomomi G, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine-and xeno-free conditions. Cell Rep 2012; 2: 1448-1460.
    • (2012) Cell Rep , vol.2 , pp. 1448-1460
    • Minami, I.1    Yamada, K.2    Otsuji Tomomi, G.3
  • 32
    • 81255179215 scopus 로고    scopus 로고
    • Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells
    • Gonzalez R, Lee JW, Schultz PG. Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells. Angew Chem Int Ed Engl 2011; 50: 11181-11185.
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 11181-11185
    • Gonzalez, R.1    Lee, J.W.2    Schultz, P.G.3
  • 33
    • 55849115999 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated without viral integration
    • Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008; 322: 945-949.
    • (2008) Science , vol.322 , pp. 945-949
    • Stadtfeld, M.1    Nagaya, M.2    Utikal, J.3    Weir, G.4    Hochedlinger, K.5
  • 34
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322: 949-953.
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 35
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009; 324: 797-801.
    • (2009) Science , vol.324 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3
  • 36
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009; 4: 472-476.
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1    Kim, C.H.2    Moon, J.I.3
  • 37
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009; 4: 381-384.
    • (2009) Cell Stem Cell , vol.4 , pp. 381-384
    • Zhou, H.1    Wu, S.2    Joo, J.Y.3
  • 38
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L, Manos PD, Ahfeldt T, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010; 7: 618-630.
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3
  • 40
    • 54949115497 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
    • Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008; 3: 568-574.
    • (2008) Cell Stem Cell , vol.3 , pp. 568-574
    • Shi, Y.1    Desponts, C.2    Do, J.T.3    Hahm, H.S.4    Scholer, H.R.5    Ding, S.6
  • 41
    • 44349103591 scopus 로고    scopus 로고
    • A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
    • DOI 10.1016/j.stem.2008.05.011, PII S1934590908002257
    • Shi Y, Do JT, Desponts C, Hahm HS, Scholer HR, Ding S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008; 2: 525-528. (Pubitemid 351729222)
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 525-528
    • Shi, Y.1    Tae Do, J.2    Desponts, C.3    Hahm, H.S.4    Scholer, H.R.5    Ding, S.6
  • 42
    • 33645132331 scopus 로고    scopus 로고
    • G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
    • Feldman N, Gerson A, Fang J, et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol 2006; 8: 188-194.
    • (2006) Nat Cell Biol , vol.8 , pp. 188-194
    • Feldman, N.1    Gerson, A.2    Fang, J.3
  • 43
    • 55749104227 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
    • Huangfu D, Osafune K, Maehr R, et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008; 26: 1269-1275.
    • (2008) Nat Biotechnol , vol.26 , pp. 1269-1275
    • Huangfu, D.1    Osafune, K.2    Maehr, R.3
  • 44
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • DOI 10.1038/nbt1418, PII NBT1418
    • Huangfu D, Maehr R, Guo W, et al. Induction of pluripotent stem cells by defined factors is greatly improved by smallmolecule compounds. Nat Biotechnol 2008; 26: 795-797. (Pubitemid 351961456)
    • (2008) Nature Biotechnology , vol.26 , Issue.7 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6    Melton, D.A.7
  • 45
    • 77950965653 scopus 로고    scopus 로고
    • Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes
    • Mali P, Chou B-K, Yen J, et al. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 2010; 28: 713-720.
    • (2010) Stem Cells , vol.28 , pp. 713-720
    • Mali, P.1    Chou, B.-K.2    Yen, J.3
  • 46
    • 73049086022 scopus 로고    scopus 로고
    • Generation of humaninduced pluripotent stem cells in the absence of exogenous Sox2
    • Li W, Zhou H, Abujarour R, et al. Generation of humaninduced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 2009; 27: 2992-3000
    • (2009) Stem Cells , vol.27 , pp. 2992-3000
    • Li, W.1    Zhou, H.2    Abujarour, R.3
  • 47
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • Onder TT, Kara N, Cherry A, et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012; 483: 598-602.
    • (2012) Nature , vol.483 , pp. 598-602
    • Onder, T.T.1    Kara, N.2    Cherry, A.3
  • 48
    • 78649647814 scopus 로고    scopus 로고
    • Reprogramming of human primary somatic cells by OCT4 and chemical compounds
    • Zhu S, Li W, Zhou H, et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010; 7: 651-655.
    • (2010) Cell Stem Cell , vol.7 , pp. 651-655
    • Zhu, S.1    Li, W.2    Zhou, H.3
  • 49
    • 84860531487 scopus 로고    scopus 로고
    • HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
    • Zhou W, Choi M, Margineantu D, et al.HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J 2012; 31: 2103-2116.
