메뉴 건너뛰기




Volumn 5, Issue 1, 2013, Pages

Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone

Author keywords

Apoptosis; Gene expression; Islets; Pioglitazone; PPAR

Indexed keywords

CASPASE 3; GLUCOSE; PIOGLITAZONE; PROTEIN BCL 2; RNA;

EID: 84871995957     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-5-1     Document Type: Article
Times cited : (7)

References (49)
  • 1
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Kahn SE, Diabetologia 2003 46 3 19 12637977 (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 2
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • The natural history of insulin secretory disfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Weyer C, Bogardus C, Mott DM, Pratley RE, J Clin Invest 1999 104 787 794 10.1172/JCI7231 10491414 (Pubitemid 29536364)
    • (1999) Journal of Clinical Investigation , vol.104 , Issue.6 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 4
    • 0036724346 scopus 로고    scopus 로고
    • Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women
    • Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women. Buchanan TA, Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, Ochoa C, Tan S, Berkowitz K, Hodis HN, Azen SP, Diabetes 2002 51 2796 2803 10.2337/diabetes.51.9.2796 12196473 (Pubitemid 34970933)
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2796-2803
    • Buchanan, T.A.1    Xiang, A.H.2    Peters, R.K.3    Kjos, S.L.4    Marroquin, A.5    Goico, J.6    Ochoa, C.7    Tan, S.8    Berkowitz, K.9    Hodis, H.N.10    Azen, S.P.11
  • 5
    • 0036517099 scopus 로고    scopus 로고
    • Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes
    • DOI 10.2337/diacare.25.3.517
    • Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Miyazaki CY, Matsuda M, DeFronzo R, Diabetes Care 2002 25 517 523 10.2337/diacare.25.3.517 11874940 (Pubitemid 41103346)
    • (2002) Diabetes Care , vol.25 , Issue.3 , pp. 517-523
    • Miyazaki, Y.1    Matsuda, M.2    DeFronzo, R.A.3
  • 6
    • 10344248699 scopus 로고    scopus 로고
    • Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes
    • DOI 10.1210/jc.2004-0705
    • Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes. Smith SA, Porter LE, Biswas N, Freed MI, J Clin Endocrinol Metabol 2004 89 6048 6053 10.1210/jc.2004-0705 (Pubitemid 39628413)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6048-6053
    • Smith, S.A.1    Porter, L.E.2    Biswas, N.3    Freed, M.I.4
  • 7
    • 0035042679 scopus 로고    scopus 로고
    • β-Cell mass dynamics in Zucker diabetic fatty rats: Rosiglitazone prevents the rise in net cell death
    • Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death. Finegood DT, McArthur MD, Kojwang D, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE, Diabetes 2001 50 1021 1029 10.2337/diabetes.50.5.1021 11334404 (Pubitemid 32374532)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1021-1029
    • Finegood, D.T.1    McArthur, M.D.2    Kojwang, D.3    Thomas, M.J.4    Topp, B.G.5    Leonard, T.6    Buckingham, R.E.7
  • 9
    • 7044260753 scopus 로고    scopus 로고
    • Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-γ-deficient mice on a high-fat diet
    • DOI 10.2337/diabetes.53.11.2844
    • Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor gamma- deficient mice on a high-fat diet. Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T, Diabetes 2004 53 2844 2854 10.2337/diabetes.53.11.2844 15504964 (Pubitemid 39425909)
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2844-2854
    • Matsui, J.1    Terauchi, Y.2    Kubota, N.3    Takamoto, I.4    Eto, K.5    Yamashita, T.6    Komeda, K.7    Yamauchi, T.8    Kamon, J.9    Kita, S.10    Noda, M.11    Kadowaki, T.12
  • 10
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
    • DOI 10.1074/jbc.273.6.3547
    • Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. Shimabukuro M, Zhou Y, Lee Y, Unger RH, J Biol Chem 1998 273 6 3547 3550 10.1074/jbc.273.6.3547 9452481 (Pubitemid 28109778)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.6 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.-T.2    Lee, Y.3    Unger, R.H.4
