Seek and destroy: The ubiquitin-proteasome system in cardiac disease

Current Hypertension Reports

Volumn 11, Issue 6, 2009, Pages 396-405

  Willis, Monte S ^a   Rodríoguez, Jessica E ^b   Schisler, Jonathan C ^b   Patterson, Cam ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; DAXX PROTEIN; DEXAMETHASONE; INSULIN; MUSCLE RING FINGER 1 PROTEIN; MUSCLE RING FINGER 2 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; RING FINGER PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR GATA 4; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

CARDIOMYOPATHY; CONFORMATIONAL TRANSITION; CONTINUOUS INFUSION; DIABETES MELLITUS; DNA REPAIR; ENDOCYTOSIS; HEART DISEASE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; QUALITY CONTROL; REPERFUSION INJURY; REVIEW; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANIMALS; CARDIOMEGALY; CARDIOMYOPATHIES; DIABETES COMPLICATIONS; DISEASE MODELS, ANIMAL; HEART DISEASES; HUMANS; MICE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 72549108344     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-009-0069-7     Document Type: Review

References (67)

1. K.D. Wilkinson 1997 Regulation of ubiquitin-dependent processes by deubiquitinating enzymes FASEB J 11 1245 1256 1:CAS:528:DyaK2sXnvVKksr0%3D 9409543
2. H.T. Kim K.P. Kim F. Lledias, et al. 2007 Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages J Biol Chem 282 17375 17386 10.1074/jbc.M609659200 1:CAS:528:DC%2BD2sXmt1eksLY%3D 17426036 (Pubitemid 47100279)
3. H.T. Kim K.P. Kim T. Uchiki, et al. 2009 S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains EMBO J 28 1867 1877 10.1038/emboj.2009.115 1:CAS:528:DC%2BD1MXkvV2ju78%3D 19387488
4. E. Leithe E. Rivedal 2004 Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment J Biol Chem 279 50089 50096 10.1074/jbc.M402006200 1:CAS:528:DC%2BD2cXhtVWjs7vI 15371442 (Pubitemid 39577820)
5. E. Leithe E. Rivedal 2004 Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43 J Cell Sci 117 1211 1220 10.1242/jcs.00951 1:CAS:528: DC%2BD2cXjsVyqs7k%3D 14970263 (Pubitemid 38456102)
6. H. Huang C.A. Joazeiro E. Bonfoco, et al. 2000 The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7 J Biol Chem 275 26661 26664 1:CAS:528:DC%2BD3cXmsVWrt7k%3D 10862606
7. H.P. Jennissen M. Laub 1988 Ubiquitin-calmodulin conjugating activity from cardiac muscle Biol Chem Hoppe Seyler 369 1325 1330 1:CAS:528: DyaL1MXhtlSqtL4%3D 2853950
8. J. Peng D. Schwartz J.E. Elias, et al. 2003 A proteomics approach to understanding protein ubiquitination Nat Biotechnol 21 921 926 10.1038/nbt849 1:CAS:528:DC%2BD3sXlvVKgur0%3D 12872131 (Pubitemid 36936199)
9. P. Xu J. Peng 2006 Dissecting the ubiquitin pathway by mass spectrometry Biochim Biophys Acta 1764 1940 1947 1:CAS:528:DC%2BD28XhtlaltL3N 17055348
10. T. Tenno K. Fujiwara H. Tochio, et al. 2004 Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains Genes Cells 9 865 875 10.1111/j.1365-2443.2004.00780.x 1:CAS:528:DC%2BD2cXovVekt7s%3D 15461659 (Pubitemid 39369020)
11. R. Varadan M. Assfalg A. Haririnia, et al. 2004 Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling J Biol Chem 279 7055 7063 10.1074/jbc.M309184200 1:CAS:528:DC%2BD2cXht1Cks7Y%3D 14645257 (Pubitemid 38248851)
12. H.H. Li M.S. Willis P. Lockyer, et al. 2007 Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of forkhead proteins J Clin Invest 117 3211 3223 10.1172/JCI31757 1:CAS:528:DC%2BD2sXht12isrzF 17965779 (Pubitemid 350096979)
13. P. Xie S. Guo Y. Fan, et al. 2009 Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation J Biol Chem 284 5488 5496 10.1074/jbc.M806487200 1:CAS:528:DC%2BD1MXitFSntbs%3D 19117950
14. M.S. Willis J.C. Schisler C. Patterson 2008 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease Future Cardiol 4 65 75 10.2217/14796678.4.1.65 1:CAS:528:DC%2BD2sXhsVChu7jF 19543439
