Protein kinase Cδ regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL

Journal of Immunology

Volumn 178, Issue 12, 2007, Pages 7814-7821

  Ma, Jennifer S Y ^a   Monu, Ngozi ^b   Shen, David T ^a   Mecklenbräuker, Ingrid ^c   Radoja, Nadežda ^d   Haydar, Tarik F ^a   Leitges, Michael ^e   Frey, Alan B ^b   Vukmanović, Stanislav ^a   Radoja, Saša ^a  

^a CHILDREN S RESEARCH INSTITUTE   (United States)

^b Kaplan Cancer Center   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^e MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; PROTEIN KINASE C; PROTEIN KINASE C DELTA; GRANZYME; LYMPHOCYTE ANTIGEN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; ENZYME REGULATION; EXOCYTOSIS; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; MICROTUBULE ORGANIZING CENTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VIRUS INFECTION; ANIMAL; CELL GRANULE; CYTOTOXIC T LYMPHOCYTE; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; ANTIGENS, CD8; CYTOPLASMIC GRANULES; EXOCYTOSIS; GRANZYMES; MICE; MICE, MUTANT STRAINS; PROTEIN KINASE C-DELTA; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE DELETION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 34250156284     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.12.7814     Document Type: Article

References (45)

1. Russell, J. H., and T. J. Ley. 2002. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20: 323-370.
2. Kagi, D., B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14: 207-302.
3. Berry, M., and R. Bleackley. 2002. Cytotoxic lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2: 401-409.
4. Blott, E. J., and G. M. Griffiths. 2002. Secretory lysosomes. Nat. Rev. Mol. Cell Biol. 3: 122-131.
5. Lancki, D. W., A. Weiss, and F. W. Fitch. 1987. Requirements for triggering of lysis by cytolytic T lymphocyte clones. J. Immunol. 138: 3646-3653.
6. Juszezak, R. J., and J. H. Russell. 1989. Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors: evidence for the involvement of protein kinase C in lymphocyte function. J. Biol. Chem. 254: 810-815.
7. + T lymphocyte effector responses. J. Immunol. 159: 582-590.
8. Sitkovsky, M. V. 1988. Mechanistic, functional and immunopharmacological implications of biochemical studies of antigen receptor-triggered cytolytic T-lymphocyte activation. Immunol. Rev. 103: 127-160.
9. 2+ signaling modulates cytolytic T lymphocyte etfector functions. J. Exp. Med. 187: 1057-1067.
10. Pardo, J., M. Buferne, M. J. Martinez-Lorenzo, J. Naval, A. M. Schmitt-Verhulst, C. Boyer, and A. Anel. 2003. Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. Int. Immunol. 15: 1441-1450.
11. Puente, L. G., J. S. He, and H. L. Ostergaard. 2006. A novel PKC regulates ERK activation and degranulation of cytotoxic T lymphocytes: plasticity in PKC regulation of ERK. Eur. J. Immunol. 36: 1009-1018.
12. Gryhko, M. J., A. T. Pores-Fernando, G. A. Wurth, and A. Zweifach. 2007. Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis. hut the θ isoform does not play a preferential role. J. Leukocyte Biol. 81: 509-519.
13. Lowin-Kropf, B., V. S. Shapiro, and A. Weiss. 1998. Cytoskeletal polarization of T cells is regulated hy an immunoreceptor tyrosine-hased activation motif-dependent mechanism. J. Cell Biol. 140: 861-871.
14. Fuller, C. L., K. S. Ravichandran, and V. L. Braciale. 1999. Phosphatidylinositol 3-kinase-dependent and -independent cytolytic effector functions. J. Immunol. 162: 6337-6340.
15. Robertson, L. K., L. R. Mireau, and H. L. Ostergaard. 2005. A role for phosphatidylinositol 3-kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation. J. Immunol. 175: 8138-8145.
16. + tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis. J. Immunol. 167: 5042-5051.
17. Berg, N. N., L. G. Puente, W. Dawicki, and H. L. Ostergaard. 1998. Sustained TCR signaling is required for mitogen-activated protein kinase activation and degranulation by cytotoxic T lymphocytes. J. Immunol. 161: 2919-2924.
18. + T cell cytolytic activity independent of mitogen-activated protein kinase / extracellular regulatory kinase signaling (MAP kinase/ ERK). Eur. J. Immunol. 29: 3971-3977.
19. 2+ influx does not underlie the role of extracellular signal-regulated kinases in cytotoxic T lymphocyte lytic granule exocytosis. J. Biol. Chem. 279: 25646-25652.