  • 11
    • 45449118936 scopus 로고    scopus 로고
    • Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic β-cells
    • DOI 10.1111/j.1463-1326.2007.00749.x
    • Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Saitoh Y, Chun-ping C, Noma K, Ueno H, Mizuta M, Nakazato M, Diabetes Obes Metab 2008 10 7 564 573 10.1111/j.1463-1326.2007. 00749.x 17593232 (Pubitemid 351850900)
    • (2008) Diabetes, Obesity and Metabolism , vol.10 , Issue.7 , pp. 564-573
    • Saitoh, Y.1    Chun-ping, C.2    Noma, K.3    Ueno, H.4    Mizuta, M.5    Nakazato, M.6
  • 12
    • 0037219411 scopus 로고    scopus 로고
    • β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC, Diabetes 2003 52 102 110 10.2337/diabetes.52.1.102 12502499 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 13
    • 0141755328 scopus 로고    scopus 로고
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    • DOI 10.2337/diabetes.52.10.2461
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Kashyap S, Belfort R, Castaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K, Diabetes 2003 52 2461 2474 10.2337/diabetes.52.10.2461 14514628 (Pubitemid 37210533)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2461-2474
    • Kashyap, S.1    Belfort, R.2    Gastaldelli, A.3    Pratipanawatr, T.4    Berria, R.5    Pratipanawatr, W.6    Bajaj, M.7    Mandarino, L.8    DeFronzo, R.9    Cusi, K.10
  • 14
    • 33947149143 scopus 로고    scopus 로고
    • β-Cell preservation with thiazolidinediones
    • DOI 10.1016/j.diabres.2006.08.015, PII S0168822706003834
    • Beta-cell preservation with thiazolidinediones. Campbell IW, Mariz S, Diabetes Res Clin Pract 2007 76 163 176 10.1016/j.diabres.2006.08.015 17052795 (Pubitemid 46402950)
    • (2007) Diabetes Research and Clinical Practice , vol.76 , Issue.2 , pp. 163-176
    • Campbell, I.W.1    Mariz, S.2
  • 15
    • 6344265234 scopus 로고    scopus 로고
    • Pioglitazone and sodium salicylate protect human β-cells against apoptosis and impaired function induced by glucose and interleukin-1β
    • DOI 10.1210/jc.2004-0446
    • Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA, J Clin Endocrinol Metabol 2004 89 5059 5066 10.1210/jc.2004-0446 (Pubitemid 39391449)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.10 , pp. 5059-5066
    • Zeender, E.1    Maedler, K.2    Bosco, D.3    Berney, T.4    Donath, M.Y.5    Halban, P.A.6
  • 16
    • 80054888506 scopus 로고    scopus 로고
    • Mechanism for antioxidative effects of thiazolidinediones in pancreatic β-cells
    • 10.1152/ajpendo.00120.2011 21846907
    • Mechanism for antioxidative effects of thiazolidinediones in pancreatic β-cells. Chung SS, Kim M, Lee JS, Ahn BY, Jung HS, Lee HM, Park KS, Am J Physiol Endocrinol Metab 2011 301 5 912 E921 10.1152/ajpendo.00120.2011 21846907
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , Issue.5
    • Chung, S.S.1    Kim, M.2    Lee, J.S.3    Ahn, B.Y.4    Jung, H.S.5    Lee, H.M.6    Park, K.S.7
  • 17
    • 84856262896 scopus 로고    scopus 로고
    • PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress
    • 10.1210/me.2011-1181 22240811
    • PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. Kono T, Ahn G, Moss DR, Gann L, Zarain-Herzberg A, Nishiki Y, Fueger PT, Ogihara T, Evans-Molina C, Mol Endocrinol 2012 26 2 257 271 10.1210/me.2011-1181 22240811
    • (2012) Mol Endocrinol , vol.26 , Issue.2 , pp. 257-271
    • Kono, T.1    Ahn, G.2    Moss, D.R.3    Gann, L.4    Zarain-Herzberg, A.5    Nishiki, Y.6    Fueger, P.T.7    Ogihara, T.8    Evans-Molina, C.9
  • 18
    • 0036535976 scopus 로고    scopus 로고
    • Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity
    • DOI 10.1016/S0006-2952(02)00860-2, PII S0006295202008602
    • Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity. Cnop M, Hannaert JC, Pipeleers DG, Biochem Pharmacol 2002 63 1281 1285 10.1016/S0006-2952(02)00860-2 11960604 (Pubitemid 34311996)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.7 , pp. 1281-1285
