Prediction of distribution of neutral, acidic and basic structurally diverse compounds between blood and brain by the nonlinear methodology

Medicinal Chemistry

Volumn 4, Issue 2, 2008, Pages 170-189

  Zhang, Huabei ^a   Hu, Shaoping ^a   Zhang, Yaling ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Absorption; Blood brain barrier; Correlation coefficients; Distribution; LogBB; Nonlinear regression analysis; PKa; QSAR model; Weight fraction

Indexed keywords

ACIDITY; ALKALINITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VOLUME; CONCENTRATION RESPONSE; CORRELATION COEFFICIENT; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RESEARCH; NONLINEAR REGRESSION ANALYSIS; ORGAN DISTRIBUTION; PRIORITY JOURNAL; BIOAVAILABILITY; HUMAN; PHARMACOKINETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TECHNIQUE;

BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; HUMANS; METHODS; PHARMACOKINETICS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42949127304     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608783789103     Document Type: Article

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