-
1
-
-
0035189927
-
Embryo-derived stem cells: Of mice and men
-
DOI 10.1146/annurev.cellbio.17.1.435
-
Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001; 17: 435-462. (Pubitemid 33096183)
-
(2001)
Annual Review of Cell and Developmental Biology
, vol.17
, pp. 435-462
-
-
Smith, A.G.1
-
2
-
-
18844396119
-
Embryonic stem cell differentiation: Emergence of a new era in biology and medicine
-
DOI 10.1101/gad.1303605
-
Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005; 19: 1129-1155. (Pubitemid 40696181)
-
(2005)
Genes and Development
, vol.19
, Issue.10
, pp. 1129-1155
-
-
Keller, G.1
-
3
-
-
36248966518
-
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
-
DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
-
Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872. (Pubitemid 350138099)
-
(2007)
Cell
, vol.131
, Issue.5
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
4
-
-
33747195353
-
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
-
DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676. (Pubitemid 44233629)
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
5
-
-
34249880066
-
Generation of germline-competent induced pluripotent stem cells
-
DOI 10.1038/nature05934, PII NATURE05934
-
Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature 2007; 448: 313-317. (Pubitemid 47080336)
-
(2007)
Nature
, vol.448
, Issue.7151
, pp. 313-317
-
-
Okita, K.1
Ichisaka, T.2
Yamanaka, S.3
-
6
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917-1920.
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
-
7
-
-
34249908901
-
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
-
DOI 10.1038/nature05944, PII NATURE05944
-
Wernig M, Meissner A, Foreman R, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007; 448: 318-324. (Pubitemid 47080337)
-
(2007)
Nature
, vol.448
, Issue.7151
, pp. 318-324
-
-
Wernig, M.1
Meissner, A.2
Foreman, R.3
Brambrink, T.4
Ku, M.5
Hochedlinger, K.6
Bernstein, B.E.7
Jaenisch, R.8
-
8
-
-
43749104249
-
A chemical approach to stem-cell biology and regenerative medicine
-
DOI 10.1038/nature07042, PII NATURE07042
-
Xu Y, Shi Y, Ding S. A chemical approach to stem-cell biology and regenerative medicine. Nature 2008; 453: 338-344. (Pubitemid 351693140)
-
(2008)
Nature
, vol.453
, Issue.7193
, pp. 338-344
-
-
Xu, Y.1
Shi, Y.2
Ding, S.3
-
9
-
-
0032127977
-
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
-
Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998; 12: 2048-2060. (Pubitemid 28323878)
-
(1998)
Genes and Development
, vol.12
, Issue.13
, pp. 2048-2060
-
-
Niwa, H.1
Burdon, T.2
Chambers, I.3
Smith, A.4
-
10
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
-
DOI 10.1016/S0092-8674(03)00847-X
-
Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003; 115: 281-292. (Pubitemid 37487702)
-
(2003)
Cell
, vol.115
, Issue.3
, pp. 281-292
-
-
Ying, Q.-L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
11
-
-
33751239783
-
Self-renewal of embryonic stem cells by a small molecule
-
DOI 10.1073/pnas.0608156103
-
Chen S, Do JT, Zhang Q, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA 2006; 103: 17266-17271. (Pubitemid 44788958)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.46
, pp. 17266-17271
-
-
Chen, S.1
Do, J.T.2
Zhang, Q.3
Yao, S.4
Yan, F.5
Peters, E.C.6
Scholer, H.R.7
Schultz, P.G.8
Ding, S.9
-
12
-
-
0034712109
-
Out of eden: Stem cells and their niches
-
DOI 10.1126/science.287.5457.1427
-
Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science 2000; 287: 1427-1430. (Pubitemid 30127126)
-
(2000)
Science
, vol.287
, Issue.5457
, pp. 1427-1430
-
-
Watt, F.M.1
Hogan, B.L.M.2
-
13
-
-
77956519710
-
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
-
Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345-1348.
