New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3′-iodo-5′-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6168-6170

  Gao, Yongjun ^a   Horti, Andrew G ^a   Kuwabara, Hiroto ^a   Ravert, Hayden T ^a   Holt, Daniel P ^a   Kumar, Anil ^a   Alexander, Mohab ^a   Wong, Dean F ^a   Dannals, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C 11; Enantiomers; nAChR; Positron emission tomography (PET)

Indexed keywords

7 METHYL 2 EXO (3' IODO 5' PYRIDINYL) 7 AZABICYCLO[2.2.1]HEPTANE; EPIBATIDINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BABOON; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG UPTAKE; ENANTIOSELECTIVITY; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOISOTOPE DISTRIBUTION; THALAMUS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPTANES; LIGANDS; MICE; MOLECULAR STRUCTURE; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC; STEREOISOMERISM;

PAPIO; RODENTIA;

EID: 55549115005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.012     Document Type: Article

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