    • (2012) EMBO J , vol.31 , pp. 2103-2116
    • Zhou, W.1    Choi, M.2    Margineantu, D.3
  • 50
    • 79959221064 scopus 로고    scopus 로고
    • Energy metabolism in human pluripotent stem cells and their differentiated counterparts
    • Varum S, Rodrigues AS, Moura MB, et al. Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One 2011; 6:e20914.
    • (2011) PLoS One , vol.6
    • Varum, S.1    Rodrigues, A.S.2    Moura, M.B.3
  • 51
    • 84868506826 scopus 로고    scopus 로고
    • Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay
    • Höing S, Rudhard Y, Reinhardt P, et al. Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. Cell Stem Cell 2012; 11: 620-632.
    • (2012) Cell Stem Cell , vol.11 , pp. 620-632
    • Höing, S.1    Rudhard, Y.2    Reinhardt, P.3
  • 52
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • DOI 10.1006/dbio.1999.9265
    • Burdon T, Stracey C, Chambers I, Nichols J, Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999; 210: 30-43. (Pubitemid 29275085)
    • (1999) Developmental Biology , vol.210 , Issue.1 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3    Nichols, J.4    Smith, A.5
  • 54
    • 62549134480 scopus 로고    scopus 로고
    • Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains
    • Yang W, Wei W, Shi C, et al. Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells 2009; 27: 383-389.
    • (2009) Stem Cells , vol.27 , pp. 383-389
    • Yang, W.1    Wei, W.2    Shi, C.3
  • 55
    • 67349183976 scopus 로고    scopus 로고
    • Metastable pluripotent states in NOD-mouse-derived ESCs
    • Hanna J, Markoulaki S, Mitalipova M, et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 2009; 4: 513-524.
    • (2009) Cell Stem Cell , vol.4 , pp. 513-524
    • Hanna, J.1    Markoulaki, S.2    Mitalipova, M.3
  • 56
    • 58049192815 scopus 로고    scopus 로고
    • Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors
    • Li W, Wei W, Zhu S, et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009; 4: 16-19.
    • (2009) Cell Stem Cell , vol.4 , pp. 16-19
    • Li, W.1    Wei, W.2    Zhu, S.3
  • 57
    • 57649181379 scopus 로고    scopus 로고
    • Capture of authentic embryonic stem cells from rat blastocysts
    • Buehr M, Meek S, Blair K, et al. Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008; 135: 1287-1298.
    • (2008) Cell , vol.135 , pp. 1287-1298
    • Buehr, M.1    Meek, S.2    Blair, K.3
  • 58
    • 57649245579 scopus 로고    scopus 로고
    • Germline competent embryonic stem cells derived from rat blastocysts
    • Li P, Tong C, Mehrian-Shai R, et al. Germline competent embryonic stem cells derived from rat blastocysts. Cell 2008; 135: 1299-1310.
    • (2008) Cell , vol.135 , pp. 1299-1310
    • Li, P.1    Tong, C.2    Mehrian-Shai, R.3
  • 59
    • 77956294479 scopus 로고    scopus 로고
    • Generation of genetically modified rats from embryonic stem cells
    • Kawamata M, Ochiya T. Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci USA 2010; 107: 14223-14228.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14223-14228
    • Kawamata, M.1    Ochiya, T.2
  • 62
    • 77952699848 scopus 로고    scopus 로고
    • Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
    • Hanna J, Cheng AW, Saha K, et al. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 2010; 107: 9222-9227.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9222-9227
    • Hanna, J.1    Cheng, A.W.2    Saha, K.3
  • 64
    • 37349052866 scopus 로고    scopus 로고
    • Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
    • DOI 10.1016/j.ydbio.2007.10.003, PII S0012160607014145
    • Smith JR, Vallier L, Lupo G, Alexander M, Harris WA, Pedersen RA. Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol 2008; 313: 107-117. (Pubitemid 350298306)
    • (2008) Developmental Biology , vol.313 , Issue.1 , pp. 107-117
    • Smith, J.R.1    Vallier, L.2    Lupo, G.3    Alexander, M.4    Harris, W.A.5    Pedersen, R.A.6
  • 66
    • 77953912037 scopus 로고    scopus 로고
    • Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity
    • Kim DS, Lee JS, Leem JW, et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev 2010; 6: 270-281.
    • (2010) Stem Cell Rev , vol.6 , pp. 270-281
    • Kim, D.S.1    Lee, J.S.2    Leem, J.W.3
  • 67
    • 79957777958 scopus 로고    scopus 로고
    • Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
    • Li W, Sun W, Zhang Y, et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci USA 2011; 108: 8299-8304.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8299-8304
    • Li, W.1    Sun, W.2    Zhang, Y.3
  • 68
    • 62149083806 scopus 로고    scopus 로고
    • Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    • Mao Y, Ge X, Frank CL, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009; 136: 1017-1031.