-
(2010)
Science
, vol.329
, pp. 1345-1348
-
-
Boitano, A.E.1
Wang, J.2
Romeo, R.3
-
14
-
-
84865564924
-
An image-based screen identifies a small molecule regulator of megakaryopoiesis
-
Boitano AE, de Lichtervelde L, Snead JL, Cooke MP, Schultz PG. An image-based screen identifies a small molecule regulator of megakaryopoiesis. Proc Natl Acad Sci USA 2012; 109: 14019-14023.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 14019-14023
-
-
Boitano, A.E.1
De Lichtervelde, L.2
Snead, J.L.3
Cooke, M.P.4
Schultz, P.G.5
-
15
-
-
34250206996
-
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
-
DOI 10.1038/nbt1310, PII NBT1310
-
Watanabe K, Ueno M, Kamiya D, et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 2007; 25: 681-686. (Pubitemid 46897207)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.6
, pp. 681-686
-
-
Watanabe, K.1
Ueno, M.2
Kamiya, D.3
Nishiyama, A.4
Matsumura, M.5
Wataya, T.6
Takahashi, J.B.7
Nishikawa, S.8
Nishikawa, S.-I.9
Muguruma, K.10
Sasai, Y.11
-
16
-
-
77952360137
-
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
-
Xu Y, Zhu X, Hahm HS, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci USA 2010; 107: 8129-8134.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 8129-8134
-
-
Xu, Y.1
Zhu, X.2
Hahm, H.S.3
-
17
-
-
77956243773
-
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells
-
Ohgushi M, Matsumura M, Eiraku M, et al. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 2010; 7: 225-239.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 225-239
-
-
Ohgushi, M.1
Matsumura, M.2
Eiraku, M.3
-
18
-
-
77956259698
-
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells
-
Chen G, Hou Z, Gulbranson DR, Thomson JA. Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 2010; 7: 240-248.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 240-248
-
-
Chen, G.1
Hou, Z.2
Gulbranson, D.R.3
Thomson, J.A.4
-
19
-
-
42649095149
-
Genetic Modification of Human Embryonic Stem Cells for Derivation of Target Cells
-
DOI 10.1016/j.stem.2008.04.003, PII S1934590908001744
-
Giudice A, Trounson A. Genetic modification of human embryonic stem cells for derivation of target cells. Cell Stem Cell 2008; 2: 422-433. (Pubitemid 351598085)
-
(2008)
Cell Stem Cell
, vol.2
, Issue.5
, pp. 422-433
-
-
Giudice, A.1
Trounson, A.2
-
20
-
-
47149117047
-
Differentiation of embryonic stem cells towards hematopoietic cells: Progress and pitfalls
-
Tian X, Kaufman DS. Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfalls. Curr Opin Hematol 2008; 15: 312-318.
-
(2008)
Curr Opin Hematol
, vol.15
, pp. 312-318
-
-
Tian, X.1
Kaufman, D.S.2
-
21
-
-
37249066122
-
Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
-
DOI 10.1002/dvdy.21366
-
Spence JR, Wells JM. Translational embryology: using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn 2007; 236: 3218-3227. (Pubitemid 350276381)
-
(2007)
Developmental Dynamics
, vol.236
, Issue.12
, pp. 3218-3227
-
-
Spence, J.R.1
Wells, J.M.2
-
22
-
-
59849107734
-
Human embryonic stem cell differentiation toward regional specific neural precursors
-
Erceg S, Ronaghi M, Stojkovic M. Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells 2009; 27: 78-87.
-
(2009)
Stem Cells
, vol.27
, pp. 78-87
-
-
Erceg, S.1
Ronaghi, M.2
Stojkovic, M.3
-
23
-
-
39349106325
-
Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
-
DOI 10.1016/j.cell.2008.02.008, PII S009286740800216X
-
Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008; 132: 661-680. (Pubitemid 351260059)
-
(2008)
Cell
, vol.132
, Issue.4
, pp. 661-680
-
-
Murry, C.E.1
Keller, G.2
-
24
-
-
0037047320
-
Directed differentiation of embryonic stem cells into motor neurons
-
Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002; 110: 385-397.