15. C. Zhang Z. Xu X.R. He, et al. 2005 CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice Am J Physiol Heart Circ Physiol 288 H2836 H2842 10.1152/ajpheart.01122.2004 1:CAS:528:DC%2BD2MXlsVyntL0%3D 15665051 (Pubitemid 40720665)
16. J. Fielitz E. van Rooij J.A. Spencer, et al. 2007 Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction Proc Natl Acad Sci U S A 104 4377 4382 10.1073/pnas.0611726104 1:CAS:528:DC%2BD2sXjsFGitrg%3D 17360532 (Pubitemid 47186234)
17. J. Fielitz M.S. Kim J.M. Shelton, et al. 2007 Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3 J Clin Invest 117 2486 2495 10.1172/JCI32827 1:CAS:528:DC%2BD2sXhtVCms7vL 17786241 (Pubitemid 47494350)
18. J.N. Min R.A. Whaley N.E. Sharpless, et al. 2008 CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control Mol Cell Biol 28 4018 4025 10.1128/MCB.00296-08 1:CAS:528:DC%2BD1cXntFanu7w%3D 18411298 (Pubitemid 351812987)
19. M.S. Willis J.C. Schisler A.L. Portbury C. Patterson 2009 Build it up-Tear it down: protein quality control in the cardiac sarcomere Cardiovasc Res 81 439 448 10.1093/cvr/cvn289 1:CAS:528:DC%2BD1MXhtlKiurg%3D 18974044
20. R. Arya V. Kedar J.R. Hwang, et al. 2004 Muscle ring finger protein- 1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy J Cell Biol 167 1147 1159 10.1083/jcb.200402033 1:CAS:528:DC%2BD2MXmsVSr 15596539 (Pubitemid 40066629)
21. M.S. Willis C. Ike L. Li, et al. 2007 Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo Circ Res 100 456 459 10.1161/01.RES.0000259559.48597.32 1:CAS:528:DC%2BD2sXitFyltr0%3D 17272810 (Pubitemid 46673255)
22. M.S. Willis M. Rojas L. Li, et al. 2009 Muscle ring finger 1 mediates cardiac atrophy in vivo Am J Physiol Heart Circ Physiol 296 H997 H1006 10.1152/ajpheart.00660.2008 1:CAS:528:DC%2BD1MXkvVygtr4%3D 19168726
23. M.S. Willis J.C. Schisler L. Li, et al. 2009 Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo Circ Res 105 80 88 10.1161/CIRCRESAHA.109.194928 1:CAS:528:DC%2BD1MXns1Cht7s%3D 19498199
24. T.J. Zhao Y.B. Yan Y. Liu H.M. Zhou 2007 The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase J Biol Chem 282 12022 12029 10.1074/jbc.M610363200 1:CAS:528:DC%2BD2sXktFeltr8%3D 17303563 (Pubitemid 47100688)
25. S. Koyama S. Hata C.C. Witt, et al. 2008 Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis J Mol Biol 376 1224 1236 10.1016/j.jmb.2007.11.049 1:CAS:528:DC%2BD1cXitVejtbg%3D 18222470
26. S.H. Witt H. Granzier C.C. Witt S. Labeit 2005 MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination J Mol Biol 350 713 722 10.1016/j.jmb.2005. 05.021 1:CAS:528:DC%2BD2MXlsl2qsLw%3D 15967462 (Pubitemid 40848669)
27. T. Centner J. Yano E. Kimura, et al. 2001 Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain J Mol Biol 306 717 726 10.1006/jmbi.2001.4448 1:CAS:528:DC%2BD3MXhslSnsrc%3D 11243782 (Pubitemid 33027694)
28. C.C. Witt S.H. Witt S. Lerche, et al. 2008 Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2 EMBO J 27 350 360 10.1038/sj.emboj.7601952 1:CAS:528:DC%2BD1cXhtVKku70%3D 18157088 (Pubitemid 351161651)
29. H.D. Kim D.J. Kim I.J. Lee, et al. 1992 Human fetal heart development after mid-term: morphometry and ultrastructural study J Mol Cell Cardiol 24 949 965 10.1016/0022-2828(92)91862-Y 1:STN:280:DyaK3s%2FlvFCjtQ%3D%3D 1433323
30. F. Li X. Wang J.M. Capasso A.M. Gerdes 1996 Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development J Mol Cell Cardiol 28 1737 1746 10.1006/jmcc.1996.0163 1:CAS:528:DyaK28XlsF2jtLs%3D 8877783 (Pubitemid 26300573)
31. S.M. Kolodziejczyk L. Wang K. Balazsi, et al. 1999 MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium Curr Biol 9 1203 1206 10.1016/S0960-9822(00)80027-5 1:CAS:528:DyaK1MXntVSltL8%3D 10531040 (Pubitemid 29527110)
