Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 24, 2007, Pages 10022-10027

  Guo, Rey Ting ^a,b,c   Cao, Rong ^d   Liang, Po Huang ^a,b,c   Ko, Tzu Ping ^b   Chang, Tao Hsin ^a,c   Hudock, Michael P ^d   Jeng, Wen Yih ^a,b   Chen, Cammy K M ^a,c   Zhang, Yonghui ^d   Song, Yongcheng ^d   Kuo, Chih Jung ^a,b,c   Yin, Fenglin ^d   Oldfield, Eric ^d   Wang, Andrew H J ^a,b,c  

^a ACADEMIA SINICA   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cell wall; Geranylgeranyl diphosphate synthase; Undecaprenyl diphosphate synthase; X ray structure

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; BPH 364; BPH 629; BPH 675; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; GERANYLGERANYL PYROPHOSPHATE; GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; ISOPRENOID PHOSPHATE; MINODRONIC ACID; SYNTHETASE; UNCLASSIFIED DRUG; UNDECAPRENYL DIPHOSPHATE SYNTHASE; ZOLEDRONIC ACID; CIS PRENYL TRANSFERASE; CIS-PRENYL TRANSFERASE; DECAPRENYLTRANSFERASE; DITERPENE; GERANYL DIPHOSPHATE; ISOENZYME; LIGAND; PYROPHOSPHATE; SESQUITERPENE; TRANSFERASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMICAL MODEL; CHEMISTRY; DIMERIZATION; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; HYDROPHOBICITY; METABOLISM; PROTEIN SECONDARY STRUCTURE; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DIPHOSPHATES; DIPHOSPHONATES; DITERPENES; FARNESYLTRANSTRANSFERASE; HYDROPHOBICITY; ISOENZYMES; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYISOPRENYL PHOSPHATES; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TRANSFERASES;

EID: 34547231214     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702254104     Document Type: Article

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