-
(2002)
Cell
, vol.110
, pp. 385-397
-
-
Wichterle, H.1
Lieberam, I.2
Porter, J.A.3
Jessell, T.M.4
-
25
-
-
13844271605
-
Specification of motoneurons from human embryonic stem cells
-
DOI 10.1038/nbt1063
-
Li XJ, Du ZW, Zarnowska ED, et al. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 2005; 23: 215-221. (Pubitemid 40255332)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.2
, pp. 215-221
-
-
Li, X.-J.1
Du, Z.-W.2
Zarnowska, E.D.3
Pankratz, M.4
Hansen, L.O.5
Pearce, R.A.6
Zhang, S.-C.7
-
26
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
DOI 10.1038/nbt1393, PII NBT1393
-
Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008; 26: 443-452. (Pubitemid 351501814)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.4
, pp. 443-452
-
-
Kroon, E.1
Martinson, L.A.2
Kadoya, K.3
Bang, A.G.4
Kelly, O.G.5
Eliazer, S.6
Young, H.7
Richardson, M.8
Smart, N.G.9
Cunningham, J.10
Agulnick, A.D.11
D'Amour, K.A.12
Carpenter, M.K.13
Baetge, E.E.14
-
27
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
DOI 10.1038/nbt1259, PII NBT1259
-
D'Amour KA, Bang AG, Eliazer S, et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006; 24: 1392-1401. (Pubitemid 44722103)
-
(2006)
Nature Biotechnology
, vol.24
, Issue.11
, pp. 1392-1401
-
-
D'Amour, K.A.1
Bang, A.G.2
Eliazer, S.3
Kelly, O.G.4
Agulnick, A.D.5
Smart, N.G.6
Moorman, M.A.7
Kroon, E.8
Carpenter, M.K.9
Baetge, E.E.10
-
28
-
-
44349175948
-
+ embryonic-stem-cell-derived population
-
DOI 10.1038/nature06894, PII NATURE06894
-
Yang L, Soonpaa MH, Adler ED, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stemcell-derived population. Nature 2008; 453: 524-528. (Pubitemid 351733312)
-
(2008)
Nature
, vol.453
, Issue.7194
, pp. 524-528
-
-
Yang, L.1
Soonpaa, M.H.2
Adler, E.D.3
Roepke, T.K.4
Kattman, S.J.5
Kennedy, M.6
Henckaerts, E.7
Bonham, K.8
Abbott, G.W.9
Linden, R.M.10
Field, L.J.11
Keller, G.M.12
-
29
-
-
65349086683
-
A small molecule primes embryonic stem cells for differentiation
-
Zhu S, Wurdak H, Wang J, et al. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell 2009; 4: 416-426.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 416-426
-
-
Zhu, S.1
Wurdak, H.2
Wang, J.3
-
30
-
-
62949210744
-
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells
-
Borowiak M, Maehr R, Chen S, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009; 4: 348-358.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 348-358
-
-
Borowiak, M.1
Maehr, R.2
Chen, S.3
-
31
-
-
84870421675
-
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine-and xeno-free conditions
-
Minami I, Yamada K, Otsuji Tomomi G, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine-and xeno-free conditions. Cell Rep 2012; 2: 1448-1460.
-
(2012)
Cell Rep
, vol.2
, pp. 1448-1460
-
-
Minami, I.1
Yamada, K.2
Otsuji Tomomi, G.3
-
32
-
-
81255179215
-
Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells
-
Gonzalez R, Lee JW, Schultz PG. Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells. Angew Chem Int Ed Engl 2011; 50: 11181-11185.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 11181-11185
-
-
Gonzalez, R.1
Lee, J.W.2
Schultz, P.G.3
-
33
-
-
55849115999
-
Induced pluripotent stem cells generated without viral integration
-
Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008; 322: 945-949.
-
(2008)
Science
, vol.322
, pp. 945-949
-
-
Stadtfeld, M.1
Nagaya, M.2
Utikal, J.3
Weir, G.4
Hochedlinger, K.5
-
34
-
-
55849117368
-
Generation of mouse induced pluripotent stem cells without viral vectors
-
Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322: 949-953.
-
(2008)
Science
, vol.322
, pp. 949-953
-
-
Okita, K.1
Nakagawa, M.2
Hyenjong, H.3
Ichisaka, T.4
Yamanaka, S.5
-
35
-
-
65649116572
-
Human induced pluripotent stem cells free of vector and transgene sequences
-
Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009; 324: 797-801.