32. J.C. Schisler M.S. Willis C. Patterson 2008 You spin me round: MaFBx/atrogin-1 feeds forward on FOXO transcription factors (like a record) Cell Cycle 7 440 443 1:CAS:528:DC%2BD1cXlslClsLY%3D 18235241
33. G. Mearini S. Schlossarek M.S. Willis L. Carrier 2008 The ubiquitin-proteasome system in cardiac dysfunction Biochim Biophys Acta 1782 749 763 1:CAS:528:DC%2BD1cXhsVCntb%2FL 18634872
34. S. Balasubramanian S. Mani H. Shiraishi, et al. 2006 Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases J Mol Cell Cardiol 41 4 669 679 10.1016/j.yjmcc.2006.04.022 1:CAS:528:DC%2BD28Xps1OksLY%3D 16928382 (Pubitemid 44374542)
35. P. Razeghi K.K. Baskin S. Sharma, et al. 2006 Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart Biochem Biophys Res Commun 342 361 364 10.1016/j.bbrc.2006.01. 163 1:CAS:528:DC%2BD28XhvVeiu7o%3D 16483544 (Pubitemid 43289002)
36. P. Razeghi S. Sharma J. Ying, et al. 2003 Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation Circulation 108 2536 2541 10.1161/01.CIR.0000096481.45105.13 1:CAS:528:DC%2BD3sXovVeku7s%3D 14610007 (Pubitemid 37444418)
37. S. Sharma J. Ying P. Razeghi, et al. 2006 Atrophic remodeling of the transplanted rat heart Cardiology 105 128 136 10.1159/000090550 16391472 (Pubitemid 43189789)
38. S.C. Bodine E. Latres S. Baumhueter, et al. 2001 Identification of ubiquitin ligases required for skeletal muscle atrophy Science 294 1704 1708 10.1126/science.1065874 1:CAS:528:DC%2BD3MXoslCjs74%3D 11679633 (Pubitemid 33104839)
39. S. Rubler J. Dlugash Y.Z. Yuceoglu, et al. 1972 New type of cardiomyopathy associated with diabetic glomerulosclerosis Am J Cardiol 30 595 602 10.1016/0002-9149(72)90595-4 1:STN:280:DyaE3s%2FjtFeksA%3D%3D 4263660
40. K.S. Spector 1998 Diabetic cardiomyopathy Clin Cardiol 21 885 887 10.1002/clc.4960211205 1:STN:280:DyaK1M%2FntVaqsw%3D%3D 9853179
41. R. Harmancey H. Taegtmeyer 2008 The complexities of diabetic cardiomyopathy: lessons from patients and animal models Curr Diab Rep 8 243 248 10.1007/s11892-008-0042-x 1:CAS:528:DC%2BD1cXotVyrurY%3D 18625124
42. S. Kobayashi K. Mao H. Zheng, et al. 2007 Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury J Biol Chem 282 21945 21952 10.1074/jbc.M703048200 1:CAS:528:DC%2BD2sXotVGlsrY%3D 17525155 (Pubitemid 47195736)
43. X. Wang Z. Hu J. Hu, et al. 2006 Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling Endocrinology 147 4160 4168 10.1210/en.2006-0251 1:CAS:528:DC%2BD28Xpt1SjtLk%3D 16777975 (Pubitemid 44268367)
44. J. Hu J.D. Klein J. Du X.H. Wang 2008 Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency Endocrinology 149 5384 5390 10.1210/en.2008-0132 1:CAS:528: DC%2BD1cXhtlWnsrrP 18653708
45. S.R. Powell S.M. Samuel P. Wang, et al. 2008 Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia J Mol Cell Cardiol 44 618 621 10.1016/j.yjmcc.2007.12.009 1:CAS:528:DC%2BD1cXjtl2lsbo%3D 18308332
46. F.G. Whitby E.I. Masters L. Kramer, et al. 2000 Structural basis for the activation of 20S proteasomes by 11S regulators Nature 408 115 120 10.1038/35040607 1:CAS:528:DC%2BD3cXotVaksb4%3D 11081519 (Pubitemid 30828271)
47. C. Depre Q. Wang L. Yan, et al. 2006 Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy Circulation 114 1821 1828 10.1161/CIRCULATIONAHA.106.637827 1:CAS:528:DC%2BD28XhtVyitb3F 17043166 (Pubitemid 44673357)
48. S. Merforth L. Kuehn A. Osmers B. Dahlmann 2003 Alteration of 20S proteasome-subtypes and proteasome activator PA28 in skeletal muscle of rat after induction of diabetes mellitus Int J Biochem Cell Biol 35 740 748 10.1016/S1357-2725(02)00381-3 1:CAS:528:DC%2BD3sXisFShtbs%3D 12672465 (Pubitemid 36369521)
49. Marfella R, Filippo CD, Portoghese M, et al.: The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control. Cardiovasc Pathol 2009 Jan 12 (Epub ahead of print).
