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Volumn 21, Issue 2, 2009, Pages 262-267

PKC inhibitors: potential in T cell-dependent immune diseases

Author keywords

[No Author keywords available]

Indexed keywords

BISINDOLYLMALEIMIDE; IMMUNOSUPPRESSIVE AGENT; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; SOTRASTAURIN; STAUROSPORINE DERIVATIVE;

EID: 64149122243     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2008.12.008     Document Type: Review
Times cited : (61)

References (54)
  • 1
    • 0035342013 scopus 로고    scopus 로고
    • Molecular controls of antigen receptor clustering and autoimmunity
    • Krawczyk C., and Penninger J.M. Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol 11 (2001) 212-220
    • (2001) Trends Cell Biol , vol.11 , pp. 212-220
    • Krawczyk, C.1    Penninger, J.M.2
  • 2
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: choreographing the social lives of cells
    • Crabtree G.R., and Olson E.N. NFAT signaling: choreographing the social lives of cells. Cell 109 Suppl. (2002) S67-S79
    • (2002) Cell , vol.109 , Issue.SUPPL
    • Crabtree, G.R.1    Olson, E.N.2
  • 3
    • 0035971436 scopus 로고    scopus 로고
    • Partners in transcription: NFAT and AP-1
    • Macian F., Lopez-Rodriguez C., and Rao A. Partners in transcription: NFAT and AP-1. Oncogene 20 (2001) 2476-2489
    • (2001) Oncogene , vol.20 , pp. 2476-2489
    • Macian, F.1    Lopez-Rodriguez, C.2    Rao, A.3
  • 4
    • 33645991527 scopus 로고    scopus 로고
    • Controlling NF-κB activation in T cells by costimulatory receptors
    • Schmitz M.L., and Krappmann D. Controlling NF-κB activation in T cells by costimulatory receptors. Cell Death Differ 13 (2006) 834-842
    • (2006) Cell Death Differ , vol.13 , pp. 834-842
    • Schmitz, M.L.1    Krappmann, D.2
  • 5
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25 (2007) 821-852
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 6
    • 37849054022 scopus 로고    scopus 로고
    • Molecular regulation of T cell anergy
    • Zheng Y., Zha Y., and Gajewski T.F. Molecular regulation of T cell anergy. EMBO Rep 9 (2008) 50-55
    • (2008) EMBO Rep , vol.9 , pp. 50-55
    • Zheng, Y.1    Zha, Y.2    Gajewski, T.F.3
  • 7
    • 41149167494 scopus 로고    scopus 로고
    • T cell fate and function: PKC θ and beyond
    • Marsland B.J., and Kopf M. T cell fate and function: PKC θ and beyond. Trends Immunol 29 (2008) 179-185
    • (2008) Trends Immunol , vol.29 , pp. 179-185
    • Marsland, B.J.1    Kopf, M.2
  • 12
    • 58149393273 scopus 로고    scopus 로고
    • PKC θ selectively controls the adhesion-stimulating molecule Rap1
    • Using molecular cell biology approaches as well as PKC isotype-deficient T cells, this study for the first time implicates PKCθ in TCR-induced Rap1 activation and LFA-1 mediated T cell adhesiveness.
    • Letschka T., Kollmann V., Pfeifhofer-Obermair C., Lutz-Nicoladoni C., Obermair G.J., Fresser F., Leitges M., Hermann-Kleiter N., Kaminski S., and Baier G. PKC θ selectively controls the adhesion-stimulating molecule Rap1. Blood 112 (2008) 4617-4627. Using molecular cell biology approaches as well as PKC isotype-deficient T cells, this study for the first time implicates PKCθ in TCR-induced Rap1 activation and LFA-1 mediated T cell adhesiveness.
