An image-based screen identifies a small molecule regulator of megakaryopoiesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages 14019-14023

  Boitano, Anthony E ^a,b   De Lichtervelde, Lorenzo ^a   Snead, Jennifer L ^b   Cooke, Michael P ^b   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; FIBRINOGEN RECEPTOR; NAPHTHYRIDINE DERIVATIVE; NAPHTHYRIDINONE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR CC; PLATELET DERIVED GROWTH FACTOR DD; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CD34 SELECTION; CELL DIFFERENTIATION; CELL EXPANSION; CELL GROWTH; CELL POPULATION; CELL SIZE; COLONY FORMING UNIT; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MYELOID PROGENITOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA;

ANTIGENS, CD34; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEGAKARYOCYTES; MICROSCOPY, CONFOCAL; NAPHTHYRIDINES; PLOIDIES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; THROMBOPOIESIS;

EID: 84865564924     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212545109     Document Type: Article

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