-
(2009)
Science
, vol.324
, pp. 797-801
-
-
Yu, J.1
Hu, K.2
Smuga-Otto, K.3
-
36
-
-
66049143859
-
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
-
Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009; 4: 472-476.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 472-476
-
-
Kim, D.1
Kim, C.H.2
Moon, J.I.3
-
37
-
-
66049135249
-
Generation of induced pluripotent stem cells using recombinant proteins
-
Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009; 4: 381-384.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 381-384
-
-
Zhou, H.1
Wu, S.2
Joo, J.Y.3
-
38
-
-
77958536106
-
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
-
Warren L, Manos PD, Ahfeldt T, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010; 7: 618-630.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 618-630
-
-
Warren, L.1
Manos, P.D.2
Ahfeldt, T.3
-
39
-
-
33846783261
-
Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase
-
DOI 10.1016/j.molcel.2007.01.017, PII S1097276507000408
-
Kubicek S, O'Sullivan RJ, August EM, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 2007; 25: 473-481. (Pubitemid 46206139)
-
(2007)
Molecular Cell
, vol.25
, Issue.3
, pp. 473-481
-
-
Kubicek, S.1
O'Sullivan, R.J.2
August, E.M.3
Hickey, E.R.4
Zhang, Q.5
Teodoro, MiguelL.6
Rea, S.7
Mechtler, K.8
Kowalski, J.A.9
Homon, C.A.10
Kelly, T.A.11
Jenuwein, T.12
-
40
-
-
54949115497
-
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
-
Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008; 3: 568-574.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 568-574
-
-
Shi, Y.1
Desponts, C.2
Do, J.T.3
Hahm, H.S.4
Scholer, H.R.5
Ding, S.6
-
41
-
-
44349103591
-
A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
-
DOI 10.1016/j.stem.2008.05.011, PII S1934590908002257
-
Shi Y, Do JT, Desponts C, Hahm HS, Scholer HR, Ding S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008; 2: 525-528. (Pubitemid 351729222)
-
(2008)
Cell Stem Cell
, vol.2
, Issue.6
, pp. 525-528
-
-
Shi, Y.1
Tae Do, J.2
Desponts, C.3
Hahm, H.S.4
Scholer, H.R.5
Ding, S.6
-
42
-
-
33645132331
-
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
-
Feldman N, Gerson A, Fang J, et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol 2006; 8: 188-194.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 188-194
-
-
Feldman, N.1
Gerson, A.2
Fang, J.3
-
43
-
-
55749104227
-
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
-
Huangfu D, Osafune K, Maehr R, et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008; 26: 1269-1275.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1269-1275
-
-
Huangfu, D.1
Osafune, K.2
Maehr, R.3
-
44
-
-
46949085597
-
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
-
DOI 10.1038/nbt1418, PII NBT1418
-
Huangfu D, Maehr R, Guo W, et al. Induction of pluripotent stem cells by defined factors is greatly improved by smallmolecule compounds. Nat Biotechnol 2008; 26: 795-797. (Pubitemid 351961456)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.7
, pp. 795-797
-
-
Huangfu, D.1
Maehr, R.2
Guo, W.3
Eijkelenboom, A.4
Snitow, M.5
Chen, A.E.6
Melton, D.A.7
-
45
-
-
77950965653
-
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes
-
Mali P, Chou B-K, Yen J, et al. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 2010; 28: 713-720.
-
(2010)
Stem Cells
, vol.28
, pp. 713-720
-
-
Mali, P.1
Chou, B.-K.2
Yen, J.3
-
46
-
-
73049086022
-
Generation of humaninduced pluripotent stem cells in the absence of exogenous Sox2
-
Li W, Zhou H, Abujarour R, et al. Generation of humaninduced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 2009; 27: 2992-3000
-
(2009)
Stem Cells
, vol.27
, pp. 2992-3000
-
-
Li, W.1
Zhou, H.2
Abujarour, R.3
-
47
-
-
84859218238
-
Chromatin-modifying enzymes as modulators of reprogramming
-
Onder TT, Kara N, Cherry A, et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012; 483: 598-602.
-
(2012)
Nature
, vol.483
, pp. 598-602
-
-
Onder, T.T.1
Kara, N.2
Cherry, A.3
-
48
-
-
78649647814
-
Reprogramming of human primary somatic cells by OCT4 and chemical compounds
-
Zhu S, Li W, Zhou H, et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010; 7: 651-655.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 651-655
-
-
Zhu, S.1
Li, W.2
Zhou, H.3
-
49
-
-
84860531487
-
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
-
Zhou W, Choi M, Margineantu D, et al.HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J 2012; 31: 2103-2116.