    • (2009) Cell , vol.136 , pp. 1017-1031
    • Mao, Y.1    Ge, X.2    Frank, C.L.3
  • 69
    • 80051806451 scopus 로고    scopus 로고
    • GSK-3 is a master regulator of neural progenitor homeostasis
    • Kim WY, Wang X, Wu Y, et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci 2009; 12: 1390-1397.
    • (2009) Nat Neurosci , vol.12 , pp. 1390-1397
    • Kim, W.Y.1    Wang, X.2    Wu, Y.3
  • 70
    • 70350732790 scopus 로고    scopus 로고
    • A chemical platform for improved induction of human iPSCs
    • Lin T, Ambasudhan R, Yuan X, et al. A chemical platform for improved induction of human iPSCs. Nat Meth 2009; 6: 805-808.
    • (2009) Nat Meth , vol.6 , pp. 805-808
    • Lin, T.1    Ambasudhan, R.2    Yuan, X.3
  • 71
    • 73049112178 scopus 로고    scopus 로고
    • Vitamin C enhances the generation of mouse and human induced pluripotent stem cells
    • Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010; 6: 71-79.
    • (2010) Cell Stem Cell , vol.6 , pp. 71-79
    • Esteban, M.A.1    Wang, T.2    Qin, B.3
  • 72
    • 82755187396 scopus 로고    scopus 로고
    • The histone demethylases jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner
    • Wang T, Chen K, Zeng X, et al. The histone demethylases jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 2011; 9: 575-587.
    • (2011) Cell Stem Cell , vol.9 , pp. 575-587
    • Wang, T.1    Chen, K.2    Zeng, X.3
  • 73
    • 84862777034 scopus 로고    scopus 로고
    • Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
    • Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet 2012; 44: 398-405.
    • (2012) Nat Genet , vol.44 , pp. 398-405
    • Stadtfeld, M.1    Apostolou, E.2    Ferrari, F.3
  • 75
    • 62149148156 scopus 로고    scopus 로고
    • Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    • Goessling W, North TE, Loewer S, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009; 136: 1136-1147.
    • (2009) Cell , vol.136 , pp. 1136-1147
    • Goessling, W.1    North, T.E.2    Loewer, S.3
  • 76
    • 84555218139 scopus 로고    scopus 로고
    • Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling
    • Ni Terri T, Rellinger Eric J, Mukherjee A, et al. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol 2011; 18: 1658-1668.
    • (2011) Chem Biol , vol.18 , pp. 1658-1668
    • Ni Terri, T.1    Rellinger Eric, J.2    Mukherjee, A.3
  • 77
    • 84862001481 scopus 로고    scopus 로고
    • Adenosine signaling promotes regeneration of pancreatic β cells in vivo
    • Andersson O, Adams Bruce A, Yoo D, et al. Adenosine signaling promotes regeneration of pancreatic β cells in vivo. Cell Metab 2012; 15: 885-894.
    • (2012) Cell Metab , vol.15 , pp. 885-894
    • Andersson, O.1    Adams Bruce, A.2    Yoo, D.3
  • 78
    • 77954266958 scopus 로고    scopus 로고
    • Discovery of a proneurogenic, neuroprotective chemical
    • Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell 2010; 142: 39-51.
    • (2010) Cell , vol.142 , pp. 39-51
    • Pieper, A.A.1    Xie, S.2    Capota, E.3
  • 79
    • 79551705492 scopus 로고    scopus 로고
    • Development of proneurogenic, neuroprotective small molecules
    • MacMillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc 2011; 133: 1428-1437.
    • (2011) J Am Chem Soc , vol.133 , pp. 1428-1437
    • MacMillan, K.S.1    Naidoo, J.2    Liang, J.3
  • 80
    • 84865229731 scopus 로고    scopus 로고
    • ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities
    • Wang Y, Kim E, Wang X, et al. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell 2012; 150: 816-830.
    • (2012) Cell , vol.150 , pp. 816-830
    • Wang, Y.1    Kim, E.2    Wang, X.3
  • 81
    • 4043117769 scopus 로고    scopus 로고
    • Modulation of hematopoietic stem cell homing and engraftment by CD26
    • DOI 10.1126/science.1097071
    • Christopherson KW, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004; 305: 1000-1003. (Pubitemid 39071774)
    • (2004) Science , vol.305 , Issue.5686 , pp. 1000-1003
    • Christopherson II, K.W.1    Hangoc, G.2    Mantel, C.R.3    Broxmeyer, H.E.4
  • 83
    • 62949195390 scopus 로고    scopus 로고
    • Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction
    • Zaruba M-M, Theiss HD, Vallaster M, et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009; 4: 313-323.
    • (2009) Cell Stem Cell , vol.4 , pp. 313-323
    • Zaruba, M.-M.1    Theiss, H.D.2    Vallaster, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.