Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 4991-4996

  Qian, Yong ^a   Zhang, Hong Jia ^a   Zhang, Hao ^a   Xu, Chen ^a   Zhao, Jing ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Anticancer; Cinnamic acid; EGFR; Metronidazole

Indexed keywords

2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL 3 (4 PHENYL)ACRYLATE; ANTINEOPLASTIC AGENT; CINNAMIC ACID DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; METRONIDAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; THREE DIMENSIONAL IMAGING;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; METRONIDAZOLE; MODELS, MOLECULAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 77955339692     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.003     Document Type: Article

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