    • Cnop, M.1    Hannaert, J.C.2    Pipeleers, D.G.3
  • 19
    • 0038772154 scopus 로고    scopus 로고
    • PPAR-γ overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells
    • DOI 10.1016/S0006-291X(03)01045-3
    • PPAR-gamma overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells. Nakamichi Y, Kikuta T, Ito E, Ohara-Imaizumi M, Nishiwaki C, Ishida H, Nagamatsu S, Biochem Biophys Res Commun 2003 306 4 832 836 10.1016/S0006- 291X(03)01045-3 12821117 (Pubitemid 36776206)
    • (2003) Biochemical and Biophysical Research Communications , vol.306 , Issue.4 , pp. 832-836
    • Nakamichi, Y.1    Kikuta, T.2    Ito, E.3    Ohara-Imaizumi, M.4    Nishiwaki, C.5    Ishida, H.6    Nagamatsu, S.7
  • 20
    • 0014042613 scopus 로고
    • Method for the isolation of intact islets of Langerhans from the rat pancreas
    • 5333500
    • Method for the isolation of intact islets of Langerhans from the rat pancreas. Lacy PE, Kostianovsky M, Diabetes 1967 16 35 39 5333500
    • (1967) Diabetes , vol.16 , pp. 35-39
    • Lacy, P.E.1    Kostianovsky, M.2
  • 21
  • 23
    • 4544341015 scopus 로고    scopus 로고
    • Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
    • Article 3. Available at: http://www.bepress.com/sagmb/vol3/iss1/art3. (Accessed on December, 15th, 2007)
    • Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments. Smyth GK, Stat Appl Genet Mol Biol 2004 3 1 Article 3. Available at: http://www.bepress.com/sagmb/vol3/iss1/art3. (Accessed on December, 15th, 2007)
    • (2004) Stat Appl Genet Mol Biol , vol.3 , Issue.1
    • Smyth, G.K.1
  • 25
    • 1542505287 scopus 로고    scopus 로고
    • RAD and the RAD study-annotator: An approach to collection, organization and exchange of all relevant information for high-throughput gene expression studies
    • DOI 10.1093/bioinformatics/btg428
    • RAD and the RAD Study-Annotator: an approach to collection, organization and exchange of all relevant information for high-throughput gene expression studies. Manduchi E, Grant GR, He H, Liu J, Mailman MD, Pizarro AD, Whetzel PL, Stoeckert CJ Jr, Bioinformatics 2004 20 4 452 459 10.1093/bioinformatics/btg428 14990441 (Pubitemid 38344324)
    • (2004) Bioinformatics , vol.20 , Issue.4 , pp. 452-459
    • Manduchi, E.1    Grant, G.R.2    He, H.3    Liu, J.4    Mailman, M.D.5    Pizarro, A.D.6    Whetzel, P.L.7    Stoeckert Jr., C.J.8
  • 26
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • 10.1186/gb-2002-3-7-research0034
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F, Genome Biol 2002 3 7 esearch0034.1 research0034.11 10.1186/gb-2002-3-7-research0034
    • (2002) Genome Biol , vol.3 , Issue.7
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2 Delta Delta C T method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 33646850389 scopus 로고    scopus 로고
    • Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets
    • Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets. Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M, Chin Med J 2006 119 7 574 580 16620699 (Pubitemid 43796863)
    • (2006) Chinese Medical Journal , vol.119 , Issue.7 , pp. 574-580
    • Tian, J.-Y.1    Li, G.2    Gu, Y.-Y.3    Zhang, H.-L.4    Zhou, W.-Z.5    Wang, X.6    Zhu, H.-D.7    Luo, T.-H.8    Luo, M.9
  • 31
    • 20944444283 scopus 로고    scopus 로고
    • Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-γ
    • DOI 10.2337/diabetes.54.5.1379
    • Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. Risérus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F, Diabetes 2005 54 5 1379 1384 10.2337/diabetes.54.5.1379 15855323 (Pubitemid 40586667)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1379-1384
    • Riserus, U.1    Tan, G.D.2    Fielding, B.A.3    Neville, M.J.4    Currie, J.5    Savage, D.B.6    Chatterjee, V.K.7    Frayn, K.N.8    O'Rahilly, S.9    Karpe, F.10
  • 32
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • DOI 10.1016/S0092-8674(00)81359-8
    • Adipogenesis and Obesity: Rounding Out the Big Picture. Spiegelman BM, Flier JS, Cell 1996 87 377 389 10.1016/S0092-8674(00)81359-8 8898192 (Pubitemid 26374313)
