Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging

Nuclear Medicine and Biology

Volumn 40, Issue 1, 2013, Pages 126-134

  Liu, Yongjuan ^a   Yu, Haijing ^a   Zhao, Lingzhou ^a   Zhang, Huabei ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

Author keywords

4 2 nAChRs; 3D QSAR; CADD; HPLC; Iodine 125; Molecular docking; Single photon emission computed tomography (SPECT)

Indexed keywords

3 ((2 PYRIDIN 2 YL)METHOXY) 5 IODOPYRIDINE; 3 ((2 PYRROLIDIN 2 YL) METHOXY) 5 ((4 IODOBENZYLOXY)METHYL)PYRIDINE; IODINE 125; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN REGION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MOLECULAR DOCKING; MOLECULAR IMAGING; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RADIOACTIVITY; RADIOCHEMISTRY; RAT; THALAMUS; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IODINE RADIOISOTOPES; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; PYRIDINES; RECEPTORS, NICOTINIC; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84871923181     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.09.005     Document Type: Article

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