20. Spitaler, M., and D. A. Cantrell. 2004. Protein kinase C and beyond. Nat. Immun. 5: 785-790.
21. 2+. Immunology 39: 109-117.
22. Haddad, E. K., X. Wu, J. A. Hammer, III, and P. A. Henkart. 2001. Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J. Cell Biol. 152: 835-842.
23. Rubio, V., T. B. Stuge, N. Singh, M. R. Betts, J. S. Weber, M. Roederer, and P. P. Lee. 2003. Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat. Med. 9: 1377-1382.
24. + T cells. J. Leukocyte Biol. 80: 827-837.
25. Pham, C. T., D. M. MacIvor, B. A. Hug, J. W. Heusel, and T. J. Ley. 1996. Long-range disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA 93: 13090-13095.
26. Stinchcombe, J. C. D. C. Barral, E. H. Mules, S. Booth, A. N. Hume, L. M. Machesky, M. C. Seabra, and G. M. Griffiths. 2001. Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152: 825-834.
27. Seabra, M. C. and C. Wasmeier. 2004. Controlling the location and activation of Rab GTPases. Curr. Opin. Cell Biol. 16: 451-457.
28. Klein, M., J. Roder, T. Haliotis, S. Korec, J. R. Jett, R. B. Herberman, P. Katz, and A. S. Fauci. 1980. Chediak-Higashi gene in humans. II: the selectivity of the defect in natural-killer and antibody-dependent cell-mediated cytotoxicity function. J. Exp. Med. 151: 1049-1058.
29. Biron, C. A., K. F. Pedersen, and R. M. Welsh. 1987. Aberrant T cells in beige mutant mice. J. Immunol. 138: 2050-2056.
30. Baetz, K., S. Isaaz, and G. M. Griffiths. 1995. Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. J. Immunol. 154: 6122-6131.
31. Radoja, S., A. B. Frey, and S. Vukmanovic. 2006. T cell receptor signaling events triggering granule exocytosis. Crit. Rev. Immunol. 26: 265-290.
32. + T cells. Immunol. Lett. 96: 291-293.
33. Miyamoto, A., K. Nakayama, H. Imaki, S. Hirose, Y. Jiang, M. Abe, T. Tsukiyama, H. Nagahama, S. Ohno, S. Hatakeyama, and K. I. Nakayama. 2002. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature 416: 865-869.
34. + T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251: 1228-1231.
35. +/+ cells. J. Immunol. 154: 6252-6261.
36. Mecklenbrauker, I., K. Saijo, N. Y. Zheng, M. Leitges, and A. Tarakhovsky. 2002. Protein kinase Cδ controls self-antigen-induced B-cell tolerance. Nature 416: 860-865.
37. Leitges, M., K. Gimborn, W. Elis, J. Kalesnikoff, M. R. Hughes, G. Krystal, and M. Huber. 2002. Protein kinase C-β is a negative regulator of antigen-induced mast cell degranulation. Mol. Cell. Biol. 22: 3970-3980.
38. Murugappan, S., F. Tuluc, R. T. Dorsam, H. Shankar, and S. P. Kunapuli. 2004. Differential role of protein kinase C δ isoform in agonist-induced dense granule secretion in human platelets. J. Biol. Chem. 279: 2360-2367.
39. Uchida, T., N. Iwashita, M. Ohara-Imaizumi, T. Ogihara, S. Nagai, J. B. Choi, Y. Tamura, N. Tada, R. Kawamori, K. Nakayama, et al. 2007. PKC-δ plays non-redundant role in insulin secretion in pancreatic β cell. J. Biol. Chem. 282: 2707-2716.
40. Arendt, C. W., B. Albrecht, T. J. Soos, and D. R. Littman. 2002. Protein kinase C-θ: signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14: 323-330.
41. Menasche, G., J. Feldmann, A. Fischer, and G. de Saint Basile. 2005. Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis. Immunol. Rev. 203: 165-179.
42. Stepp, S. E., R. Dufourcq-Lagelouse, F. Le Deist, S. Bhawan, S. Certain, P. A. Mathew, J. I. Henter, M. Bennett, A. Fischer, G. de Saint Basile, and V. Kumar. 1999. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286: 1957-1959.
43. Feldmann, J., I. Callebaut, G. Raposo, S. Certain, D. Bacq, C. Dumont, N. Lambert, M. Ouachee-Chardin, G. Chedeville, H. Tamary, et al. 2003. Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell 14: 461-473.
44. zur Stadt, U., S. Schmidt, B. Kasper, K. Beutel, A. S. Diler, J. I. Henter, H. Kabisch, R. Schneppenheim, P. Nurnberg, G. Janka, and H. C. Hennies. 2005. Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. Hum. Mol. Genet. 15: 827-834.
45. Ishii, E., S. Ohga, S. Imashuku, N. Kimura, I. Ueda, A. Morimoto, K. Yamamoto, and M. Yasukawa. 2005. Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences. Crit. Rev. Oncol. Hematol. 53: 209-223.