    • (1996) Cell , vol.87 , Issue.3 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 33
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Regulation of Peroxisome Proliferator-Activated Receptor g Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism. Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J, Molecular Cell Biology 1999 19 8 5495 5503 (Pubitemid 29339907)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.8 , pp. 5495-5503
    • Fajas, L.1    Schoonjans, K.2    Gelman, L.3    Kim, J.B.4    Najib, J.5    Martin, G.6    Fruchart, J.-C.7    Briggs, M.8    Spiegelman, B.M.9    Auwerx, J.10
  • 34
    • 0037162719 scopus 로고    scopus 로고
    • Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    • DOI 10.1016/S0092-8674(02)00872-3
    • Crucial Step in Cholesterol Homeostasis: Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER. Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS, Cell 2002 110 489 500 10.1016/S0092-8674(02)00872-3 12202038 (Pubitemid 35232292)
    • (2002) Cell , vol.110 , Issue.4 , pp. 489-500
    • Yang, T.1    Espenshade, P.J.2    Wright, M.E.3    Yabe, D.4    Gong, Y.5    Aebersold, R.6    Goldstein, J.L.7    Brown, M.S.8
  • 35
    • 3042781392 scopus 로고    scopus 로고
    • Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1
    • DOI 10.2337/diabetes.53.7.1733
    • Hormone-Sensitive Lipase Has a Role in Lipid Signaling for Insulin Secretion but Is Nonessential for the Incretin Action of Glucagon-Like Peptide 1. Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M, Diabetes 2004 53 1733 1742 10.2337/diabetes.53.7.1733 15220197 (Pubitemid 38857031)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1733-1742
    • Peyot, M.-L.1    Nolan, C.J.2    Soni, K.3    Joly, E.4    Lussier, R.5    Corkey, B.E.6    Wang, S.P.7    Mitchell, G.A.8    Prentki, M.9
  • 36
    • 0036895729 scopus 로고    scopus 로고
    • Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of β-Cells
    • 12475771
    • Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of β-Cells. Schuit F, Flamez D, De Vos A, Pipeleers D, Diabetes 2002 51 Suppl. 3 326 S332 12475771
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Schuit, F.1    Flamez, D.2    De Vos, A.3    Pipeleers, D.4
  • 37
    • 2342423022 scopus 로고    scopus 로고
    • In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions
    • DOI 10.1074/jbc.M311786200
    • In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. Miao F, Gonzalo IG, Lanting L, Natarajan R, J Biol Chem 2004 279 17 18091 18097 10.1074/jbc.M311786200 14976218 (Pubitemid 38560579)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 18091-18097
    • Miao, F.1    Gonzalo, I.G.2    Lanting, L.3    Natarajan, R.4
  • 38
    • 64649092274 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure
    • 10.1128/MCB.01179-08
    • Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG, Molecular Cell Biology Apr 2009 29 8 2053 2067 10.1128/MCB.01179-08
    • (2009) Molecular Cell Biology Apr , vol.29 , Issue.8 , pp. 2053-2067
    • Evans-Molina, C.1    Robbins, R.D.2    Kono, T.3    Tersey, S.A.4    Vestermark, G.L.5    Nunemaker, C.S.6    Garmey, J.C.7    Deering, T.G.8    Keller, S.R.9    Maier, B.10    Mirmira, R.G.11
  • 39
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1 carbon monoxide: From basic science to therapeutic applications
    • 10.1152/physrev.00011.2005 16601269
    • Heme oxygenase-1 carbon monoxide: from basic science to therapeutic applications. Ryter SW, Alam J, Choi AM, Physiol Rev 2006 86 583 650 10.1152/physrev.00011.2005 16601269
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 40
    • 0027293874 scopus 로고
    • Repair of pancreatic ß-cells: A relevant phenomenon in early IDDM
    • 10.2337/diabetes.42.10.1383 8375580
    • Repair of pancreatic ß-cells: a relevant phenomenon in early IDDM. Eizirik DL, Sandler S, Palmer JP, Diabetes 1993 42 1383 1389 10.2337/diabetes.42.10.1383 8375580