    • (2008) Blood , vol.112 , pp. 4617-4627
    • Letschka, T.1    Kollmann, V.2    Pfeifhofer-Obermair, C.3    Lutz-Nicoladoni, C.4    Obermair, G.J.5    Fresser, F.6    Leitges, M.7    Hermann-Kleiter, N.8    Kaminski, S.9    Baier, G.10
  • 13
    • 51849106466 scopus 로고    scopus 로고
    • What's next in the pipeline
    • Vincenti F., and Kirk A.D. What's next in the pipeline. Am J Transplant 8 (2008) 1972-1981
    • (2008) Am J Transplant , vol.8 , pp. 1972-1981
    • Vincenti, F.1    Kirk, A.D.2
  • 14
    • 51349152055 scopus 로고    scopus 로고
    • The PKC inhibitor AEB071 may be a therapeutic option for psoriasis
    • This is the first study that demonstrates that treatment with a PKC inhibitor may improve the symptoms of patients suffering from severe psoriasis. Long-term studies will be required as a follow-up to this two-week proof-of-concept study to fully assess safety and efficacy of AEB071.
    • Skvara H., Dawid M., Kleyn E., Wolff B., Meingassner J.G., Knight H., Dumortier T., Kopp T., Fallahi N., Stary G., et al. The PKC inhibitor AEB071 may be a therapeutic option for psoriasis. J Clin Invest 118 (2008) 3151-3159. This is the first study that demonstrates that treatment with a PKC inhibitor may improve the symptoms of patients suffering from severe psoriasis. Long-term studies will be required as a follow-up to this two-week proof-of-concept study to fully assess safety and efficacy of AEB071.
    • (2008) J Clin Invest , vol.118 , pp. 3151-3159
    • Skvara, H.1    Dawid, M.2    Kleyn, E.3    Wolff, B.4    Meingassner, J.G.5    Knight, H.6    Dumortier, T.7    Kopp, T.8    Fallahi, N.9    Stary, G.10
  • 15
    • 0017745032 scopus 로고
    • Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum
    • Takai Y., Kishimoto A., Inoue M., and Nishizuka Y. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J Biol Chem 252 (1977) 7603-7609
    • (1977) J Biol Chem , vol.252 , pp. 7603-7609
    • Takai, Y.1    Kishimoto, A.2    Inoue, M.3    Nishizuka, Y.4
  • 16
    • 55949109631 scopus 로고    scopus 로고
    • Structural basis of protein kinase C isoform function
    • Steinberg S.F. Structural basis of protein kinase C isoform function. Physiol Rev 88 (2008) 1341-1378
    • (2008) Physiol Rev , vol.88 , pp. 1341-1378
    • Steinberg, S.F.1
  • 17
    • 10344252920 scopus 로고    scopus 로고
    • Molecular genetics and structural genomics of the human protein kinase C gene module
    • Kofler K., Erdel M., Utermann G., and Baier G. Molecular genetics and structural genomics of the human protein kinase C gene module. Genome Biol (2002) 3
    • (2002) Genome Biol , pp. 3
    • Kofler, K.1    Erdel, M.2    Utermann, G.3    Baier, G.4
  • 18
    • 64149118960 scopus 로고    scopus 로고
    • Newton AC: Lipid activation of protein kinases. J Lipid Res 2008 Nov 24. [Epub ahead of print] PMID: 19033211.
    • Newton AC: Lipid activation of protein kinases. J Lipid Res 2008 Nov 24. [Epub ahead of print] PMID: 19033211.