-
(2012)
EMBO J
, vol.31
, pp. 2103-2116
-
-
Zhou, W.1
Choi, M.2
Margineantu, D.3
-
50
-
-
79959221064
-
Energy metabolism in human pluripotent stem cells and their differentiated counterparts
-
Varum S, Rodrigues AS, Moura MB, et al. Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One 2011; 6:e20914.
-
(2011)
PLoS One
, vol.6
-
-
Varum, S.1
Rodrigues, A.S.2
Moura, M.B.3
-
51
-
-
84868506826
-
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay
-
Höing S, Rudhard Y, Reinhardt P, et al. Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. Cell Stem Cell 2012; 11: 620-632.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 620-632
-
-
Höing, S.1
Rudhard, Y.2
Reinhardt, P.3
-
52
-
-
0033152966
-
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
-
DOI 10.1006/dbio.1999.9265
-
Burdon T, Stracey C, Chambers I, Nichols J, Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999; 210: 30-43. (Pubitemid 29275085)
-
(1999)
Developmental Biology
, vol.210
, Issue.1
, pp. 30-43
-
-
Burdon, T.1
Stracey, C.2
Chambers, I.3
Nichols, J.4
Smith, A.5
-
53
-
-
44349170450
-
The ground state of embryonic stem cell self-renewal
-
DOI 10.1038/nature06968, PII NATURE06968
-
Ying QL, Wray J, Nichols J, et al. The ground state of embryonic stem cell self-renewal. Nature 2008; 453: 519-523. (Pubitemid 351733324)
-
(2008)
Nature
, vol.453
, Issue.7194
, pp. 519-523
-
-
Ying, Q.-L.1
Wray, J.2
Nichols, J.3
Batlle-Morera, L.4
Doble, B.5
Woodgett, J.6
Cohen, P.7
Smith, A.8
-
54
-
-
62549134480
-
Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains
-
Yang W, Wei W, Shi C, et al. Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells 2009; 27: 383-389.
-
(2009)
Stem Cells
, vol.27
, pp. 383-389
-
-
Yang, W.1
Wei, W.2
Shi, C.3
-
55
-
-
67349183976
-
Metastable pluripotent states in NOD-mouse-derived ESCs
-
Hanna J, Markoulaki S, Mitalipova M, et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 2009; 4: 513-524.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 513-524
-
-
Hanna, J.1
Markoulaki, S.2
Mitalipova, M.3
-
56
-
-
58049192815
-
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors
-
Li W, Wei W, Zhu S, et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009; 4: 16-19.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 16-19
-
-
Li, W.1
Wei, W.2
Zhu, S.3
-
57
-
-
57649181379
-
Capture of authentic embryonic stem cells from rat blastocysts
-
Buehr M, Meek S, Blair K, et al. Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008; 135: 1287-1298.
-
(2008)
Cell
, vol.135
, pp. 1287-1298
-
-
Buehr, M.1
Meek, S.2
Blair, K.3
-
58
-
-
57649245579
-
Germline competent embryonic stem cells derived from rat blastocysts
-
Li P, Tong C, Mehrian-Shai R, et al. Germline competent embryonic stem cells derived from rat blastocysts. Cell 2008; 135: 1299-1310.
