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Giannoni F., Lyon A.B., Wareing M.D., Dias P.B., and Sarawar S.R. Protein kinase C θ is not essential for T cell-mediated clearance of murine γ-herpesvirus 68. J Virol 79 (2005) 6808-6813
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Wareing, M.D.3
Dias, P.B.4
Sarawar, S.R.5
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47
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A critical role for protein kinase C θ-mediated T cell survival in cardiac allograft rejection
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This is the first study showing a role of PKC θ in alloreactivity and graft survival of experimental organ transplants.
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Manicassamy S., Yin D., Zhang Z., Molinero L.L., Alegre M.L., and Sun Z. A critical role for protein kinase C θ-mediated T cell survival in cardiac allograft rejection. J Immunol 181 (2008) 513-520. This is the first study showing a role of PKC θ in alloreactivity and graft survival of experimental organ transplants.
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Manicassamy, S.1
Yin, D.2
Zhang, Z.3
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The selectivity of protein kinase inhibitors: a further update
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Bain J., Plater L., Elliott M., Shpiro N., Hastie C.J., McLauchlan H., Klevernic I., Arthur J.S., Alessi D.R., and Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J 408 (2007) 297-315
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Bain, J.1
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Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
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49
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A quantitative analysis of kinase inhibitor selectivity
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The most comprehensive study of kinase selectivity to date including >50% of the predicted human protein kinome. The interaction maps of 38 kinase inhibitors that are marketed or in late stage developed reveal very diverse interaction patterns.
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Karaman M.W., Herrgard S., Treiber D.K., Gallant P., Atteridge C.E., Campbell B.T., Chan K.W., Ciceri P., Davis M.I., Edeen P.T., et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26 (2008) 127-132. The most comprehensive study of kinase selectivity to date including >50% of the predicted human protein kinome. The interaction maps of 38 kinase inhibitors that are marketed or in late stage developed reveal very diverse interaction patterns.
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Nat Biotechnol
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Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
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50
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Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
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Donnelly R., Idris I., and Forrester J.V. Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research. Br J Ophthalmol 88 (2004) 145-151
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Donnelly, R.1
Idris, I.2
Forrester, J.V.3
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51
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Catalytic domain crystal structure of PKC θ
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Xu Z.B., Chaudhary D., Olland S., Wolfrom S., Czerwinski R., Malakian K., Lin L., Stahl M.L., Joseph-McCarthy D., Benander C., et al. Catalytic domain crystal structure of PKC θ. J Biol Chem 279 (2004) 50401-50409
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Xu, Z.B.1
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Czerwinski, R.5
Malakian, K.6
Lin, L.7
Stahl, M.L.8
Joseph-McCarthy, D.9
Benander, C.10
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52
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Structure of the catalytic domain of human protein kinase C β II complexed with a bisindolylmaleimide inhibitor
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Grodsky N., Li Y., Bouzida D., Love R., Jensen J., Nodes B., Nonomiya J., and Grant S. Structure of the catalytic domain of human protein kinase C β II complexed with a bisindolylmaleimide inhibitor. Biochemistry 45 (2006) 13970-13981
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Jensen, J.5
Nodes, B.6
Nonomiya, J.7
Grant, S.8
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53
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Discovery of potent and selective PKC θ inhibitors
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Cywin C.L., Dahmann G., Prokopowicz III A.S., Young E.R., Magolda R.L., Cardozo M.G., Cogan D.A., Disalvo D., Ginn J.D., Kashem M.A., et al. Discovery of potent and selective PKC θ inhibitors. Bioorg Med Chem Lett 17 (2007) 225-230
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Cywin, C.L.1
Dahmann, G.2
Prokopowicz III, A.S.3
Young, E.R.4
Magolda, R.L.5
Cardozo, M.G.6
Cogan, D.A.7
Disalvo, D.8
Ginn, J.D.9
Kashem, M.A.10
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54
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Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ inhibitors
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In this study, the discovery of a novel class of PKC inhibitors is described. The optimized compounds are selective for PKC θ over the other isotypes and a range of serine/threonine or tyrosine kinases.
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Cole D.C., Asselin M., Brennan A., Czerwinski R., Ellingboe J.W., Fitz L., Greco R., Huang X., Joseph-McCarthy D., Kelly M.F., et al. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ inhibitors. J Med Chem 51 (2008) 5958-5963. In this study, the discovery of a novel class of PKC inhibitors is described. The optimized compounds are selective for PKC θ over the other isotypes and a range of serine/threonine or tyrosine kinases.
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J Med Chem
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Cole, D.C.1
Asselin, M.2
Brennan, A.3
Czerwinski, R.4
Ellingboe, J.W.5
Fitz, L.6
Greco, R.7
Huang, X.8
Joseph-McCarthy, D.9
Kelly, M.F.10
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