Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases

Journal of Biomedicine and Biotechnology

Volumn 2008, Issue 1, 2008, Pages

  Kuo, Chih Jung ^a,b   Guo, Rey Ting ^a,b   Lu, I Lin ^c   Liu, Hun Ge ^d   Wu, Su Ying ^c   Ko, Tzu Ping ^d   Wang, Andrew H J ^a,b,d   Liang, Po Huang ^a,b,d  

^a ACADEMIA SINICA   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FARNESYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE; PEPTIDOGLYCAN; SYNTHETASE; UNDECAPRENYL PYROPHOSPHATE SYNTHASE; UNDECAPRENYL PYROPHOSPHATE SYNTHASE INHIBITOR; DECAPRENYLTRANSFERASE; TRANSFERASE;

ARTICLE; BIOSYNTHESIS; CATALYST; COMPUTER MODEL; CRYSTAL STRUCTURE; DATA BASE; DRUG MECHANISM; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; HELICOBACTER PYLORI; NONHUMAN; POLYMERIZATION; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME STABILITY; ENZYMOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HELICOBACTER PYLORI;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; ESCHERICHIA COLI; HELICOBACTER PYLORI; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 42949132874     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2008/841312     Document Type: Article

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