Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: Roles of the metal ion and conserved residues in catalysis

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20762-20774

  Guo, Rey Ting ^a,b,c   Ko, Tzu Ping ^b   Chen, Annie P C ^b,c   Kuo, Chih Jung ^b   Wang, Andrew H J ^a,b,c   Liang, Po Huang ^a,b,c  

^a ACADEMIA SINICA   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CHEMICAL BONDS; CONCENTRATION (PROCESS); CONDENSATION REACTIONS; CRYSTAL STRUCTURE; LIPIDS;

CIS-DOUBLE BONDS; FARNESYL PYROPHOSPHATE (FPP); LIPID CARRIER; UNDECAPRENYL PYROPHOSPHATE SYNTHASE (UPP);

ENZYMES;

ACID; APOENZYME; ARGININE; ASPARAGINE; ASPARTIC ACID; BASE; CARBOXYLIC ACID; FARNESYL THIOPYROPHOSPHATE; HISTIDINE; ISOPENTYL PYROPHOSPHATE; MAGNESIUM; METAL ION; MUTANT PROTEIN; PEPTIDOGLYCAN; PYROPHOSPHORIC ACID DERIVATIVE; SERINE; SYNTHETASE; TYLOXAPOL; UNCLASSIFIED DRUG; UNDECAPRENYL PYROPHOSPHATE SYNTHASE;

ARTICLE; BACTERIAL CELL WALL; CHEMICAL BOND; CIS ISOMER; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; ENZYME MECHANISM; ESCHERICHIA COLI; IONIZATION; LIPID TRANSPORT; MUTATION; POLYMERIZATION; PRIORITY JOURNAL; WILD TYPE;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CELL WALL; CONSERVED SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HEMITERPENES; HYDROGEN BONDING; KINETICS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDOGLYCAN; POLYISOPRENYL PHOSPHATES; PROTEIN FOLDING; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 20144382151     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502121200     Document Type: Article

References (36)

1. Kellogg, B. A., and Poulter, C. D. (1997) Curr. Opin. Chem. Biol. 1, 570-578
2. Ogura, K., Koyama, T., and Sagami, H. (1997) Subcell. Biochem. 28, 57-88
3. Ogura, K., and Koyama, T. (1998) Chem. Rev. 98, 1263-1276
4. Liang, P. H., Ko, T. P., and Wang, A. H.-J. (2002) Eur. J. Biochem. 269, 3339-3354
5. Asai, K.-I., Fujisaki, S., Nishimura, Y., Nishino, T., Okada, K., Nakagawa, T., Kawamukai, M., and Matsuda, H. (1994) Biochem. Biophys. Res. Commun. 202, 340-345
6. Pan, J. J., Kuo, T. H., Chen, Y. K., Yang, L. W., and Liang, P. H. (2002) Biochim. Biophys. Acta 1594, 64-73
7. Allen, C. M. (1985) Methods Enzymol. 110, 281-299
8. Robyt, J. (1998) in Essentials of Carbohydrate Chemistry, pp. 305-318, Springer-Verlag, New York
9. Shimizu, N., Koyama, T., and Ogura, K. (1998) J. Biol. Chem. 273, 19476-19481
10. Apfel, C. M., Takacs, B., Fountoulakis, M., Stieger, M., and Keck, W. (1999) J. Bacteriol. 181, 483-492
11. Guo, R. T., Kuo, C. J., Chou, C. C., Ko, T. P., Shr, H. L., Liang, P. H., and Wang, A. H.-J. (2004) J. Biol. Chem. 279, 4903-4912
12. Guo, R. T., Kuo, C. J., Ko, T. P., Chou, C. C., Liang, P. H., and Wang, A. H.-J. (2004) Biochemistry 43, 7678-7686
13. Fujihashi, M., Zhang, Y.-W., Higuchi, Y., Li, X.-Y., Koyama, T., and Miki, K. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4337-4342
14. Ko, T. P., Chen, Y. K., Robinson, H., Tsai, P. C., Gao, Y.-G., Chen, A. P.-C., Wang, A. H.-J., and Liang, P. H. (2001) J. Biol. Chem. 276, 47474-47482
15. Chang, S. Y., Ko, T. P., Liang, P. H., and Wang, A. H.-J. (2003) J. Biol. Chem. 278, 29298-29307
16. Chang, S. Y., Ko, T. P., Chen, A. P.-C., Wang, A. H.-J., and Liang, P. H. (2004) Protein Sci. 13, 971-978
17. Poulter, C. D., Argyle, J. C., and Mash, E. A. (1977) J. Am. Chem. Soc. 99, 957-959
18. Joly, A., and Edwards, P. A. (1993) J. Biol. Chem. 268, 26983-26989
19. Chen, A., Kroon, P. A., and Poulter, C. D. (1994) Protein Sci. 3, 600-607
20. Hosfield, D. J., Zhang, Y., Dougan, D. R., Broun, A., Tari, L. W., Swanson, R. V., and Finn, J. (2004) J. Biol. Chem. 279, 8526-8529
21. Chen, Y. H., Chen, A. P., Chen, C. T., Wang, A. H.-J., and Liang, P. H. (2002) J. Biol. Chem. 277, 7369-7376
22. Chang, S. Y., Chen, Y. K., Wang, A. H.-J., and Liang, P. H. (2003) Biochemistry 42, 14452-14459
23. Pan, J. J., Chiou, S. T., and Liang, P. H. (2000) Biochemistry 39, 10936-10942
24. Pan, J. J., Yang, L. W., and Liang, P. H. (2000) Biochemistry 39, 13856-13861
25. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
26. Brunger, A. T. (1993) Acta Crystallogr. Sect. D Biol. Crystallogr. 49, 24-36
27. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., GrosseKunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
28. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 392-400
29. Barton, G. J. (1993) Protein Eng. 6, 37-40
30. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
31. Esnouf, R. M. (1997) J. Mol. Graph. 15, 132-134
32. Merrit, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873
33. King, H. L., and Rilling, H. C. (1977) Biocehmistry 16, 3815-3819
34. Chen, A. P.-C., Chang, S. Y., Lin, Y. C., Sun, Y. S., Chen, C. T., Wang, A. H.-J., and Liang, P. H. (2005) Biochem. J. 386, 169-176
35. Fujikura, K., Zhang, W.-Y., Fujihashi, M., Miki, K., and Koyama, T. (2003) Biochemistry 42, 4035-4041
36. da Costa, B. M. T., Keasling, J. D., and Cornish, K. (2005) Macromolecules 6, 279-289