Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 2, 2013, Pages 448-455

  Wang, Hai Hong ^a   Qiu, Ke Ming ^a   Cui, Hong En ^a   Yang, Yu Shun ^a   Yin Luo, ^a   Xing, Man ^a   Qiu, Xiao Yang ^b   Bai, Li Fei ^c   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b SHANGQIU NORMAL UNIVERSITY   (China)

^c JIANGSU SECOND NORMAL UNIVERSITY   (China)

Author keywords

Benzodioxole; HER 2; Pyrazoline; Thiazole

Indexed keywords

2 [3 (4 BROMOPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [3 (4 CHLOROPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXOL 5 YL) 3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXOL 5 YL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXOL 5 YL) 3 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 BROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 BROMOPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 BROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 BROMOPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 BROMOPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 BROMOPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (PARA TOLYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 BROMOPHENYL)THIAZOLE; 2 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (PARA TOLYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 (4 METHOXYPHENYL)THIAZOLE; 4 (4 BROMOPHENYL) 2 [3 (4 BROMOPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOZIN 6 YL) 4,5 DIHYDRO 1H PYRAZOL ]THIAZOLE; 4 (4 BROMOPHENYL) 2 [3 (4 CHLOROPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]THIAZOLE; 4 (4 BROMOPHENYL) 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]THIAZOLE; 4 (4 BROMOPHENYL) 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]THIAZOLE; 4 (4 BROMOPHENYL) 2 [5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 3 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]THIAZOLE; ANTINEOPLASTIC AGENT; THIAZOLYL PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN; CELL STRAIN B16 F10; CELL STRAIN MCF 7; COLORIMETRY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; BENZODIOXOLES; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MCF-7 CELLS; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84871629109     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.020     Document Type: Article

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