-
(2008)
Cell
, vol.135
, pp. 1299-1310
-
-
Li, P.1
Tong, C.2
Mehrian-Shai, R.3
-
59
-
-
77956294479
-
Generation of genetically modified rats from embryonic stem cells
-
Kawamata M, Ochiya T. Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci USA 2010; 107: 14223-14228.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14223-14228
-
-
Kawamata, M.1
Ochiya, T.2
-
60
-
-
34447528757
-
New cell lines from mouse epiblast share defining features with human embryonic stem cells
-
DOI 10.1038/nature05972, PII NATURE05972
-
Tesar PJ, Chenoweth JG, Brook FA, et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007; 448: 196-199. (Pubitemid 47067378)
-
(2007)
Nature
, vol.448
, Issue.7150
, pp. 196-199
-
-
Tesar, P.J.1
Chenoweth, J.G.2
Brook, F.A.3
Davies, T.J.4
Evans, E.P.5
Mack, D.L.6
Gardner, R.L.7
McKay, R.D.G.8
-
61
-
-
34447527158
-
Derivation of pluripotent epiblast stem cells from mammalian embryos
-
DOI 10.1038/nature05950, PII NATURE05950
-
Brons IG, Smithers LE, Trotter MW, et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007; 448: 191-195. (Pubitemid 47067373)
-
(2007)
Nature
, vol.448
, Issue.7150
, pp. 191-195
-
-
Brons, I.G.M.1
Smithers, L.E.2
Trotter, M.W.B.3
Rugg-Gunn, P.4
Sun, B.5
Chuva De Sousa Lopes, S.M.6
Howlett, S.K.7
Clarkson, A.8
Ahrlund-Richter, L.9
Pedersen, R.A.10
Vallier, L.11
-
62
-
-
77952699848
-
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
-
Hanna J, Cheng AW, Saha K, et al. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 2010; 107: 9222-9227.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 9222-9227
-
-
Hanna, J.1
Cheng, A.W.2
Saha, K.3
-
63
-
-
0037019332
-
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
-
DOI 10.1038/nature00900
-
Kim JH, Auerbach JM, Rodriguez-Gomez JA, et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002; 418: 50-56. (Pubitemid 34742566)
-
(2002)
Nature
, vol.418
, Issue.6893
, pp. 50-56
-
-
Kim, J.-H.1
Auerbach, J.M.2
Rodriguez-Gomez, J.A.3
Velasco, I.4
Gavin, D.5
Lumelsky, N.6
Lee, S.-H.7
Nguyen, J.8
Sanchez-Pernaute, R.9
Bankiewicz, K.10
McKay, R.11
-
64
-
-
37349052866
-
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
-
DOI 10.1016/j.ydbio.2007.10.003, PII S0012160607014145
-
Smith JR, Vallier L, Lupo G, Alexander M, Harris WA, Pedersen RA. Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol 2008; 313: 107-117. (Pubitemid 350298306)
-
(2008)
Developmental Biology
, vol.313
, Issue.1
, pp. 107-117
-
-
Smith, J.R.1
Vallier, L.2
Lupo, G.3
Alexander, M.4
Harris, W.A.5
Pedersen, R.A.6
-
65
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
Chambers SM, Fasano CA, Papapetrou EP, Tomishima M, Sadelain M, Studer L. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009; 27: 275-280.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
Fasano, C.A.2
Papapetrou, E.P.3
Tomishima, M.4
Sadelain, M.5
Studer, L.6
-
66
-
-
77953912037
-
Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity
-
Kim DS, Lee JS, Leem JW, et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev 2010; 6: 270-281.
-
(2010)
Stem Cell Rev
, vol.6
, pp. 270-281
-
-
Kim, D.S.1
Lee, J.S.2
Leem, J.W.3
-
67
-
-
79957777958
-
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
-
Li W, Sun W, Zhang Y, et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci USA 2011; 108: 8299-8304.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 8299-8304
-
-
Li, W.1
Sun, W.2
Zhang, Y.3
-
68
-
-
62149083806
-
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
-
Mao Y, Ge X, Frank CL, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009; 136: 1017-1031.
-
(2009)
Cell
, vol.136
, pp. 1017-1031
-
-
Mao, Y.1
Ge, X.2
Frank, C.L.3
-
69
-
-
80051806451
-
GSK-3 is a master regulator of neural progenitor homeostasis
-
Kim WY, Wang X, Wu Y, et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci 2009; 12: 1390-1397.
-
(2009)
Nat Neurosci
, vol.12
, pp. 1390-1397
-
-
Kim, W.Y.1
Wang, X.2
Wu, Y.3
-
70
-
-
70350732790
-
A chemical platform for improved induction of human iPSCs
-
Lin T, Ambasudhan R, Yuan X, et al. A chemical platform for improved induction of human iPSCs. Nat Meth 2009; 6: 805-808.
-
(2009)
Nat Meth
, vol.6
, pp. 805-808
-
-
Lin, T.1
Ambasudhan, R.2
Yuan, X.3
-
71
-
-
73049112178
-
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells
-
Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010; 6: 71-79.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 71-79
-
-
Esteban, M.A.1
Wang, T.2
Qin, B.3
-
72
-
-
82755187396
-
The histone demethylases jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner
-
Wang T, Chen K, Zeng X, et al. The histone demethylases jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 2011; 9: 575-587.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 575-587
-
-
Wang, T.1
Chen, K.2
Zeng, X.3
-
73
-
-
84862777034
-
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
-
Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet 2012; 44: 398-405.
