Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2797-2802

  Holladay, Mark W ^a,b   Bai, Hao ^a   Li, Yihong ^a   Lin, Nan Horng ^a   Daanen, Jerome F ^a   Ryther, Keith B ^a   Wasicak, James T ^a   Kincaid, John F ^a   He, Yun ^a   Hettinger, Anne Marie ^a   Huang, Peggy ^a   Anderson, David J ^a   Bannon, Anthony W ^a   Buckley, Michael J ^a   Campbell, Jeffrey E ^a   Donnelly Roberts, Diana L ^a   Gunther, Karen L ^a   Kim, David J B ^a   Kuntzweiler, Theresa A ^a   Sullivan, James P ^a   Decker, Michael W ^a   Arneric, Stephen P ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b SIDDCO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; ANALGESIC AGENT; AZETIDINE DERIVATIVE; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; HOT PLATE TEST; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANALGESICS, NON-NARCOTIC; ANIMALS; AZETIDINES; AZOCINES; BINDING SITES; BRAIN; MICE; NICOTINIC AGONISTS; PAIN MEASUREMENT; PYRIDINES; QUINOLIZINES; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

ANIMALIA;

EID: 18544402515     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00504-6     Document Type: Article

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