Myofibroblast-mediated adventitial remodeling: An underestimated player in arterial pathology

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 11, 2011, Pages 2391-2396

  Coen, Matteo ^a   Gabbiani, Giulio ^a   Bochaton Piallat, Marie Luce ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

smooth muscle actin; atherosclerosis; fibroblast; restenosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ION; COLLAGEN TYPE 1; ELASTIN; ENDOTHELIN; MYOSIN LIGHT CHAIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA;

ABDOMINAL AORTA ANEURYSM; ADVENTITIA; ARTERY INTIMA; ARTICLE; BLOOD VESSEL WALL; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; VASCULAR FIBROSIS; VASODILATATION; WOUND HEALING;

ANIMALS; CARDIOVASCULAR DISEASES; CELL COMMUNICATION; CELL DIFFERENTIATION; CONNECTIVE TISSUE; FIBROBLASTS; HUMANS; MYOFIBROBLASTS; TUNICA INTIMA; TUNICA MEDIA;

EID: 80054908979     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.231548     Document Type: Article

References (58)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
2. Stenmark KR, Davie N, Frid M, Gerasimovskaya E, Das M. Role of the adventitia in pulmonary vascular remodeling. Physiology (Bethesda). 2006;21:134-145. (Pubitemid 43752509)
3. Gabbiani G, Ryan G, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia. 1971;27:549-550.
4. Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G. The myofibroblast: one function, multiple origins. Am J Pathol. 2007;170:1807-1816. (Pubitemid 47339255)
5. Short M, Nemenoff RA, Zawada WM, Stenmark KR, Das M. Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts. Am J Physiol Cell Physiol. 2004;286:C416Ac425.
6. Shi Y, Pieniek M, Fard A, O'Brien J, Mannion JD, Zalewski A. Adventitial remodeling after coronary arterial injury. Circulation. 1996;93: 340-348. (Pubitemid 26031494)
7. Hu Y, Zhang Z, Torsney E, Afzal AR, Davison F, Metzler B, Xu Q. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest. 2004;113: 1258-1265. (Pubitemid 39069924)
8. Hoshino A, Chiba H, Nagai K, Ishii G, Ochiai A. Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells. Biochem Biophys Res Commun. 2008;368:305-310.
9. Somasundaram C, Diz DI, Coleman T, Bukoski RD. Adventitial neuronal somata. J Vasc Res. 2006;43:278-288. (Pubitemid 44257046)
10. Rajsheker S, Manka D, Blomkalns AL, Chatterjee TK, Stoll LL, Weintraub NL. Crosstalk between perivascular adipose tissue and blood vessels. Curr Opin Pharmacol. 2010;10:191-196.
11. Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M, Poelmann RE. Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 1999;19:1589-1594. (Pubitemid 29323815)
12. Majesky MW. Development of coronary vessels. Curr Top Dev Biol. 2004;62:225-259. (Pubitemid 39752380)
13. Gonzalez MC, Arribas SM, Molero F, Fernandez-Alfonso MS. Effect of removal of adventitia on vascular smooth muscle contraction and relaxation. Am J Physiol Heart Circ Physiol. 2001;280:H2876-H2881.
14. Gutterman DD. Adventitia-dependent influences on vascular function. Am J Physiol. 1999;277:H1265-H1272. (Pubitemid 29522654)
15. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 2004;84:903-934. (Pubitemid 38823770)
16. Kleschyov AL, Muller B, Keravis T, Stoeckel ME, Stoclet JC. Adventitiaderived nitric oxide in rat aortas exposed to endotoxin: cell origin and functional consequences. Am J Physiol Heart Circ Physiol. 2000;279: H2743-H2751. (Pubitemid 32005863)
17. Di Wang H, Hope S, Du Y, Quinn MT, Cayatte A, Pagano PJ, Cohen RA. Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. Hypertension. 1999;33:1225-1232. (Pubitemid 29230978)
18. Patel S, Shi Y, Niculescu R, Chung EH, Martin JL, Zalewski A. Characteristics of coronary smooth muscle cells and adventitial fibroblasts. Circulation. 2000;101:524-532. (Pubitemid 30080867)
19. Schmitt-Gräff A, Desmoulière A, Gabbiani G. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch. 1994;425:3-24. (Pubitemid 24295501)
20. Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP. Isolation and phenotypic characterization of lung fibroblasts. Methods Mol Med. 2005;117:115-127.
21. Hinz B, Gabbiani G. Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000 Biol Rep. 2010;2:78.
22. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83:835-870. (Pubitemid 36828927)
23. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200:429-447. (Pubitemid 36818244)
24. Christen T, Verin V, Bochaton-Piallat M, Popowski Y, Ramaekers F, Debruyne P, Camenzind E, Van Eys G, Gabbiani G. Mechanisms of neointima formation and remodeling in the porcine coronary artery. Circulation. 2001;103:882-888. (Pubitemid 32163889)
25. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349-363. (Pubitemid 34619269)
26. Hecker L, Jagirdar R, Jin T, Thannickal VJ. Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res. 2011;317:1914-1921.
27. Follonier Castella L, Gabbiani G, McCulloch CA, Hinz B. Regulation of myofibroblast activities: calcium pulls some strings behind the scene. Exp Cell Res. 2010;316:2390-2401.
28. Amano M, Fukata Y, Kaibuchi K. Regulation and functions of Rhoassociated kinase. Exp Cell Res. 2000;261:44-51.