50. K. Avela M. Lipsanen-Nyman N. Idanheimo, et al. 2000 Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism Nat Genet 25 298 301 10.1038/77053 1:CAS:528:DC%2BD3cXkvFKlu7o%3D 10888877 (Pubitemid 30437316)
51. M. Lipsanen-Nyman J. Perheentupa J. Rapola, et al. 2003 Mulibrey heart disease: clinical manifestations, long-term course, and results of pericardiectomy in a series of 49 patients born before 1985 Circulation 107 2810 2815 10.1161/01.CIR.0000070949.76608.E2 12756154 (Pubitemid 36705991)
52. N. Karlberg H. Jalanko J. Kallijarvi, et al. 2005 Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37 Diabetes 54 3577 3581 10.2337/diabetes.54.12.3577 1:CAS:528:DC%2BD2MXht12gsL%2FE 16306379 (Pubitemid 43334353)
53. V. Kedar H. McDonough R. Arya, et al. 2004 Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I Proc Natl Acad Sci U S A 101 18135 18140 10.1073/pnas.0404341102 1:CAS:528: DC%2BD2MXjsl2lsw%3D%3D 15601779 (Pubitemid 40054086)
54. M.S. Willis H.H. Li J.E. Rodriguez, et al. 2008 MuRF1 inhibits JNK signaling in cardiac ischemia reperfusion injury by degrading phosphorylated cJun [abstract] FASEB J 22 751.11
55. S. Lange F. Xiang A. Yakovenko, et al. 2005 The kinase domain of titin controls muscle gene expression and protein turnover Science 308 1599 1603 10.1126/science.1110463 1:CAS:528:DC%2BD2MXltFems7s%3D 15802564 (Pubitemid 40807503)
56. H.H. Li V. Kedar C. Zhang, et al. 2004 Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex J Clin Invest 114 1058 1071 1:CAS:528: DC%2BD2cXovVensr0%3D 15489953
57. H. McDonough C. Patterson 2003 CHIP: a link between the chaperone and proteasome systems Cell Stress Chaperones 8 303 308 10.1379/1466-1268(2003) 008<0303:CALBTC>2.0.CO;2 1:CAS:528:DC%2BD2cXitlOisr4%3D 15115282 (Pubitemid 38222876)
58. Patterson C, Schisler JC (eds): STIP1 homology and U box-containing protein 1 - [Isoform 1]. Targeted Protein Database 2008, DOI 10.2970/tpdb.2008.130.
59. P. Xie Y. Fan H. Zhang, et al. 2009 CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation Mol Cell Biol 29 2398 2408 10.1128/MCB.01737-08 1:CAS:528: DC%2BD1MXlt1Ortbc%3D 19237536
60. J. Momand G.P. Zambetti D.C. Olson, et al. 1992 The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 69 1237 1245 10.1016/0092-8674(92)90644-R 1:CAS:528:DyaK3sXit1Ogs7o%3D 1535557
61. J.D. Grier S. Xiong A.C. Elizondo-Fraire, et al. 2006 Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4 Mol Cell Biol 26 192 198 10.1128/MCB.26.1.192-198.2006 1:CAS:528:DC%2BD28XjslaqsbY%3D 16354690
62. A. Toth P. Nickson L.L. Qin P. Erhardt 2006 Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase J Biol Chem 281 3679 3689 10.1074/jbc.M509630200 1:CAS:528:DC%2BD28XhtFSmt7k%3D 16339144 (Pubitemid 43845986)
63. R.S. Foo L.K. Chan R.N. Kitsis M.R. Bennett 2007 Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2 J Biol Chem 282 5529 5535 10.1074/jbc.M609046200 1:CAS:528:DC%2BD2sXhvVaisLg%3D 17142834 (Pubitemid 47093728)
64. N. Rosenblatt-Velin R. Lerch I. Papageorgiou C. Montessuit 2004 Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation FASEB J 18 872 874 1:CAS:528:DC%2BD2cXjvVCls7Y%3D 15117888
65. C. Rubin G. Gur Y. Yarden 2005 Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation Cell Res 15 66 71 10.1038/sj.cr.7290268 1:CAS:528:DC%2BD2MXkslGitr8%3D 15686631 (Pubitemid 41653969)
66. K. Kaabeche J. Lemonnier S. Le Mee, et al. 2004 Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation J Biol Chem 279 36259 36267 10.1074/jbc.M402469200 1:CAS:528:DC%2BD2cXmvFCntLY%3D 15190072 (Pubitemid 39128962)
67. H. Oda S. Kumar P.M. Howley 1999 Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination Proc Natl Acad Sci U S A 96 9557 9562 10.1073/pnas.96.17.9557 1:CAS:528:DyaK1MXlsVyms7Y%3D 10449731 (Pubitemid 29398769)