  • 19
    • 58149169884 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm
    • Gallegos L.L., and Newton A.C. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life 60 (2008) 782-789
    • (2008) IUBMB Life , vol.60 , pp. 782-789
    • Gallegos, L.L.1    Newton, A.C.2
  • 20
    • 0027418818 scopus 로고
    • Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    • Baier G., Telford D., Giampa L., Coggeshall K.M., Baier-Bitterlich G., Isakov N., and Altman A. Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 268 (1993) 4997-5004
    • (1993) J Biol Chem , vol.268 , pp. 4997-5004
    • Baier, G.1    Telford, D.2    Giampa, L.3    Coggeshall, K.M.4    Baier-Bitterlich, G.5    Isakov, N.6    Altman, A.7
  • 22
    • 0033625869 scopus 로고    scopus 로고
    • Protein kinase C θ: a new essential superstar on the T cell stage
    • Altman A., Isakov N., and Baier G. Protein kinase C θ: a new essential superstar on the T cell stage. Immunol Today 21 (2000) 567-573
    • (2000) Immunol Today , vol.21 , pp. 567-573
    • Altman, A.1    Isakov, N.2    Baier, G.3
  • 23
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of PKC θ during T cell activation
    • Monks C.R., Kupfer H., Tamir I., Barlow A., and Kupfer A. Selective modulation of PKC θ during T cell activation. Nature 385 (1997) 83-86
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 26
    • 33645733203 scopus 로고    scopus 로고
    • Comment on 'PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation'
    • Gruber T., Freeley M., Thuille N., Heit I., Shaw S., Long A., and Baier G. Comment on 'PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation'. Science 312 (2006) 55
    • (2006) Science , vol.312 , pp. 55
    • Gruber, T.1    Freeley, M.2    Thuille, N.3    Heit, I.4    Shaw, S.5    Long, A.6    Baier, G.7
  • 27
  • 28
    • 0035377216 scopus 로고    scopus 로고
    • Crucial importance of PKC β(I) in LFA-1-mediated locomotion of activated T cells
    • Volkov Y., Long A., McGrath S., Ni Eidhin D., and Kelleher D. Crucial importance of PKC β(I) in LFA-1-mediated locomotion of activated T cells. Nat Immunol 2 (2001) 508-514
    • (2001) Nat Immunol , vol.2 , pp. 508-514
    • Volkov, Y.1    Long, A.2    McGrath, S.3    Ni Eidhin, D.4    Kelleher, D.5
  • 30
    • 64149107933 scopus 로고    scopus 로고
    • PKC θ cooperates with atypical PKC ζ and PKC ι in NF-κB transactivation of T lymphocytes
    • Gruber T., Fresser F., Jenny M., Uberall F., Leitges M., and Baier G. PKC θ cooperates with atypical PKC ζ and PKC ι in NF-κB transactivation of T lymphocytes. Mol Immunol (2007)
    • (2007) Mol Immunol
    • Gruber, T.1    Fresser, F.2    Jenny, M.3    Uberall, F.4    Leitges, M.5    Baier, G.6
  • 33
    • 2342493308 scopus 로고    scopus 로고
    • Protein kinase C family functions in B cell activation
    • Guo B., Su T.T., and Rawlings D.J. Protein kinase C family functions in B cell activation. Curr Opin Immunol 16 (2004) 367-373
    • (2004) Curr Opin Immunol , vol.16 , pp. 367-373
    • Guo, B.1    Su, T.T.2    Rawlings, D.J.3
  • 34
    • 0347986633 scopus 로고    scopus 로고
    • Emerging and diverse roles of protein kinase C in immune cell signalling
    • Tan S.L., and Parker P.J. Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J 376 (2003) 545-552
    • (2003) Biochem J , vol.376 , pp. 545-552
    • Tan, S.L.1    Parker, P.J.2
  • 35
    • 0034996065 scopus 로고    scopus 로고
    • Protein kinase C isoenzymes: selective expression pattern of protein kinase C θ; during mouse development
    • Wilda M., Ghaffari-Tabrizi N., Reisert I., Utermann G., Baier G., and Hameister H. Protein kinase C isoenzymes: selective expression pattern of protein kinase C θ; during mouse development. Mech Dev 103 (2001) 197-200
    • (2001) Mech Dev , vol.103 , pp. 197-200
    • Wilda, M.1    Ghaffari-Tabrizi, N.2    Reisert, I.3    Utermann, G.4    Baier, G.5    Hameister, H.6
  • 36
    • 34250692040 scopus 로고    scopus 로고
    • Protein kinase C θ (PKCθ): a key player in T cell life and death
    • Hayashi K., and Altman A. Protein kinase C θ (PKCθ): a key player in T cell life and death. Pharmacol Res 55 (2007) 537-544
    • (2007) Pharmacol Res , vol.55 , pp. 537-544
    • Hayashi, K.1    Altman, A.2
  • 38
    • 48749103031 scopus 로고    scopus 로고
    • The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
    • In this study orphan receptor NR2F6, a direct substrate and effector of PKC, is established as transcriptional repressor to NFAT/AP-1 and subsequently IL-17 transcription and Nr2f6-deficient mice have hyper-reactive lymphocytes and develop autoimmune pathology.