29. Chaponnier C, Goethals M, Janmey PA, Gabbiani F, Gabbiani G, Vandekerckhove J. The specific NH2-terminal sequence Ac-EEED oFC-smooth muscle actin plays a role in polymerization in vitro and in vivo. J Cell Biol. 1995;130:887-895.
30. Hinz B, Gabbiani G, Chaponnier C. The NH2-terminal peptide oFC-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J Cell Biol. 2002;157:657-663. (Pubitemid 34839793)
31. Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD. Vascular remodeling. Hypertension. 1996;28: 505-506. (Pubitemid 26298571)
32. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-1375. (Pubitemid 17079680)
33. Gruntzig A. Transluminal dilatation of coronary-artery stenosis. Lancet. 1978;1:263.
34. De Meyer GRY, Van Put DJM, Kockx MM, Van Schil P, Bosmans R, Bult H, Buyssens N, Vanmaele R, Herman AG. Possible mechanisms of collar-induced intimal thickening. Arterioscler Thromb Vasc Biol. 1997; 17:1924-1930. (Pubitemid 28057091)
35. Pasterkamp G, Schoneveld AH, Van der Wal AC, Haudenschild CC, Clarijs RJ, Becker AE, Hillen B, Borst C. Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol. 1998;32:655-662. (Pubitemid 28435249)
36. Zalewski A, Shi Y. Vascular myofibroblasts. Lessons from coronary repair and remodeling. Arterioscler Thromb Vasc Biol. 1997;17:417-422. (Pubitemid 27133129)
37. Varnava AM, Mills PG, Davies MJ. Relationship between coronary artery remodeling and plaque vulnerability. Circulation. 2002;105:939-943. (Pubitemid 34184571)
38. Pasterkamp G, Galis ZS, de Kleijn DP. Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Biol. 2004;24: 650-657. (Pubitemid 38451599)
39. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94: 2493-2503. (Pubitemid 24379627)
40. Shi Y, O'Brien JE Jr, Ala-Kokko L, Chung W, Mannion JD, Zalewski A. Origin of extracellular matrix synthesis during coronary repair. Circulation. 1997;95:997-1006. (Pubitemid 27091546)
41. Mintz GS, Kent KM, Pichard AD, Popma JJ, Satler LF, Leon MB. Intravascular ultrasound insights into mechanisms of stenosis formation and restenosis. Cardiol Clin. 1997;15:17-29. (Pubitemid 27106414)
42. Herrmann J, Samee S, Chade A, Rodriguez Porcel M, Lerman LO, Lerman A. Differential effect of experimental hypertension and hypercholesterolemia on adventitial remodeling. Arterioscler Thromb Vasc Biol. 2005;25:447-453. (Pubitemid 40189172)
43. Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res. 2006; 99:675-691. (Pubitemid 44498302)
44. Shi Y, O'Brien JE, Mannion JD, Morrison RC, Chung WS, Fard A, Zalewski A. Remodeling of autologous saphenous vein grafts: the role of perivascular myofibroblasts. Circulation. 1997;95:2684-2693. (Pubitemid 27255498)
45. Subramanian SV, Kelm RJ, Polikandriotis JA, Orosz CG, Strauch AR. Reprogramming of vascular smooth musclë-actin gene expression as an early indicator of dysfunctional remodeling following heart transplant. Cardiovasc Res. 2002;54:539-548. (Pubitemid 34595412)
46. Sakata N, Nabeshima K, Iwasaki H, Tashiro T, Uesugi N, Nakashima O, Ito H, Kawanami T, Furuya K, Kojima M. Possible involvement of myofibroblast in the development of inflammatory aortic aneurysm. Pathol Res Pract. 2007;203:21-29. (Pubitemid 46118076)
47. Corselli M, Chen CW, Crisan M, Lazzari L, Peault B. Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol. 2010;30:1104-1109.
48. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res. 2007;100:967-978. (Pubitemid 46598921)
49. Pethig K, Heublein B, Meliss RR, Haverich A. Volumetric remodeling of the proximal left coronary artery: early versus late after heart transplantation. J Am Coll Cardiol. 1999;34:197-203.
50. Wong C, Ganz P, Miller L, Kobashigawa J, Schwarzkopf A, Valantine von Kaeper H, Wilensky R, Ventura H, Yeung AC. Role of vascular remodeling in the pathogenesis of early transplant coronary artery disease: a multicenter prospective intravascular ultrasound study. J Heart Lung Transplant. 2001;20:385-392. (Pubitemid 32303142)
51. Scott NA, Cipolla GD, Ross CE, Dunn B, Martin FH, Simonet L, Wilcox JN. Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries. Circulation. 1996;93:2178-2187. (Pubitemid 26187108)
52. De Leon H, Ollerenshaw JD, Griendling KK, Wilcox JN. Adventitial cells do not contribute to neointimal mass after balloon angioplasty of the rat common carotid artery. Circulation. 2001;104:1591-1593. (Pubitemid 32947518)
53. Fleenor BS, Bowles DK. Negligible contribution of coronary adventitial fibroblasts to neointimal formation following balloon angioplasty in swine. Am J Physiol Heart Circ Physiol. 2009;296:H1532-H1539.
54. Hao H, Gabbiani G, Camenzind E, Bacchetta M, Virmani R, Bochaton-Piallat ML. Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion. Arterioscler Thromb Vasc Biol. 2006;26:326-332. (Pubitemid 43732195)
55. Spray TL, Roberts WC. Changes in saphenous veins used as aortocoronary bypass grafts. Am Heart J. 1977;94:500-516. (Pubitemid 8202065)
56. Kent KC, Liu B. Intimal hyperplasia: still here after all these years! Ann Vasc Surg. 2004;18:135-137. (Pubitemid 38509642)
57. Tang T, Boyle JR, Dixon AK, Varty K. Inflammatory abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2005;29:353-362. (Pubitemid 40331371)
58. Hellmann DB, Grand DJ, Freischlag JA. Inflammatory abdominal aortic aneurysm. JAMA. 2007;297:395-400. (Pubitemid 46155801)