SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 2, 2012, Pages 877-885

Synthesis and biological evaluation of 4-[3-chloro-4-(3-fluorobenzyloxy) anilino]-6-(3-substituted-phenoxy)pyrimidines as dual EGFR/ErbB-2 kinase inhibitors

(5) Li, Siyuan a Guo, Chunying a Zhao, Hongli a Tang, Yun a Lan, Minbo a,b

a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

Author keywords

Docking; EGFR; ErbB 2; Inhibitor; Pyrimidine

Indexed keywords

4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (2,4,5 TRIFLUOROPHENYLAACETAMIDO)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 ACETAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 ACRYLAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 AMINOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 CINNAMAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 CYANOACETAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 DIMETHOXYCINNAMAMIDO)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 FUMARICAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 NITROPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 P FLUOROCINNAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 P NITROBENZAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 PHENOXYACETAMIDOPHENOXY)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 (3 PHENYLETHYLAMINO)PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 [3 (2 ETHOXYCARBONYLETHYLAMINO)PHENOXY]PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 [3 (3,4,5 DIMETHOXYPHENOXYACETAMIDO)PHENOXY]PYRIMIDINE; 4 [3 CHLORO 4 (3 FLUOROBENZYLOXY)ANILO] 6 [3 (3,4,5 TRIFLUOROPHENOXYACETAMIDO)PHENOXY]PYRIMIDINE; 4 [3 CHLORO 4 (FLUOROBENZYLOXY)AMINO] 6 (3 SUBSTITUTED PHENOXY)PYRIMIDINE DERIVATIVE; 4 CHLORO 6 (NITROPHENOXY)PYRIMIDINE; ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; LAPATINIB; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG BINDING; DRUG DESIGN; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PROTEIN BINDING;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; ENZYME ACTIVATION; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 84855781201 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.11.056 Document Type: Article

Times cited : (23)

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