Antibacterial drug leads targeting isoprenoid biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 123-128

  Zhu, Wei ^a   Zhang, Yonghui ^b   Sinko, William ^c   Hensler, Mary E ^c   Olson, Joshua ^c   Molohon, Katie J ^a   Lindert, Steffen ^c   Cao, Rong ^a   Li, Kai ^b   Wang, Ke ^b   Wang, Yang ^b   Liu, Yi Liang ^a   Sankovsky, Anna ^b   De Oliveira, CésarAugusto F ^c   Mitchell, Douglas A ^a,b   Nizet, Victor ^c   McCammon, J Andrew ^c   Oldfield, Eric ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug discovery; in silico high throughput screening; Peptidoglycan; Protein structure

Indexed keywords

AMIDINE; AMINE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BENZOIC ACID DERIVATIVE; ENZYME INHIBITOR; ISOPRENOID; METICILLIN; OXOACID; PHOSPHONIC ACID DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; UNDECAPRENYL DIPHOSPHATE SYNTHASE; UNDECAPRENYL DIPHOSPHATE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL CELL WALL; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENTEROCOCCUS FAECIUM; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTI-BACTERIAL AGENTS; BENZOATES; BIOSYNTHETIC PATHWAYS; CELL WALL; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHONATES; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; METHICILLIN; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINONES; STAPHYLOCOCCUS AUREUS; TERPENES;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 84871983896     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219899110     Document Type: Article

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