    • Hermann-Kleiter N., Gruber T., Lutz-Nicoladoni C., Thuille N., Fresser F., Labi V., Schiefermeier N., Warnecke M., Huber L., Villunger A., et al. The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity 29 (2008) 205-216. In this study orphan receptor NR2F6, a direct substrate and effector of PKC, is established as transcriptional repressor to NFAT/AP-1 and subsequently IL-17 transcription and Nr2f6-deficient mice have hyper-reactive lymphocytes and develop autoimmune pathology.
    • (2008) Immunity , vol.29 , pp. 205-216
    • Hermann-Kleiter, N.1    Gruber, T.2    Lutz-Nicoladoni, C.3    Thuille, N.4    Fresser, F.5    Labi, V.6    Schiefermeier, N.7    Warnecke, M.8    Huber, L.9    Villunger, A.10
  • 40
    • 34447327781 scopus 로고    scopus 로고
    • Regulation of T cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules
    • Menasche G., Kliche S., Bezman N., and Schraven B. Regulation of T cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules. Immunol Rev 218 (2007) 82-91
    • (2007) Immunol Rev , vol.218 , pp. 82-91
    • Menasche, G.1    Kliche, S.2    Bezman, N.3    Schraven, B.4
  • 41
    • 28244464872 scopus 로고    scopus 로고
    • Protein kinase C θ controls Th1 cells in experimental autoimmune encephalomyelitis
    • Salek-Ardakani S., So T., Halteman B.S., Altman A., and Croft M. Protein kinase C θ controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol 175 (2005) 7635-7641
    • (2005) J Immunol , vol.175 , pp. 7635-7641
    • Salek-Ardakani, S.1    So, T.2    Halteman, B.S.3    Altman, A.4    Croft, M.5
  • 42
    • 33644512418 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice
    • Tan S.L., Zhao J., Bi C., Chen X.C., Hepburn D.L., Wang J., Sedgwick J.D., Chintalacharuvu S.R., and Na S. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice. J Immunol 176 (2006) 2872-2879
    • (2006) J Immunol , vol.176 , pp. 2872-2879
    • Tan, S.L.1    Zhao, J.2    Bi, C.3    Chen, X.C.4    Hepburn, D.L.5    Wang, J.6    Sedgwick, J.D.7    Chintalacharuvu, S.R.8    Na, S.9
  • 43
    • 8444243253 scopus 로고    scopus 로고
    • Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C θ
    • Salek-Ardakani S., So T., Halteman B.S., Altman A., and Croft M. Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C θ. J Immunol 173 (2004) 6440-6447
    • (2004) J Immunol , vol.173 , pp. 6440-6447
    • Salek-Ardakani, S.1    So, T.2    Halteman, B.S.3    Altman, A.4    Croft, M.5
  • 44
    • 38649118188 scopus 로고    scopus 로고
    • Protein kinase C θ plays a fundamental role in different types of chronic colitis
    • This is the first study showing a role of PKC θ in experimental colitis, a mouse model similar to inflammatory bowel disease.
    • Nagahama K., Ogawa A., Shirane K., Shimomura Y., Sugimoto K., and Mizoguchi A. Protein kinase C θ plays a fundamental role in different types of chronic colitis. Gastroenterology 134 (2008) 459-469. This is the first study showing a role of PKC θ in experimental colitis, a mouse model similar to inflammatory bowel disease.
    • (2008) Gastroenterology , vol.134 , pp. 459-469
    • Nagahama, K.1    Ogawa, A.2    Shirane, K.3    Shimomura, Y.4    Sugimoto, K.5    Mizoguchi, A.6
  • 46
    • 18744364178 scopus 로고    scopus 로고
    • Protein kinase C θ is not essential for T cell-mediated clearance of murine γ-herpesvirus 68
    • Giannoni F., Lyon A.B., Wareing M.D., Dias P.B., and Sarawar S.R. Protein kinase C θ is not essential for T cell-mediated clearance of murine γ-herpesvirus 68. J Virol 79 (2005) 6808-6813
    • (2005) J Virol , vol.79 , pp. 6808-6813
    • Giannoni, F.1    Lyon, A.B.2    Wareing, M.D.3    Dias, P.B.4    Sarawar, S.R.5
  • 47
    • 47949130474 scopus 로고    scopus 로고
    • A critical role for protein kinase C θ-mediated T cell survival in cardiac allograft rejection
    • This is the first study showing a role of PKC θ in alloreactivity and graft survival of experimental organ transplants.