    • (1993) Diabetes , vol.42 , pp. 1383-1389
    • Eizirik, D.L.1    Sandler, S.2    Palmer, J.P.3
  • 41
    • 47749122129 scopus 로고    scopus 로고
    • Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
    • 10.1007/s00018-008-8100-8 18560759
    • Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities. Abaraviciene SM, Lundquist I, Salehi A, Cell Mol Life Sci 2008 65 14 2256 2265 10.1007/s00018-008-8100-8 18560759
    • (2008) Cell Mol Life Sci , vol.65 , Issue.14 , pp. 2256-2265
    • Abaraviciene, S.M.1    Lundquist, I.2    Salehi, A.3
  • 42
    • 65549099050 scopus 로고    scopus 로고
    • Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to lipotoxicity
    • 10.1002/dmrr.896 23451284
    • Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to lipotoxicity. Ghanaat-Pour H, Sjöholm A, Diabetes & Metabolism Rev 2009 25 2 163 184 10.1002/dmrr.896 23451284
    • (2009) Diabetes & Metabolism Rev , vol.25 , Issue.2 , pp. 163-184
    • Ghanaat-Pour, H.1    Sjöholm, A.2
  • 44
    • 37549055777 scopus 로고    scopus 로고
    • PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets
    • 10.1016/j.bbrc.2007.12.088 18155663
    • PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets. Vandewalle B, Moerman E, Lefebvre B, Defrance F, Gmyr V, Lukowiak B, Kerr Conte J, Pattou F, Biochem Biophys Res Commun 2008 366 4 1096 1101 10.1016/j.bbrc.2007.12.088 18155663
    • (2008) Biochem Biophys Res Commun , vol.366 , Issue.4 , pp. 1096-1101
    • Vandewalle, B.1    Moerman, E.2    Lefebvre, B.3    Defrance, F.4    Gmyr, V.5    Lukowiak, B.6    Kerr Conte, J.7    Pattou, F.8
  • 45
    • 85011526556 scopus 로고    scopus 로고
    • Troglitazone (CS-045) inhibits β-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells
    • DOI 10.1210/en.139.1.172
    • Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells Endocrinology. Ohtani KI, Shimizu H, Sato N, Mori M, Jan 1998 139 1 172 178 (Pubitemid 28166306)
    • (1998) Endocrinology , vol.139 , Issue.1 , pp. 172-178
    • Ohtani, K.-I.1    Shimizu, H.2    Sato, N.3    Mori, M.4
  • 46
    • 74949113575 scopus 로고    scopus 로고
    • Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: Evidence for acute and chronic actions as a PPARgamma agonist
    • 10.1152/ajpendo.00388.2009 19920213
    • Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist. Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K, Am J Physiol Endocrinol Metab 2010 298 2 278 E286 10.1152/ajpendo.00388.2009 19920213
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.2
    • Kanda, Y.1    Shimoda, M.2    Hamamoto, S.3    Tawaramoto, K.4    Kawasaki, F.5    Hashiramoto, M.6    Nakashima, K.7    Matsuki, M.8    Kaku, K.9
  • 47
    • 0038236522 scopus 로고    scopus 로고
    • Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and β-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat
    • DOI 10.1046/j.1365-2613.2003.00337.x
    • Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and β-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat. Pickavance LC, Widdowson PS, Foste JR, Williams G, Wilding JPH, Int J Exp Pathol 2003 84 83 89 10.1046/j.1365-2613. 2003.00337.x 12801282 (Pubitemid 36754273)
    • (2003) International Journal of Experimental Pathology , vol.84 , Issue.2 , pp. 83-89
    • Pickavance, L.C.1    Widdowson, P.S.2    Foster, J.R.3    Williams, G.4    Wilding, J.P.H.5
  • 48
    • 28744444020 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3′-kinase-dependent pathway
    • DOI 10.1210/jc.2005-0079
    • Activation of Peroxisome Proliferator-Activated Receptor-γ by Rosiglitazone Protects Human Islet Cells against Human Islet Amyloid Polypeptide Toxicity by a Phosphatidylinositol 3-Kinase-Dependent Pathway. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC, J Clin Endocrinol Metabol 2005 90 12 6678 6686 10.1210/jc.2005-0079 (Pubitemid 41759332)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.12 , pp. 6678-6686
    • Lin, C.-Y.1    Gurlo, T.2    Haataja, L.3    Hsueh, W.A.4    Butler, P.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.