Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: Evidence for disruption of cell wall biosynthesis

Journal of Antimicrobial Chemotherapy

Volumn 62, Issue 4, 2008, Pages 720-729

  Mott, John E ^a   Shaw, Bailin A ^a   Smith, James F ^a   Bonin, Paul D ^a   Romero, Donna L ^a,b   Marotti, Keith R ^a   Miller, Alita A ^a  

^a PFIZER INC   (United States)

^b Pharma Vation Consulting LLC   (United States)

Author keywords

Antibiotic discovery; HTS; Staphylococcus aureus

Indexed keywords

AMPICILLIN; ANTHRANILIC ACID DERIVATIVE; ANTIBIOTIC AGENT; BACTERIAL POLYSACCHARIDE; CHLORAMPHENICOL; CLINDAMYCIN; ERYTHROMYCIN; KANAMYCIN; LINEZOLID; MEMBRANE PROTEIN; NALIDIXIC ACID; NEOMYCIN; NORFLOXACIN; NOVOBIOCIN; PROTEIN SYNTHESIS INHIBITOR; SPECTINOMYCIN; STREPTOMYCIN; TETRACYCLINE; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BIOCHEMISTRY; BIOSYNTHESIS; CELL WALL; CONTROLLED STUDY; CROSS RESISTANCE; DRUG MECHANISM; GENE MAPPING; HIGH THROUGHPUT SCREENING; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTHRANILIC ACIDS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL WALL; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENES, ESSENTIAL; MEMBRANE PROTEINS; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; TRANSDUCTION, GENETIC;

EID: 52949091593     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn261     Document Type: Article

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