    • Manicassamy S., Yin D., Zhang Z., Molinero L.L., Alegre M.L., and Sun Z. A critical role for protein kinase C θ-mediated T cell survival in cardiac allograft rejection. J Immunol 181 (2008) 513-520. This is the first study showing a role of PKC θ in alloreactivity and graft survival of experimental organ transplants.
    • (2008) J Immunol , vol.181 , pp. 513-520
    • Manicassamy, S.1    Yin, D.2    Zhang, Z.3    Molinero, L.L.4    Alegre, M.L.5    Sun, Z.6
  • 49
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • The most comprehensive study of kinase selectivity to date including >50% of the predicted human protein kinome. The interaction maps of 38 kinase inhibitors that are marketed or in late stage developed reveal very diverse interaction patterns.
    • Karaman M.W., Herrgard S., Treiber D.K., Gallant P., Atteridge C.E., Campbell B.T., Chan K.W., Ciceri P., Davis M.I., Edeen P.T., et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26 (2008) 127-132. The most comprehensive study of kinase selectivity to date including >50% of the predicted human protein kinome. The interaction maps of 38 kinase inhibitors that are marketed or in late stage developed reveal very diverse interaction patterns.
    • (2008) Nat Biotechnol , vol.26 , pp. 127-132
    • Karaman, M.W.1    Herrgard, S.2    Treiber, D.K.3    Gallant, P.4    Atteridge, C.E.5    Campbell, B.T.6    Chan, K.W.7    Ciceri, P.8    Davis, M.I.9    Edeen, P.T.10
  • 50
    • 0346494560 scopus 로고    scopus 로고
    • Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
    • Donnelly R., Idris I., and Forrester J.V. Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research. Br J Ophthalmol 88 (2004) 145-151
    • (2004) Br J Ophthalmol , vol.88 , pp. 145-151
    • Donnelly, R.1    Idris, I.2    Forrester, J.V.3
  • 52
    • 33751570046 scopus 로고    scopus 로고
    • Structure of the catalytic domain of human protein kinase C β II complexed with a bisindolylmaleimide inhibitor
    • Grodsky N., Li Y., Bouzida D., Love R., Jensen J., Nodes B., Nonomiya J., and Grant S. Structure of the catalytic domain of human protein kinase C β II complexed with a bisindolylmaleimide inhibitor. Biochemistry 45 (2006) 13970-13981
    • (2006) Biochemistry , vol.45 , pp. 13970-13981
    • Grodsky, N.1    Li, Y.2    Bouzida, D.3    Love, R.4    Jensen, J.5    Nodes, B.6    Nonomiya, J.7    Grant, S.8
  • 54
    • 53549089928 scopus 로고    scopus 로고
    • Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ inhibitors
    • In this study, the discovery of a novel class of PKC inhibitors is described. The optimized compounds are selective for PKC θ over the other isotypes and a range of serine/threonine or tyrosine kinases.
    • Cole D.C., Asselin M., Brennan A., Czerwinski R., Ellingboe J.W., Fitz L., Greco R., Huang X., Joseph-McCarthy D., Kelly M.F., et al. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ inhibitors. J Med Chem 51 (2008) 5958-5963. In this study, the discovery of a novel class of PKC inhibitors is described. The optimized compounds are selective for PKC θ over the other isotypes and a range of serine/threonine or tyrosine kinases.
    • (2008) J Med Chem , vol.51 , pp. 5958-5963
    • Cole, D.C.1    Asselin, M.2    Brennan, A.3    Czerwinski, R.4    Ellingboe, J.W.5    Fitz, L.6    Greco, R.7    Huang, X.8    Joseph-McCarthy, D.9    Kelly, M.F.10


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