-
(2012)
Nat Genet
, vol.44
, pp. 398-405
-
-
Stadtfeld, M.1
Apostolou, E.2
Ferrari, F.3
-
74
-
-
34250883337
-
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
-
DOI 10.1038/nature05883, PII NATURE05883
-
North TE, Goessling W, Walkley CR, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 2007; 447: 1007-1011. (Pubitemid 46975751)
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1007-1011
-
-
North, T.E.1
Goessling, W.2
Walkley, C.R.3
Lengerke, C.4
Kopani, K.R.5
Lord, A.M.6
Weber, G.J.7
Bowman, T.V.8
Jang, I.-H.9
Grosser, T.10
Fitzgerald, G.A.11
Daley, G.Q.12
Orkin, S.H.13
Zon, L.I.14
-
75
-
-
62149148156
-
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
-
Goessling W, North TE, Loewer S, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009; 136: 1136-1147.
-
(2009)
Cell
, vol.136
, pp. 1136-1147
-
-
Goessling, W.1
North, T.E.2
Loewer, S.3
-
76
-
-
84555218139
-
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling
-
Ni Terri T, Rellinger Eric J, Mukherjee A, et al. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol 2011; 18: 1658-1668.
-
(2011)
Chem Biol
, vol.18
, pp. 1658-1668
-
-
Ni Terri, T.1
Rellinger Eric, J.2
Mukherjee, A.3
-
77
-
-
84862001481
-
Adenosine signaling promotes regeneration of pancreatic β cells in vivo
-
Andersson O, Adams Bruce A, Yoo D, et al. Adenosine signaling promotes regeneration of pancreatic β cells in vivo. Cell Metab 2012; 15: 885-894.
-
(2012)
Cell Metab
, vol.15
, pp. 885-894
-
-
Andersson, O.1
Adams Bruce, A.2
Yoo, D.3
-
78
-
-
77954266958
-
Discovery of a proneurogenic, neuroprotective chemical
-
Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell 2010; 142: 39-51.
-
(2010)
Cell
, vol.142
, pp. 39-51
-
-
Pieper, A.A.1
Xie, S.2
Capota, E.3
-
79
-
-
79551705492
-
Development of proneurogenic, neuroprotective small molecules
-
MacMillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc 2011; 133: 1428-1437.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 1428-1437
-
-
MacMillan, K.S.1
Naidoo, J.2
Liang, J.3
-
80
-
-
84865229731
-
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities
-
Wang Y, Kim E, Wang X, et al. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell 2012; 150: 816-830.
-
(2012)
Cell
, vol.150
, pp. 816-830
-
-
Wang, Y.1
Kim, E.2
Wang, X.3
-
81
-
-
4043117769
-
Modulation of hematopoietic stem cell homing and engraftment by CD26
-
DOI 10.1126/science.1097071
-
Christopherson KW, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004; 305: 1000-1003. (Pubitemid 39071774)
-
(2004)
Science
, vol.305
, Issue.5686
, pp. 1000-1003
-
-
Christopherson II, K.W.1
Hangoc, G.2
Mantel, C.R.3
Broxmeyer, H.E.4
-
82
-
-
0041327804
-
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
-
DOI 10.1016/S0140-6736(03)14232-8
-
Askari AT, Unzek S, Popovic ZB, et al. Effect of stromalcell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003; 362: 697-703. (Pubitemid 37101067)
-
(2003)
Lancet
, vol.362
, Issue.9385
, pp. 697-703
-
-
Askari, A.T.1
Unzek, S.2
Popovic, Z.B.3
Goldman, C.K.4
Forudi, F.5
Kiedrowski, M.6
Rovner, A.7
Ellis, S.G.8
Thomas, J.D.9
DiCorleto, P.E.10
Topol, E.J.11
Penn, M.S.12
-
83
-
-
62949195390
-
Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction
-
Zaruba M-M, Theiss HD, Vallaster M, et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009; 4: 313-323.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 313-323
-
-
Zaruba, M.-M.1
Theiss, H.D.2
Vallaster, M.3
|